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| 1 | Mucosal healing in inflammatory bowel disease: Maintain orde-escalate therapy显示文摘In the past decade, thanks to the introduction of biologic therapies, a new therapeutic goal, mucosal healing(MH), has been introduced. MH is the expression of an arrest of disease progression, resulting in minor hospitalizations, surgeries, and prolonged clinical remission. MH may be achieved with several therapeutic strategies reaching success rates up to 80% for both, ulcerative colitis(UC) and Crohn's disease(CD). Various scoring systems for UC and for the transmural CD, have been proposed to standardize the definition of MH. Several attempts have been undertaken to de-escalate therapy once MH is achieved, thus, reducing the risk of adverse events. In this review, we analysed the available studies regarding the achievement of MH and the subsequent treatment de-escalation according to disease type and administered therapy, together with non-invasive markers proposed as predictors for relapse. The available data are not encouraging since de-escalation after the achievement of MH is followed by a high number of clinical relapses reaching up to 50% within one year. Unclear is also another question, in case of combination therapies, which drug is more appropriate to stop, in order to guarantee a durable remission. Predictors of unfavourable outcome such as disease extension, perianal disease, or early onset disease appear to be inadequate to foresee behaviour of disease. Further studies are warranted to investigate the role of histologic healing for the further course of disease. | Marcello Cintolo Giuseppe Costantino Socrate Pallio Walter Fries | 2016 | World Journal of Gastrointestinal Pathophysiology2016，7，1： | 6 |
| 2 | Efficacy and safety of endoscopic papillary balloon dilation for the removal of bile duct stones: Data from a “real-life” multicenter study on Dilation-Assisted Stone Extraction显示文摘AIM To report data on Dilation-Assisted Stone Extraction(DASE) use in clinical practice and its efficacy and safety trough three Italian referral centers for biliopancreatic diseases treatment. METHODS From January 2011 to December 2015 we collected data on 120 patients treated with DASE. Technical success was obtained when the endoscopist was able to place the balloon trough the papilla inflating the balloon until the final diameter for an adequate time(at least 30 s). Clinical success was obtained after complete stone removal(no remaining stones were visible at the cholangiogram).RESULTS Forty-nine male(40.8%) and 71 female(59%) were enrolled. The mean age was 67.8 years ± 15.7. The mean common bile duct(CBD) dilation was 19.2 mm± 3.9 and the mean size of stones 15.8 ± 2.9. DASE was applied as first approach in 38%(62% after initial failure of stones extraction). Technical and clinical success was of 91% and 87% respectively. In those in which DASE failed alternative treatment were adopted. After DASE 18% of patients experienced a complication(bleeding 9%, pancreatitis 8%, perforation 0.8%). At univariable analysis, elective endoscopic retrograde cholangiopancreatography(P = 0.031), DASE as first approach(P = 0.032), and cannulation of major papilla followed by guidewire insertion(P = 0.004) were related to low risk of complications. Pre-cut was related to an increased risk of complications(P = 0.01). CONCLUSION DASE allowed a higher first-session success rate and can be consider a valid alternative to endoscopic sphincterotomy not only for bigger CBD stones. | Roberto Di Mitri Filippo Mocciaro Socrate Pallio Giulia Maria Pecoraro Andrea Tortora Claudio Zulli Simona Attardo Attilio Maurano | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，18： | 3 |
| 3 | Endoscopic ultrasound-guided ethanol ablation ofpancreatic neuroendocrine tumours:A case study andliterature review显示文摘Here we offer a review of the literature regarding endoscopic ultrasound-guided ethanol ablation for pancreatic neuroendocrine tumours and describe the case of a cystic tumour completely ablated after a multisession procedure. A total of 35 PubM ed indexed cases of treated functioning and non-functioning pancreatic neuroendocrine tumours resulted from our search, 29 of which are well-documented and summarised. Endoscopic ultrasound-guided ethanol ablation appears as a local, minimally invasive treatment of pancreatic neuroendocrine tumours, suitable for selected patients. This technique appears feasible, relatively safe and efficient, especially when applied to symptom relief in functioning tumours, aiming at loss of endocrine secretion. For non-functioning tumours, where the goal is complete tissue ablation, eus guided ethanol ablation can provide good results for patients who are unfit for surgery or for those who refuse surgical resection. Its role in 'fit for surgery' patients requires assessment through further studies. | Elia Armellini Stefano F Crinò Marco Ballarè Socrate Pallio Pietro Occhipinti | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，3： | 3 |
| 4 | Novel endoscopic management for pancreatic pseudocyst with fistula to the common bile duct显示文摘Pancreatic pseudocyst formation is a well-known complication of pancreatitis. It represents about 75% of the cystic lesions of the pancreas and might be located within or surrounding the pancreatic tissue. Sixty percent of the occurrences resolve spontaneously and only persistent, symptomatic or complicated cysts need to be treated. Complications include infection, hemorrhage, gastric outlet obstruction, splenic infarction and rupture. The formation of fistulas to other viscera is rare and most commonly occurs within the stomach, duodenum or colon. We report a case of a patient with a pancreatic pseudocyst in communication with the common bile duct. There have been only few cases reported in the literature. We successfully managed our case by performing an endoscopicultrasound-guided drainage of the pancreatic collection and a contemporaneous stenting of the common bile duct. Performed independently, both drainages are effective, safe and well-coded and the expertise on these procedures is widespread. By our knowledge this therapeutic approach was never reported in literature but we retain this is the most correct treatment for this very rare condition. | Stefano Francesco Crinò Giuseppe Scalisi Pierluigi Consolo Doriana Varvara Antonio Bottari Sebastiano Pantè Socrate Pallio | 2014 | World Journal of Gastrointestinal Endoscopy2014，6，12： | 3 |
| 5 | Depression, Anxiety and Anger in Subtypes of Irritable Bowel Syndrome Patients显示文摘 | Maria Rosaria A. Muscatello Antonio Bruno Gianluca Pandolfo Umberto Micò Simona Stilo Mariagrazia Scaffidi Pierluigi Consolo Andrea Tortora Socrate Pallio Giuseppa Giacobbe Luigi Familiari Rocco Zoccali | 2010 | Journal of Clinical Psychology in Medical Settings2010，，1： | 2 |
| 6 | Which patients with cirrhosis should undergo endoscopic screening for esophageal varices (EV) detection?显示文摘 | F. Schepis C. Camma D. Niceforo A. Magnano S. Pallio M. Cinquegrani G. D’Amico L. Pasta A. Craxi A. Saitta G. Raimondo | 2001 | Journal of Hepatology2001，，： | 1 |
| 7 | Which patients with cirrhosis should undergo endoscopic screening for esophageal varices detection?显示文摘 | Filippo Schepis Calogero Cammà Domenico Niceforo Antonio Magnano Socrate Pallio Maurizio Cinquegrani Gennaro D’Amico Linda Pasta Antonio Crax?? Antonino Saitta Giovanni Raimondo | 2001 | Hepatology2001，，2： | 1 |
| 8 | Optical Coherence Tomography in Inflammatory Bowel Disease: Prospective Evaluation of 35 Patients显示文摘 | P. Consolo M.D. G. Strangio M.D. C. Luigiano M.D. G. Giacobbe M.D. S. Pallio M.D. L. Familiari M.D. Ph.D | 2008 | Diseases of the Colon & Rectum2008，，9： | 1 |
| 9 | Gastric permeability to sucrose is increased in portal hypertensive gastropath显示文摘 | Giofre MR Meduri G Pallio S | 2000 | Eur J Gastroenterol Hepatol2000，12，5： | 1 |
| 10 | Upper Gastrointestinal Endoscopy Can Be a Reliable Screening Tool for Celiac Sprue in Adults显示文摘 | Giuseppe Magazzu Matteo Bottari Giovanni Tuccari Alessandro Arco Socrate Pallio Cristina Lucanto Andrea Tortora Gaetano Barresi | 1994 | Journal of Clinical Gastroenterology1994，，3： | 1 |
| 11 | Intraparietal esophageal leiomyomas diagnosed by endoscopic ultrasound?guidedfine?needle aspiration cytology: Cytological and immunocytochemical features intwo cases显示文摘 | P. Todaro S. Crinò A. Ieni S. Pallio P. Consolo G. Tuccari | 2014 | Oncology Letters2014，，1： | 1 |
| 12 | Gastric infection by He- licobacter pylori and antral gastritis in hyperglycemic obese and in diabetic subjects显示文摘 | Perdichizzi G Bottari M Pallio S | 1996 | New Microbiol1996，19，2： | 1 |
| 13 | Endoscopic mucosal resection for large and giant sessile and flat colorectal polyps: a single-center experience with long-term follow-up显示文摘 | C. Luigiano P. Consolo M. Scaffidi G. Strangio G. Giacobbe A. Alibrandi S. Pallio A. Tortora G. Melita L. Familiari | 2009 | Endoscopy2009，，： | 1 |
| 14 | Use of artificial intelligence in improving adenoma detection rate during colonoscopy:Might both endoscopists and pathologists be further helped显示文摘Colonoscopy remains the standard strategy for screening for colorectal cancer around the world due to its efficacy in both detecting adenomatous or precancerous lesions and the capacity to remove them intra-procedurally.Computeraided detection and diagnosis(CAD),thanks to the brand new developed innovations of artificial intelligence,and especially deep-learning techniques,leads to a promising solution to human biases in performance by guarantying decision support during colonoscopy.The application of CAD on real-time colonoscopy helps increasing the adenoma detection rate,and therefore contributes to reduce the incidence of interval cancers improving the effectiveness of colonoscopy screening on critical outcome such as colorectal cancer related mortality.Furthermore,a significant reduction in costs is also expected.In addition,the assistance of the machine will lead to a reduction of the examination time and therefore an optimization of the endoscopic schedule.The aim of this opinion review is to analyze the clinical applications of CAD and artificial intelligence in colonoscopy,as it is reported in literature,addressing evidence,limitations,and future prospects. | Emanuele Sinagra Matteo Badalamenti Marcello Maida Marco Spadaccini Roberta Maselli Francesca Rossi Giuseppe Conoscenti Dario Raimondo Socrate Pallio Alessandro Repici Andrea Anderloni | 2020 | World Journal of Gastroenterology2020，26，39： | 0 |
| 15 | Oldest biliary endoprosthesis in situ显示文摘The advantages of endoscopic retrograde cholangio-pancreatography over open surgery have made it the predominant method of treating patients with choledo-cholithiasis. After sphincterotomy, however, 10%-15% of common bile duct stones cannot be removed with a basket or balloon. The methods for managing 'irretrievable stones' include surgery, mechanical lithotripsy, intraductal or extracorporeal shock wave lithotripsy and biliary stenting. The case presented was a referred 82-year-old Caucasian woman with a 7-year-old plastic biliary endoprosthesis in situ . To the best of our knowledge the examined endoprosthesis is the oldest endo-prosthesis in situ reported in the literature. Endoscopic biliary endoprosthesis placement remains a simple and safe procedure for patients with stones that are difficult to manage by conventional endoscopic methods and for patients who are unfit for surgery or who are high surgical risks. To date no consensus has been reached regarding how long a biliary prosthesis should remain in situ . Long-term biliary stenting may have a role in selected elderly patients if stones extraction has failed because the procedure may prevent stones impaction and cholangitis. | Pierluigi Consolo Giuseppe Scalisi Stefano F Crinò Andrea Tortora Giuseppa Giacobbe Marcello Cintolo Luigi Familiari Socrate Pallio | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，7： | 0 |
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