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| 1 | Caspase-3 activation as a bifurcation point between plasticity and cell death显示文摘Death-mediating proteases such as caspases and caspase-3 in particular,have been implicated in neurodegenerative processes,aging and Alzheimer's disease.However,emerging evidence suggests that in addition to their classical role in cell death,caspases play a key role in modulating synaptic function.It is remarkable that active caspases-3,which can trigger widespread damage and degeneration,aggregates in structures as delicate as synapses and persists in neurons without causing acute cell death.Here,we evaluate this dichotomy,and discuss the hypothesis that caspase-3 may be a bifurcation point in cellular signaling,able to orient the neuronal response to stress down either pathological/apoptotic pathways or towards physiological cellular remodeling.We propose that temporal,spatial and other regulators of caspase activity are key determinants of the ultimate effect of caspase-3 activation in neurons.This concept has implications for differential roles of caspase-3 activation across the lifespan.Specifically,we propose that limited caspase-3 activation is critical for synaptic function in the healthy adult brain while chronic activation is involved in degenerative processes in the aging brain. | Shikha Snigdha Erica D Smith G Aleph Prieto Carl W Cotman | 2012 | Neuroscience Bulletin2012，28，1： | 91 |
| 2 | β-amyloid converts an acute phase injury response to chronic injury显示文摘 | Cotman CW Tenner AJ Cummings | 1996 | Nurobio Ageing1996，17，5： | 1 |
| 3 | Quantification of magnetic resonance scans for hippocampal and parahippocampal atrophyin Alzheimer's disease显示文摘 | Kesslak JP Nalcioglu 0 Cotman CW | 1991 | Neurology1991，41，： | 1 |
| 4 | Thrombin induces apoptosis in cultured neurons and astrocytes via a pathway requiring tyrosine kinase and RhoA activities显示文摘 | Donovan FM Pike CJ Cotman CW | 1997 | J Neurosci1997，17，14： | 1 |
| 5 | The excitatory amin acid receptors :pharmacology , and distinct properties in the function of the central nevous system 显示文摘 | Monaqhan DT Bridges RJ Cotman CW | 1989 | Anny Rev Phamacol Toxicol1989，29，： | 1 |
| 6 | The excitatory amino acid receptors:their eleases,pharmacology and distinct properties in the function of the central nervous system显示文摘 | Monaghan DT Bridges RJ Cotman CW | 1989 | Annu Rev Pharmacol Toxicol1989，29，10： | 1 |
| 7 | Melatonin treatment in old mice enables a more youthful response to LPS in the brain显示文摘 | Perreau VM Bondy SC Cotman CW Sharman KG Sharman EH | 2007 | J Neuroimmunol2007，182，12： | 1 |
| 8 | Perihoeral administration of a long-chain fatty alcohol promotes septaleholinergic neurous survival after tim bria-fomix transaction显示文摘 | Borg J Kesslak P J Cotman C W | 1990 | Brain Res1990，，： | 1 |
| 9 | A potential role for apoptosis neurodegeneration and Alzheimer's disease 显示文摘 | Cotman C W | 1995 | Mol Neurobiol1995，10，1： | 1 |
| 10 | Thrombin induces apoptosis in cultured neurons and astrocytes via a pathway requiring tyrosine kinase and RhoA activities显示文摘 | Pike C J Cotman CW | 1997 | J Neurosci1997，17，14： | 1 |
| 11 | Exposure to hydrogen peroxide induces cell death via apoptosis in cultured rat cortical neurons显示文摘 | Whittemore ER Loo DT Cotman CW | 1994 | Neuroreport1994，5，12： | 1 |
| 12 | In Situ Preceding of Dense Al2O3-Ti Aluminide Interpenetrating Phase Composites显示文摘 | Hervitz D Cotman I Gutmanas E Y | 2002 | Janrnal of the European Ceramic Society2002，22，： | 1 |
| 13 | thrombin Receptor activation protect neuron and astrocytes from cell death produced environmental insults显示文摘 | Vanghan PJ Pike CJ Cotman CW | 1995 | Neuron Sci1995，15，7： | 1 |
| 14 | Trophie effects of interleukin-4,-7,-8 on hippocampal neuronal cultures: potential involvement of glial-derived factors显示文摘 | Araujo DM Cotman CW | 1993 | Brain Res1993，600，1： | 1 |
| 15 | Thrombin induces apoptosis in cultured neurons and astrocytes via a pathway requiring tyrosine kinase and RhoA activites显示文摘 | Donovan FM Pike CJ cotman CW | 1997 | J Neurosci1997，17，： | 1 |
| 16 | Quantification of magnetic resonance scans for hippocampal and parahippocampal atrophy in Alzheimers disease显示文摘 | Kesslak JP Nalcioglu O Cotman CW | 1991 | Neurology1991，41，1： | 1 |
| 17 | Fenton's oxidative treatment of municipal landfill leaehat as an alternative to biological process 显示文摘 | GOTVAJN A Z ZAGORC-KONCAN J COTMAN M | 2011 | Desalination2011，275，123： | 1 |
| 18 | beta - Amyloidconverts an acute phase injury response to chronic injuryresponses显示文摘 | COTMAN CW TENNER AJ CUMMINGS BJ | 1996 | Neurobiol Aging1996，17，5： | 1 |
| 19 | Thrombin induces apoptosis in cultured neurons and astrocytes via a pathway requiring tyrosine kinase and RhoA activities显示文摘 | Donovan FM Pike CJ Cotman CW | 1997 | J Neurosci1997，17，14： | 1 |
| 20 | Exercise enhances and protects brain function显示文摘 | Cotman C W Engesser Cesarc | 2002 | Exe Sport Sei Rev2002，30，： | 1 |
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