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| 1 | Long and noncoding RNAs (Inc-RNAs) determine androgen receptor dependent gene expression in prostate cancer growth in vivo显示文摘活动过度的雄激素受体(AR ) 活动仍然是前列腺癌症和电阻的发作和前进的一个关键决定因素到当前的治疗。管理的机制阉割抵抗前列腺癌症糟糕被理解,但是定义这些分子的事件是必要的以便从前列腺癌症影响死亡。杨等。表明知道是在治疗的 overexpressed 的那二 lnc-RNAs 抵抗前列腺癌症, PRNCR1 (也作为 PCAT8 知道)并且 PCGEM1 ,跳到 AR 提高ligand依赖、ligand独立的 AR 基因表示和这些相互作用的顺序包含了的前列腺癌症 cells.1 的增长到 acetylated AR 和 DOT1L 的一个随后的协会的 PRNCR1 的绑定,为 lncRNA PCGEM1 的顺序的招募被要求到 AR 氨基的终点。 | Richard G Pestell Zuoren Yu | 2014 | Asian Journal of Andrology2014，16，2： | 2 |
| 2 | MAT1 correlates with molecular subtypes and predicts poor survival in breast cancer显示文摘Objective:Menage a trois 1(MAT1)is a targeting subunit of cyclin-dependent kinase-activating kinase and general transcription factor IIH kinase,which modulates cell cycle,transcription and DNA repair.Its dysregulation is responsible for diseases including cancers.To further explore the role of MAT1 in breast cancer,we investigated the pathways in which MAT1 might be involved,the association between MAT1 and molecular subtypes,and the role of MAT1 in clinical outcomes of breast cancer patients.Methods:We conducted immunohistochemistry staining on tissue microarray and immunofluorescence staining on sections of MAT1 stable breast cancer cells.Also,we performed Kyoto Encyclopedia of Genes and Genomes pathway analysis,correlation analysis and prognosis analysis on public databases.Results:MAT1 was involved in multiple pathways including normal physiology signaling and disease-related signaling.Furthermore,MAT1 positively correlated with the protein status of estrogen receptor and progesterone receptor,and was enriched in luminal-type and human epidermal growth factor receptor 2-enriched breast cancer in comparison with basal-like subtype at both m RNA and protein levels.Correlation analysis revealed significant association between MAT1 m RNA amount and epithelial markers,mesenchymal markers,cancer stem cell markers,apoptosis markers,transcription markers and oncogenes.Consistently,the results of immunofluorescence stain indicated that MAT1 overexpression enhanced the protein abundance of epidermal growth factor receptor,vimentin,sex determining region Y-box 2 and sine oculis homeobox homolog 1.Importantly,Kaplan-Meier Plotter analysis reflected that MAT1 could serve as a prognostic biomarker predicting worse relapse-free survival and metastasis-free survival.Conclusions:MAT1 is correlated with molecular subtypes and is associated with unfavorable prognosis for breast cancer patients. | Hanxiao Xu Xianguang Bai Shengnan Yu Qian Liu Richard G Pestell Kongming Wu | 2018 | Chinese Journal of Cancer Research2018，30，3： | 2 |
| 3 | Influence of anesthesia proce dure on malignant tumor outcome显示文摘 | Fukui K Werner C Pestel G | 2012 | Anaesthesist2012，61，3： | 1 |
| 4 | Assessing intravascular volume by difference in pulse pressure in pigs submitted to graded hemorrhage显示文摘 | Pestel G J Hiltebrand L B Fukui K | 2006 | Shock2006，26，4： | 1 |
| 5 | Assessing intravascular volume by difference in pulse pressure (dPP) in pigs submitted to graded hemorrhage显示文摘 | Pestel G J Hiltebrand LB Fukui K | 2006 | Shock2006，26，4： | 1 |
| 6 | Cancer stem cells 显示文摘 | YU Z L PESTELL T G LISANTI M P et ol | 2012 | Int J Bioehem Cell Biol2012，44，12： | 1 |
| 7 | STAT3 as an oncogene显示文摘 | Bromberg J F Wrzeszczynska M H Devgan G Zhao Y Pestell R G Albanese C | 1999 | Cell1999，98，： | 1 |
| 8 | Amyloid beta peptide stimulates nitric oxide production in astrocytes through an NF kappaB - dependent mechanism 显示文摘 | AKAMA K T ALBANESE C PESTELL R G | 1998 | Proc Natl Acad Sci U S A1998，95，10： | 1 |
| 9 | Influence of anesthesia procedure on malignant tumor outcome显示文摘 | Fukui K Werner C Pestel G | | 0，，03： | 1 |
| 10 | STAT3 as an oncogene 显示文摘 | Bromberg J F Wrzeszczynska M H Devgan G Zhao Y Pestell R G Albanese C | 1999 | Cell1999，98，： | 1 |
| 11 | Stat3 as an Oncogene显示文摘 | Jacqueline F Bromberg Melissa H Wrzeszczynska Geeta Devgan Yanxiang Zhao Richard G Pestell Chris Albanese James E Darnell | 1999 | Cell1999，，3： | 1 |
| 12 | Grain refinement of steel ingots by solidification in a moving electromagnetic field显示文摘 | LANGENBERG F C PESTEL G HONEYCUTT C R | 1961 | Trans Metall Soc AIME1961，221，： | 1 |
| 13 | BRCA1 gene in breast cancer显示文摘 | ROSEN E M FAN S PESTELL R G | 2003 | J Cell Physiol2003，196，1： | 1 |
| 14 | Amyloid β-peptide stimulates nitric oxide production in astrocyte through an NF-μB-dependent mechanism显示文摘 | AKAMA K T ALBANESE C PESTELL R G | 1998 | Proc Natl Acad Sci USA1998，95，10： | 1 |
| 15 | New roles of cyclin D1显示文摘 | PESTELL R G | 2013 | Am J Pathol2013，183，1： | 1 |
| 16 | NF-κB and cell-cycle regulation: the cyclin connection显示文摘 | David Joyce Chris Albanese Jay Steer Maofu Fu Boumediene Bouzahzah Richard G Pestell | 2001 | Cytokine and Growth Factor Reviews2001，，： | 1 |
| 17 | Assess- ing intravascular volume by difference in pulse pressure in pigs submitted to graded hemorrhage显示文摘 | PESTEL G J HILTEBRAND L B FUKUI K | 2006 | Shock2006，26，4： | 1 |
| 18 | Spatial-ly discrete, light-driven protein expression显示文摘 | Lin W Albanese C Pestell R G Lawrence D S | 2002 | ChemistryBiology2002，9，12： | 1 |
| 19 | Intestinal tumor progression is associated with altered function of KLF5显示文摘 | BATEMAN N M TAN D PESTELL R G | | 0，，13： | 1 |
| 20 | CyclinD1 is required for S phase traversal in bovine tracheal myocytes 显示文摘 | Xiong W Pestell RG Watanabe G | 1997 | Annu Rev Physiol1997，272，： | 1 |
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