|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Autoimmune liver serology:Current diagnostic and clinical challenges显示文摘Liver-related autoantibodies are crucial for the correct diagnosis and classification of autoimmune liver diseas-es(AiLD),namely autoimmune hepatitis types 1 and 2(AIH-1 and 2),primary biliary cirrhosis(PBC),and the sclerosing cholangitis variants in adults and children.AIH-1 is specified by anti-nuclear antibody(ANA) and smooth muscle antibody(SMA).AIH-2 is specified by antibody to liver kidney microsomal antigen type-1(anti-LKM1) and anti-liver cytosol type 1(anti-LC1).SMA,ANA and anti-LKM antibodies can be present in de-novo AIH following liver transplantation.PBC is specified by antimitochondrial antibodies(AMA) react-ing with enzymes of the 2-oxo-acid dehydrogenase complexes(chiefly pyruvate dehydrogenase complex E2 subunit) and disease-specific ANA mainly react-ing with nuclear pore gp210 and nuclear body sp100.Sclerosing cholangitis presents as at least two variants,first the classical primary sclerosing cholangitis(PSC) mostly affecting adult men wherein the only(and non-specific) reactivity is an atypical perinuclear antineutro-phil cytoplasmic antibody(p-ANCA),also termed peri-nuclear anti-neutrophil nuclear antibodies(p-ANNA) and second the childhood disease called autoimmune sclerosing cholangitis(ASC) with serological features resembling those of type 1 AIH.Liver diagnostic serol-ogy is a fast-expanding area of investigation as new purified and recombinant autoantigens,and automatedtechnologies such as ELISAs and bead assays,become available to complement(or even compete with) tradi-tional immunofluorescence procedures.We survey for the first time global trends in quality assurance impact-ing as it does on(1) manufacturers/purveyors of kits and reagents,(2) diagnostic service laboratories that fulfill clinicians' requirements,and(3) the end-user,the physician providing patient care,who must properly interpret test results in the overall clinical context. | Dimitrios P Bogdanos Diego Vergani Pietro Invernizzi Ian R Mackay | 2008 | World Journal of Gastroenterology2008，14，21： | 40 |
| 2 | 英国胃肠病学会关于胃癌风险患者的诊断和管理指南显示文摘胃癌预后较差,部分原因在于诊断较晚。胃癌的危险因素包括幽门螺杆菌(H.pylori,HP)感染和胃癌家族史,尤其是遗传性弥漫性胃癌和恶性贫血。胃癌发展的阶段包括慢性胃炎、胃黏膜萎缩(GA)、胃黏膜肠化生(GIM)和异型增生。胃癌早期发现和提高生存率的关键是在内镜检查前以非侵入性方式识别高危人群。然而,尽管生物标志物可能有助于检测慢性萎缩性胃炎,但尚无足够的证据支持其用于人群筛查。高质量内镜检查是胃癌早期发现的重要组成部分,图像增强内镜结合组织病理学活检是GA和GIM最佳的诊断方法,并能准确进行风险分层。按照悉尼标准从胃窦、角切迹、小弯和大弯进行活检,既能明确诊断,也能对胃癌进行风险分层。理想状态应当是在高质量内镜检查中对GA或GIM区域活检。英国属于低危地区,可根据需要接受常规诊断性胃镜检查,但没有足够证据支持筛查,对于广泛GA或GIM的患者,每3年检查内镜。对于胃异型增生和早期癌,只要满足标准,内镜下黏膜切除术或内镜黏膜下剥离术的治疗有效,成功率高,复发率低。 | Matthew Banks David Graham Marnix Jansen TakujiGotoda Sergio Coda Massimiliano di Pietro NoriyaUedo Pradeep Bhandari D Mark Pritchard Ernst J Kuipers Manuel Rodriguez-Justo Marco R Novelli KrishRagunath Neil Shepherd Mario Dinis-Ribeiro 乌雅罕(译) 张冬雪(译) 牛占岳(校) 刘鑫(校) 丁士刚(译/校) | 2020 | 中华胃肠内镜电子杂志2020，7，2： | 10 |
| 3 | Etiopathogenesis of primary biliary cirrhosis显示文摘Primary biliary cirrhosis(PBC) is an autoimmune disease of the liver characterized by progressive bile duct destruction eventually leading to cirrhosis and liver failure.The serological hallmark of the disease is the presence of circulating antimitochondrial antibodies(AMA).These reflect the presence of autoreactive T and B cells to the culprit antigens,the E2 subunits of mitochondrial 2-oxo-acid dehydrogenase enzymes,chiefly pyruvate dehydrogenase(PDC-E2).The disease results from a combination of genetic and environmental risk factors.Genetic predisposition is indicated by the higher familial incidence of the disease particularly among siblings and the high concordance rate among monozygotic twins.Environmental triggering events appear crucial to disrupt a pre-existing unstable immune tolerance of genetic origin allowing,after a long latency,the emergence of clinical disease.Initiating mimetopes of the vulnerable epitope of the PDC-E2 autoantigen can be derived from microbes that utilize the PDC enzyme or,alternatively,environmental xenobiotics/chemical compounds that modify the structure of native proteins to make them immunogenic.A further alternative as a source of antigen is PDC-E2 derived from apoptotic cells.In the effector phase the biliary ductular cell,by reason of itsproclivity to express the antigen PDC-E2 in the course of apoptosis,undergoes a multilineage immune attack comprised of CD4+ and CD8+ T cells and antibody.In this article,we critically review the available evidence on etiopathogenesis of PBC and present interpretations of complex data,new developments and theories,and nominate directions for future research. | Ana Lleo Pietro Invernizzi Ian R Mackay Harry Prince Ren-Qian Zhong M Eric Gershwin | 2008 | World Journal of Gastroenterology2008，14，21： | 9 |
| 4 | Capsule endoscopy of the future: What's on the horizon?显示文摘Capsule endoscopes have evolved from passively moving diagnostic devices to actively moving systems with potential therapeutic capability. In this review,we will discuss the state of the art, define the current shortcomings of capsule endoscopy, and address research areas that aim to overcome said shortcomings.Developments in capsule mobility schemes are emphasized in this text, with magnetic actuation being the most promising endeavor. Research groups are working to integrate sensor data and fuse it with robotic control to outperform today's standard invasive procedures, but in a less intrusive manner. With recent advances in areas such as mobility, drug delivery, and therapeutics, we foresee a translation of interventional capsule technology from the bench-top to the clinical setting within the next 10 years. | Piotr R Slawinski Keith L Obstein Pietro Valdastri | 2015 | World Journal of Gastroenterology2015，21，37： | 8 |
| 5 | Pancreatic fistula after a pancreaticoduodenectomy for ductal adenocarcinoma and its association with morbidity: a multicentre study of the F rench S urgical A ssociation显示文摘 | Pietro Addeo Jean Robert Delpero Francois Paye Elie Oussoultzoglou Pascal R Fuchshuber Alain Sauvanet Antonio Sa Cunha Yves Patrice Le Treut Mustapha Adham Jean‐Yves Mabrut Laurence Chiche Philippe Bachellier | 2014 | HPB2014，，1： | 2 |
| 6 | Pancreatic cancer cells surviving gemcitabine treatment express markersof stem cell differentiation and epithelial-mesenchymal transition显示文摘 | Karl Quint Manuel Tonigold Pietro Di Fazio Roberta Montalbano Susanne Lingelbach Felix Rückert Beate Alinger Matthias Ocker Daniel Neureiter | 2012 | International Journal of Oncology2012，，6： | 2 |
| 7 | No evidence of involvement of Chlamydia pneumoniae in lung cancer by means of quantitative real-time polyrnerase chain reaction 显示文摘 | Sessa R Santino l Di Pietro M | 2008 | Int J Dnmunopathol Pharmacol2008，21，2： | 1 |
| 8 | Pro-and anti-apoptotic effects of p53 in cisplatin-treated humantesticular cancer are cell context-dependent显示文摘 | di Pietro A Koster R Boersma-van Eck W | 2012 | Cell Cy-cle2012，11，24： | 1 |
| 9 | Bone marrow endothelial cells in multiple myeloma secrete CXC-chemokines that mediate interactions with plasma cells显示文摘 | Pellegrino A Ria R Di Pietro G | | 0，，： | 1 |
| 10 | Conjunetival epithelium improvement after systemic pilocarpine in patients with Sj~gren's syndrome显示文摘 | Aragona P di Pietro R Spinella R | 2006 | Br J Ophthalmol2006，90，2： | 1 |
| 11 | Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) regulates en dothelial nitric oxide synthase (eNOS) activity and its localization within the human vein endothelial cells (HUVEC) in culture 显示文摘 | Di Pietro R Mariggio M A Guarnieri S | 2006 | J Cell Biochem2006，97，78： | 1 |
| 12 | Secure vinualization for cloud compu- ting显示文摘 | LOMBARDI F Di PIETRO R | 2010 | Journal of Network and Computer Applications2010，34，4： | 1 |
| 13 | Secure virtualization for cloudcomputing显示文摘 | Lombardi F Di Pietro R | 2011 | Journal of Network and Computer Applications2011，34，4： | 1 |
| 14 | Bone marrow endothelial cells in multiple myeloma secrete CXC-chemokines that mediate interactions with plasma cells显示文摘 | Pellegrino A Ria R Di Pietro G | 2005 | Br J Haematol2005，129，2： | 1 |
| 15 | Secure Virtualization for Cloud Computing显示文摘 | Lombardi F Di Pietro R | 2011 | Journal of Network and Computer Applications2011，34，4： | 1 |
| 16 | Cyto- plasmic p21 expression levels determine cisplatin resist- ance in human testicularcancer显示文摘 | Koster R di Pietro A Timmer-Bosscha H | 2010 | J Cliu Invest2010，120，10： | 1 |
| 17 | High titer of autoantibodies to GAD identifies a specific phenotype of adult-onset autoimmune diabetes显示文摘 | Buzzetti R Di Pietro S Giaccari A | 2007 | Diabetes Care2007，30，4： | 1 |
| 18 | Estimating preferential water flow parameters using a binary genetic algorithm inverse method显示文摘 | MAJDALANI S ANGULO-JARAMILLO R Di PIETRO L | 2008 | Environmental Modelling & Software2008，23，7： | 1 |
| 19 | Detection of chlamydia pneumoniae in atherosclerotic coronary arteries显示文摘 | Sessa R Pietro M Schiavoni G | 2004 | Int J Immunopathol Pharmacol2004，17，3： | 1 |
| 20 | Effects of the application of anti-browning substances on the metabolic activity and sugar composition of fresh-cut potatoes显示文摘 | Pietro R Federico G G Fernando M | 2007 | Postharvest Biology and Technology2007，，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员