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| 1 | Paroxetine ameliorates prodromal emotional dysfunction and late-onset memory deficit in Alzheimer’s disease mice显示文摘Background Neuropsychiatric symptoms(NPS)such as depression,anxiety,apathy,and irritability occur in prodromal phases of clinical Alzheimer’s disease(AD),which might be an increased risk for later developing AD.Here we treated young APP/PS1 AD model mice prophylactically with serotonin-selective re-uptake inhibitor(SSRI)paroxetine and investigated the protective role of anti-depressant agent in emotional abnormalities and cognitive defects during disease progress.Methods To investigate the protective role of paroxetine in emotional abnormalities and cognitive defects during disease progress,we performed emotional behaviors of 3 months old APP/PS1 mouse following oral administration of paroxetine prophylactically starting at 1 month of age.Next,we tested the cognitive,biochemical and pathological,effects of long term administration of paroxetine at 6 months old.Results Our results showed that AD mice displayed emotional dysfunction in the early stage.Prophylactic administration of paroxetine ameliorated the initial emotional abnormalities and preserved the eventual memory function in AD mice.Conclusion Our data indicate that prophylactic administration of paroxetine ameliorates the emotional dysfunction and memory deficit in AD mice.These neuroprotective effects are attributable to functional restoration of glutamate receptor(GluN2A)in AD mice. | Peng-Hui Ai Si Chen Xian-Dong Liu Xiao-Na Zhu Yuan-Bo Pan Dong-Fu Feng Shengdi Chen Nan-Jie Xu Suya Sun | 2020 | Translational Neurodegeneration2020，9，2： | 1 |
| 2 | 精神疾病的思维障碍相关基因研究进展显示文摘思维障碍是精神疾病常见的临床症状,思维障碍发生机理至今未明。思维障碍与精神分裂症患者伴发暴力攻击行为有关系[1,2],增加了暴力犯罪及肇事肇祸的风险[3]。有研究发现精神分裂症的关系妄想的病理基础可能是在听觉、视觉水平过多的关注无关信息,以及心理防御机制的不成熟[4]。逻辑学家以溯因推理作为逻辑认知模型,认为妄想信念可被看作对病态体验赋予的荒谬解释[5]。精神分裂症的幻觉、妄想神经生理机制的研究中认为与静息态脑网络突显网络的结构有关[6]。 | 吴晶茹 吴晶玉 张宪武 刘永义 | 2022 | 内蒙古医学杂志2022，54，2： | 0 |
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