|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Osteoprotegerin: A Novel Secreted Protein Involved in the Regulation of Bone Density显示文摘 | W.S Simonet D.L Lacey C.R Dunstan M Kelley M.-S Chang R Lüthy H.Q Nguyen S Wooden L Bennett T Boone G Shimamoto M DeRose R Elliott A Colombero H.-L Tan G Trail J Sullivan E Davy N Bucay L Renshaw-Gegg T.M Hughes D Hill W Pattison P Campbell S Sander G Van | 1997 | Cell1997，，2： | 6 |
| 2 | Guanylyl cyclase C signaling axis and colon cancer prevention显示文摘Colorectal cancer(CRC) is a major cause of cancerrelated mortality and morbidity worldwide. While improved treatments have enhanced overall patient outcome, disease burden encompassing quality of life, cost of care, and patient survival has seen little benefit. Consequently, additional advances in CRC treatments remain important, with an emphasis on preventative measures. Guanylyl cyclase C(GUCY2C), a transmembrane receptor expressed on intestinal epithelial cells, plays an important role in orchestrating intestinal homeostatic mechanisms. These effects are mediated by the endogenous hormones guanylin(GUCA2A) and uroguanylin(GUCA2B), which bind and activate GUCY2 C to regulate proliferation, metabolism and barrier function in intestine. Recent studies have demonstrated a link between GUCY2 C silencing and intestinal dysfunction, including tumorigenesis. Indeed, GUCY2 C silencing by the near universal loss of its paracrine hormone ligands increases colon cancer susceptibility in animals and humans. GUCY2C's role as a tumor suppressor has opened the door to a new paradigm for CRC prevention by hormone replacement therapy using synthetic hormone analogs, such as the FDA-approved oral GUCY2 C ligand linaclotide(Linzess^(TM)). Here we review the known contributions of the GUCY2 C signaling axis to CRC, and relate them to a novel clinical strategy targeting tumor chemoprevention. | Amanda M Pattison Dante J Merlino Erik S Blomain Scott A Waldman | 2016 | World Journal of Gastroenterology2016，22，36： | 2 |
| 3 | Tbe relationship between acute stress disorder and posttraumatic stress disorder in severely injured trauma survivors 显示文摘 | Creamer M O'Donnell ML Pattison P | 2004 | Behav Res Ther2004，42，3： | 1 |
| 4 | Psychiatric morbidity following injury显示文摘 | O'Donnell M L Creamer M Pattison P | 2004 | AmJPsychiatry2004，161，3： | 1 |
| 5 | Psychiatfic mor-bidity following in- jury显示文摘 | 0' Donnell ML Creamer M Pattison P | 2004 | Am J Psychiatry2004，161，3： | 1 |
| 6 | Three-dimensional, nano-structured PLGA scaffolds for bladder tissue replacement applications显示文摘 | Pattison M A Wurster S Webster T J | 2005 | Biomaterials2005，26，15： | 1 |
| 7 | Observations on swollen head syndrom in broiler and broiler breeder chickens显示文摘 | Pattison M Chettle N Randall C J | 1989 | Vet Rec1989，125，： | 1 |
| 8 | Three- dimensional, nano-structured PLGA scaffolds for bladder tissue replacement applications显示文摘 | Pattison M A Wurster S Webster T J | 2005 | Biomaterials2005，26，15： | 1 |
| 9 | The relationship between acute stress disorder and posttraumatic stress disorder in severely injured trauma survivors显示文摘 | Creamer M O'Donnell ML Pattison P | 2004 | Behav Res Ther2004，42，3： | 1 |
| 10 | Reversed experimental calibration of the garnet-clinopyroxene Fe-Mg exchange thermometer 显示文摘 | Pattison D R M Newton R C | 1989 | Contributions to Mineralogy and Petrology1989，101，： | 1 |
| 11 | Petrogenetic significance of orthopyroxene free garnet-r-clinopyroxene+Plagioclase quratz bearing me- tabasites with respect to the amphibolitc and granulite facies 显示文摘 | Pattison D R M | 2003 | Journal of Metamorphic Geology2003，21，： | 1 |
| 12 | Enhanced autophagy ameliorates cardiac proteinopathy 显示文摘 | BHUIYAN M S PATTISON J S OSINSKA H | 2013 | J Clin Invest2013，123，12： | 1 |
| 13 | Absolute rate constants for the peptide bonds 显示文摘 | Pattison D I Davies M J | 2001 | Chemistry Research in Toxicology2001，14，： | 1 |
| 14 | Specific B lymphocyte suppression by infectious bursal agent (Gumboro disease virus)in chickens显示文摘 | Hudson L Pattison M Thantrey N | 1975 | Eur J Immunol1975，5，： | 1 |
| 15 | Psychiatric morbidity following injury显示文摘 | O'Donnell ML Creamer M Pattison P et el | 2004 | Am J Psychiatry2004，161，3： | 1 |
| 16 | Transcriptional regulation of IL-10 and its cell-specific role in vivo 显示文摘 | MacKenzie K F Pattison M J Arthur J S | 2014 | Crit Rev Immunol2014，34，4： | 1 |
| 17 | Social climates in community groups: toward a taxonomy 显示文摘 | Politser P E Pattison E M | 1980 | Community Mental Health Journal1980，16，3： | 1 |
| 18 | A study of the mechanical properties of fresh and preserved human femoral vein wall and valve cusps 显示文摘 | Ackroyd JS Pattison M Browse NL | 1985 | Br J Surg1985，72，2： | 1 |
| 19 | Accelerated chondrocyte functions on NaOH-treated PLGA scaffolds显示文摘 | PATTISON M A PARK K | 2005 | Biomaterials2005，，26： | 1 |
| 20 | EPR studies of chromium(V) intermediates generated via reduction of chromium(VI) by DOPA and related catechol(amine)s:potential role for oxidized amino acids in chromium-induced cancers显示文摘 | Lay P A Davies M J | 2000 | Inorg Chem2000，39，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员