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| 1 | Clinical significance of NOD2/CARD15 and Toll-like receptor 4 gene single nucleotide polymorphisms in inflammatory bowel disease显示文摘AIM: To evaluate the role of genetic factors in the pathogenesis of Crohn's disease (CD) and ulcerative colitis (UC), we investigated the single nucleotide poly- morphisms (SNPs) of NOD2/CARD15 (R702W, G908R and L1007fi nsC), and Toll-like receptor 4 (TLR4) genes (D299G and T399I) in a selected inflammatory bowel disease (IBD) population coming from Southern Italy. METHODS: Allele and genotype frequencies of NOD2/ CARD15 (R702W, G908R and L1007finsC) and TLR4 (D299G and T399I) SNPs were examined in 133 CD pa-tients, in 45 UC patients, and in 103 healthy controls. A genotype-phenotype correlation was performed. RESULTS: NOD2/CARD15 R702W mutation was sig-nificantly more frequent in CD (9.8%) than in controls (2.4%, P = 0.001) and in UC (2.3%, P = 0.03). No sig-nificant difference was found between UC patients and control group (P > 0.05). In CD and UC patients, no signifi cant association with G908R variant was found. L1007f insC SNP showed an association with CD (9.8%) compared with controls (2.9%, P = 0.002) and UC patients (2.3%, P = 0.01). Moreover, in CD patients, G908R and L1007finsC mutations were significantly associated with different phenotypes compared to CD wild-type patients. No association of IBD with the TLR4 SNPs was found in either cohort (allele frequencies: D299G-controls 3.9%, CD 3.7%, UC 3.4%, P > 0.05; T399I-controls 2.9%, CD 3.0%, UC 3.4%, P > 0.05). CONCLUSION: These findings confirm that, in our IBD patients selected from Southern Italy, the NOD2/ CARD15, but not TLR4 SNPs, are associated with in-creased risk of CD. | Luciana Rigoli Claudio Romano Rosario Alberto Caruso Maria A Lo Presti Chiara Di Bella Vincenzo Procopio Giuseppina Lo Giudice Maria Amorini Giuseppe Costantino Maria D Sergi Caterina Cuppari Giovanna Elisa Calabrò Romina Gallizzi Carmelo Damiano Salpietro Walter Fries | 2008 | World Journal of Gastroenterology2008，14，28： | 8 |
| 2 | Surgical treatment of synchronous colorectal liver and lung metastases: the usefulness of thoracophrenolaparotomy for single stage resection显示文摘When suitable, surgery still remains the therapeutic option to be preferred for patients carrier of colorectal liver and lung metastases. Since thoracophrenolaparotomy should be helpful during liver resection for some of these patients, simultaneous removal of right lung metastases can be proposed through this approach. Eleven consecutive patients(median age of 53 years) carrier of colorectal liver and lung metastases, underwent single session surgical resection of both liver and right lung lesions by means of J-shaped thoracophrenolaparotomy. The median number of liver metastases removed was 5(range 2-30) and of lung metastases removed was 2(range 1-3). Lung metastases were located in the upper lobe in 1 patient, in the middle lobe in 2, in the lower lobe in 6, and in the upper and lower lobe in 2. Mortality and major morbidity were nil. Two patients had a minor morbidity: one had wound infection and bile leakage treated conservatively and the other had transient fever. Mean overall survival was 24.4 months. An aggressive surgical approach should be undertaken for colorectal metastases: in case of multifocal liver disease with complex presentations, J-shaped thoracophrenolaparotomy could be considered as safe approach for combined liver and right lung metastasectomies. | Daniele Del Fabbro Marco Alloisio Fabio Procopio Matteo Cimino Matteo Donadon Angela Palmisano Luca Viganò Guido Torzilli | 2016 | Hepatobiliary & Pancreatic Diseases International2016，15，2： | 3 |
| 3 | Are capecitabine and oxaliplatin (XELOX) suitable treatments for progressing low-grade and high-grade neuroendocrine tumours?显示文摘 | Emilio Bajetta Laura Catena Giuseppe Procopio Sara Dosso Ettore Bichisao Leonardo Ferrari Antonia Martinetti Marco Platania Elena Verzoni Barbara Formisano Roberto Bajetta | 2007 | Cancer Chemotherapy and Pharmacology2007，，： | 2 |
| 4 | Nested stromal-epithelial tumour of the liver:An unusual liver entity显示文摘Nested stromal-epithelial tumours(NSETs)of the liver have been reported to be extremely unusual primary hepatic neoplasms.To date,few cases have been described in the literature.NSETs have been defined as non-hepatocytic and non-biliary tumours of the liver consisting of nests of epithelial and spindled cells,myofibroblastic stroma and variable intralesional calcification and ossification.Here,we report a case of a young female who underwent liver resection for a large hepatic lesion that proved to be a calcifying NSET on pathological examination.Details about the clinical and histopathological features of the tumour are reported. | Fabio Procopio Luca Di Tommaso Silvia Armenia Vittorio Quagliuolo Massimo Roncalli Guido Torzilli | 2014 | World Journal of Hepatology2014，6，3： | 2 |
| 5 | In obesity glucose load loses its early inhibitory, but maintains its late stimulatory effect on somatotrope secretion 显示文摘 | Grottoli S Procopio M Maccario M | 1997 | J Clin Endocrinol Metab1997，82，7： | 1 |
| 6 | The in vivo effects of general and epidural anesthesia on human immune function 显示文摘 | Procopio M A Rassias A J DeLeo J A | 2001 | Anesth Analg2001，93，2： | 1 |
| 7 | Antibiotics produced by Streptomyces显示文摘 | Procopio RE Silva IR Martins MK | 2012 | Brazilian Joumal of Infectious Diseases2012，16，5： | 1 |
| 8 | Apoptosis and myostatin mRNA are upregulated in the skeletal muscle of patients with chronic kidney disease显示文摘 | VERZOLA D PROCOPIO V SOFIA A | 2011 | Kidney Int2011，79，7： | 1 |
| 9 | Circulating inflamma-miRs in aging and age-related diseases显示文摘 | Olivieri F Rippo M R Procopio A D | 2013 | Front Genet2013，4，： | 1 |
| 10 | Peripheral tissue release of interleukin 6 in patients with chronic kidney disease:effects of end-stage renal disease and microinflammatory state显示文摘 | Garibotto G Sofia A Procopio Y | 2006 | Kidney Int2006，70，2： | 1 |
| 11 | 5-Lipoxygenase regulates senescence-like growth arrest by promoting ROS-dependent p53 activation显示文摘 | Catalano A Rodilossi S Caprari P Coppola V Procopio A | 2005 | EMBO J2005，24，1： | 1 |
| 12 | Sorafenib tolera- bility in elderly patients with advanced renal cell carcino-ma :results from a large pooled analysis 显示文摘 | Procopio G Bellmunt J Dutcher J | 2013 | Br J Cancer2013，108，2： | 1 |
| 13 | Renal cell cancer andsorafenib : skin toxicity and treatment outcome 显示文摘 | Bajetta E Procopio G Verzoni E | 2007 | Tumori2007，93，2： | 1 |
| 14 | Effectiveness and utility of hyaluronic acid in osteoarthritis显示文摘 | Migliore A Procopio S | 2015 | Clin Cases Miner Bone Metab2015，12，1： | 1 |
| 15 | Interaction of free fatty acids and arginine on growth hormone secretion in man 显示文摘 | I Maccario M Procopio M Loche S | 1994 | Metabolism1994，43，： | 1 |
| 16 | The in vivo effect of general and epidural anesthesia on human immune function显示文摘 | PROCOPIO M A RASSIAS A J DELEO J A | 2001 | Anesth Analg2001，93，2： | 1 |
| 17 | One-stage ultrasonographically guided hepatectomy for multiple bilobar colorectal metastases:a feasible and effective alternative to the 2-stage approach显示文摘 | Torzilli G Procopio F Botea F | | 0，，01： | 1 |
| 18 | Tailoring the area of hepatic resection using inflow and outflow modulation显示文摘The performance of hepatic surgery without a parenchyma-sparing strategy carries significant risks for patient survival because of the not negligible occurrence of postoperative liver failure.The key factor of modern hepatic surgery is the use of the intraoperative ultrasound(IOUS),not only to stage the disease,but more importantly to guide resection with the specific aim to maximize the sparing of the functional parenchyma.Whether in patients with hepatocellular carcinoma and underlying liver cirrhosis,or in patients with colorectal liver metastasis,IOUS allows the performance of the so-called 'radical but conservative surgery',which is the pivotal factor to offer a chance of cure to an increasing proportion of patients,who until few years ago were considered only for palliative care.Using some new IOUS-guided surgical maneuvers,which are based on the liver inflow and outflow modulations,more precise anatomically subsegmental-and segmentaloriented resections can be effectively performed.The present work describes the rationale and the surgical technique for a precise tailoring of the area of hepatic resection using the most recent attainments in IOUS.Such important technical achievements should be a fundamental part of the surgical armamentarium of the modern liver surgeon. | Matteo Donadon Fabio Procopio Guido Torzilli | 2013 | World Journal of Gastroenterology2013，19，7： | 1 |
| 19 | Ch- aracterization of Ti4AIN3显示文摘 | PROCOPIO A T BARSOUM M W RAGHY T EL | 2000 | Metallurgical And Material Transactions2000，31，2： | 1 |
| 20 | Tumor vessel development and maturation impose limits onthe effectiveness of anti-vascular therapy 显示文摘 | Gee MS Procopio WN Makonnen S | 2003 | AmJ Pathol2003，162，1： | 1 |
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