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1Livestock breeding for the 21st century: the promise of the editing revolution显示文摘In recent years there has been a veritable explosion in the use of genome editors to create sitespecific changes,both in vitro and in vivo,to the genomes of a multitude of species for both basic research and biotechnology.Livestock,which form a vital component of most societies,are no exception.While selective breeding has been hugely successful at enhancing some production traits,the rate of progress is often slow and is limited to variants that exist within the breeding population.Genome editing provides the potential to move traits between breeds,in a single generation,with no impact on existing productivity or to develop de novo phenotypes that tackle intractable issues such as disease.As such,genome editors provide huge potential for ongoing livestock development programs in light of increased demand and disease challenge.This review will highlight some of the more notable agricultural applications of this technology in livestock.Chris PROUDFOOT Gus MCFARLANE Bruce WHITELAW Simon LILLICO 2020Frontiers of Agricultural Science and Engineering2020,7,2:2
2Combined Inhibition of CCL2, CX3CR1, and CCR5 Abrogates Ly6Chi and Ly6Clo Monocytosis and Almost Abolishes Atherosclerosis in Hypercholesterolemic Mice显示文摘Christophe Combadière Stéphane Potteaux Mathieu Rodero Tabassome Simon Adeline Pezard Bruno Esposito Régine Merval Amanda Proudfoot Alain Tedgui Ziad Mallat 2008Circulation2008,,13:2
3Calcium Regulates Key Components of Vascular Smooth Muscle Cell–Derived Matrix Vesicles to Enhance Mineralization显示文摘Alexander N. Kapustin John D. Davies Joanne L. Reynolds Rosamund McNair Gregory T. Jones Anissa Sidibe Leon J. Schurgers Jeremy N. Skepper Diane Proudfoot Manuel Mayr Catherine M. Shanahan 2011Circulation Research2011,,1:2
4Biology of Calcification in Vascular Cells: Intima versus Media显示文摘Diane Proudfoot Catherine M. Shanahan 2001Herz2001,,4:2
5Effect of different levels of dietary sorbic acid on general performance and incidence of leg abnormalities of commercial broilers reared to roaster weight显示文摘HULAN H W PROUDFOOT F G 1984Pouh Sci1984,63,9:1
6Matrix gla protein is regulated by a mechanism functionally related to the calcium-sensing receptor显示文摘Farzaneh Far A Proudfoot D Weissberg P L et al 2000Biochem Biophys Res Commun2000,277,3:1
7Impact of a nurse-led clinic for chronic constipation in children显示文摘Ismail N Ratchford I Proudfoot C 0,,:1
8Inhibition of lipoprotein oxidation by prenylated xanthones derived from mangostin 显示文摘Mahabusarakam W Proudfoot J Taylor W 2000Free Radic Res2000,33,5:1
9Expression of mineralisation-regulating proteins in association with human vascular calcification显示文摘Shanahan CM Proudfoot D Tyson K 2000Z Kardiol2000,8,:1
10Molecular mechanisms mediating vascular calcification:role of matrix Gla protein显示文摘Proudfoot D Shanahan C M 2006Nephrology2006,11,5:1
11Specific di- etary polyphenols attenuate atherosclerosis in apolipopro- rein E-knockout mice by alleviating inflammation and en- dothelial dysfunction 显示文摘Loke W M Proudfoot J M Hodgson J M 2010Arteriosclerosis Thrombosis and Vascular Biology2010,30,4:1
12Differential effects of CC chemokines on CC chemokine receptor 5 (CCR5) phosphorylation and identification of phosphorylation sites on the CCR5 carboxyl terminus显示文摘 Mack M Proudfoot AE 1999J Biol Chem1999,274,13:1
13Anticoagulant rodenticides 显示文摘Watt BE Proudfoot AT Bradberry SM 2005Toxicol Rev2005,24,4:1
14Paraquat poisoning:significance of plasma-paraquat concentration显示文摘Proudfoot AT Stewart MS Levitt T 1979Lancet1979,2,8138:1
15The effects of feedinguntreated and formic acid-treated colostrum ad libitum on intakeand immunoglobulin levels in dairy calves显示文摘Collings L Proudfoot K L Veira D M 2011Canadian Journal ofAnimal Science2011,91,1:1
16Vascular smooth muscle cel phenotypic plasticity and the regulation of vascular calcification显示文摘Iyemere VP Proudfoot D Weissberg PL 0,,03:1
17Sodium fluo_roacetate poisoning显示文摘PROUDFOOT A T BRADBERRY S M VALE J A 2006Toxicol Rev2006,25,4:1
18The role of Gla protein in vascular calcification显示文摘 Proudfoot D Farzaneh Far A 1998Crit Rev Eukaryot Gene Expr1998,8,34:1
19Inhibition of lipoprotein oxidation by prenylatted xanthones derived from mangostin显示文摘 Proudfoot J Taylor W 2000Free Radic Res2000,33,5:1
20The strategy of blocking the chemokine system to combat disease显示文摘Proudfoot AE Power CA Wells TN 2000Immunol Rev2000,,177:1
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