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| 1 | Locally advanced nasopharyngeal carcinoma:Current and emerging treatment strategies显示文摘Although nasopharyngeal carcinoma(NPC)is a widespread malignant tumor,it is particularly frequent in Southeast Asia.Although T1 tumors can be effectively controlled with exclusive radiotherapy,this treatment modality is insufficient for most NPC patients,who present with locally advanced disease at diagnosis.In fact,for stages ranging from T2b N0 to T4 N3,definitive scientific evidence supports the use of concurrent platinum-based chemotherapy with standard external beam radiotherapy.This treatment approach has shown a statistically significant advantage in terms of overall survival,with respect to radiotherapy alone.Several trials have also investigated the use of neoadjuvant and adjuvant chemotherapy in combination with radiotherapy or chemo-radiotherapy.Platinum compounds,anthracyclines and taxanes are among the chemotherapy agents employed.This review focuses on the clinical results obtained in the field of adjuvant/concurrent/neoadjuvant chemotherapy for locally advanced NPC,for which exclusive concurrent chemo-radiotherapy currently represents the standard treatment approach. | Francesco Perri Davide Bosso Carlo Buonerba Giuseppe Di Lorenzo Giuseppina Della Vittoria Scarpati | 2011 | World Journal of Clinical Oncology2011，2，12： | 24 |
| 2 | Combined chemo-radiotherapy in locally advanced nasopharyngeal carcinomas显示文摘AIM:To provide efficacy and safety data about the combined use of radiotherapy and chemo-radiotherapy in nasopharyngeal carcinoma(NPC).METHODS:We reviewed data of 40 patients with locally advanced NPC treated with induction chemotherapy followed by concomitant chemo-radiotherapy(CCRT)(22/40 patients)or CCRT alone(18/40)from March 2006 to March 2012.Patients underwent fiberoscopy with biopsy of the primitive tumor,and computed tomography scan of head,neck,chest and abdomen with and without contrast.Cisplatin was used both as induction and as concomitant chemotherapy,while 3D conformal radiation therapy was delivered to the nasopharynx and relevant anatomic regions(total dose,70 Gy).The treatment was performed using 6 MV photons of the linear accelerator administered in 2 Gy daily fraction for five days weekly.This retrospective analysis was approved by the review boards of the participating institutions.Patients gave their consent to treatment and to anonymous analysis of clinical data.RESULTS:Thirty-three patients were males and 7 were females.Median follow-up time was 58 mo(range,1-92 mo).In the sub-group of twenty patients with a follow-up time longer than 36 mo,the 3-year survival and disease free survival rates were 85%and 75%,respectively.Overall response rate both in patients treated with induction chemotherapy followed by CCRT and in those treated with CCRT alone was 100%.Grade 3 neutropenia was the most frequent acute side-effect and it occurred in 20 patients.Grade 2 mucositis was seen in 29 patients,while grade 2 xerostomia was seen in 30 patients.Overall toxicity was manageable and it did not cause any significant treatment delay.In the whole sample population,long term toxicity included grade 2 xerostomia in 22 patients,grade 1 dysgeusia in 17 patients and grade 1 subcutaneous fibrosis in 30 patients.CONCLUSION:Both CCRT and induction chemotherapy followed by CCRT showed excellent activity in locally advanced NPC.The role of adjuvant chemotherapy remains to be defined. | Francesco Perri Giuseppina Della Vittoria Scarpati Carlo Buonerba Giuseppe Di Lorenzo Francesco Longo Paolo Muto Concetta Schiavone Fabio Sandomenico Francesco Caponigro | 2013 | World Journal of Clinical Oncology2013，4，2： | 22 |
| 3 | Measuring consciousness in coma and related states显示文摘Consciousness is a prismatic and ambiguous concept that still eludes any universal definition. Severe acquired brain injuries resulting in a disorder of con-sciousness(DOC) provide a model from which insights into consciousness can be drawn. A number of recent studies highlight the difficulty in making a diagnosis in patients with DOC based only on behavioral assessments. Here we aim to provide an overview of how neuroimaging techniques can help assess patients with DOC. Such techniques are expected to facilitate a more accurate understanding of brain function in states of unconsciousness and to improve the evaluation of thepatient's cognitive abilities by providing both diagnostic and prognostic indicators. | Carol Di Perri Aurore Thibaut Lizette Heine Andrea Soddu Athena Demertzi Steven Laureys | 2014 | World Journal of Radiology2014，6，8： | 11 |
| 4 | Plasminogen kringle 5-engineered glioma cells block migration of tumor- associated macrophages and suppress tumor vascularization and progres- sion.显示文摘 | Perri SR Nalbantoglu J Annabi B Koty Z Lejeune L Francois M Di Falco MR Beliveau R Galipeau J | 2005 | 中国神经肿瘤杂志2005，3，3： | 8 |
| 5 | Optimal management of a patient with recurrent nasopharyngeal carcinoma显示文摘Nasopharyngeal carcinoma is rare in western countries, accounting for less than 1% of all malignancies. Despite prognosis is satisfactory for newly diagnosed, non-metastatic disease, management of recurrent disease is challenging, with a survival expectancy of approximately 6 mo with the use of chemotherapy as the sole salvage treatment. We report a case of recurrent nasopharyngeal carcinoma treated with a combination of chemotherapy, radiotherapy and surgery in the context of a multidisciplinary approach. A durable complete response was achieved. | Francesco Perri Italo Dell’Oca Paolo Muto Concetta Schiavone Corrado Aversa Franco Fulciniti Raffaele Solla Giuseppina Della Vittoria Scarpati Carlo Buonerba Giuseppe Di Lorenzo Francesco Caponigro | 2014 | World Journal of Clinical Cases2014，2，7： | 8 |
| 6 | Anaplastic thyroid carcinoma:A comprehensive review of current and future therapeutic options显示文摘Anaplastic thyroid carcinoma(ATC)is the rarest,but deadliest histologic type among thyroid malignancies,with a dismal median survival of 3-9 mo.Even though ATC accounts for less than 2%of all thyroid tumors,it is responsible for 14%-39%of thyroid carcinoma-related deaths.ATC clinically presents as a rapidly growing mass in the neck,associated with dyspnoea,dysphagia and vocal cord paralysis.It is usually locally advanced and often metastatic at initial presentation.For operable diseases,the combination of radical surgery with adjuvant radiotherapy or chemotherapy,using agents such as doxorubicin and cisplatin,is the best treatment strategy.Cytotoxic drugs for advanced/metastatic ATC are poorly effective.On the other hand,targeted agents might represent a viable therapeutic option.Axitinib,combretastatin A4,sorafenib and imatinib have been tested in small clinical trials of ATC,with a promising disease control rate ranging from 33%to 75%.Other clinical trials of targeted therapy for thyroid carcinoma are currently ongoing.Biological agents that are under investigation include pazopanib,gefitinib and everolimus.With the very limited therapeutic armamentarium available at the present time,targeted therapy constitutes an exciting new horizon for ATC.In future,biological agents will probably represent the standard of care for this aggressive malignancy,in the same fashion as it has recently occurred for other chemo-refractory tumors,such as kidney and hepatic cancer. | Francesco Perri Giuseppe Di Lorenzo Giuseppina Della Vittoria Scarpati Carlo Buonerba | 2011 | World Journal of Clinical Oncology2011，2，3： | 5 |
| 7 | Major lipids, apolipoproteins, and risk of vascular disease显示文摘 | Di Angelantonio E Sarwar N Perry P | 2009 | JAMA2009，302，18： | 1 |
| 8 | Development and validation of a HPLC-UV method for the quantification of antiepileptic drugs in dried plasma spots显示文摘 | Sara Baldelli Dario Cattaneo Luciana Giodini Lorena Baietto Giovanni Di Perri Antonio D’Avolio Emilio Clementi | 2015 | Clinical Chemistry and Laboratory Medicine (CCLM)2015，，3： | 1 |
| 9 | Determination by gas chromatography/mass spectrometry of p-phenylenediamine in hair dyes after conversion to an imine derivative显示文摘 | Di Gioia M L Leggio A Le Pera A Liguori A Napoli A Perri F | | 0，，： | 1 |
| 10 | A multicentre trial to evaluate the efficacy and tolerability of alpha- glycerylphosphorylcholine versus cytosine diphosphocholine in patients with vascular dementia 显示文摘 | Di Perri R Coppola G Ambrosio LA | 1991 | J Int Med Res1991，19，4： | 1 |
| 11 | A case of ovarioleu- kodystrophy without eIF2B4mutations显示文摘 | Gaudiano C Di Perri C Scali O | 2008 | Journal of the Neu- rological Sciences2008，268，12： | 1 |
| 12 | Major lipids, apolipoproteins, and risk of vascular disease 显示文摘 | Di Angelantonio E Sarwar N Perry P | 2009 | Jama2009，302，： | 1 |
| 13 | Recent outbreak of aseptic meningitis in Italy due to Echovirus 30 and phylogenetic relationship with other European circulating strains显示文摘 | Maria Grazia Milia Francesco Cerutti Gabriella Gregori Elisa Burdino Tiziano Allice Tina Ruggiero Maria Proia Giulia De Rosa Eugenia Enrico Filippo Lipani Giovanni Di Perri Valeria Ghisetti | 2013 | Journal of Clinical Virology2013，，： | 1 |
| 14 | Efficacy and safety of maraviroc versus efavirenz, both with zidovudine/lamivudine: 96-week results from the MERIT study显示文摘 | Sierra-Madero J Di Perri G Wood R | 2010 | HIV Clinical Trials2010，11，3： | 1 |
| 15 | Mixed gangliocytoma-adenoma of the sella: case report显示文摘 | Perry DI McGinn GJ Del Bigio MR | 2002 | Can Assoc Rediol J2002，53，2： | 1 |
| 16 | S100A12 provokes mast cell activation: A potential amplification pathway in asthma and innate immunity显示文摘 | Zheng Yang Wei Xing Yan Hong Cai Nicodemus Tedla Chris Armishaw Nick Di Girolamo Hong Wei Wang Taline Hampartzoumian Jodie L. Simpson Peter G. Gibson John Hunt Prue Hart J. Margaret Hughes Michael A. Perry Paul F. Alewood Carolyn L. Geczy | 2007 | The Journal of Allergy and Clinical Immunology2007，，1： | 1 |
| 17 | Major lipids, apolipoproteins, and risk of vascular disease 显示文摘 | DI ANGELANTONIO E SARW AR N PERRY P | 2009 | JAMA2009，302，18： | 1 |
| 18 | Offer of rapid testing and alternative biological samples as practical tools to implement HIV screening programs显示文摘 | Parisi MR Soldini L Di Perri G | 2009 | New Microbiol2009，32，4： | 1 |
| 19 | Cytokine gene polymorphisms in gastric cancer patients from two Italian areas at high and low cancer prevalence显示文摘 | F. Perri A. Piepoli C. Bonvicini A. Gentile M. Quitadamo M. Di Candia R. Cotugno F. Cattaneo M.R. Zagari L. Ricciardiello M. Gennarelli F. Bazzoli G.N. Ranzani A. Andriulli | 2005 | Cytokine2005，，5： | 1 |
| 20 | Limbic hy- perconnectivity in the vegetative state 显示文摘 | Di Perri C Bastianello S Bartsch A | 2013 | Neurology2013，81，16： | 1 |
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