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| 1 | Spontaneous bacterial peritonitis: The clinical challenge of a leaky gut and a cirrhotic liver显示文摘Spontaneous bacterial peritonitis(SBP) is a frequent, life-threatening bacterial infection in patients with liver cirrhosis and ascites. Portal hypertension leads to increased bacterial translocation from the intestine. Failure to eliminate invading pathogens due to immune defects associated with advanced liver disease on the background of genetic predisposition may result in SBP. The efficacy of antibiotic treatment and prophylaxis has declined due to the spread of multi-resistant bacteria. Patients with nosocomial SBP and with prior antibiotictreatment are at a particularly high risk for infection with resistant bacteria. Therefore, it is important to adapt empirical treatment to these risk factors and to the local resistance profile. Rifaximin, an oral, nonabsorbable antibiotic, has been proposed to prevent SBP, but may be useful only in a subset of patients. Since novel antibiotic classes are lacking, we have to develop prophylactic strategies which do not induce bacterial resistance. Farnesoid X receptor agonists may be a candidate, but so far, clinical studies are not available. New diagnostic tests which can be carried out quickly at the patient's site and provide additional prognostic information would be helpful. Furthermore, we need tools to predict antibiotic resistance in order to tailor first-line antibiotic treatment of spontaneous bacterial peritonitis to the individual patient and to reduce mortality. | Philipp Lutz Hans Dieter Nischalke Christian P Strassburg Ulrich Spengler | 2015 | World Journal of Hepatology2015，7，3： | 12 |
| 2 | Gastroenteropancreatic neuroendocrine tumours显示文摘 | Irvin M Modlin Kjell Oberg Daniel C Chung Robert T Jensen Wouter W de Herder Rajesh V Thakker Martyn Caplin Gianfranco Delle Fave Greg A Kaltsas Eric P Krenning Steven F Moss Ola Nilsson Guido Rindi Ramon Salazar Philippe Ruszniewski Anders Sundin | 2008 | Lancet Oncology2008，，1： | 8 |
| 3 | A longitudinal study of SARS-CoV-2-infected patients reveals a high correlation between neutralizing antibodies and COVID-19 severity显示文摘Understanding the immune responses elicited by SARS-CoV-2 infection is critical in terms of protection against reinfection and,thus,for public health policy and vaccine development for COVID-19.In this study,using either live SARS-CoV-2 particles or retroviruses pseudotyped with the SARS-CoV-2 S viral surface protein(Spike),we studied the neutralizing antibody(nAb)response in serum samples from a cohort of 140 SARS-CoV-2 qPCR-confirmed infections,including patients with mild symptoms and also more severe forms,including those that required intensive care.We show that nAb titers correlated strongly with disease severity and with anti-spike IgG levels.Indeed,patients from intensive care units exhibited high nAb titers;conversely,patients with milder disease symptoms had heterogeneous nAb titers,and asymptomatic or exclusive outpatient-care patients had no or low nAbs.We found that nAb activity in SARS-CoV-2-infected patients displayed a relatively rapid decline after recovery compared to individuals infected with other coronaviruses.Moreover,we found an absence of cross-neutralization between endemic coronaviruses and SARS-CoV-2,indicating that previous infection by human coronaviruses may not generate protective nAbs against SARS-CoV-2.Finally,we found that the D614G mutation in the spike protein,which has recently been identified as the current major variant in Europe,does not allow neutralization escape.Altogether,our results contribute to our understanding of the immune correlates of SARS-CoV-2-induced disease,and rapid evaluation of the role of the humoral response in the pathogenesis of SARS-CoV-2 is warranted. | Vincent Legros Solène Denolly Manon Vogrig Bertrand Boson Eglantine Siret Josselin Rigaill Sylvie Pillet Florence Grattard Sylvie Gonzalo Paul Verhoeven Omran Allatif Philippe Berthelot Carole Pélissier Guillaume Thiery Elisabeth Botelho-Nevers Guillaume Millet Jérôme Morel Stéphane Paul Thierry Walzer François-Loïc Cosset Thomas Bourlet Bruno Pozzetto | 2021 | Cellular & Molecular Immunology2021，18，2： | 3 |
| 4 | Improved clinical outcome using polytetrafluoroethylene-coated stents for tips: Results of a randomized study显示文摘 | Christophe Bureau Juan carlos Garcia-Pagan Philippe Otal Gilles Pomier-Layrargues Valérie Chabbert Carlos Cortez Pierre Perreault Jean marie Péron Juan G. Abraldes Louis Bouchard José Ignacio Bilbao Jaume Bosch Hervé Rousseau Jean pierre Vinel | 2004 | Gastroenterology2004，，2： | 3 |
| 5 | Pandemic influenza 2009: Impact of vaccination coverage on critical illness in children, a Canada and France observational study显示文摘AIM To study the impact of vaccination critical illness due to H1N1pdm09, we compared the incidence and severity of H1N1pdm09 infection in Canada and France.METHODS We studied two national cohorts that included children with documented H1N1pdm09 infection, admitted to a pediatric intensive care unit(PICU) in Canada and in France between October 1, 2009 and January 31, 2010.RESULTS Vaccination coverage prior to admission to PICUs was higher in Canada than in France(21% vs 2% of children respectively, P < 0.001), and in both countries, vaccination coverage prior to admission of these critically ill patients was substantially lower than in the general pediatric population(P < 0.001). In Canada, 160 children(incidence = 2.6/100000 children) were hospitalized in PICU compared to 125 children(incidence = 1.1/100000) in France(P < 0.001). Mortality rates were similar in Canada and France(4.4% vs 6.5%, P = 0.45, respectively), median invasive mechanical ventilation duration and mean PICU length of stay were shorter in Canada(4 d vs 6 d, P = 0.02 and 5.7 d vs 8.2 d, P = 0.03, respectively). H1N1pdm09 vaccination prior to PICU admission was associated with a decreased risk of requiring invasive mechanical ventilation(OR = 0.30, 95%CI: 0.11-0.83, P = 0.02).CONCLUSION The critical illness due to H1N1pdm09 had a higher incidence in Canada than in France. Critically ill children were less likely to have received vaccination prior to hospitalization in comparison to general population and children vaccinated had lower risk of ventilation. | Olivier Fléchelles Olivier Brissaud Robert Fowler Thierry Ducruet Philippe Jouvet the Pediatric Canadian Critical Care Trials Group H1N1 Collaborative and Groupe Francophone de Réanimation et Urgences Pédiatriques | 2016 | World Journal of Clinical Pediatrics2016，5，4： | 2 |
| 6 | Noise Dressing of Financial Correlation Matrices 显示文摘 | PHILIPPE B MARC P | 1999 | Physical Review Letters1999，83，7： | 1 |
| 7 | Autochthonous eukary- otic diversity in hydrothermal sediment and experimental microeol- onizers at the Mid-Atlantic Ridge 显示文摘 | Lopez-Gareia P Philippe H Gail F | 2003 | Proc Natl Acad Sci USA2003，100，2： | 1 |
| 8 | 1,3-Diary-4,5,6,7-tetrahydro-2H-isoindole deriv atives:a new series of potent and selective COX-2 inhibitors in which a sulfonyl group is not a structural requisite显示文摘 | Bernard P Charles T Philippe P | 2000 | J Med Chem2000，43，24： | 1 |
| 9 | Dementia patients显示文摘 | Philippe T Fabrice L Pierre-Marie P | 2006 | Journal of Ceriatric Psychiatry2006，21，： | 1 |
| 10 | Cellulose ethers influence on water retention and consistency in cement-based mortars 显示文摘 | Laetitia P Philippe M Alexandre G | 2011 | Cement and Concrete Research2011，41，1： | 1 |
| 11 | Trace analysis of sulfonylurea herbicides and their metabolites in water using a combination of off- line or on-line solid-phase extraction and liquid chromatography- tandem mass spectrometry 显示文摘 | Francois P Philippe B Lucien K | 2007 | Analytical and Bioanalytieal Chemistry2007，388，56： | 1 |
| 12 | Soluble triggering receptor expressed on myeloid cells-1 is released in patients with stable chronic obstructive pulmonary disease 显示文摘 | Markus P Christian T Philipp H | 2007 | Chn Devel Immunol2007，11，55： | 1 |
| 13 | Isolation and genetic characterization of H5N2 influenza viruses from pigs in korea显示文摘 | Jun H L Philippe N Q P Min Suk S | 2009 | Journal of Virology2009，83，9： | 1 |
| 14 | Electrostatic deflections and electronmechanical resonance of carbon nanotubes显示文摘 | PHILIPPE P WANG Z L DANIEL U | 1999 | Science1999，283，： | 1 |
| 15 | Carbon-nanofibre-reinforced poly (ether ether ketone) composites显示文摘 | Jan S Philipp W Milo S P Shaffer | 2002 | Composites:Part A2002，33，8： | 1 |
| 16 | Wavelet packet filterbanks for low time delay audio coding显示文摘 | Philippe P de Saint-Martin F M Lever M | 1999 | IEEE Transactions on Speech and Audio Processing1999，7，3： | 1 |
| 17 | Organochlorine exposure and risk of breast cancer显示文摘 | Annette P H Philippe G Torben J | 1998 | Lancet1998，352，： | 1 |
| 18 | The importance of the SMN genes in the genetics of sporadic ALS 显示文摘 | Philippe C William C Julien P | 2009 | Amyothophic Lateral Sclerosis2009，10，56： | 1 |
| 19 | A literature review of cardiopulmonary bypass models for rats显示文摘 | Philippe K Terence G Chandi P | 1999 | Perfusion1999，14，6： | 1 |
| 20 | Evolution of patterns of differential gene expression:A comparison of the temporal and spatial patterns of isozyme lotus expression in two closely related fish species显示文摘 | Philipp D P | 1979 | J EXP Zool1979，210，： | 1 |
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