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| 1 | Clinical significance of NOD2/CARD15 and Toll-like receptor 4 gene single nucleotide polymorphisms in inflammatory bowel disease显示文摘AIM: To evaluate the role of genetic factors in the pathogenesis of Crohn's disease (CD) and ulcerative colitis (UC), we investigated the single nucleotide poly- morphisms (SNPs) of NOD2/CARD15 (R702W, G908R and L1007fi nsC), and Toll-like receptor 4 (TLR4) genes (D299G and T399I) in a selected inflammatory bowel disease (IBD) population coming from Southern Italy. METHODS: Allele and genotype frequencies of NOD2/ CARD15 (R702W, G908R and L1007finsC) and TLR4 (D299G and T399I) SNPs were examined in 133 CD pa-tients, in 45 UC patients, and in 103 healthy controls. A genotype-phenotype correlation was performed. RESULTS: NOD2/CARD15 R702W mutation was sig-nificantly more frequent in CD (9.8%) than in controls (2.4%, P = 0.001) and in UC (2.3%, P = 0.03). No sig-nificant difference was found between UC patients and control group (P > 0.05). In CD and UC patients, no signifi cant association with G908R variant was found. L1007f insC SNP showed an association with CD (9.8%) compared with controls (2.9%, P = 0.002) and UC patients (2.3%, P = 0.01). Moreover, in CD patients, G908R and L1007finsC mutations were significantly associated with different phenotypes compared to CD wild-type patients. No association of IBD with the TLR4 SNPs was found in either cohort (allele frequencies: D299G-controls 3.9%, CD 3.7%, UC 3.4%, P > 0.05; T399I-controls 2.9%, CD 3.0%, UC 3.4%, P > 0.05). CONCLUSION: These findings confirm that, in our IBD patients selected from Southern Italy, the NOD2/ CARD15, but not TLR4 SNPs, are associated with in-creased risk of CD. | Luciana Rigoli Claudio Romano Rosario Alberto Caruso Maria A Lo Presti Chiara Di Bella Vincenzo Procopio Giuseppina Lo Giudice Maria Amorini Giuseppe Costantino Maria D Sergi Caterina Cuppari Giovanna Elisa Calabrò Romina Gallizzi Carmelo Damiano Salpietro Walter Fries | 2008 | World Journal of Gastroenterology2008，14，28： | 8 |
| 2 | The in vivo effects of general and epidural anesthesia on human immune function 显示文摘 | Procopio M A Rassias A J DeLeo J A | 2001 | Anesth Analg2001，93，2： | 1 |
| 3 | Apoptosis and myostatin mRNA are upregulated in the skeletal muscle of patients with chronic kidney disease显示文摘 | VERZOLA D PROCOPIO V SOFIA A | 2011 | Kidney Int2011，79，7： | 1 |
| 4 | Circulating inflamma-miRs in aging and age-related diseases显示文摘 | Olivieri F Rippo M R Procopio A D | 2013 | Front Genet2013，4，： | 1 |
| 5 | Peripheral tissue release of interleukin 6 in patients with chronic kidney disease:effects of end-stage renal disease and microinflammatory state显示文摘 | Garibotto G Sofia A Procopio Y | 2006 | Kidney Int2006，70，2： | 1 |
| 6 | 5-Lipoxygenase regulates senescence-like growth arrest by promoting ROS-dependent p53 activation显示文摘 | Catalano A Rodilossi S Caprari P Coppola V Procopio A | 2005 | EMBO J2005，24，1： | 1 |
| 7 | Effectiveness and utility of hyaluronic acid in osteoarthritis显示文摘 | Migliore A Procopio S | 2015 | Clin Cases Miner Bone Metab2015，12，1： | 1 |
| 8 | The in vivo effect of general and epidural anesthesia on human immune function显示文摘 | PROCOPIO M A RASSIAS A J DELEO J A | 2001 | Anesth Analg2001，93，2： | 1 |
| 9 | Ch- aracterization of Ti4AIN3显示文摘 | PROCOPIO A T BARSOUM M W RAGHY T EL | 2000 | Metallurgical And Material Transactions2000，31，2： | 1 |
| 10 | High-resolution transmission electron microscopy of Ti4AlN3 or Ti3Al2N2 revisited 显示文摘 | BARSOUM M W FARBER L LEVIN I PROCOPIO A E1-RAGHY T BERNER A | 1999 | Journal of the American Ceramic Society1999，82，9： | 1 |
| 11 | Characterization of Ti4 A1N3显示文摘 | Procopio A T Barsoum M W El-Raghy T | 2000 | Metallurgical and Materials Transactions A2000，31，： | 1 |
| 12 | Effectiveness and utility of hyal- uronic acid in osteoarthritis 显示文摘 | MIGLIORE A PROCOPIO S | 2015 | Clin Cases Miner Bone Metab2015，12，1： | 1 |
| 13 | Safety and activity of sorafenib in different histotypes of advanced renal cell carcinoma显示文摘 | Procopio G Verzoni E Gevorgyan A | 2007 | Oncol2007，，： | 1 |
| 14 | Synthesis of Ti4AlN3 and Phase Equilibria in the Ti-AI-N System显示文摘 | Procopio A T EI-Raghy T Barsoum M W | 2000 | Metallurgical and Materials Transactions A2000，31，： | 1 |
| 15 | Molecular modeling,synthesis,and preliminary biological evaluation of glutathione-S-transferase inhibitors as potential therapeutic agents显示文摘 | Procopio A Alcaro S Cundari S | 2005 | J Med Chem2005，48，19： | 1 |
| 16 | Effectiveness and utility of hyaluronic acid in osteoarthritis显示文摘 | MIGLIORE A PROCOPIO S | 2015 | Clin Cases Miner Bone Metab2015，12，1： | 1 |
| 17 | alpha-Tocopheryl succinate iiahibits proliferation of mcsothelioma cells by selective down-regulation of fibroblast growth factor receptors 显示文摘 | Stapelberg M Tomasetti M Alleva R Gellert N Procopio A Neuzil J | 2004 | Biochem Biophys Res Commun2004，318，63： | 1 |
| 18 | Peripheral tissue release of interleukin-6 in patients with chronic kidney diseases:Effects of end-stage renal disease and microinflammatory state显示文摘 | G Garibotto A Sofia V Procopio | 2006 | Kidney Int2006，70，： | 1 |
| 19 | Transcription factor FOXO3a controls the persistence of memory CD4( + ) T cells during HIV infection显示文摘 | Julien van Greveny nghe Francesc A Procopio Zhong he | 2008 | Nat Med2008，14，： | 1 |
| 20 | A novel assay to measure the magnitude of the inducible viral reservoir in HIV-infected individuals 显示文摘 | PROCOPIO F A FROMENTIN R KULPA D A | 2015 | EBioMedicine2015，2，8： | 1 |
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