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| 1 | Long and noncoding RNAs (Inc-RNAs) determine androgen receptor dependent gene expression in prostate cancer growth in vivo显示文摘活动过度的雄激素受体(AR ) 活动仍然是前列腺癌症和电阻的发作和前进的一个关键决定因素到当前的治疗。管理的机制阉割抵抗前列腺癌症糟糕被理解,但是定义这些分子的事件是必要的以便从前列腺癌症影响死亡。杨等。表明知道是在治疗的 overexpressed 的那二 lnc-RNAs 抵抗前列腺癌症, PRNCR1 (也作为 PCAT8 知道)并且 PCGEM1 ,跳到 AR 提高ligand依赖、ligand独立的 AR 基因表示和这些相互作用的顺序包含了的前列腺癌症 cells.1 的增长到 acetylated AR 和 DOT1L 的一个随后的协会的 PRNCR1 的绑定,为 lncRNA PCGEM1 的顺序的招募被要求到 AR 氨基的终点。 | Richard G Pestell Zuoren Yu | 2014 | Asian Journal of Andrology2014，16，2： | 2 |
| 2 | The Role of Breast Cancer Stem Cells in Metastasis and Therapeutic Implications显示文摘 | Marco A. Velasco-Velázquez Vladimir M. Popov Michael P. Lisanti Richard G. Pestell | 2011 | The American Journal of Pathology2011，，1： | 2 |
| 3 | Cancer stem cells显示文摘 | Zuoren Yu Timothy G. Pestell Michael P. Lisanti Richard G. Pestell | 2012 | International Journal of Biochemistry and Cell Biology2012，，12： | 2 |
| 4 | MAT1 correlates with molecular subtypes and predicts poor survival in breast cancer显示文摘Objective:Menage a trois 1(MAT1)is a targeting subunit of cyclin-dependent kinase-activating kinase and general transcription factor IIH kinase,which modulates cell cycle,transcription and DNA repair.Its dysregulation is responsible for diseases including cancers.To further explore the role of MAT1 in breast cancer,we investigated the pathways in which MAT1 might be involved,the association between MAT1 and molecular subtypes,and the role of MAT1 in clinical outcomes of breast cancer patients.Methods:We conducted immunohistochemistry staining on tissue microarray and immunofluorescence staining on sections of MAT1 stable breast cancer cells.Also,we performed Kyoto Encyclopedia of Genes and Genomes pathway analysis,correlation analysis and prognosis analysis on public databases.Results:MAT1 was involved in multiple pathways including normal physiology signaling and disease-related signaling.Furthermore,MAT1 positively correlated with the protein status of estrogen receptor and progesterone receptor,and was enriched in luminal-type and human epidermal growth factor receptor 2-enriched breast cancer in comparison with basal-like subtype at both m RNA and protein levels.Correlation analysis revealed significant association between MAT1 m RNA amount and epithelial markers,mesenchymal markers,cancer stem cell markers,apoptosis markers,transcription markers and oncogenes.Consistently,the results of immunofluorescence stain indicated that MAT1 overexpression enhanced the protein abundance of epidermal growth factor receptor,vimentin,sex determining region Y-box 2 and sine oculis homeobox homolog 1.Importantly,Kaplan-Meier Plotter analysis reflected that MAT1 could serve as a prognostic biomarker predicting worse relapse-free survival and metastasis-free survival.Conclusions:MAT1 is correlated with molecular subtypes and is associated with unfavorable prognosis for breast cancer patients. | Hanxiao Xu Xianguang Bai Shengnan Yu Qian Liu Richard G Pestell Kongming Wu | 2018 | Chinese Journal of Cancer Research2018，30，3： | 2 |
| 5 | Influence of anesthesia proce dure on malignant tumor outcome显示文摘 | Fukui K Werner C Pestel G | 2012 | Anaesthesist2012，61，3： | 1 |
| 6 | Assessing intravascular volume by difference in pulse pressure in pigs submitted to graded hemorrhage显示文摘 | Pestel G J Hiltebrand L B Fukui K | 2006 | Shock2006，26，4： | 1 |
| 7 | Cancer stem cells显示文摘 | Yu Z Pestell TG Lisanti MP | 2012 | Int J Biochem Cell Biol2012，44，12： | 1 |
| 8 | Cellular stress induces the tyrosine phosphorylation of caveolin-1 (Tyr (14 via activation of p38 mitogen-activated protein ki显示文摘 | Volonté D Galbiati F Pestell RG | | 0，，11： | 1 |
| 9 | New roles of cyclin D1 显示文摘 | Pestell RG | 2013 | Am J Pathol2013，183，1： | 1 |
| 10 | Amyloid β-peptide stimulates nitric oxide production in astrocyte through an NFκ-B dependent mechanism显示文摘 | Akama KT Albanese C Pestell RG | 1998 | Proc Natl Acad Sci USA1998，95，： | 1 |
| 11 | ErbPr2-induced mammary tumor growth:the role cyclinD1 and p27^Kip1 显示文摘 | Hulit J Lee R J Pestell RG | 2002 | Biochem Pharm2002，64，56： | 1 |
| 12 | Assessing intravascular volume by difference in pulse pressure (dPP) in pigs submitted to graded hemorrhage显示文摘 | Pestel G J Hiltebrand LB Fukui K | 2006 | Shock2006，26，4： | 1 |
| 13 | Intestinal tumor pro gression is associated with altered function of KLF5显示文摘 | Bateman NW Tan D Pestell RG | 2004 | J Biol Chem2004，279，12： | 1 |
| 14 | Hemodynamic parameters change earlier than tissue oxygen tension in hemorrhage 显示文摘 | Pestel GJ Fukui K Kimberger O | 2010 | J Surg Res2010，160，2： | 1 |
| 15 | Cell cycle independent activity of cyclin D1显示文摘 | Pestell K | 2003 | Drug Discov Today2003，8，20： | 1 |
| 16 | The type 1 insu- lin-like growth factor receptor and resistance to DACHI 显示文摘 | DeAngelis T Wu K Pestell R | | Ceil Cycle 201l0，10，2： | 1 |
| 17 | Amyloidalβ peptide stimulates nitric oxide production in astrocytes through an NF-KB 显示文摘 | Akama KT Albanese C Pestell RG | 1998 | Proc Natl Acad Sic1998，9，5： | 1 |
| 18 | Activation of G proteins by receptoRstimulated diphosphate kinase in dictyostelium显示文摘 | BominaaRAA Molijn AC Pestel M | 1993 | Embo J1993，12，6： | 1 |
| 19 | Cancer stem cells 显示文摘 | YU Z L PESTELL T G LISANTI M P et ol | 2012 | Int J Bioehem Cell Biol2012，44，12： | 1 |
| 20 | STAT3 as an oncogene显示文摘 | Bromberg J F Wrzeszczynska M H Devgan G Zhao Y Pestell R G Albanese C | 1999 | Cell1999，98，： | 1 |
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