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| 1 | Ruptured hepatocellular carcinoma following chemoembolization:a western experience显示文摘BACKGROUND: Transcatheter arterial chemoembolization (TACE) is a recommended first line therapy for unresectable hepatocellular carcinoma (HCC). Serious complications such as neutropenic sepsis and hepatic decompensation are well known, but rupture of HCC following TACE is a rare and potentially fatal complication. The aim of this study was to identify the incidence of ruptured HCC following TACE and the associated risk factors. METHODS: A retrospective analysis was performed using our liver database with 'chemoembolization', 'ruptured HCC' covering the patients who received chemoembolization from January 1995 to December 2005. There were no exclusions. RESULTS: A total of 294 patients received chemoemboliza- tion in 530 sessions during the 10-year period. Of these, 2 ruptured following treatment (incidence 0.68%). The mean age was 65 years and the interval between the treatment and rupture was 2 and 24 days. The common factors were male sex, large tumor size (range 11-13 cm), and exophytic tumor growth. One patient died 2 days after rupture with hepatic decompensation while the second is alive after a 6-month follow up without tumor recurrence. CONCLUSIONS: Ruptured HCC following TACE is a rare but serious complication. Large tumor size, male sex, and exophytic growth of tumor may be predisposing factors for rupture. | Narendra Battula Parthi Srinivasan Mansoor Madanur Srinivas Prabhu Chava Oliver Priest Mohamed Rela Nigel Heaton | 2007 | Hepatobiliary & Pancreatic Diseases International2007，6，1： | 17 |
| 2 | Developing a donation after cardiac death risk index for adult and pediatric liver transplantation显示文摘AIM To identify objective predictive factors for donor after cardiac death(DCD) graft loss and using those factors, develop a donor recipient stratification risk predictive model that could be used to calculate a DCD risk index(DCD-RI) to help in prospective decision making on organ use.METHODS The model included objective data from a single institute DCD database(2005-2013, n = 261). Univariate survival analysis was followed by adjusted Cox-regressional hazard model. Covariates selected via univariate regression were added to the model via forward selection, significance level P = 0.3. The warm ischemic threshold was clinically set at 30 min. Points were given to each predictor in proportion to their hazard ratio. Using this model, the DCD-RI was calculated. The cohort was stratified to predict graft loss risk and respective graft survival calculated.RESULTS DCD graft survival predictors were primary indication for transplant(P = 0.066), retransplantation(P = 0.176), MELD > 25(P = 0.05), cold ischemia > 10 h(P = 0.292) and donor hepatectomy time > 60 min(P = 0.028).According to the calculated DCD-RI score three risk classes could be defined of low(DCD-RI < 1), standard(DCD-RI 2-4) and high risk(DCD-RI > 5) with a 5 years graft survival of 86%, 78% and 34%, respectively.CONCLUSION The DCD-RI score independently predicted graft loss(P < 0.001) and the DCD-RI class predicted graft survival(P < 0.001). | Shirin Elizabeth Khorsandi Emmanouil Giorgakis Hector Vilca-Melendez John O'Grady Michael Heneghan Varuna Aluvihare Abid Suddle Kosh Agarwal Krishna Menon Andreas Prachalias Parthi Srinivasan Mohamed Rela Wayel Jassem Nigel Heaton | 2017 | World Journal of Transplantation2017，7，3： | 3 |
| 3 | Spontaneous rupture of hepatocellular carcinoma: a Western experience显示文摘 | Narendra Battula Mansoor Madanur Oliver Priest Parthi Srinivasan John O’Grady Michael A. Heneghan Matthew Bowles Paolo Muiesan Nigel Heaton Mohamed Rela | 2009 | The American Journal of Surgery2009，，2： | 2 |
| 4 | Biliary Complications After Liver Transplantation Using Grafts from Donors After Cardiac Death: Results from a Matched Control Study in a Single Large Volume Center显示文摘 | Michelle L. DeOliveira Wayel Jassem Roberto Valente Shirin Elizabeth Khorsandi Gregorio Santori Andreas Prachalias Parthi Srinivasan Mohamed Rela Nigel Heaton | 2011 | Annals of Surgery2011，，5： | 2 |
| 5 | Design, Optimization and Evaluation of a Dual-Radius Spherical Microphone Array显示文摘 | Craig T. Jin Nicolas Epain Abhaya Parthy | 2014 | IEEE/ACM Transactions on Audio, Speech and Langua2014，，1： | 1 |
| 6 | Acoustic Holography with aConcentric Rigid and Open Spherical Microphone Array显示文摘 | Parthy A Van Schaik C J A A | 2009 | 1(5) :2173-21762009，1，5： | 1 |
| 7 | Utility of Drain Fluid Amylase Measurement on the First Postoperative Day after Pancreaticoduodenectomy显示文摘 | Robert Sutcliffe Narendra Battula Ali Haque Amir Ali Parthi Srinivasan Simon Atkinson Mohamed Rela Nigel Heaton Andreas Prachalias | 2012 | World Journal of Surgery2012，，4： | 1 |
| 8 | Involvement of adenosine and standardization of aqueous extract of garlic(Allium sativum Linn.)on cardioprotective and cardiodepressant properties in ischemic preconditioning and myocardial ischemia-reperfusion induced cardiac injury显示文摘The present study investigated the effect of garlic(Allium sativum Linn.)aqueous extracts on ischemic preconditioning and ischemia-reperfusion induced cardiac injury,as well as adenosine involvement in ischemic preconditioning and garlic extract induced cardioprotection.A model of ischemia-reperfusion injury was established using Langendorff apparatus.Aqueous extract of garlic dose was standardized(0.5%,0.4%,0.3%,0.2%,0.1%,0.07%,0.05%,0.03%,0.01%),and the 0.05% dose was found to be the most effective.Higher doses(more than 0.05%)were highly toxic,causing arrhythmia and cardiodepression,whereas the lower doses were ineffective.Garlic exaggerated the cardioprotective effect of ischemic preconditioning.The cardioprotective effect of ischemic preconditioning and garlic cardioprotection was significantly attenuated by theophylline(1,000 μmol/L)and 8-SPT(10 mg/kg,i.p.)and expressed by increased myocardial infarct size,increased LDH level,and reduced nitrite and adenosine levels.These findings suggest that adenosine is involved in the pharmacological and molecular mechanism of garlic induced cardioprotection and mediated by the modulation of nitric oxide. | Ashish Kumar Sharma Arshee Munajjam Bhawna Vaishnav Richa Sharma Ashok Sharma Kunal Kishore Akash Sharma Divya Sharma Rita Kumari Ashish Tiwari Santosh Kumar Singh Samir Gaur Vijay Singh Jatav Barthu Parthi Srinivasan Shyam Sunder Agarwal | 2012 | The Journal of Biomedical Research2012，26，1： | 1 |
| 9 | Design, optimization and evaluation of a dual-radius spherical microphone array显示文摘 | JIN C T EPAIN N PARTHY A | 2014 | IEEE Transactions on Audio Speech and Language Processing2014，22，1： | 1 |
| 10 | Design ? optimizationand evaluation of a dual-radius spherical microphonearray 显示文摘 | Jin C T Epain N Parthy A | 2014 | IEEE Transactions on Audio Speech andLanguage Processing2014，22，1： | 1 |
| 11 | Sclerosing encapsulating peritonitis after orthotopic liver transplantation显示文摘 | Donal M Parthi S John O | 2001 | Am J Surg2001，182，2： | 1 |
| 12 | Biliary Complications After Liver Transplantation Using Grafts from Donors After Cardiac Death: Results from a Matched Control Study in a Single Large Volume Center显示文摘 | Michelle L. DeOliveira Wayel Jassem Roberto Valente Shirin Elizabeth Khorsandi Gregorio Santori Andreas Prachalias Parthi Srinivasan Mohamed Rela Nigel Heaton | 2011 | Annals of Surgery2011，，5： | 1 |
| 13 | Biliary Complications After Liver Transplantation Using Grafts from Donors After Cardiac Death: Results from a Matched Control Study in a Single Large Volume Center显示文摘 | Michelle L. DeOliveira Wayel Jassem Roberto Valente Shirin Elizabeth Khorsandi Gregorio Santori Andreas Prachalias Parthi Srinivasan Mohamed Rela Nigel Heaton | 2011 | Annals of Surgery2011，，5： | 1 |
| 14 | Living related liver transplantation in biliary atresia with absent inferior vena cava显示文摘 | Parthi Srinivasan Matthew J Paolo Muiesan | 2001 | Liver Transplantation2001，7，4： | 1 |
| 15 | Surgical portosystemic shunts to facilitate major intrabdominal surgery显示文摘The effective management of patients with chronic liver disease (CLD) and portal hypertension (PHT) has significantly prolonged their survival. Hence, there is an emerging number of patients who will require major elective intrabdominal surgery for reasons unrelated to their CLD (e.g., colorectal cancer). | Michail Pizanias Elissaios Kontis Evangelos Prassas Parthi Srinivasan Andreas Prachalias | 2019 | Hepatobiliary & Pancreatic Diseases International2019，18，5： | 1 |
| 16 | Pancreaticoduodenectomy with radical lymphadenectomy is not contraindicated for patients with established chronic liver disease and portal hypertension显示文摘BACKGROUND: hronic liver disease has been considered a contraindication to radical surgery for intra-abdominal tumors because of the risk of decompensation. METHODS: In a retrospective analysis of all patients undergoing pancreaticoduodenectomy for cancer treated from January 2000 to December 2006 at our center, 4 patients were identified with operable pancreatic tumors and well-compensated chronic liver disease. The preoperative staging, decompression of the biliary tree, liver biopsy, Child-Turcot-Pugh and MELD scores were described.RESULTS: All patients underwent pancreaticoduodenectomy successfully with minimal blood loss, and no peri-operative blood transfusions or liver decompensation. There was no postoperative mortality. Two patients received adjuvant chemotherapy. One patient died with recurrent disease at 18 months, one is alive with disease recurrence, and two are alive and disease free.CONCLUSION: Patients with pancreatic cancer and well-compensated chronic liver disease should routinely be considered for radical surgery at specialist hepatobiliary centres with expertise available to manage complex liver disease. | Harsheet Sethi Parthi Srinivasan Gabriele Marangoni Andreas Prachalias Mohamed Rela Nigel Heaton | 2008 | Hepatobiliary & Pancreatic Diseases International2008，7，1： | 0 |
| 17 | Non-functioning well-differentiated neuroendocrine tumor of the extrahepatic bile duct:an unusual suspect?显示文摘BACKGROUND:Neuroendocrine tumors(NETs)arising in the biliary tree are extremely rare,and 37 cases were identified in the English literature. METHODS:A well-differentiated NET was found arising from the junction of the cystic and common hepatic ducts, in a 51-year-old male presenting with pedal edema and weight loss with abnormal liver enzymes and a normal serum bilirubin level.No mass was seen on radiological imaging and biopsy of the liver was suggestive of an early cholangiopathy.A bile leak complicating the liver biopsy led to an ERCP that demonstrated a filling defect suggestive of a mass in the common bile duct(CBD). RESULTS:He underwent a successful excision of the tumor with a Roux-en-Y hepaticojejunostomy.The diagnosis of NET was made on histological and immunohistochemical analysis of the resected specimen.He remains well and disease free 22 months after surgery. CONCLUSIONS:Recognition of biliary NET continues to be a challenge and an increased awareness of these tumors in rare sites will result in optimal management of these tumors. | Harsheet Sethi Mansoor Madanur Parthi Srinivasan Bernard Portmann Nigel Heaton Mohamed Rela | 2007 | Hepatobiliary & Pancreatic Diseases International2007，6，5： | 0 |
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