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| 1 | Prediction of severe acute pancreatitis:Current knowledge and novel insights显示文摘Acute pancreatitis (AP) is a common and potentially lethal acute inflammatory process with a highly variable clinical course. It is still unclear why some patients progress to organ failure and others do not. Physicians, ability to predict which patients will develop severe disease is limited. Routine clinical and laboratory data and multi-factorial clinical scores measured on admission and during the first 48 h of hospitalization are currently the standards of care used to estimate the magnitude of the inflammatory response to injury. Current literature highlights several common environmental, metabolic and genetic factors that increase the risk of AP development and subsequent adverse sequelae. Several cytokines have been found to play a critical role in the pathogenesis of AP by driving the subsequent inflammatory response, to include tumor necrosis factor-α (TNF-α), Interleukin-1 (IL-1), IL-6 and monocyte chemotactic protein-1 (MCP-1). Large, prospective studies are still needed to address these questions by identifying AP risk factors and serum biomarkers of severe disease. | Georgios I Papachristou | 2008 | World Journal of Gastroenterology2008，14，41： | 48 |
| 2 | Clinical outcomes of isolated renal failure compared to other forms of organ failure in patients with severe acute pancreatitis显示文摘AIM To assess differences in clinical outcomes of isolated renal failure(RF) compared to other forms of organ failure(OF) in patients with severe acute pancreatitis(SAP).METHODS Using a prospectively maintained database of patients with acute pancreatitis admitted to a tertiary medical center between 2003 and 2016, those with evidence of persistent OF were classified to renal, respiratory, cardiovascular, or multi-organ(2 or more organs). Data regarding demographics, comorbidities, etiology of acute pancreatitis, and clinical outcomes were prospectively recorded. Differences in clinical outcomes after development of isolated RF in comparison to other forms of OF were determined using independent t and Mann-Whitney U tests for continues variables, and χ~2 test for discrete variables.RESULTS Among 500 patients with acute pancreatitis, 111 patients developed persistent OF: mean age was 54 years, and 75(67.6%) were male. Forty-three patients had isolated OF: 17(15.3%) renal, 25(21.6%) respiratory, and 1(0.9%) patient with cardiovascular failure. No differences in demographics, etiology of acute pancreatitis, systemic inflammatory response syndrome scores, or development of pancreatic necrosis were seen between patients with isolated RF vs isolated respiratory failure. Patients with isolated RF were less likely to require nutritional support(76.5% vs 96%, P = 0.001), ICU admission(58.8% vs 100%, P = 0.001), and had shorter mean ICU stay(2.4 d vs 15.7 d, P < 0.001), compared to isolated respiratory failure. None of the patients with isolated RF or isolated respiratory failure died.CONCLUSION Among patients with SAP per the Revised Atlanta Classification, approximately 15% develop isolated RF. This subgroup seems to have a less protracted clinical course compared to other forms of OF. Isolated RF might be weighed less than isolated respiratory failure in risk predictive modeling of acute pancreatitis. | Amir Gougol Mohannad Dugum Anwar Dudekula Phil Greer Adam Slivka David C Whitcomb Dhiraj Yadav Georgios I Papachristou | 2017 | World Journal of Gastroenterology2017，23，29： | 20 |
| 3 | Cardiovascular disease: Risk factors and applicability of a risk model in a Greek cohort of renal transplant recipients显示文摘AIM To investigate the incidence and the determinants of cardiovascular morbidity in Greek renal transplant recipients(RTRs) expressed as major advance cardiac event(MACE) rate. METHODS Two hundred and forty-two adult patients with a functioning graft for at least three months and availabledata that were followed up on the August 31, 2015 at two transplant centers of Western Greece were included in this study. Baseline recipients' data elements included demographics, clinical characteristics, history of comorbid conditions and laboratory parameters. Follow-up data regarding MACE occurrence were collected retrospectively from the patients' records and MACE risk score was calculated for each patient. RESULTS The mean age was 53 years(63.6% males) and 47 patients(19.4%) had a pre-existing cardiovascular disease(CVD) before transplantation. The mean estimated glomerular filtration rate was 52 ± 17 mL /min per 1.73 m2. During follow-up 36 patients(14.9%) suffered a MACE with a median time to MACE 5 years(interquartile range: 2.2-10 years). Recipients with a MACE compared to recipients without a MACE had a significantly higher mean age(59 years vs 52 years, P < 0.001) and a higher prevalence of pre-existing CVD(44.4% vs 15%, P < 0.001). The 7-year predicted mean risk for MACE was 14.6% ± 12.5% overall. In RTRs who experienced a MACE, the predicted risk was 22.3% ± 17.1% and was significantly higher than in RTRs without an event 13.3% ± 11.1%(P = 0.003). The discrimination ability of the model in the Greek database of RTRs was good with an area under the receiver operating characteristics curve of 0.68(95%CI: 0.58-0.78).CONCLUSION In this Greek cohort of RTRs, MACE occurred in 14.9% of the patients, pre-existing CVD was the main risk factor, while MACE risk model was proved a dependable utility in predicting CVD post RT. | Nikolaos-Andreas Anastasopoulos Evangelia Dounousi Evangelos Papachristou Charalampos Pappas Eleni Leontaridou Eirini Savvidaki Dimitrios Goumenos Michael Mitsis | 2017 | World Journal of Transplantation2017，7，1： | 3 |
| 4 | Bone and high-density lipoprotein:The beginning of a beautiful friendship显示文摘There is a tight link between bone and lipid metabolic pathways.In this vein,several studies focused on the exploration of high-density lipoprotein(HDL)in the pathobiology of bone diseases,with emphasis to the osteoarthritis(OA)and osteoporosis,the most common bone pathologies.Indeed,epidemiological and in vitro data have connected reduced HDL levels or dysfunctional HDL with cartilage destruction and OA development.Recent studies uncovered functional links between HDL and OA fueling the interesting hypothesis that OA could be a chronic element of the metabolic syndrome.Other studies have linked HDL to bone mineral density.Even though at epidemiological levels the results are conflicting,studies in animals as well as in vitro experiments have shown that HDL facilitates osteoblastogensis and bone synthesis and most probably affects osteoclastogenesis and osteoclast bone resorption.Notably,reduced HDL levels result in increased bone marrow adiposity affecting bone cells function.Unveiling the mechanisms that connect HDL and bone/cartilage homeostasis may contribute to the design of novel therapeutic agents for the improvement of bone and cartilage quality and thus for the treatment of related pathological conditions. | Dionysios J Papachristou Harry C Blair | 2016 | World Journal of Orthopedics2016，7，2： | 3 |
| 5 | Behavioral Testability Insertion for Datapath/Controller Circuits显示文摘 | Carletta J Papachristou C A | 1997 | Journal of Electronic Testing:Theory and Applications1997，11，： | 2 |
| 6 | WONCA研究论文摘要汇编——社区医疗中用药错误存在问题及解决办法的重要性分级:一项基于重要性排列法促进用药安全的研究显示文摘背景用药错误的研究主要集中在医院内。本文旨在研究社区医疗中的用药错误,调查引起用药错误的主要原因并提出相关的解决办法。方法 2013年9月—2014年11月,使用重要性排列法对用药错误存在问题及解决办法进行确定和分级。500位来自伦敦西北部的社区医师参加了开放式问卷调查,回收有效问卷113份,存在问题有48个,相关解决办法有45种。从500位社区医师中随机抽选57位,对存在问题及解决办法进行评分,并根据评分情况,列出用药错误存在问题及解决办法的重要性级别表。结果前3个存在问题是:给患者开药的不同的医生在用药方面的看法不完全一致性,不适当的用药指导以及质量较差的出院总结。前3个解决办法是:设计标准的出院总结模板,减少不必要的处方以及最大限度的减少多药疗法。结论社区医师在用药管理、用药流程质量控制及用药指导方面给出了一系列建议。认为,这些可行的负担得起的干预方式在很大程度上可以预防用药错误的发生。 | TUDOR CAR L PAPACHRISTOU N GALLAGHER J 本刊编辑部 | 2017 | 中国全科医学2017，20，2： | 2 |
| 7 | Comparison of Existing Clinical Scoring Systems to Predict Persistent Organ Failure in Patients With Acute Pancreatitis显示文摘 | Rawad Mounzer Christopher J. Langmead Bechien U. Wu Anna C. Evans Faraz Bishehsari Venkata Muddana Vikesh K. Singh Adam Slivka David C. Whitcomb Dhiraj Yadav Peter A. Banks Georgios I. Papachristou | 2012 | Gastroenterology2012，，7： | 2 |
| 8 | Early weight bearing after posterior malleolar fractures: An experimental and prospective clinical study显示文摘 | George Papachristou Nicolas Efstathopoulos Constantin Levidiotis Efstathios Chronopoulos | 2003 | The Journal of Foot and Ankle Surgery2003，，2： | 2 |
| 9 | Peroral Endoscopic Drainage/Debridement of Walled-off Pancreatic Necrosis显示文摘 | Georgios I. Papachristou Naoki Takahashi Prabhleen Chahal Michael G. Sarr Todd H. Baron | 2007 | Annals of Surgery2007，，6： | 2 |
| 10 | IL-18 is correlated with type-2 immune response in children with steroid sensitivenephrotic syndrome显示文摘 | Printza N Papachristou F Tzimouli V | | 0，，02： | 1 |
| 11 | Bone metastases:molecular mechanisms and novel therapeutic interventions显示文摘 | Papachristou DJ Basdra EK Papavassillion AG | 2012 | Med Res Rev2012，32，3： | 1 |
| 12 | Supplementation of melatonin protects human lymphocytes in vitro from the genotoxic activity of melphalan 显示文摘 | Lialiaris T Lyratzopoulos E Papachristou F | 2008 | Mutagenesis2008，23，5： | 1 |
| 13 | Clini- cal evaluation and changes of the respiratory epithelium function after administration of Pidotimod in Greek chil- dren with recurrent respiratory tract infections 显示文摘 | Aivazis V Hatzimiehail A Papachristou A | 2002 | Minerva Pediatr2002，54，4： | 1 |
| 14 | Venture Capital and Inno- vation in Europe显示文摘 | George Geronikolaou Papachristou G A | 2008 | Mpra Paper2008，3，35： | 1 |
| 15 | Follicular fluid levels of vascular endothelial growth factor and leptin are associated with pregnancy outcome of normal women participating in intracytoplasmic sperm injection cycles 显示文摘 | Asimakopoulos B Nikolettos N Papachristou DN | 2005 | Physiol Res2005，54，3： | 1 |
| 16 | Forage value of Mediterra- nean deciduous woody fodder species and its implication to man- agement of silvo-pastoral systems for goats 显示文摘 | Papachristou T G Papanastasis V P | 1994 | Agroforesry Sys- tems1994，27，3： | 1 |
| 17 | A comparison of direct endoscopic necrosectomy with transmural endoscopic drainage for the treatment of walled-off pancreatic necrosis显示文摘 | Gardner TB Chahal P Papachristou GI | 2009 | Gastrointest Endosc2009，69，6： | 1 |
| 18 | Comparison of BISAP,Ranson's,APACHE-II,and CTSI scores in predicting organ failure,complications,and mortality in acute pancreatitis显示文摘 | Papachristou GI Muddana V Yadav D | 2010 | Am J Gastroenterol2010，105，2： | 1 |
| 19 | Is the Monocyte Chemotactic Protein-1 ?2518 G Allele a Risk Factor for Severe Acute Pancreatitis?显示文摘 | Georgios I. Papachristou David A. Sass Haritha Avula Janette Lamb Anna Lokshin M. Michael Barmada Adam Slivka David C. Whitcomb | 2005 | Clinical Gastroenterology and Hepatology2005，，5： | 1 |
| 20 | Load application induces changes in the expression levels of Box-9, FGFR-3 and VEGF in condylar ehon- drocytes显示文摘 | Papadopoulou AK Papachristou D J Chatzopoulos SA | 2007 | FEBS Lett2007，581，10： | 1 |
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