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| 1 | Glutamine prevents oxidative stress in a model of mesenteric ischemia and reperfusion显示文摘AIM: To evaluate preventative effects of glutamine in an animal model of gut ischemia/reperfusion(I/R).METHODS: Male Wistar rats were housed in a controlled environment and allowed access to food and water ad libitum. Twenty male Wistar rats were divided into four experimental groups:(1) control group(control)- rats underwent exploratory laparotomy;(2) control + glutamine group(control-GLU)- rats were subjected to laparotomy and treated intraperitoneally with glutamine 24 and 48 h prior to surgery;(3) I/R group- rats were subjected to occlusion of the superior mesenteric artery for 30 min followed by 15 min of reperfusion; and(4) ischemia/reperfusion + glutamine group(G + I/R)- rats were treated intraperitoneally with glutamine 24 and 48 h before I/R. Local and systemic injuries were determined by evaluating intestinal and lung segments for oxidative stress using lipid peroxidation and the activity of superoxide dismutase(SOD), interleukin-6(IL-6) and nuclear factor kappa beta(NFkB) after mesenteric I/R. RESULTS: Lipid peroxidation of the membrane was increased in the animals subjected to I/R(P < 0.05). However, the group that received glutamine 24 and 48 h before the I/R procedure showed levels of lipid peroxidation similar to the control groups(P < 0.05). The activity of the antioxidant enzyme SOD was decreased in the gut of animals subjected to I/R when compared with the control group of animals not subjected to I/R(P < 0.05). However, the group that received glutamine 24 and 48 h before I/R showed similar SOD activity to both control groups not subjected to I/R(P < 0.05). The mean area of NF-kB staining for each of the control groups was similar. The I/R group showed the largest area of staining for NF-kB. The G + I/R group had the second highest amount of staining, but the mean value was much lower than that of the I/R group(P < 0.05). For IL-6, control and control-GLU groups showed similar areas of staining. The I/R group contained the largest area of IL-6 staining, followed by the G + I/R animals; however, this area was significantly lower than that of the group that underwent I/R without glutamine(P < 0.05). CONCLUSION: These results demonstrate that pretreatment with glutamine prevents mucosal injury and improves gut and lung recovery after I/R injury in rats. | Gilmara Pandolfo Zabot Gustavo Franco Carvalhal Norma Possa Marroni Renata Minuzzo Hartmann Vinícius Duval da Silva Henrique Sarubbi Fillmann | 2014 | World Journal of Gastroenterology2014，20，32： | 7 |
| 2 | Personality traits and emotional patterns in irritable bowel syndrome显示文摘The review focuses on those personality traits(neuroticism, extraversion, openness to experience, agreeableness, and conscientiousness), constructs(alexithymia and distressed- Type D personality) and emotional patterns(negative and positive) that are of particular concern in health psychology, with the aim to highlight their potential role on the pathogenesis, onset, symptom clusters, clinical course, and outcome of irritable bowel syndrome(IBS). Personality traits and emotional patterns play key roles in affecting autonomic, immune, inflammatory, and endocrine functions, thus contributing not only to IBS clinical expression and symptomatic burden, but also to disease physiopathology. In this sense, psychological treatments should address those personality traits and emotional features that are constitutive of, and integral to IBS. The biopsychosocial model of illness applied to IBS acknowledges the interaction between biological, psychological, environmental, and social factors in relation to pain and functional disability. A holistic approach to IBS should take into account the heterogeneous nature of the disorder, and differentiate treatments for different types of IBS, also considering the marked individual differences in prevalent personality traits and emotional patterns. Beyond medications, and lifestyle/dietary interventions, psychological and educational treatments may provide the optimal chance of addressing clinical symptoms, comorbid conditions, and quality of life in IBS patients. | Maria Rosaria A Muscatello Antonio Bruno Carmela Mento Gianluca Pandolfo Rocco A Zoccali | 2016 | World Journal of Gastroenterology2016，22，28： | 7 |
| 3 | Glutamine prevents oxidative stress in a model of portal hypertension显示文摘AIM To evaluate the protective effects of glutamine in a model of portal hypertension(PH) induced by partial portal vein ligation(PPVL).METHODS Male Wistar rats were housed in a controlled environment and were allowed access to food and water ad libitum. Twenty-four male Wistar rats were divided into four experimental groups:(1) control group(SO)-rats underwent exploratory laparotomy;(2) control + glutamine group(SO + G)-rats were subjected to laparotomy and were treated intraperitoneally with glutamine;(3) portal hypertension group(PPVL)-rats were subjected to PPVL; and(4) PPVL + glutamine group(PPVL + G)-rats were treated intraperitoneally with glutamine for seven days. Local injuries were determined by evaluating intestinal segments for oxidative stress using lipid peroxidation and the activities of glutathione peroxidase(GPx), endothelial nitric oxide synthase(e NOS) and inducible nitric oxide synthase(i NOS) after PPVL.RESULTS Lipid peroxidation of the membrane was increased in the animals subjected to PH(P < 0.01). However, the group that received glutamine for seven days after the PPVL procedure showed levels of lipid peroxidation similar to those of the control groups(P > 0.05). The activity of the antioxidant enzyme GTx was decreased in the gut of animals subjected to PH compared with that in the control group of animals not subjected to PH(P < 0.01). However, the group that received glutamine for seven days after the PPVL showed similar GTx activity to both the control groups not subjected to PH(P > 0.05). At least 10 random, non-overlapping images of each histological slide with 200 × magnification(44 pixel = 1 μm) were captured. The sum means of all áreas, of each group were calculated. The mean areas of e NOS staining for both of the control groups were similar. The PPVL group showed the largest area of staining for e NOS. The PPVL + G group had the second highest amount of staining, but the mean value was much lower than that of the PPVL group(P < 0.01). For i NOS, the control(SO) and control + G(SO + G) groups showed similar areas of staining. The PPVL group contained the largest area of i NOS staining, followed by the PPVL + G group; however, this area was significantly smaller than that of the group that underwent PH without glutamine(P < 0.01).CONCLUSION Treatment with glutamine prevents gut mucosal injury after PH in rats. | Gilmara Pandolfo Zabot Gustavo Franco Carvalhal Norma Possa Marroni Francielli Licks Renata Minuzzo Hartmann Vinícius Duval da Silva Henrique Sarubbi Fillmann | 2017 | World Journal of Gastroenterology2017，23，25： | 3 |
| 4 | Depression, Anxiety and Anger in Subtypes of Irritable Bowel Syndrome Patients显示文摘 | Maria Rosaria A. Muscatello Antonio Bruno Gianluca Pandolfo Umberto Micò Simona Stilo Mariagrazia Scaffidi Pierluigi Consolo Andrea Tortora Socrate Pallio Giuseppa Giacobbe Luigi Familiari Rocco Zoccali | 2010 | Journal of Clinical Psychology in Medical Settings2010，，1： | 2 |
| 5 | Carbon properties and their role in supercapacitors显示文摘 | A.G. Pandolfo A.F. Hollenkamp | 2006 | Journal of Power Sources2006，，1： | 2 |
| 6 | Effective bowel cleansing before colonoscopy: a randomized study of split-dosage versus non-split dosage regimens of high-volume versus low-volume polyethylene glycol solutions显示文摘 | Riccardo Marmo Gianluca Rotondano Giovanni Riccio Armando Marone Maria Antonia Bianco Italo Stroppa Anna Caruso Nicola Pandolfo Stefano Sansone Elena Gregorio Giuseppe D’Alvano Nicoletta Procaccio Pina Capo Clelia Marmo Livio Cipolletta | 2010 | Gastrointestinal Endoscopy2010，，2： | 2 |
| 7 | Modern surgical strategies for perianal Crohn's disease显示文摘One of the most challenging phenotypes of Crohn’s disease is perianal fistulizing disease(PFCD).It occurs in up to 50%of the patients who also have symptoms in other parts of the gastrointestinal tract,and in 5%of the cases it occurs as the first manifestation.It is associated with severe symptoms,such as pain,fecal incontinence,and a significant reduction in quality of life.The presence of perianal disease in conjunction with Crohn’s disease portends a significantly worse disease course.These patients require close monitoring to identify those at risk of worsening disease,suboptimal biological drug levels,and signs of developing neoplasm.The last 2 decades have seen significant advancements in the management of PFCD.More recently,newer biologics,cell-based therapies,and novel surgical techniques have been introduced in the hope of improved outcomes.However,in refractory cases,many patients face the decision of having a stoma made and/or a proctectomy performed.In this review,we describe modern surgical management and the most recent advances in the management of complex PFCD,which will likely impact clinical practice. | Gilmara Pandolfo Zabot Ornella Cassol Rogerio Saad-Hossne Willem Bemelman | 2020 | World Journal of Gastroenterology2020，26，42： | 2 |
| 8 | Carbon properties and their role in supercapacitors显示文摘 | Pandolfo A G Hollenkamp A F | 2006 | J Power Sources2006，157，1： | 1 |
| 9 | IL-6 Promotes compensatory liver regeneration in cirrhotic rat after partial hepatectomy显示文摘 | Guido A.M. Tiberio Laura Tiberio Anna Benetti Edoardo Cervi Nadia Montani Michel Dreano Gianni Garotta Katia Cerea Nathalie Steimberg GianPietro Pandolfo Andrea Ferrari-Bravo Giovanna Mazzoleni Stefano M. Giulini Luisa Schiaffonati | 2008 | Cytokine2008，，3： | 1 |
| 10 | Effect of aripiprazoleaugmentation of clozapine in schizophrenia : a double-blind, place-bo-controlled study 显示文摘 | Muscatello MR Bruno A Pandolfo G | 2011 | Schizophr Res2011，127，： | 1 |
| 11 | Carbon properties and their role in supercapacitors 显示文摘 | Pandolfo A G Hollenkamp A F | 2006 | Journal of Power Sources2006，157，： | 1 |
| 12 | The radiology of the pterygoid canal:normal and pathologic finding显示文摘 | Gaeta M Blandino A | 1987 | Am J Neuroradioly1987，8，3： | 1 |
| 13 | Depression, anxiety and anger in subtypes of irritable bowel syndrome patients 显示文摘 | Muscalello MRA Bruno A Pandolfo G | 2010 | J Clinical Psychology Medical Settings2010，17，： | 1 |
| 14 | Evaluation of a Ag | Ag+ reference electrode for use in room temperature ionic liquids显示文摘 | SNOOK G BEST A PANDOLFO A HOLLENKAMP A | 2006 | Electrochemistry Communications2006，8，9： | 1 |
| 15 | Topiramate augmentation of clzapine in schizophrenia: a double- blind, placebo- controlled study 显示文摘 | Muscatello MR Bruno A Pandolfo G | 2011 | J Psychopharmacol2011，25，5： | 1 |
| 16 | Activated carbons prepared from shells of different coconut shell 显示文摘 | PANDOLFO A G AMINI-AMOLI M KILLINGLEY J S | 1994 | Carbon1994，32，5： | 1 |
| 17 | Differential susceptibility following 13-amyloid peptide-(1-40)administration in C57BL/6 and Swiss albino mice:Evidence for a dissociation between :ognitive deficits and the glutathione system respons显示文摘 | Prediger RDS Franco J L Pandolfo P | 2007 | BehavBrain Res2007，177，2： | 1 |
| 18 | Carbon properties and their role in supercapacitors 显示文摘 | Pandolfo A G Hollenkamp A F | 2006 | J Power Sources2006，157，1： | 1 |
| 19 | Topiramate augmentation of clozapine in sehizophrenia z a double blind,placebo--controlled study显示文摘 | Muscatello M Bruno A Pandolfo G | 2011 | J Psychopharmacolo- gy2011，25，5： | 1 |
| 20 | Evaluation of the anterior ethmoidal artery by 3D dual volume rotational digital subtraction angiography and native multidetector CT with multiplanar reformations, initial findings显示文摘 | Pandolfo I Vinci S Salamone I | 2007 | Eur Radiol2007，17，6： | 1 |
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