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| 1 | A Snapshot of the Effective Indications and Results of Surgery for Hepatocellular Carcinoma in Tertiary Referral Centers: Is It Adherent to the EASL/AASLD Recommendations?: An Observational Study of the HCC East-West Study Group显示文摘 | Guido Torzilli Jacques Belghiti Norihiro Kokudo Tadatoshi Takayama Lorenzo Capussotti Gennaro Nuzzo Jean-Nicolas Vauthey Michael A. Choti Eduardo De Santibanes Matteo Donadon Emanuela Morenghi Masatoshi Makuuchi | 2013 | Annals of Surgery2013，，5： | 7 |
| 2 | Tumor microenvironment in primary liver tumors: A challenging role of natural killer cells显示文摘In the last years,several studies have been focused on elucidate the role of tumor microenvironment(TME)in cancer development and progression.Within TME,cells from adaptive and innate immune system are one of the main abundant components.The dynamic interactions between immune and cancer cells lead to the activation of complex molecular mechanisms that sustain tumor growth.This important cross-talk has been elucidate for several kind of tumors and occurs also in patients with liver cancer,such as hepatocellular carcinoma(HCC)and intrahepatic cholangiocarcinoma(iCCA).Liver is well-known to be an important immunological organ with unique microenvironment.Here,in normal conditions,the rich immune-infiltrating cells cooperate with non-parenchymal cells,such as liver sinusoidal endothelial cells and Kupffer cells,favoring self-tolerance against gut antigens.The presence of underling liver immunosuppressive microenvironment highlights the importance to dissect the interaction between HCC and iCCA cells with immune infiltrating cells,in order to understand how this cross-talk promotes tumor growth.Deeper attention is,in fact,focused on immune-based therapy for these tumors,as promising approach to counteract the intrinsic anti-tumor activity of this microenvironment.In this review,we will examine the key pathways underlying TME cell-cell communications,with deeper focus on the role of natural killer cells in primary liver tumors,such as HCC and iCCA,as new opportunities for immune-based therapeutic strategies. | Michela Anna Polidoro Joanna Mikulak Valentina Cazzetta Ana Lleo Domenico Mavilio Guido Torzilli Matteo Donadon | 2020 | World Journal of Gastroenterology2020，26，33： | 4 |
| 3 | Surgical treatment of synchronous colorectal liver and lung metastases: the usefulness of thoracophrenolaparotomy for single stage resection显示文摘When suitable, surgery still remains the therapeutic option to be preferred for patients carrier of colorectal liver and lung metastases. Since thoracophrenolaparotomy should be helpful during liver resection for some of these patients, simultaneous removal of right lung metastases can be proposed through this approach. Eleven consecutive patients(median age of 53 years) carrier of colorectal liver and lung metastases, underwent single session surgical resection of both liver and right lung lesions by means of J-shaped thoracophrenolaparotomy. The median number of liver metastases removed was 5(range 2-30) and of lung metastases removed was 2(range 1-3). Lung metastases were located in the upper lobe in 1 patient, in the middle lobe in 2, in the lower lobe in 6, and in the upper and lower lobe in 2. Mortality and major morbidity were nil. Two patients had a minor morbidity: one had wound infection and bile leakage treated conservatively and the other had transient fever. Mean overall survival was 24.4 months. An aggressive surgical approach should be undertaken for colorectal metastases: in case of multifocal liver disease with complex presentations, J-shaped thoracophrenolaparotomy could be considered as safe approach for combined liver and right lung metastasectomies. | Daniele Del Fabbro Marco Alloisio Fabio Procopio Matteo Cimino Matteo Donadon Angela Palmisano Luca Viganò Guido Torzilli | 2016 | Hepatobiliary & Pancreatic Diseases International2016，15，2： | 3 |
| 4 | A Comprehensive Meta-regression Analysis on Outcome of Anatomic Resection Versus Nonanatomic Resection for Hepatocellular Carcinoma显示文摘 | Alessandro Cucchetti Matteo Cescon Giorgio Ercolani Eleonora Bigonzi Guido Torzilli Antonio D. Pinna | 2012 | Annals of Surgical Oncology2012，，12： | 3 |
| 5 | Nested stromal-epithelial tumour of the liver:An unusual liver entity显示文摘Nested stromal-epithelial tumours(NSETs)of the liver have been reported to be extremely unusual primary hepatic neoplasms.To date,few cases have been described in the literature.NSETs have been defined as non-hepatocytic and non-biliary tumours of the liver consisting of nests of epithelial and spindled cells,myofibroblastic stroma and variable intralesional calcification and ossification.Here,we report a case of a young female who underwent liver resection for a large hepatic lesion that proved to be a calcifying NSET on pathological examination.Details about the clinical and histopathological features of the tumour are reported. | Fabio Procopio Luca Di Tommaso Silvia Armenia Vittorio Quagliuolo Massimo Roncalli Guido Torzilli | 2014 | World Journal of Hepatology2014，6，3： | 2 |
| 6 | Multiple focal nodular hyperplasias induced by oxaliplatin-based chemotherapy显示文摘Focal nodular hyperplasia (FNH) is a benign condition that affects normal liver with low prevalence. Recently, the extensive use of oxaliplatin to treat patients with colorectal cancer has been reported to be associated with the development of different liver injuries, as well as focal liver lesions. The present work describes two patients with multiple bilateral focal liver lesions mis-diagnosed as colorectal liver metastases, and treated with liver resection. The first patient had up to 15 small bilateral focal liver lesions, with magnetic resonance imaging consistent with colorectal liver metastases (CLM), and fluorodeoxyglucose (FDG)-positron emission tomography (PET) negative. The second patient had up to 5 small focal liver lesions, with computed tomography consistent with CLM, and FDG-PET negative. They had parenchyma sparing liver surgery, with uneventful postoperative course. At the histology the diagnosis was multiple FNHs. The risks of oxaliplatin- based chemotherapy regimens in development of liver injuries, such as FNH, should not be further denied.The value of the modern multidisciplinary management of patients with colorectal cancer relies also on the precise estimation of the risk/benefit for each patient. | Matteo Donadon Luca Di Tommaso Massimo Roncalli Guido Torzilli | 2013 | World Journal of Hepatology2013，5，6： | 2 |
| 7 | Extension of the frontiers of surgical indications in the treatment of liver metastases from colorectal cancer:long-term results显示文摘 | Minagawa M Makuuehi M Torzilli G | 2000 | Ann Surg2000，231，4： | 1 |
| 8 | Intraoperative ultrasonography in liver cancer显示文摘 | Torzilli G Makuuchi M | 2003 | Surg Oncol Clin N Am2003，12，1： | 1 |
| 9 | Mechanical load inhibits IL-I induced matrix degradation in articular cartilage 显示文摘 | Torzilli PA Bhargava M Park S | 2010 | Osteoarthritis Cartilage2010，18，1： | 1 |
| 10 | Effect of impact load on articular cartilage: developoment of an intra-articular fracture model显示文摘 | Torzilli PA Grigiene R | 1997 | J Orthop Trauma1997，11，： | 1 |
| 11 | One-stage ultrasonographically guided hepatectomy for multiple bilobar colorectal metastases:a feasible and effective alternative to the 2-stage approach显示文摘 | Torzilli G Procopio F Botea F | | 0，，01： | 1 |
| 12 | Tailoring the area of hepatic resection using inflow and outflow modulation显示文摘The performance of hepatic surgery without a parenchyma-sparing strategy carries significant risks for patient survival because of the not negligible occurrence of postoperative liver failure.The key factor of modern hepatic surgery is the use of the intraoperative ultrasound(IOUS),not only to stage the disease,but more importantly to guide resection with the specific aim to maximize the sparing of the functional parenchyma.Whether in patients with hepatocellular carcinoma and underlying liver cirrhosis,or in patients with colorectal liver metastasis,IOUS allows the performance of the so-called 'radical but conservative surgery',which is the pivotal factor to offer a chance of cure to an increasing proportion of patients,who until few years ago were considered only for palliative care.Using some new IOUS-guided surgical maneuvers,which are based on the liver inflow and outflow modulations,more precise anatomically subsegmental-and segmentaloriented resections can be effectively performed.The present work describes the rationale and the surgical technique for a precise tailoring of the area of hepatic resection using the most recent attainments in IOUS.Such important technical achievements should be a fundamental part of the surgical armamentarium of the modern liver surgeon. | Matteo Donadon Fabio Procopio Guido Torzilli | 2013 | World Journal of Gastroenterology2013，19，7： | 1 |
| 13 | Interstitial percutaneous therapies in primary and secondary livertumors显示文摘 | Torzilli G Livraghi T Olivari N | 1999 | Ann Ital Chir1999，70，2： | 1 |
| 14 | No-mortality liver resection forhepatocellular carcinoma in cirrhotic and noncirrhotic patients: Is there a way? Aprospective analysis of our approach显示文摘 | Torzilli G Makuuchi M Inoue K | 1999 | Arch Surg1999，134，9： | 1 |
| 15 | Extension of the frontiers of surgical indications in the treatment of liver metastases from colorectal cancer:long-term results显示文摘 | Minagawa M Makuuchi M Torzilli G | 2000 | Ann Surg2000，231，4： | 1 |
| 16 | Accurate preoper ative evaluation of liver mass lesions without fine-needle biopsy显示文摘 | Torzilli G Minagawa M Takayama T | 1999 | Hepatology1999，30，4： | 1 |
| 17 | Ultrasound-guided finge compression in liver subsegmentectomy for hepatocellular carcinoma显示文摘 | Torzilli G Makuuchi M | 2004 | Surg Endosc2004，18，1： | 1 |
| 18 | FTIR micro- scopic imaging of collagen and proteoglycan in bovine cartilage显示文摘 | Camacho N P West P Torzilli P A | 2001 | Biopolymers2001，62，1： | 1 |
| 19 | Advances in the surgical treatment of colorectal cancer liver metastasis through ultrasound 显示文摘 | Torzilli G | 2011 | Surg Today2011，41，9： | 1 |
| 20 | No-mortality liver resection for hepatocellular carcinoma in cirrhotic and noncirrhotic patients: is there a way? A prospective analysis of our ap- proach显示文摘 | TORZILLI G MAKUUCHI M INOUE K | 1999 | Archives of Surgery1999，134，9： | 1 |
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