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| 1 | Systemic inflammation in colorectal cancer: Underlying factors,effects, and prognostic significance显示文摘Systemic inflammation is a marker of poor prognosis preoperatively present in around 20%-40%of colorectal cancer patients.The hallmarks of systemic inflammation include an increased production of proinflammatory cytokines and acute phase proteins that enter the circulation.While the low-level systemic inflammation is often clinically silent,its consequences are many and may ultimately lead to chronic cancer-associated wasting,cachexia.In this review,we discuss the pathogenesis of cancer-related systemic inflammation,explore the role of systemic inflammation in promoting cancer growth,escaping antitumor defense,and shifting metabolic pathways,and how these changes are related to less favorable outcome. | Anne E Tuomisto Markus J Makinen Juha P Vayrynen | 2019 | World Journal of Gastroenterology2019，25，31： | 27 |
| 2 | Are there new approaches for diagnosis, therapy guidance and outcome prediction of sepsis?显示文摘Beside many efforts to improve outcome, sepsis is still one of the most frequent causes of death in critically ill patients. It is the most common condition with high mortality in intensive care units. The complexity of the septic syndrome comprises immunological aspects- i.e.,sepsis induced immunosuppression- but is not restricted to this fact in modern concepts. So far, exact mechanisms and variables determining outcome and mortality stay unclear. Since there is no typical risk profile, early diagnosis and risk stratification remain difficult, which hinders rapid and effective treatment initiation. Due to the heterogeneous nature of sepsis, potential therapy options should be adapted to the individual. Biomarkers like C-reactive protein and procalcitonin are routinely used as complementary tools in clinical decision-making. Beyond the acute phase proteins, a wide bunch of promising substances and non-laboratory tools with potential diagnostic and prognostic value is under intensive investigation. So far, clinical decision just based on biomarker assessment is not yet feasible. However, biomarkers should be considered as a complementary approach. | Dubravka Kojic Benedikt H Siegler Florian Uhle Christoph Lichtenstern Peter P Nawroth Markus A Weigand Stefan Hofer Thorsten Brenner | 2015 | World Journal of Experimental Medicine2015，5，2： | 14 |
| 3 | Sodium glucose co-transporter 2 inhibition reduces succinate levels in diabetic mice显示文摘BACKGROUND Type 1 diabetes(T1D) is associated with major chronic microvascular complications which contribute significantly to diabetes associated morbidity.The protein primarily responsible for glucose reabsorption in the kidney is sodium glucose co-transporter 2(SGLT2). Presently, SGLT2 inhibitors are widely used in diabetic patients to improve blood glucose levels and prevent cardiovascular and renal complications. Given the broad therapeutic application of SGLT2 inhibitors, we hypothesised that SGLT2 inhibition may exert its protective effects via alterations of the gut microbiome and tested this in a type 1 diabetic mouse model of diabetic retinopathy.AIM To determine whether the treatment with two independent SGLT2 inhibitors affects gut health in a type 1 diabetic mouse model.METHODS The SGLT2 inhibitors empagliflozin or dapagliflozin(25 mg/kg/d) or vehicle dimethylsulfoxide(DMSO) were administered to C57 BL/6 J, Akita, Kimba and Akimba mice at 10 wk of age for 8 wk via their drinking water. Serum samples were collected and the concentration of succinate and the short chain fatty acid(SCFA) butyric acid was measured using gas chromatography-mass spectrometry. Enzyme-linked immunosorbent assay(ELISA) was performed to determine the concentration of insulin and leptin. Furthermore, the norepinephrine content in kidney tissue was determined using ELISA. Pancreatic tissue was collected and stained with haematoxylin and eosin and analysed using brightfield microscopy.RESULTS Due to the presence of the Akita allele, both Akita and Akimba mice showed a reduction in insulin production compared to C57 BL/6 J and Kimba mice.Furthermore, Akita mice also showed the presence of apoptotic bodies within the pancreatic islets. The acinar cells of Akita and Akimba mice showed swelling which is indicative of acute injury or pancreatitis. After 8 wk of SGLT2 inhibition with dapagliflozin, the intermediate metabolite of gut metabolism known as succinate was significantly reduced in Akimba mice when compared to DMSO treated mice. In addition, empagliflozin resulted in suppression of succinate levels in Akimba mice. The beneficial SCFA known as butyric acid was significantly increased in Akita mice after treatment with dapagliflozin when compared to vehicle treated mice. The norepinephrine content in the kidney was significantly reduced with both dapagliflozin and empagliflozin therapy in Akita mice and was significantly reduced in Akimba mice treated with empagliflozin.In non-diabetic C57 BL/6 J and Kimba mice, serum leptin levels were significantly reduced after dapagliflozin therapy.CONCLUSION The inhibition of SGLT2 reduces the intermediate metabolite succinate, increases SCFA butyric acid levels and reduces norepinephrine content in mouse models of T1 D. Collectively, these improvements may represent an important mechanism underlying the potential benefits of SGLT2 inhibition in T1 D and its complications. | Lakshini Y Herat Natalie C Ward Aaron L Magno Elizabeth P Rakoczy Marcio G Kiuchi Markus P Schlaich Vance B Matthews | 2020 | World Journal of Gastroenterology2020，26，23： | 3 |
| 4 | Slacklining and stroke: A rehabilitation case study considering balance and lower limb weakness显示文摘To ascertain the effectiveness of slacklining as a supplementary therapy for elderly stroke patients who are functionally non-progressing. This case study involved an 18-mo prospective observation of the management of an 87-year-old female stroke-patient of the left hemisphere with reduced balance, reduced lower limb muscular activation, hypertonia, and concurrent postural deficits. This entailed the initial acute care phase through to discharge to home and 18-mo final status in her original independent living setting. The introduction of slacklining as an adjunct therapy was made 12 mo post incident. Slacklining involves balance retention on a tightened band where external environmental changes cause a whole-body dynamic response to retain equilibrium. It is a complex neuromechanical task enabling individualized self-developed response strategies to be learned and adapted. This facilitates the innate process of balance retention, lower-limb and core muscle activation, and stable posture through a combination of learned motor skills and neurological system down regulation. Individuals adopt and follow established sequential motor learning stages where the acquired balance skillsare achieved in a challenging composite-chain activity. Slacklining could be considered an adjunct therapy for lower limb stroke rehabilitation where function is compromised due to decreased muscle recruitment, decreased postural control and compromised balance. Initial inpatient rehabilitation involved one-month acute-care, one-month rehabilitation, and one-month transitional care prior to home discharge. A further six months of intensive outpatient rehabilitation was provided with five hourly sessions per week including:supervised and self-managed hydrotherapy, plus one individual and two group falls' prevention sessions. These were supported by daily home exercises. At 12 mo post incident, recovery plateaued, then regressed following three falls. Rehabilitation was subsequently modified with the hydrotherapy retained and the group sessions replaced with an additional individual session supplemented with slacklining. The slacklining followed stages one and two of a standardized five-stage protocol. Self-reported functional progression resumed with improvement by 14 mo which further increased and was sustained 18 mo(Students' t test P < 0.05). Slacklining's external stimulations activate global-body responses through innate balance, optimal postural and potentially down-regulated reflex control. Incorporated into stroke rehabilitation programs, slacklining can provide measurable functional gains. | Charles P Gabel Natalie Rando Markus Melloh | 2016 | World Journal of Orthopedics2016，7，8： | 2 |
| 5 | Profound neutralization evasion and augmented host cell entry are hallmarks of the fast-spreading SARS-CoV-2 lineage XBB.1.5显示文摘Since late 2022, the share of infections caused by the SARS-CoV2 lineage XBB.1.5 has gradually increased in the United States,resulting in XBB.1.5 becoming the dominating SARS-CoV-2lineage in the United States and a similar trend is likely to soontake place also in European countries. However, information onthe virological properties of XBB.1.5 is scarce. Here, weconducted an initial virological assessment of the SARS-CoV-2XBB.1.5 lineage. | Markus Hoffmann Prerna Arora Inga Nehlmeier Amy Kempf Anne Cossmann Sebastian R.Schulz Gema Morillas Ramos Luis A.Manthey Hans-Martin Jäck Georg M.N.Behrens Stefan Pöhlmann | 2023 | Cellular & Molecular Immunology2023，20，4： | 2 |
| 6 | Rapid and robust slope failure appraisal using aerial photogrammetry and 3D slope stability models显示文摘Slope failures are an inevitable aspect of economic pit slope designs in the mining industry.Large open pit guidelines and industry standards accept up to 30%of benches in open pits to collapse provided that they are controlled and that no personnel are at risk.Rigorous ground control measures including real time monitoring systems at TARP(trigger-action-response-plan)protocols are widely utilized to prevent personnel from being exposed to slope failure risks.Technology and computing capability are rapidly evolving.Aerial photogrammetry techniques using UAV(unmanned aerial vehicle)enable geotechnical engineers and engineering geologists to work faster and more safely by removing themselves from potential line-of-fire near unstable slopes.Slope stability modelling software using limit equilibrium(LE)and finite element(FE)methods in three dimensions(3D)is also becoming more accessible,user-friendly and faster to operate.These key components enable geotechnical engineers to undertake site investigations,develop geotechnical models and assess slope stability faster and in more detail with less exposure to fall of ground hazards in the field.This paper describes the rapid and robust process utilized at BHP Limited for appraising a slope failure at an iron ore mine site in the Pilbara region of Western Australia using a combination of UAV photogrammetry and 3D slope stability models in less than a shift(i.e.less than 12 h). | Neil Bar Michael Kostadinovski Michael Tucker Glen Byng Rully Rachmatullah Arturo Maldonado Markus Pötsch Andreas Gaich Alison McQuillan Thamer Yacoub | 2020 | International Journal of Mining Science and Technology2020，30，5： | 2 |
| 7 | Technical Progress, Structural Change, and the Environmental Kuznets Curve 显示文摘 | Markus P | 2002 | Ecological Economics2002，，42： | 1 |
| 8 | IUPAC collaborative trial study of a method to detect genetically modified soy beans and maize in dried powder显示文摘 | Peter B Klaus P | 1999 | Journal of AOAC International1999，82，4： | 1 |
| 9 | RAPD variation among and within small and large populations of the rare clonal plant Ranunculm reptans(Ranuneulaeeae ) 显示文摘 | MARKUS F RENE H DANIEL P | 2000 | American Journal of Botany2000，87，： | 1 |
| 10 | Information Hiding-A Survey显示文摘 | Fabien A P Petitcolas Ross J Anderson Markus G Kuhn | 1999 | Prpceedings of the IEEE1999，87，7： | 1 |
| 11 | Technical progress, Structural change, and the Environ- mental kuznets curve显示文摘 | P Markus | 2002 | Ecological Economics2002，，42： | 1 |
| 12 | Technical Progress, Structural Change, and the Environmental Kuznets Curve显示文摘 | Markus P | 2002 | Ecological Economics2002，42，3： | 1 |
| 13 | Association between degenerative aortic valve disease and long-term exposure to cardiovascular risk factors:results of the longitudinal populationbased KORA/MONICA survey显示文摘 | STRITZKE J LINSEL-NITSCHKE P MARKUS M R | 2009 | Eur Heart J2009，30，： | 1 |
| 14 | Pyridinyl polythiazole class peptide antiriotic microtic micrococcin pi, Secreted by foodbornh staphylococcus e guorm Ws2733, is biosynthesized nonribosomally显示文摘 | Markus C C Torsten S Kevin P F | 2001 | Eu J Biochem2001，268，： | 1 |
| 15 | Information hiding: a survey显示文摘 | FABIEN A P P ROSS J A MARKUS G K | 1999 | Proceedings of the IEEE Special Issue on Protection of Multimedia Content1999，87，7： | 1 |
| 16 | The transport geography of logistics and freight distribution显示文摘 | MARKUS H RODRIGUE J P | 2004 | Journal of Transport Geography2004，12，： | 1 |
| 17 | Soluble triggering receptor expressed on myeloid cells-1 is released in patients with stable chronic obstructive pulmonary disease 显示文摘 | Markus P Christian T Philipp H | 2007 | Chn Devel Immunol2007，11，55： | 1 |
| 18 | Possible selves显示文摘 | Markus H Nurius P | 1986 | American Psychologist1986，41，： | 1 |
| 19 | Information Hiding-A Survey显示文摘 | Ross J Anderson Markus G Kuhn | 1999 | Proceedings of the IEEE Special Issue on Protection of Multimedia Content1999，87，7： | 1 |
| 20 | High-sensitivity C-reactive protein is not associated with carotid intima-media progression:the carotid atherosclerosis progression study显示文摘 | Lorenz MW Karbstein P Markus HS | 2007 | Stroke2007，38，6： | 1 |
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