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| 1 | Haplotype of prostaglandin synthase 2/cyclooxygenase 2 is involved in the susceptibility to inflammatory bowel disease显示文摘AIM: Prostaglandin G/H synthase 2 (PTGS2 or COX2) is one of the key factors in the cellular response to inflammation.PTGS2 is expressed in the affected intestinal segments of patients with inflammatory bowel diseases (IBD). In IBD patients, non-steroidal anti-inflammatory drugs, which have been shown to reduce both the production and activity of PTGS2, may activate IBD and aggravate the symptoms.We aimed at examining genetic variants of PTGS2 that may be risk factors for IBD.METHODS: We genotyped 291 individuals diagnosed with IBD and 367 controls from the Dutch population for the five most frequent polymorphisms of the PTGS2 gene.Clinical data were collected on all patients. DNA was extracted via normal laboratory methods. Genotyping was carried out using multiplex PCR followed by the Invader Assay and the 5' exonuclease assay (TaqMan). New polymorphism screening was performed by pre-screening with denaturing high-performance liquid chromatography,followed by fluorescent sequencing.RESULTS: Allele 5209G was weakly associated with Crohn's disease (odds ratio [OR] 1.63, 95% confidence interval [CI] 1.03-2.57), and allele 8473T with ulcerative colitis (OR 1.50, 95%CI 1.00-2.27). The haplotype including both alleles showed a strong association with IBD (OR 13.15, 95%CI 3.17-116.15). This haplotype, while rare (-0.3%) in the general population, is found more frequently in patients (3.5%).CONCLUSION: Our data suggest that this haplotype of PTGS2 contributes to the susceptibility of IBD. | David G Cox J Bart A Crusius Petra HM Peeters H Bas Bueno-de-Mesquita A Salvador Pe(n|~)a Federico Canzian | 2005 | World Journal of Gastroenterology2005，11，38： | 10 |
| 2 | Ralstonia solanacearum, a widespread bacterial plant pathogen in the post-genomic era显示文摘 | Peeters N Guidot A | 2013 | Molec- ular Plant Pathology2013，14，7： | 1 |
| 3 | Pseudorabies virus envelope glycoproteins gpSO and gII are essential for virus penetration, but only glI is involved in membrane fusion显示文摘 | Peeters B de Wind N Hooisma M | 1992 | J Virol1992，66，2： | 1 |
| 4 | Glycoprotein H of pseudorabies virus is essential for entry cell-to-cell spread of the virus显示文摘 | PEETERS B WIND N BROER R | 1992 | Virol1992，，： | 1 |
| 5 | RNA editing in ribosome-less plastids of iojap maize显示文摘 | Halter C P Peeters N M Hanson M R | | 0，，： | 1 |
| 6 | The effect of extreme water level decrease on hydrochemistry and phytoplankton in a shallow eutrophic lake显示文摘 | AFF1> Tiina N?ges AFF1> Peeter N?ges | 1999 | Hydrobiologia1999，，0： | 1 |
| 7 | Mechanism of the catalytic deperoxidation of tert-butyl hydroperoxide with cobalt(Ⅱ) acetylacetonate 显示文摘 | Turrà N Neuenschwander U Baiker A Peeters J Hermans I | 2010 | Chemistry-A European Journal2010，16，13： | 1 |
| 8 | Quantitative diffusion tensor imaging in cerebral palsy due to periventricular white matter injury 显示文摘 | Thomas B Eyssen N Peeters R | 2005 | Brain2005，128，： | 1 |
| 9 | Fal risk:the clinical relevance of fal s and how to integrate fal risk with fracture risk显示文摘 | Peeters G Van School N M Lips P | | 0，，06： | 1 |
| 10 | Physical interactionbetween RRS1?R,aprotein conferring resistance to bacterial wilt,and PopP2,a type III effector targeted to the plant nucleus显示文摘 | DESLANDES L OLIVIER J PEETERS N | 2003 | Proceedings of the NationalAcademy of Sciences2003，100，13： | 1 |
| 11 | The structure and spectrum of the anisotropically confined two-dimensional Yukawa system显示文摘 | Candido L Rino J P Studart N Peeters F M | 1998 | J Phys:Condens Matter1998，10，11： | 1 |
| 12 | The PPR motif-a TPR-related motif prevalent in plant organellar proteins显示文摘 | SMALL I D PEETERS N | 2000 | Trends Biochem Sci2000，25，： | 1 |
| 13 | Effects of alteplase beyond 3 h after stroke in the Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET): a placebo-controlled randomised trial显示文摘 | Stephen M Davis Geoffrey A Donnan Mark W Parsons Christopher Levi Kenneth S Butcher Andre Peeters P Alan Barber Christopher Bladin Deidre A De Silva Graham Byrnes Jonathan B Chalk John N Fink Thomas E Kimber David Schultz Peter J Hand Judith Frayne Graeme | 2008 | Lancet Neurology2008，，4： | 1 |
| 14 | Robustness testing of a liquid chromatography method for the determination of vorozole and its related compounds in oral tablets显示文摘 | JIMIDAR M NIEMEIJER N PEETERS R | 1998 | J Pharm Biomed Anal1998，18，4： | 1 |
| 15 | Efficacy of laserlriven irrigation versus ultrasonic in removing an airlock from the apical third of a narrow root canal显示文摘 | Peeters HH Gutknecht N | 2014 | Aust Emh J2014，40，2： | 1 |
| 16 | Solid state characterization and crystal structure from X-ray powder diffraction of two polymorphic forms of ranitidine base 显示文摘 | Armas HND Peeters OM Blaton N | 2009 | J Pharm Sci2009，98，： | 1 |
| 17 | Meeting risk with resilience: High daily life reward experience preserves mental health 显示文摘 | Geschwind N Peeters F Jacobs N etc | 2010 | Acta Psychiatr Scand2010，122，2： | 1 |
| 18 | Long-term chan ges and seasonal development of phytoplankton in a strongly stratified hypertrophic lake显示文摘 | Kersti K Reet L Peeter N Ingmar O | 2005 | Hydrobiologia2005，547，： | 1 |
| 19 | Mindfulness training in - creases momentary positive emotions and reward experience in adults vulnerable to depression:a randomized controlled trial 显示文摘 | Geschwind N Peeters F Drukker M | | J Consul Clin Psychol0，79，5： | 1 |
| 20 | Predotar :a tool for rapidly screening proteomes for N-terminal targeting sequences 显示文摘 | Small I Peeters N Legeai F | 2004 | Proteomics2004，4，6： | 1 |
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