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| 1 | Impact of an acute hemodynamic response-guided protocol for primary prophylaxis of variceal bleeding显示文摘AIM To evaluate the long-term outcome of an acute hemodynamic response-guided protocol in which acute responders to intravenous propranolol received traditional nonselective beta-blockers(NSBBs) and acute nonresponders received carvedilol.METHODS Retrospective review of a protocol for primary prophylaxis of variceal bleeding guided by the acute hemodynamic response to intravenous propranolol. Fifty-two acute responders treated with traditional NSBB(i.e. propranolol or nadolol) were compared with 24 acute nonresponders receiving carvedilol. A second hemodynamic study was performed in 27 and 13 patients, respectively. The primary endpoint was development of first or further decompensation. Secondary endpoints included death from any cause, association between acute and chronic hemodynamic response, and baseline clinical and laboratory variables related to the acute hemodynamic response.RESULTS Acute responders and acute nonresponders presented similar 1, 2, and 3-year probabilities of first decompensation(NSBB: 0%, 13.7%, 26.1% vs carvedilol: 0%, 20%, 20%, P = 0.968) or further decompensation(21.2%, 26.1%, 40.9% vs 21.2%, 50.0%, 50.0%, P = 0.525). A previous episode of hepatic encephalopathy was the only independent predictor of decompensation [hazard ratio(95% confidence interval): 8.03(2.76-23.37)]. Mortality rates were similar in acute responders and acute nonresponders with compensated(P = 0.428) or decompensated cirrhosis(P = 0.429). No clinical, laboratory, endoscopic or hemodynamic parameter predicted the acute hemodynamic response. In patients receiving traditional NSBB, the acute and chronic changes of hepatic venous pressure gradient were correlated(r = 0.59, P = 0.001). Up to 69.2% of acute nonresponders gained chronic response with carvedilol.CONCLUSION Early identification and treatment with carvedilol of acute nonresponders to intravenous propranolol improves the clinical outcome of this high-risk group of patients, probably due to its greater effects for reducing portal pressure. | José Ignacio Fortea ángela Puente Patricia Ruiz Iranzu Ezcurra Javier Vaquero Antonio Cuadrado María Teresa Arias-Loste Joaquín Cabezas Susana Llerena Paula Iruzubieta Carlos Rodríguez-Lope Patricia Huelin Fernando Casafont Emilio Fábrega Javier Crespo | 2018 | World Journal of Clinical Cases2018，6，13： | 6 |
| 2 | Stabilization of all-trans-lycopene from tomato by encapsulationusing cyclodextrins显示文摘 | Gracia Patricia Blanch a Mar?' a Luisa Ruiz del Castillo a Mar?' a del Mar Ca | 2007 | Food Chemistry2007，，105： | 1 |
| 3 | High expression level of x6 integrin in human breast carcinoma is correlated with reduced survival显示文摘 | Kay Friedrichs Patricia Ruiz Folker Franke | 1995 | Cancer Res1995，55，： | 1 |
| 4 | Survival after curative pancreaticoduodenectomy for ampullary adenocarcinoma in a South American population:A retrospective cohort study显示文摘BACKGROUND Ampullary adenocarcinoma(AAC)is a rare neoplasm that accounts for only 0.2%of all gastrointestinal cancers.Its incidence rate is lower than 6 cases per million people.Different prognostic factors have been described for AAC and are associated with a wide range of survival rates.However,these studies have been exclusively conducted in patients originating from Asian,European,and North American countries.AIM To evaluate the histopathologic predictors of overall survival(OS)in South American patients with AAC treated with curative pancreaticoduodenectomy(PD).METHODS We analyzed retrospective data from 83 AAC patients who underwent curative(R0)PD at the National Cancer Institute of Peru between January 2010 and October 2020 to identify histopathologic predictors of OS.RESULTS Sixty-nine percent of patients had developed intestinal-type AAC(69%),23%had pancreatobiliary-type AAC,and 8%had other subtypes.Forty-one percent of patients were classified as Stage I,according to the AJCC 8 th Edition.Recurrence occurred primarily in the liver(n=8),peritoneum(n=4),and lung(n=4).Statistical analyses indicated that T3 tumour stage[hazard ratio(HR)of 6.4,95%confidence interval(CI)of 2.5-16.3,P<0.001],lymph node metastasis(HR:4.5,95%CI:1.8-11.3,P=0.001),and pancreatobiliary type(HR:2.7,95%CI:1.2-6.2,P=0.025)were independent predictors of OS.CONCLUSION Extended tumour stage(T3),pancreatobiliary type,and positive lymph node metastasis represent independent predictors of a lower OS rate in South American AAC patients who underwent curative PD. | Ramiro Manuel Fernandez-Placencia Paola Montenegro Melvy Guerrero Mariana Serrano Emperatriz Ortega Mercedes Bravo Lourdes Huanca Stéphane Bertani Juan Manuel Trejo Patricia Webb Jenny Malca-Vasquez Luis Taxa Alberto Lachos-Davila Juan Celis-Zapata Carlos Luque-Vasquez Eduardo Payet Eloy Ruiz Francisco Berrospi | 2022 | World Journal of Gastrointestinal Surgery2022，14，1： | 1 |
| 5 | Sex-specific pathways in early cardiac response to pressure overload in mice显示文摘Pressure overload(PO) first causes cardiac hypertrophy and then heart failure(HF), which are associated with sex differences in cardiac morphology and function. We aimed to identify genes that may cause HF-related sex differences. We used a transverse aortic constriction(TAC) mouse model leading to hypertrophy without sex differences in cardiac function after 2 weeks, but with sex differences in hypertrophy 6 and 9 weeks after TAC. Cardiac gene expression was analyzed 2 weeks after surgery. Deregulated genes were classified into functional gene ontology(GO) categories and used for pathway analysis. Classical marker genes of hypertrophy were similarly upregulated in both sexes(α-actin, ANP, BNP, CTGF). Thirty-five genes controlling mitochondrial function(PGC-1, cytochrome oxidase, carnitine palmitoyl transferase, acyl-Co A dehydrogenase, pyruvate dehydrogenase kinase) had lower expression in males compared to females after TAC. Genes encoding ribosomal proteins and genes associated with extracellular matrix remodeling exhibited relative higher expression in males(collagen 3, matrix metalloproteinase 2, TIMP2, and TGFβ2, all about twofold) after TAC. We confirmed 87% of the gene expression by real-time polymerase chain reaction. By GO classification, female-specific genes were related to mitochondria and metabolism and males to matrix and biosynthesis. Promoter studies confirmed the upregulation of PGC-1 by E2. Less downregulation of metabolic genes in female hearts and increased protein synthesis capacity and deregulation of matrix remodeling in male hearts characterize the sex-specific early response to PO. These differences could contribute to subsequent sex differences in cardiac function and Hf. | Henning Witt Carola Schubert Juliane Jaekel Daniela Fliegner Adam Penkalla Klaus Tiemann Joerg Stypmann Stefan Roepcke Sebastian Brokat Shokoufeh Mahmoodzadeh Eva Brozova Mercy M.Davidson Patricia Ruiz Noppinger Christian Grohé Vera Regitz-Zagrosek | 2015 | 世界最新医学信息文摘2015，15，A0： | 1 |
| 6 | Detection of the adulteration of olive oils by solid phase microextraction and multidimensional gas chromatography显示文摘 | Gema Flores Maria Luisa Ruiz del Castillo Gracia Patricia Blanch | | 0，，01： | 1 |
| 7 | Nephrin mutations cause childhood - onsent and adult -onset focal segmental glomerulosclerosis 显示文摘 | SHEILA SAN'TIN RAFAEL GARCfA - MASET PATRICIA RUIZ | 2009 | Kidney Internation- al2009，，72： | 1 |
| 8 | Preyssler catalyst: An efcient catalyst for es- terification of cinnamic acids with phenols and imidoalco- hols 显示文摘 | Diego M Ruiz Gustavo P Romanelli Patricia G Va'zqu- ez | 2010 | Applied Catalysis A : General2010，374，： | 1 |
| 9 | Early-Age Behavior of Concrete Overlays on Continuously Reinforced Concrete Pavements 显示文摘 | Kim Seong-Min Nelson Patricia Kim Ruiz Ma- uricio | 2003 | Transportation Research Record: Journal of the Transportation Research Board2003，，1823： | 1 |
| 10 | Human papillomavirus genotype attribution in invasive cervical cancer: a retrospective cross-sectional worldwide study显示文摘 | Silvia de Sanjose Wim GV Quint Laia Alemany Daan T Geraets Jo Ellen Klaustermeier Belen Lloveras Sara Tous Ana Felix Luis Eduardo Bravo Hai-Rim Shin Carlos S Vallejos Patricia Alonso de Ruiz Marcus Aurelho Lima Nuria Guimera Omar Clavero Maria Alejo Anton | 2010 | Lancet Oncology2010，，11： | 1 |
| 11 | Human papillomavirus genotype attribution in invasive cervical cancer: a retrospective cross-sectional worldwide study显示文摘 | Silvia de Sanjose Wim GV Quint Laia Alemany Daan T Geraets Jo Ellen Klaustermeier Belen Lloveras Sara Tous Ana Felix Luis Eduardo Bravo Hai-Rim Shin Carlos S Vallejos Patricia Alonso de Ruiz Marcus Aurelho Lima Nuria Guimera Omar Clavero Maria Alejo Anton | 2010 | Lancet Oncology2010，，11： | 1 |
| 12 | Age- and Training-Dependent Development of Arrhythmogenic Right Ventricular Cardiomyopathy in Heterozygous Plakoglobin-Deficient Mice显示文摘 | Paulus Kirchhof Larissa Fabritz Melanie Zwiener Henning Witt Michael Sch?fers Stephan Zellerhoff Matthias Paul Timur Athai Karl-Heinz Hiller Hideo A. Baba Günter Breithardt Patricia Ruiz Thomas Wichter Bodo Levkau | 2006 | Circulation2006，，17： | 1 |
| 13 | Early tacrolimus exposure does not impact long-term outcomes after liver transplantation显示文摘BACKGROUND Tacrolimus trough levels(TTL)during the first weeks after liver transplantation(LT)have been related with long-term renal function and hepatocellular carcinoma recurrence.Nevertheless,the significance of trough levels of tacrolimus during the early post-transplant period for the long-term outcome is under debate AIM To evaluate the effect of TTL during the first month on the long-term outcomes after LT.METHODS One hundred fifty-five LT recipients treated de novo with once-daily tacrolimus were retrospectively studied.Patients with repeated LT or combined transplantation were excluded as well as those who presented renal dysfunction prior to transplantation and/or those who needed induction therapy.Patients were classified into 2 groups according to their mean TTL within the first month after transplantation:≤10(n=98)and>10 ng/mL(n=57).Multivariate analyses were performed to assess risk factors for patient mortality.RESULTS Mean levels within the first month post-transplant were 7.4±1.7 and 12.6±2.2 ng/mL in the≤10 and>10 groups,respectively.Donor age was higher in the high TTL group 62.9±16.8 years vs 45.7±17.5 years(P=0.002)whilst mycophenolate-mofetil was more frequently used in the low TTL group 32.7%vs 15.8%(P=0.02).Recipient features were generally similar across groups.After a median follow-up of 52.8 mo(range 2.8-81.1),no significant differences were observed in:Mean estimated glomerular filtration rate(P=0.69),hepatocellular carcinoma recurrence(P=0.44),de novo tumors(P=0.77),new-onset diabetes(P=0.13),or biopsy-proven acute rejection rate(12.2%and 8.8%,respectively;P=0.50).Eighteen patients died during the follow-up and were evenly distributed across groups(P=0.83).Five-year patient survival was 90.5%and 84.9%,respectively(P=0.44),while 5-year graft survival was 88.2%and 80.8%,respectively(P=0.42).Early TTL was not an independent factor for patient mortality in multivariate analyses.CONCLUSION Differences in tacrolimus levels restricted to the first month after transplant did not result in significant differences in long-term outcomes of LT recipients. | Mikel Gastaca Patricia Ruiz Javier Bustamante Lorea Martinez-Indart Alberto Ventoso JoséRamón Fernandez Ibone Palomares Mikel Prieto Milagros Testillano Patricia Salvador Maria Senosiain Maria Jesus Suárez Andres Valdivieso | 2021 | World Journal of Hepatology2021，13，3： | 0 |
| 14 | Sex-specific pathways in early cardiac response to pressure overload in mice显示文摘Pressure overload(PO)first causes cardiac hypertrophy and then heart failure(HF),which are associated with sex differences in cardiac morphology and function.We aimed to identify genes that may cause HF-related sex differences.We used a transverse aortic constriction(TAC)mouse model leading to hypertrophy without sex differences in cardiac function after 2 weeks,but with sex differences in hypertrophy 6 and 9 weeks after TAC.Cardiac gene expression was analyzed 2 weeks after surgery.Deregulated genes were classified into functional gene ontology(GO)categories and used for pathway analysis.Classical marker genes of hypertrophy were similarly upregulated in both sexes(α-actin,ANP,BNP,CTGF).Thirty-five genes controlling mitochondrial function(PGC-1,cytochrome oxidase,carnitine palmitoyl transferase,acyl-CoA dehydrogenase,pyruvate dehydrogenase kinase)had lower expression in males compared to females after TAC.Genes encoding ribosomal proteins and genes associated with extracellular matrix remodeling exhibited relative higher expression in males(collagen 3,matrix metalloproteinase 2,TIMP2,and TGFβ2,all about twofold)after TAC.We confirmed 87%of the gene expression by real-time polymerase chain reaction.By GO classification,female-specific genes were related to mitochondria and metabolism and males to matrix and biosynthesis.Promoter studies confirmed the upregulation of PGC-1 by E2.Less downregulation of metabolic genes in female hearts and increased protein synthesis capacity and deregulation of matrix remodeling in male hearts characterize the sex-specific early response to PO.These differences could contribute to subsequent sex differences in cardiac function and HF. | Henning Witt Carola Schubert Juliane Jaekel Daniela Fliegner Adam Penkalla Klaus Tiemann Joerg Stypmann Stefan Roepcke Sebastian Brokat Shokoufeh Mahmoodzadeh Eva Brozova Mercy M.Davidson Patricia Ruiz Noppinger Christian Grohé Vera Regitz-Zagrosek | 2016 | 世界最新医学信息文摘2016，16，2： | 0 |
| 15 | Sex-specific pathways in early cardiac response to pressure overload in mice显示文摘Pressure overload(PO) first causes cardiac hypertrophy and then heart failure(HF), which are associated with sex differences in cardiac morphology and function. We aimed to identify genes that may cause HF-related sex differences. We used a transverse aortic constriction(TAC) mouse model leading to hypertrophy without sex differences in cardiac function after 2 weeks, but with sex differences in hypertrophy 6 and 9 weeks after TAC. Cardiac gene expression was analyzed 2 weeks after surgery. Deregulated genes were classified into functional gene ontology(GO) categories and used for pathway analysis. Classical marker genes of hypertrophy were similarly upregulated in both sexes(α-actin, ANP, BNP, CTGF). Thirty-five genes controlling mitochondrial function(PGC-1, cytochrome oxidase, carnitine palmitoyl transferase, acyl-CoA dehydrogenase, pyruvate dehydrogenase kinase) had lower expression in males compared to females after TAC. Genes encoding ribosomal proteins and genes associated with extracellular matrix remodeling exhibited relative higher expression in males(collagen 3, matrix metalloproteinase 2, TIMP2, and TGFβ2, all about twofold) after TAC. We confirmed 87% of the gene expression by real-time polymerase chain reaction. By GO classification, female-specific genes were related to mitochondria and metabolism and males to matrix and biosynthesis. Promoter studies confirmed the upregulation of PGC-1 by E2. Less downregulation of metabolic genes in female hearts and increased protein synthesis capacity and deregulation of matrix remodeling in male hearts characterize the sex-specific early response to PO. These differences could contribute to subsequent sex differences in cardiac function and HF. | Henning Witt Carola Schubert Juliane Jaekel Daniela Fliegner Adam Penkalla Klaus Tiemann Joerg Stypmann Stefan Roepcke Sebastian Brokat Shokoufeh Mahmoodzadeh Eva Brozova Mercy M.Davidson Patricia Ruiz Noppinger Christian Grohé Vera Regitz-Zagrosek | 2015 | 世界最新医学信息文摘2015，15，99： | 0 |
| 16 | Immunotherapy in triple-negative breast cancer:A literature review and new advances显示文摘Triple-negative breast cancer(TNBC)is a highly complex,heterogeneous disease and historically has limited treatment options.It has a high probability of disease recurrence and rapid disease progression despite adequate systemic treatment.Immunotherapy has emerged as an important alternative in the management of this malignancy,showing an impact on progression-free survival and overall survival in selected populations.In this review we focused on immunotherapy and its current relevance in the management of TNBC,including various scenarios(metastatic and early-neoadjuvant,adjuvant-),new advances in this subtype and the research of potential predictive biomarkers of response to treatment. | Guillermo Arturo Valencia Patricia Rioja Zaida Morante Rossana Ruiz Hugo Fuentes Carlos A Castaneda Tatiana Vidaurre Silvia Neciosup Henry L Gomez | 2022 | World Journal of Clinical Oncology2022，13，3： | 0 |
| 17 | Endoscopic recommendations for colorectal cancer screening and surveillance in patients with inflammatory bowel disease:Review of general recommendations显示文摘Screening for colorectal cancer(CRC) in patients with inflammatory bowel disease(IBD) is recommended by all scientific societies. However, there are differences in the recommendations they make regarding screening and surveillance. We address a series of questions that come up in the daily clinical practice of a physician. The first two questions that are raised are:(1) Who should be offered screening for CRC? and(2) When should the first colonoscopy be performed? The next step is to decide who should undergo endoscopic surveillance and at what intervals they should be performed. Chromoendoscopy is emerging as the recommended endoscopic technique for screening and surveillance. The terminology for describing lesions detected with endoscopy is also changing. The management of visible lesions or non-visible dysplasia is also a motive for the review. We end the review by addressing the followup for endoscopically resected lesions. These questions often cannot be answered easily due to the varying degrees of evidence available; therefore, we have made some general recommendations based on those made by the various guidelines and consensuses. The first screening colonoscopy should be offered 8 years after a IBD diagnosis and we recommend that patients be stratified according to the individual risk for each for endoscopic surveillance intervals. | Jose María Huguet Patricia Suárez Luis Ferrer-Barceló Lucía Ruiz Ana Monzó Ana Belén Durá Javier Sempere | 2017 | World Journal of Gastrointestinal Endoscopy2017，9，6： | 0 |
| 18 | Sex-specific pathways in early cardiac response to pressure overload in mice显示文摘Pressure overload(PO) first causes cardiac hypertrophy and then heart failure(HF), which are associated with sex differences in cardiac morphology and function. We aimed to identify genes that may cause HF-related sex differences. We used a transverse aortic constriction(TAC) mouse model leading to hypertrophy without sex differences in cardiac function after 2 weeks, but with sex differences in hypertrophy 6 and 9 weeks after TAC. Cardiac gene expression was analyzed 2 weeks after surgery. Deregulated genes were classified into functional gene ontology(GO) categories and used for pathway analysis. Classical marker genes of hypertrophy were similarly upregulated in both sexes(α-actin, ANP, BNP, CTGF). Thirty-five genes controlling mitochondrial function(PGC-1, cytochrome oxidase, carnitine palmitoyl transferase, acyl-Co A dehydrogenase, pyruvate dehydrogenase kinase) had lower expression in males compared to females after TAC. Genes encoding ribosomal proteins and genes associated with extracellular matrix remodeling exhibited relative higher expression in males(collagen 3, matrix metalloproteinase 2, TIMP2, and TGFβ2, all about twofold) after TAC. We confirmed 87% of the gene expression by real-time polymerase chain reaction. By GO classification, female-specific genes were related to mitochondria and metabolism and males to matrix and biosynthesis. Promoter studies confirmed the upregulation of PGC-1 by E2. Less downregulation of metabolic genes in female hearts and increased protein synthesis capacity and deregulation of matrix remodeling in male hearts characterize the sex-specific early response to PO. These differences could contribute to subsequent sex differences in cardiac function and Hf. | Henning Witt Carola Schubert Juliane Jaekel Daniela Fliegner Adam Penkalla Klaus Tiemann Joerg Stypmann Stefan Roepcke Sebastian Brokat Shokoufeh Mahmoodzadeh Eva Brozova Mercy M.Davidson Patricia Ruiz Noppinger Christian Grohé Vera Regitz-Zagrosek | 2015 | 世界最新医学信息文摘2015，15，90： | 0 |
| 19 | Sex-specific pathways in early cardiac response to pressure overload in mice显示文摘Pressure overload(PO) first causes cardiac hypertrophy and then heart failure(HF),which are associated with sex differences in cardiac morphology and function.We aimed to identify genes that may cause HF-related sex differences.We used a transverse aortic constriction(TAC) mouse model leading to hypertrophy without sex differences in cardiac function after 2 weeks,but with sex differences in hypertrophy 6 and 9 weeks after TAC.Cardiac gene expression was analyzed 2 weeks after surgery.Deregulated genes were classified into functional gene ontology(GO) categories and used for pathway analysis.Classical marker genes of hypertrophy were similarly upregulated in both sexes(α-actin,ANP,BNP,CTGF).Thirty-five genes controlling mitochondrial function(PGC-1,cytochrome oxidase,carnitine palmitoyl transferase,acyl-CoA dehydrogenase,pyruvate dehydrogenase kinase) had lower expression in males compared to females after TAC.Genes encoding ribosomal proteins and genes associated with extracellular matrix remodeling exhibited relative higher expression in males(collagen 3,matrix metalloproteinase 2,TIMP2,and TGFβ2,all about twofold) after TAC.We confirmed 87% of the gene expression by real-time polymerase chain reaction.By GO classification,female-specific genes were related to mitochondria and metabolism and males to matrix and biosynthesis.Promoter studies confirmed the upregulation of PGC-1 by E2.Less downregulation of metabolic genes in female hearts and increased protein synthesis capacity and deregulation of matrix remodeling in male hearts characterize the sex-specific early response to PO.These differences could contribute to subsequent sex differences in cardiac function and HF. | Henning Witt Carola Schubert Juliane Jaekel Daniela Fliegner Adam Penkalla Klaus Tiemann Joerg Stypmann Stefan Roepcke Sebastian Brokat Shokoufeh Mahmoodzadeh Eva Brozova Mercy M.Davidson Patricia Ruiz Noppmger Christian Grohe Vera Regitz-Zagrosek | 2016 | 世界最新医学信息文摘2016，16，4： | 0 |
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