|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Nonalcoholic fatty liver disease and aging: Epidemiology to management显示文摘Nonalcoholic fatty liver disease(NAFLD) is common in the elderly, in whom it carries a more substantial burden of hepatic(nonalcoholic steatohepatitis, cirrhosis and hepatocellular carcinoma) and extra-hepatic manifestations and complications(cardiovascular disease, extrahepatic neoplasms) than in younger age groups. Therefore, proper identification and management of this condition is a major task for clinical geriatricians and geriatric hepatologists. In this paper, the epidemiology and pathophysiology of this condition are reviewed, and a full discussion of the link between NAFLD and the aspects that are peculiar to elderly individuals is provided; these aspects include frailty, multimorbidity, polypharmacy and dementia. The proper treatment strategy will have to consider the peculiarities of geriatric patients, so a multidisciplinary approach is mandatory. Non-pharmacological treatment(diet and physical exercise) has to be tailored individually considering the physical limitations of most elderly people and the need for an adequate caloric supply. Similarly, the choice of drug treatment must carefully balance the benefits and risks in terms of adverse events and pharmacological interactions in the common context of both multiple health conditions and polypharmacy. In conclusion, further epidemiological and pathophysiological insight is warranted. More accurate understanding of the molecular mechanisms of geriatric NAFLD will help in identifying the most appropriate diagnostic and therapeutic approach for individual elderly patients. | Marco Bertolotti Amedeo Lonardo Chiara Mussi Enrica Baldelli Elisa Pellegrini Stefano Ballestri Dante Romagnoli Paola Loria | 2014 | World Journal of Gastroenterology2014，20，39： | 15 |
| 2 | Pathogenesis and significance of hepatitis C virus steatosis:An update on survival strategy of a successful pathogen显示文摘Hepatitis C virus(HCV)is a successful pathogen on the grounds that it exploits its host’s metabolism to build up viral particles;moreover it favours its own survival by inducing chronic disease and the development of specific anatomic changes in the infected organ.Steatosis,therefore,is associated with HCV infection by necessity rather than by chance alone.Approximately6%of HCV patients have steatohepatitis.Interestingly,HCV steatosis occurs in the setting of multiple metabolic abnormalities(hyperuricemia,reversible hypocholesterolemia,insulin resistance,arterial hypertension and expansion of visceral adipose tissue)collectively referred to as'hepatitis C-associated dysmetabolic syndrome'(HCADS).General,nonalcoholic fatty liver disease(NAFLD)-like,mechanisms of steatogenesis(including increased availability of lipogenic substrates and de novo lipogenesis;decreased oxidation of fatty substrates and export of fatty substrates)are shared by all HCV genotypes.However,genotype 3 seemingly amplifies such steatogenic molecular mechanisms reported to occur in NAFLD via more profound changes in microsomal triglyceride transfer protein;peroxisome proliferator-activated receptor alpha;sterol regulatory element-binding proteins and phosphatase and tensin homologue.HCV steatosis has a remarkable clinical impact in as much as it is an acknowledged risk factor for accelerated fibrogenesis;for impaired treatment response to interferon and ribavirin;and development of hepatocellular carcinoma.Recent data,moreover,suggest that HCV-steatosis contributes to premature atherogenesis via both direct and indirect mechanisms.In conclusion,HCV steatosis fulfills all expected requirements necessary to perpetuate the HCV life cycle.A better understanding of the physiology of HCADS will likely result in a more successful handling of disease with improved antiviral success rates. | Amedeo Lonardo Luigi Elio Adinolfi Luciano Restivo Stefano Ballestri Dante Romagnoli Enrica Baldelli Fabio Nascimbeni Paola Loriaca | 2014 | World Journal of Gastroenterology2014，20，23： | 14 |
| 3 | Clinical features and natural history of cryptogenic cirrhosis compared to hepatitis C virus-related cirrhosis显示文摘AIM To characterize natural history of cryptogenic cirrhosis(CC) and compare its clinical features and outcomes to those of hepatitis C virus(HCV)-related cirrhosis.METHODS A prospective cohort of 102 consecutive patients at their first diagnosis of CC were enrolled in this study. The clinical data and outcomes were compared to an ageand Child-pugh class-matched cohort of 110 patients with HCV-related cirrhosis. Diagnosis of cirrhosis was based on compatible clinical and laboratory parameters, ultrasound/endoscopic parameters and, whenever possible, on histological grounds and transient elastography. All cases of cirrhosis without a definite etiology were enrolled in the CC group. The parameters assessed were:(1) severity of liver disease at the time of first diagnosis;(2) liver decompensation during follow-up;(3) hepatocellular carcinoma(HCC);(4) orthotopic liver transplantation; and(5) death. The independent associated factors were evaluated by multiple logistic regression analysis, and survival and its determinants by the Kaplan-Meier model, log-rank test and Cox regression.RESULTS At the first observation, median age was 66 and 65 years and male gender was 36% and 58% for CC and HCV cirrhosis, respectively. CC showed Child-pugh class A/B/C of 47%/31%/22%, respectively. Compared to HCV cirrhosis, CC exhibited a significantly higher prevalence of metabolic syndrome(12% vs 54%, respectively), overweight/obesity, high BMI, impaired glucose tolerance, high blood pressure, dyslipidemia, hyperuricemia, cardiovascular diseases, extrahepatic cancer, and gallstones. Over a median period of 42 mo of follow-up, liver decompensation, HCC development and death for CC and HCV-related cirrhosis were 60.8%, and 54.4%, 16.7% and 17.2%, 39.2% and 30%, respectively. The median survival was 60 mo for CC. Independent predictors of death were age and Childpugh class at diagnosis. CC showed an approximately twofold higher incidence of HCC in Child-pugh class A.CONCLUSION Undiagnosed nonalcoholic fatty liver disease has an etiologic role in CC that is associated with a poor prognosis, early HCC development, high risk of cardiovascular disease and extrahepatic cancer. | Luca Rinaldi Fabio Nascimbeni Mauro Giordano Chiara Masetti Barbara Guerrera Annalisa Amelia Maria Chiara Fascione Stefano Ballestri Dante Romagnoli Rosa Zampino Riccardo Nevola Enrica Baldelli Natalina Iuliano Valerio Rosato Amedeo Lonardo Luigi Elio Adinolfi | 2017 | World Journal of Gastroenterology2017，23，8： | 5 |
| 4 | Development of an HPLC–UV assay method for the simultaneous quantification of nine antiretroviral agents in the plasma of HIV-infected patients显示文摘A new method using high-performance liquid chromatography coupled with ultra violet detection(HPLC–UV)was developed and validated for the simultaneous quantification of atazanavir,dolutegravir,darunavir,efavirenz,etravirine lopinavir,raltegravir,rilpivirine and tipranavir in human plasma.For the first time we reported here the development and validation of an HPLC–UV assay to quantify the frequently administered 9antiretroviral compounds including dolutegravir and rilpivirine.A simple solid phase extraction procedure was applied to 500 μL aliquots of plasma.The chromatographic separation of the drugs and internal standard(quinoxaline) was achieved with a gradient of acetonitrile and sodium acetate buffer on a C_(18) reverse-phase analytical column with a 25 min analytical run time.Calibration curves were optimised according to the therapeutic range of drug concentrations in patients,and the coefficient of determination(r^2) was higher than0.99 for all analytes.Mean intraday and interday precisions(RSD) for all compounds were less than 15.0%,and the mean accuracy(% deviation from nominal concentration) was also found to be less than 15.0%.Extraction recovery range was between 80% and 120% for all drugs analysed.The solid phase extraction and HPLC–UV method enable a specific,sensitive,and reliable simultaneous determination of nine antiretroviral agents in plasma.Good extraction efficiency and low limit of HPLC–UV quantification make this method suitable for use in clinical trials and therapeutic drug monitoring. | Nitin Charbe Sara Baldelli Valeria Cozzi Simone Castoldi Dario Cattaneo Emilio Clementi | 2016 | Journal of Pharmaceutical Analysis2016，6，6： | 4 |
| 5 | TSH stimulates leptin secretion by a direct effect on adipocytes 显示文摘 | C Menendez R Baldelli JP Camina | 2003 | Journal of Endocrinology2003，176，1： | 1 |
| 6 | Characterization and induction of human pre-adipocytes显示文摘 | Raposio E Guida C Baldelli I | 2007 | Toxicol In vitro2007，21，2： | 1 |
| 7 | Locoregional treatments of unresectable liver metastases from colorectal cancer显示文摘 | Cascinu S Catalano V Baldelli AM | 1998 | Cancer Treatment Reviews1998，24，1： | 1 |
| 8 | BDNF,NT-3 and NGF induce distinct new Ca2+ channel synthesis in developing hippocampal neurons显示文摘 | Baldelli P Forni PE Carbone E | 2000 | Eur J Neurosci2000，12，11： | 1 |
| 9 | Surface structure at the ionic liquid-electrified metal interface 显示文摘 | Baldelli S | 2008 | Acc Chem Res2008，41，3： | 1 |
| 10 | Peroxisome proliferator-activated receptor gamma co-activator lalpha (PGC-lalpha) and sirtuin 1 (SIRT1) reside in mitochondria: possible direct function in mitochondrial biogenesis 显示文摘 | Aquilano K Vigilanza P Baldelli S | 2010 | Biol Chern2010，285，21： | 1 |
| 11 | Development and validation of a HPLC-UV method for the quantification of antiepileptic drugs in dried plasma spots显示文摘 | Sara Baldelli Dario Cattaneo Luciana Giodini Lorena Baietto Giovanni Di Perri Antonio D’Avolio Emilio Clementi | 2015 | Clinical Chemistry and Laboratory Medicine (CCLM)2015，，3： | 1 |
| 12 | A phase II study of weekly docetaxel as salavage chemotherapy for advanced gastric cancer 显示文摘 | Graziano F Catalano V Baldelli AM | 2000 | Ann oncol2000，11，： | 1 |
| 13 | A phase II study of weekly docetaxel as salvage chemotherapy for advanced gastric cancer 显示文摘 | Graziano F Catalano Y Baldelli A | 2000 | Ann Oncol2000，11，10： | 1 |
| 14 | p53 orchestrates the PGC- let-mediated antioxidant response upon mild redox and metabolic imbalance显示文摘 | Aquilano K Baldelli S Pagliei B | 2013 | Antioxid Redox Signal2013，18，4： | 1 |
| 15 | Simultaneous determination of everolimus and cyclosporine concentrations by HPLC with ultraviolet detection 显示文摘 | Baldelli S Zenoni S Merlini S | 2006 | Clinica Chimica Acta2006，364，12： | 1 |
| 16 | Two year follow up of acromegallc patients treated with slow release lanreotide (30 rag) 显示文摘 | BALDELLI R COLAO A RAZZORE P | 2000 | J Clin Endocrinol Metab2000，85，： | 1 |
| 17 | Proepileptie influence of a focal vascular lesion affecting entorhinal'cortex - CA3 connections after status epileptieus显示文摘 | Biagini G Baldelli E Longo D | 2008 | J Neuropathol Exp Neuro12008，67，7： | 1 |
| 18 | A phase Ⅱ study of weekly docetaxel as salvage chemotherapy for advanced gastric cancer显示文摘 | Graziano F Catalano V Baldelli AM | 2000 | Ann Oncol2000，11，： | 1 |
| 19 | 显示文摘 | Seoane LM Tovar S Baldelli R | 2000 | Eur J Endocrinol2000，143，5： | 1 |
| 20 | Proepileptic influence of a focal vascular lesion affecting entorhinal cortex-CA3 connections after status epilepticus 显示文摘 | Biagini G Baldelli E Longo D | 2008 | Neuropathol Exp Neurol2008，67，7： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员