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| 1 | Anti-anxiety effect of Valeriana jatamansi Jones extract via regulation of the hypothalamus-pituitary-adrenal axis显示文摘BACKGROUND:Hypothalamus-pituitary-adrenal (HPA) axis dysfunction has been closely linked to anxiety.Previous studies have shown that Valeriana jatamansi Jones extract exhibits clear anxio-lytic effects, but it is unclear about the mechanism underlying regulation of the HPA axis dysfunction in these anxiolytic effects.OBJECTIVE:To observe the effects of Valeriana jatamansi Jones (Zhizhu Xiang) extract on HPA axis function in a rat model of anxiety, and to compare these effects with positive control estazolam.DESIGN, TIME AND SETTING:Randomized, controlled, animal experiment was performed at Chengdu University of Traditional Chinese Medicine, China, between February and September in 2006.MATERIALS:Estazolam was purchased from Shanghai Jiufu Pharmaceutical, China; Valeriana jatamansi Jones was purchased from the Lotus Pond Market for Chinese Herbal Medicine in Chengdu.It consisted of iridoids and flavonoid components.METHODS:A total of 72 Sprague Dawley rats, aged 2 months, were randomly assigned to 6 groups:low-, medium-, and high-dose Valeriana jatamansi Jones groups intragastrically injected with 0.3, 0.6, and 0.9 g/kg per day Valeriana jatamansi Jones extract, respectively; estazolam group intragastrically injected with 1.5 mg/kg per day estazolam; model and normal groups administered 5 mL physiological saline.Anxiety was established in all groups, except the normal group, through the use of elevated plus-maze test at 7 days following drug administration.MAIN OUTCOME MEASURES:Blood β-endorphin and corticosterone levels were determined using enzyme-linked immunosorbent assay following treatment with Valeriana jatamansi Jones extract.Expressions of HPA axis-related genes were measured by cDNA microarray.RESULTS:Blood β-endorphin and corticosterone levels were significantly greater in the model group than in the normal group.Compared with the model group, levels decreased with Valeriana jatamansi Jones extract or estazolam treatment, particularly in the low-dose Valeriana jatamansi Jones group (P<0.01).cDNA microarray results demonstrated that corticotropin-releasing hormone and Orexin, which are associated with HPA axis function, were differentially expressed; expression increased in the model group, but decreased in rats treated with Valeriana jatamansi Jones extract.CONCLUSION:Valeriana jatamansi Jones extract plays a role in regulating HPA axis function in a rat model of anxiety, and this effect was superior to estazolam. | Zhiyong Yan Tian'e Zhang Ting Xiao Lingzhen Pan Jinzhi Qin Zhanping Zhang Changying Zuo | 2010 | Neural Regeneration Research2010，5，14： | 9 |
| 2 | Barley:a potential cereal for producing healthy and functional foods显示文摘Barley is the fourth largest cereal crop in the world.It is mainly used for feeding,beer production and food.Barley is receiving more attention from both agricultural and food scientists because of its special chemical composition and health benefits.In comparison with other cereal crops,including wheat,rice and maize,barley grains are rich in dietary fiber(such asβ-glucan)and tocols,which are beneficial to human health.It is well proved that diets rich in those chemicals can provide protection against hypertension,cardiovascular disease,and diabetes.Barley has been widely recognized to have great potential as a healthy or functional food.In this review,we present information about studies on the phys-ical structure of the barley grain and the distribution of its main chemical components,nutrient and functional composition of barley grain and their health benefits,and the approaches of improving and utilizing the nutrient and functional chemicals in barley grain.With the development of processing technologies,functional components in barley grains,especiallyβ-glucan,can be efficiently extracted and concentrated.Moreover,nutrient and functional components in barley grains can be efficiently improved by precise breeding and agronomic approaches.The review high-lights the great potential of barley used as healthy and functional foods,and may be instructive for better utilization of barley in food processing. | La Geng Mengdi Li Guoping Zhan Lingzhen Ye | 2022 | Food Quality and Safety2022，6，2： | 3 |
| 3 | SCL-90 test results of the family members of patients with schizophrenia in China:a meta-analysis显示文摘Objective To evaluate the mental health status of family members of patients with schizophrenia in China.Methods Wan Fang,CNKI,VIP,CBM,Springer Link,Science Direct and Pub Med databases were searched to collect the relevant studies published prior to August 2016 that were about the psychological health status of the family members of patients with schizophrenia measured with the SCL-90 scale and Software Stata 11.0 was used for their meta-analysis.Results A total of 20 studies was included in this meta-analysis.Scores of somatization affection,obsessive-compulsive symptoms,interpersonal sensitivity,depression,anxiety,hostility,phobic anxiety,and paranoia ideation of the family members were significantly higher than those of general population norms in 2006(P<0.05).Scores of somatization affection,interpersonal sensitivity,depression,anxiety,hostility,phobic anxiety,paranoia ideation,and psychoticism of the family members were significantly higher than control group(P<0.05).Moreover,the difference was not statistically significant between male and female family members in mental health status(P>0.05).Conclusion Compared with the general population,psychological distress was more reported in the family members of patients with schizophrenia.There was no statistic significantly difference between male and female members. | LI Shiming CAO Lingzhen CHEN Jia YANG Queping | 2017 | 国际精神病学杂志2017，44，6： | 3 |
| 4 | The genome and gene editing system of sea barleygrass provide a novel platform for cereal domestication and stress tolerance studies显示文摘The tribe Triticeae provides important staple cereal crops and contains elite wild species with wide geneticdiversity and high tolerance to abiotic stresses. Sea barleygrass (Hordeum marinum Huds.), a wildTriticeae species, thrives in saline marshlands and is well known for its high tolerance to salinity and waterlogging. Here, a 3.82-Gb high-quality reference genome of sea barleygrass is assembled de novo, with 3.69Gb (96.8%) of its sequences anchored onto seven chromosomes. In total, 41 045 high-confidence (HC)genes are annotated by homology, de novo prediction, and transcriptome analysis. Phylogenetics, nonsynonymous/synonymous mutation ratios (Ka/Ks), and transcriptomic and functional analyses provide genetic evidence for the divergence in morphology and salt tolerance among sea barleygrass, barley, andwheat. The large variation in post-domestication genes (e.g. IPA1 and MOC1) may cause interspecies differences in plant morphology. The extremely high salt tolerance of sea barleygrass is mainly attributed tolow Na+ uptake and root-to-shoot translocation, which are mainly controlled by SOS1, HKT, and NHX transporters. Agrobacterium-mediated transformation and CRISPR/Cas9-mediated gene editing systems weredeveloped for sea barleygrass to promote its utilization for exploration and functional studies of hubgenes and for the genetic improvement of cereal crops. | Liuhui Kuang Qiufang Shen Liyang Chen Lingzhen Ye Tao Yan Zhong-Hua Chen Robbie Waugh Qi Li Lu Huang Shengguan Cai Liangbo Fu Pengwei Xing Kai Wang Jiari Shao Feibo Wu Lixi Jiang Dezhi Wu Guoping Zhang | 2022 | Plant Communications2022，3，5： | 2 |
| 5 | Solid lipid dispersion of calcitriol with enhanced dissolution and stability显示文摘Solid dispersion of calcitriol with lipophilic surfactants and triglycerides was developed by melt-mixing method to modify the release and enhance stability of the drug.The solid dispersions were characterized by differential scanning calorimetry(DSC),hot stage polarized optical microscopy(HSPM),infrared spectroscopy(FTIR)and stability studies.The solid dispersion significantly enhanced the stability of calcitriol,which could be attributed to the high antioxidant activity of the solid lipid dispersion.The rapid dissolution rate from the solid dispersion was attributed to the amorphous or solid solution state of drug with improved specific surface area and wettability than the drug crystals.Therefore,solid dispersion of calcitriol with D-a-tocopheryl polyethylene glycol 1000 succinate(TPGS)offers a good approach to modify the release and enhance stability of calcitriol.The influence of lipophilic solid dispersion on drug bioavailability needs further investigation. | Ting Yuan Lingzhen Qin Zhouhua Wang Jinyuan Nie Zhefei Guo Ge Li Chuanbin Wu | 2013 | Asian Journal of Pharmaceutical Sciences2013，8，1： | 2 |
| 6 | Metal-organic layers as reusable solid fluorination reagents and heterogeneous catalysts for aromatic fluorination显示文摘Reusable solid fluorination reagents and heterogeneous catalysts are ideally suited for late-stage fluorination with fast and clean conversion and simplified work-up.Here we report Pd-functionalized two-dimensional metal-organic layers(MOLs)as solid reagents and heterogeneous catalysts to efficiently fluorinate a broad scope of aromatic compounds.Site isolation in the MOLs provides a unique opportunity to stabilize highly active F-containing species for the chemical conversion.A terpyridine(TPY)-based ligand on the MOL,together with a 2-chloro-1,10-phenanthroline(phenCl)as a co-ligand,chelates Pd^(Ⅱ)toform a reactive center.After treatment with Selectfluor/H_(2)0,an(N-fluoroxy)-(2-chloro)-phenanthrolinium[N-(FO)-phenCl^(+)]moiety is produced from the co-ligand on the Pd center.This active species serves as a stochiometric solid fluorination reagent,which shows different regioselectivities and reactivities as compared to homogeneous catalysts that involves Pd^(Ⅲ/Ⅳ)-F intermediates in catalytic cycles.The MOLs can also be used as heterogeneous catalysts for fluorination using Selectfluor.This work highlights opportunities in using MOLs to stabilize unique active sites for late-stage fluorination. | Wenjie Shi Lingzhen Zeng Lingyun Cao Ying Huang Cheng Wang Wenbin Lin | 2021 | Nano Research2021，14，2： | 2 |
| 7 | Optimal harvesting policies for periodic Gompertz systems显示文摘 | Lingzhen Dong Lansun Chen Lihua Sun | 2006 | Nonlinear Analysis: Real World Applications2006，，2： | 2 |
| 8 | Improving the solidification structure of commercially pure aluminium with electropulse acting on liquid metal显示文摘The effect of electropulse on the solidification structure of commercially pure aluminium was studied. The orthogonal array L9 was used to determine the effect of three process parameters of electropulse modification (EPM), which were pulse current intensity, pulse frequency, and treating time. For each factor, three levels were chosen to cover the experimental region. According to the ex-perimental results, the solidification structure of commercially pure aluminium was modified from large grains with columnar crystals to finer grains with equiaxed crystals, by allowing the electropulse to act on liquid aluminium. However, the solidification structures could be refined differently at different EPM parameters. Certain EPM parameters should be selected to get the optimum solidification structure. Among the three parameters, pulse frequency was the most important factor influencing the solidification structure, the secondary factor was current intensity, and treating time was the third one. The optimum parameters were the pulse frequency of 5 Hz, the current intensity of 68 A, and the treating time of 10 s. | Heng Cui Yanbing Zong Daqiang Cang Lingzhen Li Jun Zhang | 2007 | Journal of University of Science and Technology Beijing2007，14，4： | 2 |
| 9 | Development of Public Housing Post-reform China显示文摘 | Jie Chen Lingzhen Yao Hongwei Wang | 2017 | China & World Economy2017，25，4： | 1 |
| 10 | The Study of Predator-prey with Defensive Ability of Prey and Impulsive Perturbations on the Predator显示文摘 | ZHANG Shuwen DONG Lingzhen CHEN Lansun | 2005 | Chaos Solitons and Fractals(S 0960-0779)2005，23，： | 1 |
| 11 | Existence and exponential stability of anti-periodic solutions of Hopfield neural networks with impulses显示文摘 | Shi Peilin Dong Lingzhen | | 0，，02： | 1 |
| 12 | A low cross-po?larization smooth-walled horn with improved bandwidth显示文摘 | Zeng Lingzhen Bennett C L Chuss D T | 2010 | IEEE Trans on AP2010，58，4： | 1 |
| 13 | Baicalein protects Human melanocytes from H 2 O 2 -induced apoptosis via inhibiting mitochondria-dependent caspase activation and the p38 MAPK pathway显示文摘 | Bangmin Liu Zhe Jian Qiang Li Kai Li Zhiyong Wang Ling Liu Lingzhen Tang Xiuli Yi Hua Wang Chunying Li Tianwen Gao | 2012 | Free Radical Biology and Medicine2012，，2： | 1 |
| 14 | Spray and mixing characteristics of liquid jet in a tubular gas-liquid atomization mixer显示文摘For the design and optimization of a tubular gas-liquid atomization mixer,the atomization and mixing characteristics of liquid jet breakup in the limited tube space is a key problem.In this study,the primary breakup process of liquid jet columnwas analyzed by high-speed camera,then the droplet size and velocity distribution of atomized droplets were measured by Phase-Doppler anemometry(PDA).The hydrodynamic characteristics of gas flow in tubular gas-liquid atomization mixer were analyzed by computational fluid dynamics(CFD)numerical simulation.The results indicate that the liquid flow rate has little effect on the atomization droplet size and atomization pressure drop,and the gas flowrate is themain influence parameter.Under all experimental gas flowconditions,the liquid jet column undergoes a primary breakup process,forming larger liquid blocks and droplets.When the gas flow rate(Qg)is less than 127 m^(3)·h^(−1),the secondary breakup of large liquid blocks and droplets does not occur in venturi throat region.The Sauter mean diameter(SMD)of droplets measured at the outlet is more than 140μm,and the distribution is uneven.When Qg>127 m^(3)·h^(−1),the large liquid blocks and droplets have secondary breakup process at the throat region.The SMD of droplets measured at the outlet is less than 140μm,and the distribution is uniform.When 127 | Lingzhen Kong Jiaqing Chen Tian Lan Huan Sun Kuisheng Wang | 2021 | Chinese Journal of Chemical Engineering2021，34，6： | 1 |
| 15 | Periodic solutions for a two-species nonautonomous competition system with diffusion and impulses显示文摘 | Lingzhen Dong Lansun Chen Peilin Shi | 2006 | Chaos Solitons and Fractals2006，，5： | 1 |
| 16 | The Study of Predator-prey System with Defensive Ability of Prey and Impulsive Perturbations on the Predator显示文摘 | SHUWEN Z LINGZHEN D LANSUN C | 2005 | Chaos Solutions & Fractals2005，23，： | 1 |
| 17 | The effect of constraint on CTOD fracture toughness of API X65 steel显示文摘 | Kejiang Han Jian Shuai Xiaomin Deng Lingzhen Kong Xing Zhao Michael Sutton | 2014 | Engineering Fracture Mechanics2014，，： | 1 |
| 18 | ATF4 Is a Substrate of RSK2 and an Essential Regulator of Osteoblast Biology显示文摘 | Xiangli Yang Koichi Matsuda Peter Bialek Sylvie Jacquot Howard C Masuoka Thorsten Schinke Lingzhen Li Stefano Brancorsini Paolo Sassone-Corsi Tim M Townes Andre Hanauer Gerard Karsenty | 2004 | Cell2004，，3： | 1 |
| 19 | Ti3SiC2 material: An application for electromagnetic interference shielding 显示文摘 | Shi Suilin Zhang Lingzhen Li Junshou | 2008 | Applied Physics I etters2008，93，17： | 1 |
| 20 | Periodic intensity variations on the pulse-train of a passively mode-locked fiber ring laser显示文摘 | Yang Lingzhen Zhu Jianfeng Qiao Zhanduo | | 0，，19： | 1 |
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