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| 1 | Exploring the efficacy of natural products in alleviating Alzheimer’s disease显示文摘Alzheimer's disease (hereafter AD) is a progressive neurodegenerative disorder that affects the central nervous system. There are multiple factors that cause AD, viz., accumulation of extracellular Amyloid-beta 42 plaques, intracellular hyper-phosphorylated Tau tangles, generation of reactive oxygen species due to mitochondrial dysfunction and genetic mutations. The plaques and tau tangles trigger aberrant signaling, which eventually cause cell death of the neurons. As a result, there is shrinkage of brain, cogrdtive defects, behavioral and psychological problems. To date, there is no direct cure for AD. Thus, scientists have been testing various strategies like screening for the small inhibitor molecule library or natural products that may block or prevent onset of AD. Historically, natural products have been used in many cultures for the treatment of various diseases. The research on natural products have gained importance as the active compounds extracted from them have medicinal values with reduced side effects, and they are bioavailable. The natural products may target the proteins or members of signaling pathways that get altered in specific diseases. Many natural products are being tested in various animal model systems for their role as a potential therapeutic target for AD, and to address questions about how these natural products can rescue AD or other neurodegenerative disorders. Some of these products are in clinical trials and results are promising because of their neuroprotective, anti-inflammatory, antioxidant, anti-amyloidogenic, anticholinesterase activities and easy availability. This review summarizes the use of animal model systems to identify natural products, which may serve as potential therapeutic targets for AD. | Prajakta Deshpande Neha Gogia Amit Singh | 2019 | Neural Regeneration Research2019，14，8： | 4 |
| 2 | Starch based nanofibrous scaffolds for wound healing applications显示文摘Starch is an attractive polymer for wound healing applications because of its wide availability,low cost,biocompatibility,biodegradability and wound-healing property.Here,we have fabricated starch-based nanofibrous scaffolds by electrospinning for wound healing applications.The diameter of the optimized nanofibers was determined by field emission scanning electron microscopy(FE-SEM)and was found to be in the range of 110e300 nm.The mechanical strength(0.5e0.8 MPa)of the nanofibrous scaffolds was attuned using polyvinyl alcohol(plasticizer)and glutaraldehyde(crosslinking agent),to impart them with sufficient durability for skin tissue engineering.Absence of negative interactions between the polymers was confirmed by Attenuated Total Reflectance-Fourier Transform Infrared Spectroscopy(ATR-FTIR),differential scanning microscopy(DSC)and thermal gravimetric analysis(TGA).Cellular assays with L929 mouse fibroblast cells indicated the ability of the scaffolds to promote cellular proliferation,without exhibiting any toxic effect to the cells.Thus,the nanofibrous scaffolds demonstrated potential for wound healing applications. | Vijaya Sadashiv Waghmare Pallavi Ravindra Wadke Sathish Dyawanapelly Aparna Deshpande Ratnesh Jain Prajakta Dandekar | 2018 | Bioactive Materials2018，3，3： | 3 |
| 3 | Molecular dynamics study on growth of carbon dioxide and methane hydrate from a seed crystal显示文摘In the current work,molecular dynamics simulation is employed to understand the intrinsic growth of carbon dioxide and methane hydrate starting from a seed crystal of methane and carbon dioxide respectively.This comparison was carried out because it has relevance to the recovery of methane gas from natural gas hydrate reservoirs by simultaneously sequestering a greenhouse gas like CO2.The seed crystal of carbon dioxide and methane hydrate was allowed to grow from a super-saturated mixture of carbon dioxide or methane molecules in water respectively.Two different concentrations(1:6 and 1:8.5)of CO2/CH4 molecules per water molecule were chosen based on gas–water composition in hydrate phase.The molecular level growth as a function of time was investigated by all atomistic molecular dynamics simulation under suitable temperature and pressure range which was well above the hydrate stability zone to ensure significantly faster growth kinetics.The concentration of CO2 molecules in water played a significant role in growth kinetics,and it was observed that maximizing the CO2 concentration in the aqueous phase may not result in faster growth of CO2 hydrate.On the contrary,methane hydrate growth was independent of methane molecule concentration in the aqueous phase.We have validated our results by performing experimental work on carbon dioxide hydrate where it was seen that under conditions appropriate for liquid CO2,the growth for carbon dioxide hydrate was very slow in the beginning. | Prajakta Nakate Bappa Ghosh Subhadip Das Sudip Roy Rajnish Kumar | 2019 | Chinese Journal of Chemical Engineering2019，27，9： | 2 |
| 4 | An Interferon-free Antiviral Regimen for HCV after Liver Transplantation显示文摘 | Paul Y. Kwo Parvez S. Mantry Eoin Coakley Helen S. Te Hugo E. Vargas Robert Brown Fredric Gordon Josh Levitsky Norah A. Terrault James R. Burton Wangang Xie Carolyn Setze Prajakta Badri Tami Pilot-Matias Regis A. Vilchez Xavier Forns | 2014 | The New England Journal of Medicine2014，，25： | 2 |
| 5 | DIVERSE CARDIOPROTECTIVE SIGNALING MECHANISMS OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR-γ LIGANDS, 15-DEOXY-Δ12,14-PROSTAGLANDIN J2 AND CIGLITAZONE, IN REPERFUSION INJURY: ROLE OF NUCLEAR FACTOR-κB, HEAT SHOCK FACTOR 1, AND AKT显示文摘 | Basilia Zingarelli Paul W. Hake Prajakta Mangeshkar Michael O'Connor Timothy J. Burroughs Giovanna Piraino Alvin Denenberg Hector R. Wong | 2007 | Shock2007，，5： | 1 |
| 6 | Dose-dependent differential expression of protein kinase C isozymes in mouse lymphocytes after gamma irradiation in vivo and in vitro 显示文摘 | Prajakta A Malini K Naresh C | 2003 | Radiation Res2003，159，4： | 1 |
| 7 | Eco- nomic dispatch for a microgrid considering renewable energy cost functions 显示文摘 | Noel Augustine Sindhu Suresh Prajakta Moghe | 2012 | Innovative Smart Grid Technologies2012，1，7： | 1 |
| 8 | Effect of nano-copper oxide and copper chromite on the thermal decomposition of ammonium perchlorate显示文摘 | Prajakta R P Krishnamurthy V N Satyawati S J | | 0，，04： | 1 |
| 9 | Growth of SnO2/WisO49 nanowire hierarchical heterostructure and their application as chemical sensor 显示文摘 | SEN S PRAJAKTA K ANKIT S | 2010 | Sens Actuators B2010，147，2： | 1 |
| 10 | Novel controlled-Release breakers for high-temperature fractur- ing显示文摘 | Prajakta Patil Ramesh Muthusamy Nisha Pandya | | SPE0，1646，： | 1 |
| 11 | Effect of Nano-Copper Oxide and Copper Chro- mite on the Thermal Decomposition of Ammonium Per- chlorate显示文摘 | Prajakta R Patil Krishnamurthy V N Satyawati S Joshi | 2008 | Propellents Explosives Pyrotechnics2008，33，： | 1 |
| 12 | Hippo signaling:bridging the gap between cancer and neurodegenerative disorders显示文摘During development,regulation of organ size requires a balance between cell proliferation,growth and cell death.Dysregulation of these fundamental processes can cause a variety of diseases.Excessive cell proliferation results in cancer whereas excessive cell death results in neurodegenerative disorders.Many signaling pathways known-to-date have a role in growth regulation.Among them,evolutionarily conserved Hippo signaling pathway is unique as it controls both cell proliferation and cell death by a variety of mechanisms during organ sculpture and development.Neurodegeneration,a complex process of progressive death of neuronal population,results in fatal disorders with no available cure to date.During normal development,cell death is required for sculpting of an organ.However,aberrant cell death in neuronal cell population can result in neurodegenerative disorders.Hippo pathway has gathered major attention for its role in growth regulation and cancer,however,other functions like its role in neurodegeneration are also emerging rapidly.This review highlights the role of Hippo signaling in cell death and neurodegenerative diseases and provide the information on the chemical inhibitors employed to block Hippo pathway.Understanding Hippo mediated cell death mechanisms will aid in development of reliable and effective therapeutic strategies in future. | Neha Gogia Anuradha Venkatakrishnan Chimata Prajakta Deshpande Aditi Singh Amit Singh | 2021 | Neural Regeneration Research2021，16，4： | 1 |
| 13 | Signaling interactions among neurons impact cell fitness and death in Alzheimer's disease显示文摘The pathology of Alzheimer’s disease involves a long preclinical period,where the characteristic clinical symptoms of the changes in the brain are undetectable.During the preclinical period,homeostatic mechanisms may help prevent widespread cell death.Evidence has pointed towards selective cell death of diseased neurons playing a potentially protective role.As the disease progresses,dysregulation of signaling pathways that govern cell death contributes to neurodegeneration.Aberrant activation of the c-Jun N-terminal kinase pathway has been established in human and animal models of Alzheimer’s disease caused by amyloid-beta 42-or tau-mediated neurodegeneration.Clonal mosaic studies in Drosophila that examine amyloid-beta 42 in a subset of neurons suggest complex interplay between amyloid-beta 42-expressing and wild-type cells.This review examines the role of c-Jun N-terminal kinase signaling in the context of cell competition and short-range signaling interactions between amyloid-beta 42-expressing and wild-type neurons.Cell competition is a conserved phenomenon regulating tissue integrity by assessing the fitness of cells relative to their neighbors and eliminating suboptimal cells.Somatic clones of amyloid-beta 42 that juxtapose genetically distinct neuronal cell populations show promise for studying neurodegeneration.Generating genetic mosaics with labeled clones of amyloid-beta 42-or tau-expressing and wild-type neurons will allow us to understand how short-range signaling alterations trigger cell death in neurons and thereby contribute to the progression of Alzheimer’s disease.These approaches have the potential to uncover biomarkers for early Alzheimer’s disease detection and new therapeutic targets for intervention. | Catherine Yeates Prajakta Deshpande Madhuri Kango-Singh Amit Singh | 2023 | Neural Regeneration Research2023，18，4： | 0 |
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