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| 1 | Lack of association between UGT1A7,UGT1A9,ARP,SPINK1 and CFTR gene polymorphisms and pancreatic cancer in Italian patients显示文摘AIM: To investigate simultaneously UGT1A7, UGT1A9, ARP, SPINK and CFTR genes to verify whether genetic polymorphisms predispose to the development of pancreatic cancer (PC). METHODS: Genomic DNA of 61 pancreatic cancer patients and 105 healthy controls (HC) were analyzed. UGT1A7 genotyping was determined by PCR-RFLP analysis. Specific PCR and sequencing were used to analyze genetic variants of UGT1A9, ARP, SPINK1 and CFTR genes. RESULTS: Four different alleles (*1: WT; *2: N129K and R131K; *3: N129K, R131K, and W208R; and *4: W208R) in UGT1A7 and three different alleles (*1: WT; *4: Y242X; and *5: D256N) in UGT1A9 were detected. All UGT1A polymorphisms were observed at similar frequency in PC patients and HC. Seven different alleles in ARP were found in PC patients and HC at similar frequency. The SPINK1 mutations N34S and P55S occurred in five PC patients with a prevalence (4.1%) not significantly different from that observed (2.0%) in HC. The only CFTR ΔF508 mutation was recognized in three PC patients with a prevalence (4.9%) similar to HC. CONCLUSION: UGT1A7, UGT1A9, ARP, SPINK1 and CFTR gene polymorphisms are not associated with PC in Italian patients. | Ada Piepoli Annamaria Gentile Maria Rosa Valvano Daniela Barana Cristina Oliani Rosa Cotugno Michele Quitadamo Angelo Andriulli Francesco Perri | 2006 | World Journal of Gastroenterology2006，12，39： | 3 |
| 2 | Cancer - related fatigue in the elderly 显示文摘 | Giacalone A Quitadamo D Zanet E | 2013 | Support Care Cancer2013，21，10： | 1 |
| 3 | Identifying MicroRNA and Gene Expression Networks Using Graph Communities显示文摘Integrative network analysis is powerful in helping understand the underlying mechanisms of genetic and epigenetic perturbations for disease studies.Although it becomes clear that micro RNAs,one type of epigenetic factors,have direct effect on target genes,it is unclear how micro RNAs perturb downstream genetic neighborhood.Hence,we propose a network community approach to integrate micro RNA and gene expression profiles,to construct an integrative genetic network perturbed by micro RNAs.We apply this approach to an ovarian cancer dataset from The Cancer Genome Atlas project to identify the fluctuation of micro RNA expression and its effects on gene expression.First,we perform expression quantitative loci analysis between micro RNA and gene expression profiles via both a classical regression framework and a sparse learning model.Then,we apply the spin glass community detection algorithm to find genetic neighborhoods of the micro RNAs and their associated genes.Finally,we construct an integrated network between micro RNA and gene expression based on their community structure.Various disease related micro RNAs and genes,particularly related to ovarian cancer,are identified in this network.Such an integrative network allows us to investigate the genetic neighborhood affected by micro RNA expression that may lead to disease manifestation and progression. | Benika Hall Andrew Quitadamo Xinghua Shi | 2016 | Tsinghua Science and Technology2016，21，2： | 1 |
| 4 | Performances evaluation and optimization of brain computer interface systems in a copy spelling task 显示文摘 | B1ANCHI L QUITADAMO L R GARREFFA G | 2007 | IEEE Trans- actions on Neural Systems and Rehabilitation Engineering2007，15，2： | 1 |
| 5 | Peer-Led Team Learning: A Prospective Method for Increasing Critical Thinking in Undergraduate Science Courses显示文摘 | Ian J Quitadamo C Jayne Brahler Gregory J Crouch | 2009 | Science Educator2009，18，1： | 1 |
| 6 | Patterns of symptoms in functional dyspepsia: role of Helicobacter pylori infection and delayed gastric emptying显示文摘 | Francesco Perri Rocco Clemente Virginia Festa Vito Annese Michele Quitadamo Paul Rutgeerts Angelo Andriulli | 1998 | The American Journal of Gastroenterology1998，，： | 1 |
| 7 | Comparison of a monoclonal antigen stool test (Hp StAR) with the ^(13)C-urea breath test in monitoring Helicobacter pylori eradication therapy显示文摘AIM: To evaluate the agreement between a mAb-based stool test (HP StAR) and the urea breath test (UBT) in monitoring (H pylori) infection after eradication therapy.METHODS: Patients with discordant results on UBT and Hp StAR underwent endoscopy with biopsies for rapid urease test, culture, and histology to confirm H pylori status.RESULTS: Among 250 patients (50±14 years), 240 (96.0%) had concordant UBT and Hp StAR tests with a significant correlation between DOB and A values (R = 0.87; P<0.0001).The remaining 10 (4.0%) patients had discordant tests (positive Hp StAR and negative UBT) with the Hp StAR inaccurate in five cases (false positive) and UBT inaccurate in the other five cases (false negative). The 'maximal expected' sensitivity, specificity, +PV, -PV, +LR, and -LR were 91%, 100%, 100%, 97.4%, ∞, and 8.2 respectively,for the UBT, and 100%, 97.4%, 91%, 100%, 38.8, and 0,respectively, for the Hp StAR. Overall accuracy for both tests was 98%.CONCLUSION: Both the UBT and the Hp StAR are equally accurate in monitoring H pylori infection. Nowadays,the choice of the 'best' non-invasive H pylori test in the post-treatment setting should be done not only in terms of diagnostic accuracy but also in view of cost and local facilities. | Francesco Perri Michele Quitadamo Rosalba Ricciardi Ada Piepoli Rosa Cotugno Annamaria Gentile Alberto Pilotto Angelo Andriulli | 2005 | World Journal of Gastroenterology2005，11，37： | 1 |
| 8 | Antisecretory vs antiproteasic drugs in the prevention of post-ERCP pancreatitis : the evidence-based medicine derived from a meta-analysis study显示文摘 | Andriulli A Caruso N Quitadamo M et aI | 2003 | JOP2003，4，45： | 1 |
| 9 | HLA-DQA1 and DQB1 genes and Helicobacter pylori infection in Italian patients with gastric adenocarcinoma显示文摘 | Perri F Piepoli A Quitadamo M | 2002 | Tissue Antigens2002，59，1： | 1 |
| 10 | Peer Led Team Learning:a prospective method for increasing critical thinking in undergraduate science courses显示文摘 | Ian J Quitadamo C Jayne Brahler Gregory J Crouch | 2009 | Sci Educ2009，18，1： | 1 |
| 11 | Peer-led team learning: A prospective method for increasing critical thinking in undergraduate science courses显示文摘 | Quitadamo I J Brahler C J Crouch G J | 2009 | Sci Educ2009，18，1： | 1 |
| 12 | Peer-Led Team Learning:A Prospective Method for Increasing Critical Thinking in Undergraduate Science Courses显示文摘 | Quitadamo I J Brahler 达 C J Crouch G J | | 0，，01： | 1 |
| 13 | Cytokine gene polymorphisms in gastric cancer patients from two Italian areas at high and low cancer prevalence显示文摘 | F. Perri A. Piepoli C. Bonvicini A. Gentile M. Quitadamo M. Di Candia R. Cotugno F. Cattaneo M.R. Zagari L. Ricciardiello M. Gennarelli F. Bazzoli G.N. Ranzani A. Andriulli | 2005 | Cytokine2005，，5： | 1 |
| 14 | Peer-Led Team Learning: A Prospective Method for Increasing Critical Thinking in Under- graduate Science Courses 显示文摘 | lan J Quitadamo C Jayne Brabler Gregory J Crouch | 2009 | Science Educator2009，18，1： | 1 |
| 15 | Intraduodenal Lipase Activity in Celiac Disease Assessed by Means of 13C Mixed-Triglyceride Breath Test显示文摘 | Francesco Perri Maria Pastore Virginia Festa Rocco Clemente Michele Quitadamo Mario R. D’Altilia Grazia Niro Paolo Paolucci Angelo Andriulli | 1998 | Journal of Pediatric Gastroenterology & Nutrition1998，，4： | 1 |
| 16 | Peer-led team learning: a prospective method for increasing critical thinking in undergraduate sci- ence courses显示文摘 | Quitadamo I J Brahler C J Crouch G J | 2009 | Sci Educ2009，18，1： | 1 |
| 17 | Peer-led team learning: a prospective method for increasing critical thinking in undergraduate science courses 显示文摘 | QUITADAMO IJ BRAWLER CJ CROUCH GJ | 2009 | Sci Educ2009，18，1： | 1 |
| 18 | Intraluminal lipase activity in with celiac disease assessee by means of e 'mixed triglyeerides' breath test 显示文摘 | Perri F Pastore MR Quitadamo M | 1998 | Gut1998，，： | 1 |
| 19 | European pedi- atricians' approach to children with GER symptoms: Survey of the implementation of 2009 Naspghan - Espghan guidelines显示文摘 | Quitadamo P Papadopoulou A Wenzl T | 2014 | J Pediatr Gastroenterol Nutr2014，58，4： | 1 |
| 20 | Trau- matic diaphragmatic rupture: personal experi- ence显示文摘 | Sacco R Quitadamo S Rotolo N | 2003 | Acta Bio Med2003，74，2： | 1 |
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