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| 1 | Erianin,a novel dibenzyl compound in Dendrobium extract,inhibits lung cancer cell growth and migration via calcium/calmodulin-dependent ferroptosis显示文摘Ferroptosis,a novel form of programmed cell death,is characterized by iron-dependent lipid peroxidation and has been shown to be involved in multiple diseases,including cancer.Stimulating ferroptosis in cancer cells may be a potential strategy for cancer therapy.Therefore,ferroptosis-inducing drugs are attracting more attention for cancer treatment.Here,we showed that erianin,a natural product isolated from Dendrobium chrysotoxum Lindl,exerted its anticancer activity by inducing cell death and inhibiting cell migration in lung cancer cells.Subsequently,we demonstrated for the first time that erianin induced ferroptotic cell death in lung cancer cells,which was accompanied by ROS accumulation,lipid peroxidation,and GSH depletion.The ferroptosis inhibitors Fer-1 and Lip-1 but not Z-VAD-FMK,CQ,or necrostatin-1 rescued erianin-induced cell death,indicating that ferroptosis contributed to erianin-induced cell death.Furthermore,we demonstrated that Ca^(2+)/CaM signaling was a critical mediator of erianin-induced ferroptosis and that blockade of this signaling significantly rescued cell death induced by erianin treatment by suppressing ferroptosis.Taken together,our data suggest that the natural product erianin exerts its anticancer effects by inducing Ca^(2+)/CaMdependent ferroptosis and inhibiting cell migration,and erianin will hopefully serve as a prospective compound for lung cancer treatment. | Peng Chen Qibiao Wu Jiao Feng Lili Yan Yitian Sun Shuiping Liu Yu Xiang Mingming Zhang Ting Pan Xiaying Chen Ting Duan Lijuan Zhai Bingtao Zhai Wengang Wang Ruonan Zhang Bi Chen Xuemeng Han Yicong Li Liuxi Chen Ying Liu Xingxing Huang Ting Jin Wenzheng Zhang Hong Luo Xiaohui Chen Yongqiang Li Qiujie Li Guohua Li Qin Zhang Lvjia Zhuo Zuyi Yang Huifen Tang Tian Xie Xiaoping Ouyang Xinbing Sui | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 42 |
| 2 | Efficacy and safety of a novel anti-HER2 therapeutic antibody RC48 in patients with HER2-overexpressing,locally advanced or metastatic gastric or gastroesophageal junction cancer:a single-arm phase II study显示文摘Background:Current treatment options for human epidermal growth factor receptor 2(HER2)-overexpressing gastric cancer at third-line have shown limited clinical benefit.Further,there is no specific treatment for HER2 immunohistochemistry(IHC)2+and fluorescence in-situ hybridization-negative patients.Here,we report the efficacy and safety of a novel anti-HER2 antibody RC48 for patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer.Methods:Patients with HER2-overexpressing(IHC 2+or 3+),locally advanced or metastatic gastric or gastroesophageal junction cancer who were under at least second-line therapy were eligible and received RC482.5 mg/kg alone every 2 weeks.The primary endpoint was the objective response rate(ORR)assessed by an independent review committee.Secondary endpoints included progressionfree survival(PFS),overall survival(OS),duration of response,time to progression,disease control rate,and safety.Results:Of 179 patients screened,125 were eligible and received RC48 treatment.The ORR was 24.8%(95%confidence interval[CI]:17.5%-33.3%).The median PFS and OS were 4.1 months(95%CI:3.7-4.9 months)and 7.9 months(95%CI:6.7-9.9 months),respectively.The most frequently reported adverse events were decreased white blood cell count(53.6%),asthenia(53.6%),hair loss(53.6%),decreased neutrophil count(52.0%),anemia(49.6%),and increased aspartate aminotransferase level(43.2%).Serious adverse events(SAEs)occurred in 45(36.0%)patients,and RC48-related SAEs were mainly decreased neutrophil count(3.2%).Seven patients had adverse events that led to death were not RC48-related.Conclusions:RC48 showed promising activity with manageable safety,suggesting potential application in patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer who have previously received at least two lines of chemotherapy. | Zhi Peng Tianshu Liu Jia Wei Airong Wang Yifu He Liuzhong Yang Xizhi Zhang Nanfeng Fan Suxia Luo Zhen Li Kangsheng Gu Jianwei Lu Jianming Xu Qingxia Fan Ruihua Xu Liangming Zhang Enxiao Li Yuping Sun Guohua Yu Chunmei Bai Yong Liu Jiangzheng Zeng Jieer Ying Xinjun Liang Nong Xu Chao Gao Yongqian Shu Dong Ma Guanghai Dai Shengmian Li Ting Deng Yuehong Cui Jianmin Fang Yi Ba Lin Shen | 2021 | Cancer Communications2021，41，11： | 29 |
| 3 | Decreased regional homogeneity in major depression as revealed by resting-state functional magnetic resonance imaging显示文摘Backgroud 功能的成像研究在任务或休息状态期间在消沉在 cortico 边的网络显示反常活动。现在的工作是探索休息状态在消沉与地区性的同质(ReHo ) 显示出的反常自发的活动功能的用 fMRI 的磁性的回声成像(fMRI ).Methods,地区性的大脑活动的差别在在沮丧对健康的参加者放松状态被测量。第一与主要压抑的混乱和 16 控制诊断的十六个参加者在放松状态期间被扫描。一个新奇方法基于 ReHo 被用来在左丘脑越过整个 brain.Results ReHo 检测自发的血液动力学的回答,左时间的脑叶,左小脑的以后的脑叶,并且双边的枕骨的脑叶被发现显著地在放松 depression.Conclusions 的状态与健康控制相比在消沉被减少反常自发的活动在左丘脑,左时间的脑叶,左小脑的以后的脑叶,和双边的枕骨的脑叶存在。并且 ReHo 可以是在在放松消沉的状态理解不同大脑活动的一本潜在的参考书。 | PENG Dai-hui JIANG Kai-da FANG Yi-ru XU Yi-feng SHEN Ting LONG Xiang-yu LIU Jun ZANG Yu-feng | 2011 | Chinese Medical Journal2011，，3： | 28 |
| 4 | Magma mixing of granites at Lianghe:In-situ zircon analysis for trace elements, U-Pb ages and Hf isotopes显示文摘In this paper, we report an integrated study of trace element, U-Pb age and Hf isotopic composition of zircons from alkali feldspar granites, granodiorites and diorite enclaves in a recently discovered ring complex at Lianghe in western Yunnan, Chi na. The granitoids showed identical U-Pb ages of 127, 115 and 122 Ma, from felsic to mafic, but had different zircon trace el ements and Hf isotopic compositions. Trace element content decreased with a gradual increase in εHf(t) values of ?9.1 to ?5.4, ?4.5 to 0, and 3.6 to 6.2, respectively. Results indicate that changes in zircon trace elements generally correlate with changes in Hf isotope signatures within single samples and among various granitoids. These relationships reflect the mixing of felsic and mafic magmas. Evidence indicates that depleted mantle-derived mafic magma underplating caused ancient crustal melting, and then formed large-scale granites in Lianghe during the Early Cretaceous. These granodiorites were formed mainly by the mix ing of mafic magma and granitic magma. | CONG Feng LIN ShiLiang ZOU GuangFu LI ZaiHui XIE Tao PENG ZhiMin LIANG Ting | 2011 | Science China Earth Sciences2011，54，9： | 26 |
| 5 | A reappraisal of CTLA-4 checkpoint blockade in cancer immunotherapy显示文摘anti-CTLA-4 抗体由阻止 B7-CTLA-4 相互作用接近否定发信号引起肿瘤拒绝,这被假定。在比临床上有效的 dosing 完成的血浆层次更加高的集中,令人惊讶地, anti-CTLA-4 抗体 Ipilimumab 不由 CTLA-4 也不 CTLA-4 绑定堵住任何一 B7 trans-endocytosis 到使不能调动或联系房间的 B7。因而, Ipilimumab 不从人性化的任何一个 CTLA4 基因在树枝状的房间(DC ) 上增加 B7 (Ctla4 h/h ) 或人的 CD34 + 茎重新组成房间的 NSG 老鼠。在 Ctla4 高效地表示人和老鼠 CTLA4 基因,绑在人的 anti-CTLA-4 抗体然而并非老鼠 CTLA-4 的 h/m 老鼠导致 Treg 弄空和 Fc 受体依赖者肿瘤拒绝。堵住的抗体 L3D10 比得上在引起肿瘤拒绝的非阻塞的 Ipilimumab。显著地,输在人类化期间堵住活动的 L3D10 子孙在导致 Treg 弄空和肿瘤拒绝仍然保持充分能干。有效地在淋巴的器官堵住 CD4 T 细胞激活和 de novo CD8 T 细胞 priming 的 Anti-B7 抗体否定地不影响 Ipilimumab 的 immunotherapeutic 效果。因此,临床上有效的 anti-CTLA-4 mAb 由独立于检查点封锁的机制引起肿瘤拒绝但是依赖于主人 Fc 受体。我们为 CTLA-4 检查点的一个重评价的数据电话封锁假设并且为安全、有效的 anti-CTLA-4 mAbs 的下一代提供新卓见。 | Xuexiang Du Fei Tang Mingyue Liu Juanjuan Su Yan Zhang Wei Wu Martin Devenport Christopher A Lazarski Peng Zhang Xu Wang Peiying Ye Changyu Wang Eugene Hwang Tinghui Zhu Ting Xu Pan Zheng Yang Liu | 2018 | Cell Research2018，28，4： | 25 |
| 6 | Cap-assisted endoscopic sclerotherapy for hemorrhoids: Methods, feasibility and efficacy显示文摘AIM: To evaluate the methodology, feasibility, safety and efficacy of a novel method called cap-assisted endoscopic sclerotherapy(CAES) for internal hemorrhoids.METHODS: A pilot study on CAES for grade Ⅰ to Ⅲ internal hemorrhoids was performed. Colon and terminal ileum examination by colonoscopy was performed for all patients before starting CAES. Polypectomy and excision of anal papilla fibroma were performed if polyps or anal papilla fibroma were found and assessed to be suitable for resection under endoscopy. CAES was performed based on the requirement of the cap, endoscope, disposable endoscopic long injection needle, enough insufflated air and sclerosing agent.RESULTS: A total of 30 patients with grade Ⅰ to Ⅲ internal hemorrhoids was included. The follow-up was more than four weeks. No bleeding was observed after CAES. One(3.33%) patient claimed mild tenesmus within four days after CAES in that an endoscopist performed this procedure for the first time. One hundred percent of patients were satisfied with this novel procedure, especially for those patients who underwent CAES in conjunction with polypectomy or excision of anal papilla fibroma.CONCLUSION: CAES as a novel endoscopic sclerotherapy should be a convenient, safe and effective flexible endoscopic therapy for internal hemorrhoids. | Ting Zhang Li-Juan Xu Jie Xiang Zhi He Zhao-Yuan Peng Guang-Ming Huang Guo-Zhong Ji Fa-Ming Zhang | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，19： | 22 |
| 7 | Baicalin induces ferroptosis in bladder cancer cells by downregulating FTH1显示文摘Ferroptosis is a non-apoptotic regulated cell death caused by iron accumulation and subsequent lipid peroxidation.Currently,the therapeutic role of ferroptosis on cancer is gaining increasing interest.Baicalin an active component in Scutellaria baicalensis Georgi with anticancer potential various cancer types;however,the effects of baicalein on bladder cancer and the underlying molecular mechanisms remain largely unknown.In the study,we investigated the effect of baicalin on bladder cancer cells5637 and KU-19-19.As a result,we show baicalin exerted its anticancer activity by inducing apoptosis and cell death in bladder cancer cells.Subsequently,we for the first time demonstrate baicalin-induced ferroptotic cell death in vitro and in vivo,accompanied by reactive oxygen species(ROS) accumulation and intracellular chelate iron enrichment.The ferroptosis inhibitor deferoxamine but not necrostatin-1,chloroquine(CQ),N-acetyl-L-cysteine,L-glutathione reduced,or carbobenzoxy-valyl-alanyl-aspartyl-[O-methyl]-fluoromethylketone(Z-VAD-FMK) rescued baicalin-induced cell death,indicating ferroptosis contributed to baicalin-induced cell death.Mechanistically,we show that ferritin heavy chain1(FTH1) was a key determinant for baicalin-induced ferroptosis.Overexpression of FTH1 abrogated the anticancer effects of baicalin in both 5637 and KU19-19 cells.Taken together,our data for the first time suggest that the natural product baicalin exerts its anticancer activity by inducing FTH1-dependent ferroptosis,which will hopefully provide a prospective compound for bladder cancer treatment. | Na Kong Xiaying Chen Jiao Feng Ting Duan Shuiping Liu Xueni Sun Peng Chen Ting Pan Lili Yan Ting Jin Yu Xiang Quan Gao Chengyong Wen Weirui Ma Wencheng Liu Mingming Zhang Zuyi Yang Wengang Wang Ruonan Zhang Bi Chen Tian Xie Xinbing Sui Wei Tao | 2021 | Acta Pharmaceutica Sinica B2021，11，12： | 23 |
| 8 | p53 upregulated by HIF-la promotes hypoxiainduced G2/M arrest and renal fibrosis in vitro and in vivo显示文摘Hypoxia plays an important role in the genesis and progression of renal fibrosis.The underlying mechanisms, however, have not been sufficiently elucidated. We examined the role of p53 in hypoxia-induced renal fibrosis in cell culture (human and rat renal tubular epithelial cells) and a mouse unilateral ureteral obstruction (UUO) model. Cell cycle of tubular cells was determined by flow cytometry, and the expression of profibrogenic factors was determined by RT-PCR, immunohistochemistry, and western blotting. Chromatin immunoprecipitation and luciferase reporter experiments were performed to explore the effect of HIF-lα on p53 expression. We showed that, in hypoxic tubular cells, p53 upregulation suppressed the expression of CDK1 and cyclins Bl and DI, leading to cell cycle (G2/M) arrest (or delay) and higher expression of TGF-β, CTGF, collagens, and fibronectin. p53 suppression by siRNA or by a specific p53 inhibitor (PIF-α) triggered opposite effects preventing the G2/M arrest and profibrotic changes. In vivo experiments in the UUO model revealed similar antifibrotic results following intraperitoneal administration of PIF-α(2.2 mg/kg). Using gain-of-function, loss-of-function, and luciferase assays, we further identified an HRE3 region on the p53 promoter as the HIF-lα-binding site. The HIF-la-HRE3 binding resulted in a sharp transcriptional activation of p53. Collectively, we show the presence of a hypoxia-activated, p53-responsive profibrogenic pathway in the kidney. During hypoxia, p53 upregulation induced by HIF-la suppresses cell cycle progression, leading to the accumulation of G2/M cells, and activates profibrotic TGF-β and CTGF-mediated signaling pathways, causing extracellular matrix production and renal fibrosis. | Limin Liu Peng Zhang Ming Bai Lijie He Lei Zhang Ting Liu Zhen Yang Menglu Duan Minna Liu Baojian Liu Rui Du Qi Qian Shiren Sun | 2019 | Journal of Molecular Cell Biology2019，11，5： | 18 |
| 9 | Ferroptosis:mechanisms and links with diseases显示文摘Ferroptosis is an iron-dependent cell death,which is different from apoptosis,necrosis,autophagy,and other forms of cell death.The process of feroptotic cell death is defined by the accumulation of lethal lipid species derived from the peroxidation of lipids,which can be prevented by iron chelators(e.g.deferiprone,deferoxamine)and small lipophilic antioxidants(e.g,ferrostatin,liproxstatin).This review summarizes current knowledge about the regulatory mechanism of ferroptosis and its association withseveral pathways,including iron,lipid,and cysteine metabolism.We have further discussed the contribution of ferroptosis to thepathogenesis of several diseases such as cancer,ischemia/reperfusion,and various neurodegenerative diseases(e.g.Alzheimersdisease and Parkinson's disease),and evaluated the therapeutic applications of ferroptosis inhibitors in clinics. | Hong-fa Yan Ting Zou Qing-zhang Tuo Shuo Xu Hua Li Abdel Ali Belaidi Peng Lei | 2021 | Signal Transduction and Targeted Therapy2021，6，3： | 16 |
| 10 | De Novo Plant Genome Assembly Based on Chromatin Interactions: A Case Study of Arabidopsis thaliana显示文摘Dear Editor, Genome assembly is typically a two-stage process:paired sequencing reads are joined into contigs,and contigs are assembled into scaffolds.Over the past 10 years,next-generation sequencing (NGS) technologies have become inexpensive,routine,and widespread.As a result,most plant genomes that are sequenced by NGS produce 'drafts' that are always contig or scaffold maps remaining in a more or less advanced stage of completion (Claros et al.,2012).Slow advances in the technology for the de novo assembly of scaffolds into chromosome-scale scaffolds have become the main restriction to the completion of and high-quality genome sequence acquisition. | Ting Xie | 2015 | Molecular Plant2015，8，3： | 15 |
| 11 | Liver development in zebrafish (Danio rerio)显示文摘Liver is one of the largest internal organs in the body and its importance for metabolism, detoxification and homeostasis has been well established. In this review, we summarized recent progresses in studying liver initiation and development during embryogenesis using zebrafish as a model system. We mainly focused on topics related to the specification of hepatoblasts from endoderm, the formation and growth of liver bud, the differentiation of hepatocytes and bile duct cells from hepatoblasts, and finally the role of mesodermal signals in controlling liver development in zebrafish. | Ting Tao Jinrong Peng | 2009 | Journal of Genetics and Genomics2009，36，6： | 14 |
| 12 | Developing gene-tagged molecular markers for evaluation of genetic association of apple SWEET genes with fruit sugar accumulation显示文摘Sugar content is an important component of fruit quality.Although sugar transporters are known to be crucial for sugar accumulation,the role of genes encoding SWEET sugar transporters in fruit sugar accumulation remains elusive.Here we report the effect of the SWEET genes on fruit sugar accumulation in apple.A total of 25 MdSWEET genes were identified in the apple genome,and 9 were highly expressed throughout fruit development.Molecular markers of these 9 MdSWEET genes were developed and used for genotyping of 188 apple cultivars.The association of polymorphic MdSWEET genes with soluble sugar content in mature fruit was analyzed.Three genes,MdSWEET2e,MdSWEET9b,and MdSWEET15a,were significantly associated with fruit sugar content,with MdSWEET15a and MdSWEET9b accounting for a relatively large proportion of phenotypic variation in sugar content.Moreover,both MdSWEET9b and MdSWEET15a are located on chromosomal regions harboring QTLs for sugar content.Hence,MdSWEET9b and MdSWEET15a are likely candidates regulating fruit sugar accumulation in apple.Our study not only presents an efficient way of implementing gene functional study but also provides molecular tools for genetic improvement of fruit quality in apple-breeding programs. | Qiaoling Zhen Ting Fang Qian Peng Liao Liao Li Zhao Albert Owiti Yuepeng Han | 2018 | Horticulture Research2018，5，1： | 12 |
| 13 | Abnormal functional connectivity with mood regulating circuit in unmedicated individual with major depression: a resting-state functional magnetic resonance study显示文摘 | PENG Dai-hui SHEN Ting ZHANG Jie HUANG Jia LIU Jun LIU Shu-yong JIANG Kai-da XU Yi-feng FANG Yi-ru | 2012 | Chinese Medical Journal2012，，20： | 12 |
| 14 | Clinical significance of Fas and FasL protein expression in gastric carcinoma and local lymph node tissues显示文摘AIM:To investigate the relation of Fas and Fas ligand (FasL) protein expression with carcinogenesis and metastasis of gastric carcinoma.METHODS: Immunohistochemistry was used to detect Fas and FasL protein expression in 64 gastric carcinoma tissue samples and 20 normal gastric tissue samples. Relation between FasL and Fas expression, age and gender of gastric cancer patients, and pathological subtype and lymph node metastasis of gastric cancer was analyzed.RESULTS: The Fas expression level was significantly higher in normal gastric tissue samples than in gastric carcinoma tissue samples (85.0% vs 25.0%, P<0.001), while the FasL expression level was signif icantly lower in normal gastric tissue samples than in gastric carcinoma tissue samples (30.0% vs 81.3%, P<0.001). The Fas expression level was significantly higher in invasive lymph nodes than in non-invasive lymph nodes (82.9% vs 56.5%, P<0.003) and in well-differentiated gastric carcinoma tissue samples than in poorly-differentiated gastric carcinoma tissue samples (50.0% vs 18.0%, P=0.015). The FasL expression level was significantly lower in well-differentiated gastric carcinoma tissue samples than in poorly-differentiated gastric carcinoma tissue samples (42.9% vs 84.0%, P=0.021). The Fas and FasL expression levels (25.0% and 81.3%) were signif icantly different in gastric carcinoma tissue samples (P<0.001), but had a non-linear correlation (P=0.575).CONCLUSION: Abnormal Fas and FasL expressions in gastric carcinoma and lymph node tissues are involved in carcinogenesis and metastasis of gastric cancer. | Li, Qian Peng, Jie Li, Xin-Hua Liu, Ting Liang, Qing-Chun Zhang, Gui-Ying | 2010 | World Journal of Gastroenterology2010，16，10： | 11 |
| 15 | Casticin induces caspase-mediated apoptosis via activation of mitochondrial pathway and upregulation of DR5 in human lung cancer cells显示文摘Objective:To assess if casticin induces caspase-mediated apoptosis via activation of mitochondrial pathway and upregulation of DR5 in human lung cancer ceils.Methods:Human non-small-cell lung carcinoma cell lines H460,AS49 and H157 were cultured in vitro.The cytotoxic activities were determined using MTT assay.The apoptotic cells death was examined by flow cytometry using PI staining and DMA agarose gel electrophoresis.The activities of caspase-3, -8 and -9 were measured via ELISA.Cellular fractionation was determined by flow cytometry to assess release of cytochrome c and the mitochondrial transmembrane potential.Bcl-2/Bcl-XL/ XIAP/Bid/ DR5 and DR4 proteins were analyzed using western blot.Results:The concentrations required for a 50%decrease in cell growth(IC50) ranged from 1.8 to 3.2 Jt M.Casticin induced rapid apoptosis and triggered a series of effects associated with apoptosis by way of mitochondrial pathway,including the depolarization of the mitochondrial membrane,release of cytochrome c from mitochondria,activation of procaspase-9 and -3,and increase of DNA fragments.Moreover, the pan caspase inhibitor zVAD-FMK and the caspase-3 inhibitor zOEVD-FMK suppressed casticin-induced apoptosis.In addition,casticin induced XIAP and Bcl-XL down-regulation, Bax upregulation and Bid clearage.In H157 cell line,casticin increased expression of DRS at protein levels but not affect the expression of DR4.The prelreatmenl with DR5/Fc chimera protein effectively attenuated casticin-induced apoptosis in H157 cells.No correlation was found between cell sensitivity to casticin and that to p53 status,suggesting that casticin induce a p53- independent apoptosis.Conclusions:Our results demonstrate that casticin induces caspase-mediated apoptosis via activation of mitochondrial pathway and upregulation of DRS in human lung cancer cells. | Yuan Zhou Yi Peng Qi-Qi Mao Xia Li Ming-Wu Chen Ting Su Li Tian Nai-Quan Mao Ling-Zhi Long Mei-Fang Quan Fei Liu Su-Fang Zhou Yong-Xiang Zhao | 2013 | Asian Pacific Journal of Tropical Medicine2013，6，5： | 11 |
| 16 | Grey GM(1,1) Model with Function-Transfer Method for Wear Trend Prediction and its Application显示文摘Trend forecasting is an important aspect in fault diagnosis and work state supervision. The principle, where Grey theory is applied in fault forecasting, is that the forecast system is considered as a Grey system; the existing known information is used to infer the unknown information’s character, state and development trend in a fault pattern, and to make possible forecasting and decisions for future development. It involves the whitenization of a Grey process. But the traditional equal time interval Grey GM (1,1) model requires equal interval data and needs to bring about accumulating addition generation and reversion calculations. Its calculation is very complex. However, the non equal interval Grey GM (1,1) model decreases the condition of the primitive data when establishing a model, but its requirement is still higher and the data were pre processed. The abrasion primitive data of plant could not always satisfy these modeling requirements. Therefore, it establishes a division method suited for general data modeling and estimating parameters of GM (1,1), the standard error coefficient that was applied to judge accuracy height of the model was put forward; further, the function transform to forecast plant abrasion trend and assess GM (1,1) parameter was established. These two models need not pre process the primitive data. It is not only suited for equal interval data modeling, but also for non equal interval data modeling. Its calculation is simple and convenient to use. The oil spectrum analysis acted as an example. The two GM (1,1) models put forward in this paper and the new information model and its comprehensive usage were investigated. The example shows that the two models are simple and practical, and worth expanding and applying in plant fault diagnosis. | LUO You xin 1 , PENG Zhu 2 , ZHANG Long ting 1 , GUO Hui xin 1 , CAI An hui 1 1Department of Mechanical Engineering, Changde Teachers University, Changde 415003, P.R. China 2 Engineering Technology Board, Changsha Cigare | 2001 | International Journal of Plant Engineering and Management2001，6，4： | 11 |
| 17 | Trimer procyanidin oligomers contribute to the protective effects of cinnamon extracts on pancreatic 13-cells in vitro显示文摘 | Peng SUN Ting WANG Lu CHEN Bang-wei YU Qi JIA Kai-xian CHEN Hui-min FAN Yi-ming LI He-yao WANG | 2016 | Acta Pharmacologica Sinica2016，37，8： | 9 |
| 18 | Mode-locked 2.8-μm fluoride fiber laser:from soliton to breathing pulse显示文摘The mode-locked fluoride fiber laser(MLFFL)is an exciting platform for directly generating ultrashort pulses in the mid-infrared(mid-IR).However,owing to difficulty in managing the dispersion in fluoride fiber lasers,MLFFLs are restricted to the soliton regime,hindering pulse-energy scaling.We overcame the problem of dispersion management by utilizing the huge normal dispersion generated near the absorption edge of an infrared-bandgap semiconductor and promoted MLFFL from soliton to breathing-pulse mode-locking.In the breathing-pulse regime,the accumulated nonlinear phase shift can be significantly reduced in the cavity,and the pulse-energy-limitation effect is mitigated.The breathing-pulse MLFFL directly produced a pulse energy of 9.3 nJ and pulse duration of 215 fs,with a record peak power of 43.3 kW at 2.8μm.Our work paves the way for the pulse-energy and peak-power scaling of mid-IR fluoride fiber lasers,enabling a wide range of applications. | Zhipeng Qin Guoqiang Xie Hongan Gu Ting Hai Peng Yuan Jingui Ma Liejia Qian | 2019 | Advanced Photonics2019，1，6： | 9 |
| 19 | Pharmacokinetics of the prototype and hydrolyzed carboxylic forms of ginkgolides A, B, and K administered as a ginkgo diterpene lactones meglumine injection in beagle dogs显示文摘Ginkgo diterpene lactones meglumine injection(GDLI)is a commercially available product used for neuroprotection.However,the pharmacokinetic properties of the prototypes and hydrolyzed carboxylic forms of the primary components in GDLI,i.e.,ginkgolide A(GA),ginkgolide B(GB),and ginkgolide K(GK),have never been fully evaluated in beagle dogs.In this work,a simple,sensitive,and reliable method based on ultra-fast liquid chromatography-tandem mass spectrometry(UFLC-MS/MS)was developed,and the prototypes and total amounts of GA,GB,and GK were determined in beagle dog plasma.The plasma concentrations of the hydrolyzed carboxylic forms were calculated by subtracting the prototype concentrations from the total lactone concentrations.For the first time,the pharmacokinetics of GA,GB,and GK were fully assessed in three forms,i.e.,the prototypes,the hydrolyzed carboxylic forms,and the total amounts,after intravenous administration of GDLI in beagle dogs.It was shown that ginkgolides primarily existed in the hydrolyzed form in plasma,and the ratio of hydrolysates to prototype forms of GA and GB decreased gradually to a homeostatic ratio.All of the three forms of the three ginkgolides showed linear exposure of AUC to the dosages.GA,GB,and GK showed a constant half-life approximately 2.7,3.4,and 1.2 h,respectively,which were consistent for the forms at three dose levels(0.3,1.0,and 3.0 mg·kg^(-1))and after a consecutive injection of GDLI for 7 days(1.0 mg·kg^(-1)). | WANG Shu-Yao A Ji-Ye FEI Fei GENG Jian-Liang PENG Ying OUYANG Bing-Chen WANG Pei JIN Xiao-Liang ZHAO Yu-Qing WANG Jian-Kun GENG Ting LI Yan-Jing HUA NG Wen-Zhe WANG Zhen-Zhong XIAO Wei WANG Guang-Ji | 2017 | Chinese Journal of Natural Medicines2017，15，10： | 9 |
| 20 | Analysis of reference gene expression for real-time PCR based on relative quantitation and dual spike-in strategy in the silkworm Bombyx mori显示文摘为即时量的聚合酶链反应(qPCR ) ,一般来说,正规化策略把引用基因用作控制并且不应该响应改变条件变化避免这基因的试验性的错误表示的介绍。然而,许多参考基因的表示被报导了更加变化,没有适当正规化,目标基因的表示侧面能被曲解。在这研究,七的表达式层次通常使用了引用基因(行为, GAPDH, 28srRNA, RPL3, -tubulin, UBC,和 TBP ) 与 20-hydroxyecdysone (20E ) 并且与卢丁在不同开发时间点并且响应处理被检测。表示稳定性用 geNorm 和 NormFinder 软件被分析。重要变化在正常纸巾之中并且在试验性地对待的纸巾之间被发现。双刺在里面策略也在正常纸巾之中并且在试验性地对待的纸巾之间揭示了参考基因的表示层次的重要变化。Glutathione-S-transferase 西格马 1 (GSTs1 ) ,它在胖身体有高表达式水平并且与抵抗的机制有关,被用作目标基因验证这二条途径的可行性和差别。 | Ran Peng Yuanfen Zhai Hua Ding Tianyuan Di Ting Zhang Bing Li Weide Shen Zhengguo Wei | 2012 | Acta Biochimica et Biophysica Sinica2012，44，7： | 8 |
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