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| 1 | Developing a donation after cardiac death risk index for adult and pediatric liver transplantation显示文摘AIM To identify objective predictive factors for donor after cardiac death(DCD) graft loss and using those factors, develop a donor recipient stratification risk predictive model that could be used to calculate a DCD risk index(DCD-RI) to help in prospective decision making on organ use.METHODS The model included objective data from a single institute DCD database(2005-2013, n = 261). Univariate survival analysis was followed by adjusted Cox-regressional hazard model. Covariates selected via univariate regression were added to the model via forward selection, significance level P = 0.3. The warm ischemic threshold was clinically set at 30 min. Points were given to each predictor in proportion to their hazard ratio. Using this model, the DCD-RI was calculated. The cohort was stratified to predict graft loss risk and respective graft survival calculated.RESULTS DCD graft survival predictors were primary indication for transplant(P = 0.066), retransplantation(P = 0.176), MELD > 25(P = 0.05), cold ischemia > 10 h(P = 0.292) and donor hepatectomy time > 60 min(P = 0.028).According to the calculated DCD-RI score three risk classes could be defined of low(DCD-RI < 1), standard(DCD-RI 2-4) and high risk(DCD-RI > 5) with a 5 years graft survival of 86%, 78% and 34%, respectively.CONCLUSION The DCD-RI score independently predicted graft loss(P < 0.001) and the DCD-RI class predicted graft survival(P < 0.001). | Shirin Elizabeth Khorsandi Emmanouil Giorgakis Hector Vilca-Melendez John O'Grady Michael Heneghan Varuna Aluvihare Abid Suddle Kosh Agarwal Krishna Menon Andreas Prachalias Parthi Srinivasan Mohamed Rela Wayel Jassem Nigel Heaton | 2017 | World Journal of Transplantation2017，7，3： | 3 |
| 2 | Biliary Complications After Liver Transplantation Using Grafts from Donors After Cardiac Death: Results from a Matched Control Study in a Single Large Volume Center显示文摘 | Michelle L. DeOliveira Wayel Jassem Roberto Valente Shirin Elizabeth Khorsandi Gregorio Santori Andreas Prachalias Parthi Srinivasan Mohamed Rela Nigel Heaton | 2011 | Annals of Surgery2011，，5： | 2 |
| 3 | Gamma-glutamyltransferase and risk of cancer in a cohort of 545,460 persons – the Swedish AMORIS study显示文摘 | Mieke Van Hemelrijck Wayel Jassem Goran Walldius Ian S. Fentiman Niklas Hammar Mats Lambe Hans Garmo Ingmar Jungner Lars Holmberg | 2011 | European Journal of Cancer2011，，13： | 1 |
| 4 | The role of michondria in ischemia/reperfusion injury显示文摘 | Wayel Jassem Susan V Fuggle | 2002 | Transplantation2002，73，： | 1 |
| 5 | The role of mitochondria in ischemia/reperfusion injury显示文摘 | Wayel Jassem Susan V. Fuggle Mohamed Rela Dicken D.H . Koo Nigel D. Heaton | 2002 | Transplantation2002，，4： | 1 |
| 6 | Biliary Complications After Liver Transplantation Using Grafts from Donors After Cardiac Death: Results from a Matched Control Study in a Single Large Volume Center显示文摘 | Michelle L. DeOliveira Wayel Jassem Roberto Valente Shirin Elizabeth Khorsandi Gregorio Santori Andreas Prachalias Parthi Srinivasan Mohamed Rela Nigel Heaton | 2011 | Annals of Surgery2011，，5： | 1 |
| 7 | Biliary Complications After Liver Transplantation Using Grafts from Donors After Cardiac Death: Results from a Matched Control Study in a Single Large Volume Center显示文摘 | Michelle L. DeOliveira Wayel Jassem Roberto Valente Shirin Elizabeth Khorsandi Gregorio Santori Andreas Prachalias Parthi Srinivasan Mohamed Rela Nigel Heaton | 2011 | Annals of Surgery2011，，5： | 1 |
| 8 | Intrinsic T-cell regulator miR-142-3p/5p-a novel therapeutic target?显示文摘Systemic lupus erythematosus(SLE)is an autoimmune disease characterized by the presence of autoantibodies against various self-antigens.Systemic inflammation affects the skin,joints,central nervous system and,in particular,kidneys through so-called lupus nephritis(LN).1 The exact pathogenesis of systemic lupus erythematosus remains unclear.However,a growing body of evidence suggests that B-cells,a source of autoantibodies and effector T-cells,contribute to the pathogenesis of SLE by secreting cytokines.T-cell/B-cell interaction via their costimulation is crucial for an orchestrated immune response.This interaction is modulated by IL-21-producing T-follicular helper(Tfh)cells,which are located mainly in germinal centers.Tfh cells are required to help B-cells secrete high-affinity IgG antibodies. | Sebastian Dolff Wayel H.Abdulahad Benjamin Wilde | 2021 | Cellular & Molecular Immunology2021，18，2： | 0 |
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