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| 1 | Pediatric functional constipation treatment with Bifi dobacterium-containing yogurt:A crossover,double-blind,controlled trial显示文摘AIM: To evaluate the treatment of pediatric functional chronic intestinal constipation (FCIC) with a probiotic goat yogurt. METHODS: A crossover double-blind formula-controlled trial was carried out on 59 students (age range: 5-15 years) of a public school in Belo Horizonte, MG, Brazil, presenting a FCIC diagnostic, according to Roma Ⅲ criteria. The students were randomized in two groups to receive a goat yogurt supplemented with 109 colony forming unit/mL Bifidobacterium longum (B.longum) (probiotic) daily or only the yogurt for a period of 5 wk (formula). Afterwards, the groups were intercrossed for another 5 wk. Defecation frequency, stool consistency and abdominal and defecation pain were assessed.RESULTS: Both treatment groups demonstrated improvement in defecation frequency compared to baseline. However, the group treated with probiotic showed most signif icant improvement in the f irst phase of the study. An inversion was observed after crossing over, resulting in a reduction in stool frequency when this group was treated by formula. Probiotic and formula improved stool consistency in the f irst phase of treatment, but the improvement obtained with probiotic was significantly higher (P = 0.03). In the second phase of treatment, the group initially treated with probiotic showed worseningstool consistency when using formula. However, the difference was not signif icant. A signif icant improvement in abdominal pain and defecation pain was observed with both probiotic and formula in the first phase of treatment, but again the improvement was more signif icant for the group treated with B. longum during phase I (P < 0.05). When all data of the crossover study were analyzed, significant differences were observed between probiotic yogurt and yogurt only for defecation frequency (P = 0.012), defecation pain (P = 0.046) and abdominal pain (P = 0.015). | Paula VP Guerra Luiza N Lima Tassia C Souza Vanessa Mazochi Francisco J Penna Andreia M Silva Jacques R Nicoli Elizabet V Guimares | 2011 | World Journal of Gastroenterology2011，17，34： | 25 |
| 2 | 欧洲儿科胃肠肝病学与营养学会对于早产儿肠内营养需求的建议显示文摘欧洲儿科胃肠病学与营养学会(ESPGAN)于1987年发布了早产儿肠内营养指南。2007年3月,ESPGAN专家组提出了新的推荐指南。指南目的是为早产儿所需营养素(数量和质量)提供指导,从而使早产儿的宫外生长速度与宫内生长速度类似,并满足各组织器官功能的发育成熟。 | 赵莉(摘译) 贲晓明(审校) Agostoni C Buonocore G Carnielli VP | 2012 | 中国新生儿科杂志2012，27，5： | 8 |
| 3 | Current and future applications of magnetic resonance imaging and spectroscopy of the brain in hepatic encepha-lopathy显示文摘肝的脑病(他) 普通 neuro 精神病学的畸形,它从肝细胞失败或 portosystemic 与肝疾病和结果复杂化病人的功课正在推延。表明他是广泛地可变的并且从温和无临床症状的骚乱包含一个系列到深昏迷。研究兴趣集中于传播导出勇气的毒素的角色,特别地氨,胀大的大脑的开发和在导致全球 CNS 消沉和混乱功能的服的 neurotransmitter 系统的变化。直到最近,服的功能的直接调查有在人是困难的。然而,当磁性的回声光谱学( 1H 太太)检测的质子在大脑生物化学变化时,新磁性的回声成像( MRI )技术在大脑体积( coregistered MRI )和损害大脑功能( fMRI )提供对变化的评价的一个非侵略的工具,包括服的 osmolytes 的直接测量,例如 myoinositol ,充斥管理对细胞的动态平衡内在的过程的使挫折和夫酸安,包括细胞内部的水的累积。这些细胞内部的 osmolytes 的集中与 hyperammonaemia 改变。有 neuropsychiatric 缺陷并且自从先生系列的严厉的检测太太的代谢物畸形相互关联向正常术后疗法回来,技术可能具有在客观耐心的监视并且在估计各种各样的治疗政体的有效性的使用。 | VP Bob Graver M Alex Dresner Daniel M Forton Serena Counsell David J Larkman Nayna Patel Howard C Thomas Simon D Taylor-Robinson | 2006 | World Journal of Gastroenterology2006，12，19： | 8 |
| 4 | 间质干细胞移植修复脊髓损伤:从基础研究到临床转化显示文摘脊髓损伤是一类通常由创伤所致感觉和运动功能受损的临床常见疾病,其病理生理改变主要发生初损伤过程及二次损伤过程,可直接导致器官功能障碍、组织坏死、感觉和运动功能的不可逆病变,甚至死亡的严重后果。为抑制二次损伤和修复受损的中枢神经系统,国内、外开展了广泛的探索与尝试,修复手段包括药物治疗、手术减压、生物材料移植、自体外周神经移植等方法,但临床疗效并不满意。干细胞具有可促进神经细胞再生及直接分化成神经样细胞的可能,同时具有抗炎、抗凋亡、抗氧化应激、促分泌营养因子及促血管再生等多重疗效,因此干细胞移植修复脊髓损伤近年来为脊髓损伤患者带来了新的希望。在众多类型的干细胞中,间质干细胞由于其具有机体内分布广、分化潜能强、分离难度低、体外保存扩增易操作及可避免伦理道德等特点,并已在体外、动物和临床等不同层面进行了一系列尝试,取得了一定的成果。近年来,间质干细胞移植在脊髓损伤的修复研究过程中取得了重要进展,随着多项临床试验的结束,已有临床报道提示间质干细胞在修复脊髓损伤的临床转化方面具有良好的前景,同时也对其临床转化提出了更深层、更具体的思考和要求。本文将基于近三年内最新报道的文献和笔者研究团队的近期研究成果,对间质干细胞移植修复脊髓损伤从基础研究到临床转化以及其发展前景做一系统综述。 | 张超 Chekhonin VP Blyukhovetskiy AS 李波 冯世庆 | 2016 | 中华骨科杂志2016，36，6： | 6 |
| 5 | Duodenal diverticulum and associated pancreatitis:Case report with brief review of literature显示文摘Pancreatitis in the elderly is a problem of increasing occurrence and is associated with severe complications.Periampullary diverticula(PAD) are extraluminal outpouchings of the duodenum rarely associated with pancreatitis.The presence of PAD should be excluded before diagnosing idiopathic pancreatitis,particularly in the elderly.However,when a duodenal diverticulum is found in the absence of any additional pathology,only then should the symptoms be attributed to the diverticulum.We describe a case of duodenal diverticulum presenting with pancreatitis to emphasize the importance of this commonly neglected etiology. | Mian Muhammad Rizwan Harpeet Singh VP Chandar Maria Zulfiqar Veera Singh | 2011 | World Journal of Gastrointestinal Endoscopy2011，3，3： | 3 |
| 6 | Frequent amplification of a chr19q13.41 microRNA polycistron in aggressive primitive neuroectodermal brain tumors显示文摘 | Li M Lee KF Lu Y Clarke I Shih D Eberhart C Collins VP Van Meter T Picard D Zhou L Boutros PC Modena P Liang ML Scherer SW Bouffet E Rutka JT Pomeroy SL Lau CC Taylor MD Gajjar A Dirks PB Hawkins CE Huang A. | 2009 | 中国神经肿瘤杂志2009，7，4： | 3 |
| 7 | 钻井指标—新的钻头性能评价方法显示文摘 | Perr.,VP 孙明光 | 1999 | 国外钻井技术1999，14，1： | 3 |
| 8 | Hepatic artery infusion chemotherapy: gastroduodenal complications显示文摘 | Chuang VP Wallace S Stroehlein J | 1981 | AJR1981，137，2： | 2 |
| 9 | Cytochrome C in the apoptotic and antioxidant cascades显示文摘 | Skulachev VP | | 0，，： | 2 |
| 10 | 药代动力学与生物利用度研究中生物样本分析方法的合格性查证显示文摘在药代动力学、生物利用度(bioavailability)与生物等效度的研究中,重要的是必须采用具有特征的且经充分合格性查证(Validated)的现代化分析方法,以获得能供满意解释的可靠数据。分析方法经常在改进,需要强调:每一种分析技术都具有自己的因药而异的特点。分析技术的适用性受研究工作最终目标的影响。用于每种药物或代谢物的分析方法,需要各自明确的合格性查证标准.当样本进行多中心分析时,必须在每个实验室对分析方法进行合格性查证,并为每个实验室提供适当的合格性查证信息,使各实验室之间的测定结果具有相互可信性。 | Shan VP 曾衍霖 | 1993 | 国外医药(合成药.生化药.制剂分册)1993，14，4： | 2 |
| 11 | Macroporous polymer foams by hydrocarbon templating显示文摘 | Shastri VP Martin I Langer R | 2000 | Pro Nat Acad Sci USA2000，97，5： | 2 |
| 12 | Management of horizontal root - fractured teeth : report of three cases 显示文摘 | Westphalen VP de Sousa MH da Silva Neto UX | 2008 | Dent Traumatol2008，24，4： | 1 |
| 13 | Stereotaxlc needle-core biopsy and fine needle aipiration cytologic evaluation of nonpalpable breast lesions显示文摘 | Jackson VP Reynolds HE | 1999 | Radiology1999，181，： | 1 |
| 14 | Optimum solution structure for a repairable inventory problem显示文摘 | Simpson VP | 1978 | Operations Research1978，26，2： | 1 |
| 15 | Effects of tumor necrosis factor alpha on host immune response in chronic persistent tuberculosis: possible role for limiting pathology显示文摘 | Mohan VP Scanga CA Yu K Scott HM Tanaka KE Tsang E Tsai MM Flynn JL Chan J | 2001 | Infect Immune2001，69，3： | 1 |
| 16 | Incidence and duration of recurrence of respiratory tuberculosis in adults 显示文摘 | Gavrilenko VS Tavolzhanskii VP Oksachenko OO Miller VA Kozlova MK Spevak Ⅳ | 1993 | Probl Tuberk1993，，2： | 1 |
| 17 | Comparative analysis of different methods in the treatment of patients with acute calculous cholecystitis and choledocholithiasis 显示文摘 | Bashilov VP Brekhov EI Malov I | 2005 | Khirurgiia(Mosk)2005，17，10： | 1 |
| 18 | Immunomicelles:targeted pharmaceutical carriers for poorly soluble drugs显示文摘 | Torchilin VP Lukyanov AN Gao Z | 2003 | Proc Natl Acad Sci U S A2003，100，10： | 1 |
| 19 | Vascular access stenosis:prospects for prevention and therapy显示文摘 | Sukhatme VP | 1996 | Kidney Internaational1996，49，4： | 1 |
| 20 | Inhibition of the relative movement of actin and myosin by caldesmon and calponin显示文摘 | Shirinsky VP Biryukov KG Hettasch JM | 1992 | J Biol Chem1992，267，15： | 1 |
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