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| 1 | The p53-induced lincRNA-p21 derails somatic cell reprogramming by sustaining H3K9me3 and CpG methylation at pluripotency gene promoters显示文摘最近的研究在众多的生物过程增加了我们长 noncoding RNA (lncRNAs ) 的理解,但是很少在体的房间 reprogramming 检验了他们的角色。通过表示介绍并且功能的屏蔽,我们鉴别了大 intergenic noncoding RNA p21 (lincRNA-p21 ) 损害 reprogramming。尤其是, lincRNA-p21 被 p53 导致,但是不在 reprogramming 支持 apoptosis 或房间老朽。相反, lincRNA-p21 与 H3K9 methyltransferase SETDB1 和维护 DNA methyltransferase DNMT1 联系,它被 RNA 有约束力的蛋白质 HNRNPK 便于。因而, lincRNA-p21 由在 pluripotency 基因倡导者支撑 H3K9me3 或 CpG methylation 阻止 reprogramming。我们的结果在 reprogramming 提供卓见进 lncRNAs 的角色并且建立在 p53 和 heterochromatin 规定之间的一个新奇连接。 | Xichen Bao Haitao Wu Xihua Zhu Xiangpeng Guo Andrew P Hutchins Zhiwei Luo Hong Song Yongqiang Chen Keyu Lai Menghui Yin Lingxiao Xu Liang Zhou Jiekai Chen Dongye Wang Baoming Qin Jon Frampton Hung-Fat Tse Duanqing Pei Huating Wang Biliang Zhang Miguel A Esteban | 2015 | Cell Research2015，25，1： | 21 |
| 2 | Up-regulation of mitochondrial chaperone TRAP1 in ulcerative colitis associated colorectal cancer显示文摘AIM:To characterize tumor necrosis factor receptorassociated protein 1(TRAP1)expression in the progression of ulcerative colitis(UC)-associated colorectal cancer.METHODS:Chronic UC is an inflammatory bowel disease that predisposes to colorectal cancer.Immunohistochemical analysis was used to evaluate TRAP1expression on tissue microarrays containing colonic tissues from 42 UC progressors(patients with cancer or dysplasia)and 38 non-progressors(dysplasia/cancer free patients).Statistical analyses of the TRAP1immunohistochemistry staining were performed using Graph Pad Prism.Differences in the TRAP1 level between non-progressors and progressors were tested for statistical significance using the Mann-Whitney test.Receiver operating characteristic curve method was used to quantify marker performance in distinguishing diseased cases from controls.RESULTS:TRAP1 was up-regulated in the colon tissues from UC progressors,but not in the colon tissues from UC non-progressors.Moreover,up-regulation of TRAP1 preceded the neoplastic changes:it was present in both the dysplastic and non-dysplastic tissues of UC progressors.When TRAP1 staining in rectal tissue was used as a diagnostic marker,it could distinguish progressors from non-progressors with 59%sensitivity and 80%specificity.Our study further showed that the increase of TRAP1 expression positively correlated with the degree of inflammation in the colorectal cancer tissues,which could be related to the increased oxidation present in the colonic mucosa from UC progressors.We then investigated the cellular proteome changes underlying oxidative stress,and found that oxidative stress could induce up-regulation of TRAP1 along with several other negative modulators of apoptosis.CONCLUSION:These results suggest that oxidative stress in long standing UC could lead to the increase of cytoprotective protein TRAP1,which in turn could promote cancer progression by preventing or protecting the oxidative damaged epithelial cells from undergoing apoptosis.TRAP1 could be a potential diagnostic marker for UC associated colorectal cancer. | Ru Chen Sheng Pan Keith Lai Lisa A Lai David A Crispin Mary P Bronner Teresa A Brentnall | 2014 | World Journal of Gastroenterology2014，20，45： | 9 |
| 3 | A comparison of the effects of problem-based learning and lecturing on the development of student's critical thinking显示文摘 | Tiwari A Lai P So M | 2006 | Medical Education2006，40，6： | 1 |
| 4 | Distribution of EGF and its receptor in growing red deer antler显示文摘 | Barling P M Lai A K Nicholson L F | 2005 | Cell Biol Int2005，29，3： | 1 |
| 5 | A comparison of the effects of prob-lem based learning and lecturing on the development of stu-dents'critical thinking显示文摘 | Tiwari A Lai P So M | 2006 | Medical education2006，40，6： | 1 |
| 6 | Long- term results of distal urethral advancement glanuloplasty for distal hypospadias显示文摘 | Caione P Capozza N Lais A | 1997 | J Urol1997，158，32： | 1 |
| 7 | Evaluation of human se- rum albumin cobalt binding assay for the assessment of myocardial is chemia and myocar- dial infarction显示文摘 | BHAGAVAN N V LAI E M RIOS P A | 2003 | Clin Chen2003，49，4： | 1 |
| 8 | Locating the boundary between the Holocene and the Pleistocene in Chinese loess using luminescence 显示文摘 | Lai Z P Wintle A G | 2006 | The Holocene2006，16，： | 1 |
| 9 | Evaluation of huaman serum albumin cobalt binding assay for the assessment of mayocardial infarction显示文摘 | Bhagavan N V Lai E M Rios P A | 2003 | Clin Chem2003，49，5： | 1 |
| 10 | A comparison of the effects of prob- lem- based learning and lecturing on the development of students, critical thinking显示文摘 | Tiwari A Lai P So M | 2006 | Mede Duc2006，40，6： | 1 |
| 11 | Thermal imaging and analysis at submicrometer scsle using atomic force microscope显示文摘 | LAI J CARREJO J P MAJUMDAR A | 1993 | ASME-HTD1993，253，： | 1 |
| 12 | A comparison of the effects of problembased learning and lecturing on the development of students' critical thinking显示文摘 | Tiwari A Lai P So M | 2006 | Medical Education2006，40，： | 1 |
| 13 | Evaluation of human serum albumin cobalt binding assay for the assessment of myocardial is chemia and myocardial infarction显示文摘 | Bhagavan N V Lai E M Rios P A | | 0，，04： | 1 |
| 14 | Ultrasound-mediated microbubble enhancement of radiation therapy studied using three-dimensional high-frequency power Doppler ultrasound显示文摘 | Kwok SJ El Kaffas A Lai P | 2013 | Ultrasound Med Biol2013，39，11： | 1 |
| 15 | The ORION statement: guidelines for transparent reporting of outbreak reports and intervention studies of nosocomial infection显示文摘 | Sheldon P Stone Ben S Cooper Chris C Kibbler Barry D Cookson Jenny A Roberts Graham F Medley Georgia Duckworth Rosalind Lai Shah Ebrahim Erwin M Brown Phil J Wiffen Peter G Davey | 2007 | The Lancet Infectious Diseases2007，，4： | 1 |
| 16 | Arsenic trioxide prevents radiation-enhanced tumor invasiveness and inhibits matrix metalloproteinase-9 through downregulation of nuclear factor kappaB 显示文摘 | Wei L H Lai K P Chen C A | 2005 | Oneogene2005，24，3： | 1 |
| 17 | Association between QRS duration and outcome with cardiac resynchronization therapy: a systematic review and recta-analysis 显示文摘 | Bryant A R Wilton S B Lai M P | 2013 | Journal ofelectrocardiology2013，46，2： | 1 |
| 18 | Evaluation of human serum albumin cobalt binding assay for the assessment of myocardial ischemia and myocardial infarction 显示文摘 | Bhagavan N V Lai E M Rios P A | 2003 | Clin Chem2003，49，4： | 1 |
| 19 | Effect of biodegradable chelating agents on heavy metals phytoextraction with Mirabilis jalapa and on its associated bacteria显示文摘 | Cao A Carucci A Lai T La Colla P Tamburini E | | 0，，04： | 1 |
| 20 | High serum levels of soluble IL-2 receptor,cytokines,and C reactive protein correlate with impairment of T cell response in patients with advanced epithelial ovarian cancer显示文摘 | Maccio A Lai P Santona MC | 1998 | Gynecol Oncol1998，69，3： | 1 |
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