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| 1 | Inhibition of hepatitis B virus DNA replicative intermediate forms by recombinant interferon-γ显示文摘AIM: To evaluate the in vitro anti-HBV activity of recombinant human IFN-γ, alone and in combination with lamivudine. METHODS: A recombinant baculovirus-HBV/HepG2 culture system was developed which could support productive HBV infection in vitro. Expression of HBsAg and HBeAg in infected HepG2 culture medium was detected by commercial enzyme immunoassays. HBV DNA replication intermediates were detected in infected cells by Southern hybridization and viral DNA load was determined by dot hybridization. RESULTS: IFN-γat 0.1 to 5μg/L efficiently down regulated HBsAg expression in transduced HepG2 cells. At 5μg/L, IFN-γalso suppressed HBV DNA replication in these cells. While treatment with a combination of lamivudine and IFN-γshowed no additive effect, sequential treatment first with lamivudine and then IFN-γwas found to be promising. In this culture system the best HBV suppression was observed with a pulse of 2μmol/L lamivudine for two days, followed by 1μg/L IFN-γfor another four days. Compared to treatment with lamivudine alone, the sequential use of 0.2μmol/L lamivudine for two days, followed by 5μg/L IFN-γfor six days showed a 72% reduction in HBV cccDNA pool. CONCLUSION: This in vitro study warrants further evaluation of a combination of IFN-γand lamivudine, especially in IFN-αnon-responder chronic hepatitis B patients. A reduced duration of lamivudine treatment would also restrict the emergence of drug-resistant HBV mutants. | Mohammad Khalid Parvez Deepak Sehgal Shiv Kumar Sarin Seemi Farhat Basir Shahid Jameel | 2006 | World Journal of Gastroenterology2006，12，19： | 10 |
| 2 | Risk of contrast-induced nephropathy in hospitalized patients with cirrhosis显示文摘AIM:To evaluate the incidence of contrast-induced nephropathy(CIN)in cirrhotic patients and to identify risk factors for the development of CIN.METHODS:We performed a retrospective review of 216 consecutive patients with cirrhosis who underwent computed tomography(CT)with intravenous contrast at the University of Rochester between the years 2000-2005.We retrospectively examined factors associated with a high risk for CIN,defined as a decrease in creatinine clearance of 25%or greater within one week after receiving contrast.RESULTS:Twenty-five percent of our patients developed CIN,and 74%of these patients had ascites seen on CT.Of the 75%of patients who did not develop CIN,only 46%had ascites.The presence of ascites was a significant risk factor for the development of CIN(P=0.0009,OR 3.38,95%CI 1.55-7.34)in multivariate analysis.Patient age,serum sodium,Model for End-stage Liver Disease score,diuretic use,and the presence of diabetes were not found to be significant risk factors for the development of CIN.Of the patients who developed CIN,11%developed chronic renal insufficiency,defined as a creatinine clearance less than baseline for 6 wk.CONCLUSION:Our results suggest that in hospitalized cirrhotic patients,especially those with ascites,the risk of CIN is substantial. | Nilesh Lodhia Michael Kader Thalia Mayes Parvez Mantry Benedict Maliakkal | 2009 | World Journal of Gastroenterology2009，15，12： | 9 |
| 3 | Hypoxia-inducible factor 2α is a negative regulator of osteoblastogenesis and bone mass accrual显示文摘Osteoblasts,which are the bone-forming cells,operate in a hypoxic environment.The transcription factors hypoxia-inducible factor-1α(HIF1)and HIF2 are key mediators of the cellular response to hypoxia.Both are expressed in osteoblasts.HIF1 is known to be a positive regulator of bone formation.Conversely,the role of HIF2 in the control osteoblast biology is still poorly understood.In this study,we used mouse genetics to demonstrate that HIF2 is an inhibitor of osteoblastogenesis and bone mass accrual.Moreover,we provided evidence that HIF2 impairs osteoblast differentiation at least in part,by upregulating the transcription factor Sox9.Our findings constitute a paradigm shift,as activation of the hypoxia-signaling pathway has traditionally been associated with increased bone formation through HIF1.Inhibiting HIF2 could thus represent a therapeutic approach for the treatment of the low bone mass observed in chronic diseases,osteoporosis,or aging. | Christophe Merceron Kavitha Ranganathan Elizabeth Wang Zachary Tata Shreya Makkapati Mohd Parvez Khan Laura Mangiavini Angela Qing Yao Laura Castellini Benjamin Levi Amato J.Giaccia Ernestina Schipani | 2019 | Bone Research2019，7，1： | 7 |
| 4 | HBV and HIV co-infection:Impact on liver pathobiology and therapeutic approaches显示文摘The consequences of hepatitis B virus(HBV) and human immunodeficiency virus(HIV) co-infection on progression of severe liver diseases is a serious public health issue,worldwide. In the co-infection cases,about 90% of HIV-infected population is seropositive for HBV where approximately 5%-40% individuals are chronically infected. In HIV co-infected individuals,liverrelated mortality is estimated over 17 times higher than those with HBV mono-infection. The spectrum of HIVinduced liver diseases includes hepatitis,steatohepatitis,endothelialitis,necrosis,granulomatosis,cirrhosis andcarcinoma. Moreover,HIV co-infection significantly alters the natural history of hepatitis B,and therefore complicates the disease management. Though several studies have demonstrated impact of HIV proteins on hepatocyte biology,only a few data is available on interactions between HBV and HIV proteins. Thus,the clinical spectrum as well as the complexity of the co-infection offers challenging fronts to study the underlying molecular mechanisms,and to design effective therapeutic strategies. | Mohammad Khalid Parvez | 2015 | World Journal of Hepatology2015，7，1： | 3 |
| 5 | Heavy metal pollution of coal mine-affected agricultural soils in the northern part of Bangladesh显示文摘 | Mohammad A.H. Bhuiyan Lutfar Parvez M.A. Islam Samuel B. Dampare Shigeyuki Suzuki | 2009 | Journal of Hazardous Materials2009，，1： | 3 |
| 6 | Probing protein–protein interaction in biomembranes using Fourier transform infrared spectroscopy显示文摘 | Parvez I. Haris | 2013 | BBA - Biomembranes2013，，10： | 2 |
| 7 | Effects of Adalimumab Therapy on Incidence of Hospitalization and Surgery in Crohn’s Disease: Results From the CHARM Study显示文摘 | Brian G. Feagan Remo Panaccione William J. Sandborn Geert R. D’Haens Stefan Schreiber Paul J. Rutgeerts Edward V. Loftus Kathleen G. Lomax Andrew P. Yu Eric Q. Wu Jingdong Chao Parvez Mulani | 2008 | Gastroenterology2008，，5： | 2 |
| 8 | An Interferon-free Antiviral Regimen for HCV after Liver Transplantation显示文摘 | Paul Y. Kwo Parvez S. Mantry Eoin Coakley Helen S. Te Hugo E. Vargas Robert Brown Fredric Gordon Josh Levitsky Norah A. Terrault James R. Burton Wangang Xie Carolyn Setze Prajakta Badri Tami Pilot-Matias Regis A. Vilchez Xavier Forns | 2014 | The New England Journal of Medicine2014，，25： | 2 |
| 9 | GDF15 promotes prostate cancer bone metastasis and colonization through osteoblastic CCL2 and RANKL activation显示文摘Bone metastases occur in patients with advanced-stage prostate cancer(PCa). The cell-cell interaction between PCa and the bone microenvironment forms a vicious cycle that modulates the bone microenvironment, increases bone deformities, and drives tumor growth in the bone. However, the molecular mechanisms of PCa-mediated modulation of the bone microenvironment are complex and remain poorly defined. Here, we evaluated growth differentiation factor-15(GDF15) function using in vivo preclinical PCa-bone metastasis mouse models and an in vitro bone cell coculture system. Our results suggest that PCa-secreted GDF15 promotes bone metastases and induces bone microarchitectural alterations in a preclinical xenograft model. Mechanistic studies revealed that GDF15 increases osteoblast function and facilitates the growth of PCa in bone by activating osteoclastogenesis through osteoblastic production of CCL2 and RANKL and recruitment of osteomacs. Altogether, our findings demonstrate the critical role of GDF15 in the modulation of the bone microenvironment and subsequent development of PCa bone metastasis. | Jawed Akhtar Siddiqui Parthasarathy Seshacharyulu Sakthivel Muniyan Ramesh Pothuraju Parvez Khan Raghupathy Vengoji Sanjib Chaudhary Shailendra Kumar Maurya Subodh Mukund Lele Maneesh Jain Kaustubh Datta Mohd Wasim Nasser Surinder Kumar Batra | 2022 | Bone Research2022，10，1： | 2 |
| 10 | 'Proaclive' management of percntaneously inserted central catheters results in decreased incidence of infection in the ELBW population显示文摘 | Golombek SG Roham AJ Parvez B Salice AL LaGamma EF | 2002 | J Perinatol2002，22，3： | 1 |
| 11 | Survey and mechanism of skin depigmenting and lightening agents 显示文摘 | Parvez S Kang M Chung HS | 2006 | Phytother Res2006，20，11： | 1 |
| 12 | Survey and mechanism of skin depigmenting and lightening agents 显示文摘 | Parvez S Kang M Chung HS | 2006 | Phytother Res2006，20，11： | 1 |
| 13 | Toxicity assessment of organic pollutants:Reliability of bioluminescence inhibition assay and univariate QSAR models using freshly prepared Vibrio fischeri显示文摘 | Shahid Parvez Chandra Venkataraman Suparna Mukherji | | 0，，07： | 1 |
| 14 | Probiotics and their fermented food products are beneficial for health显示文摘 | PARVEZ S MALIK K A Ah KANG S | 2006 | J Appl Microbiol2006，100，6： | 1 |
| 15 | 'Proactive' ma-nagement of percutaneously inserted central catheters results in decreased incidence of infection in the ELBW population显示文摘 | Golombek S G Rohan A J Parvez B | 2002 | J Perinatol2002，22，3： | 1 |
| 16 | Contrast media-induced lipid peroxidation in the rat kidney显示文摘 | Parvez Z Rahman MA0 Moncada R | 1989 | Invest Radiol1989，24，9： | 1 |
| 17 | No reference image quality assessment for JPEG2000 based on spatial features显示文摘 | Parvez Sazzad Z M Kawayoke Y Horita Y | 2008 | Signal Processing: Image Communication2008，23，4： | 1 |
| 18 | Heavymetal pollution of coal mine-affected agricultural soils inthe northern part of Bangladesh 显示文摘 | Bhuiyan MAH Parvez L Islam M A | 2010 | Journal ofHazardous Materials2010，173，： | 1 |
| 19 | Naturally occurring tyrosinase inhibitors: Mechanism and applications in skin health, cosmetics and agriculture industries显示文摘 | Parvez S Kang M Chung H S | 2007 | Phytotherapy Research2007，21，： | 1 |
| 20 | High temperature neutron diffraction study of the Al2 O3-Y2 O3 system显示文摘 | Medraj M Hammond R Parvez M A | 2006 | Journal of the European Ceramic Society2006，26，16： | 1 |
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