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| 1 | Axial strain enhances osteotomy repair with a concomitant increase in connexin43 expression显示文摘The mechanical environment is known to influence fracture healing. We speculated that connexin43(Cx43) gap junctions, which impact skeletal homeostasis, fracture healing and the osteogenic response to mechanical load,may play a role in mediating the response of the healing bone to mechanical strain. Here, we used an established rat fracture model, which uses a 2 mm osteotomy gap stabilized by an external fixator, to examine the impact of various cyclical axial loading protocols(2%, 10%, and 30% strain) on osteotomy healing. We examined the presence of Cx43 in the osteotomy-healing environment and assessed how mechanical strain modulates Cx43 expression patterns in the callus. We demonstrated that increased cyclical axial strain results in increased radiographic and histologic bone formation. In addition, we show by immunohistochemistry that Cx43 is abundantly expressed in the healing callus, with the expression most robust in samples exposed to increased cyclical axial strain. These data are consistent with the concept that an increase in Cx43 expression by mechanical load may be part of the mechanisms by which mechanical forces enhances fracture healing. | Rishi R Gupta Hyunchul Kim Yu-Kwan Chan Carla Hebert Leah Gitajn David J Yoo Robert V O’Toole Adam H Hsieh Joseph P Stains | 2015 | Bone Research2015，3，2： | 2 |
| 2 | Influence of zinc on calcium magnesium, sodium, potassium and phosphorus nutrition of soybeam(Glyeine max) in sodie soils 显示文摘 | Gupta S P Gupta V K | 1984 | Indian Journal of Ecology1984，11，2： | 1 |
| 3 | Probabilistic assessment of financial losses caused by interruptions and voltage sags: part Ⅰ-the methodology显示文摘 | Milanovic J V Gupta C P | 2006 | IEEE Trans on Power Develivery2006，21，2： | 1 |
| 4 | Cultural Clusters: Methodology and Findings 显示文摘 | GUPTA V HANGES P J DORFMAN P | 2002 | Journal of World Business2002，，37： | 1 |
| 5 | MnO2 decorated graphene nanoribhons with superior permittivity and excel- lent microwave shielding properties 显示文摘 | Gupta T K Singh B P Singh V N | 2014 | J Mater Chem A2014，2，12： | 1 |
| 6 | Development of soft sensor for neural network based control of distillation column显示文摘 | RANI A SINGH V GUPTA J R P | 2013 | ISA Transactions2013，52，3： | 1 |
| 7 | Thermal-Mechanical Modeling of the Rolling-Plus-Sliding with Frictional Heating of a Locomotive Wheel 显示文摘 | Gupta V Hahn G T Bostias P C et aI | 1995 | Transactions of ASME1995，117，8： | 1 |
| 8 | Probabilistic assessment of financial Iossesdue to interruptions and voltage sags-part Ⅱ: practical implementation显示文摘 | Milanovic J V Gupta C P | 2006 | IEEE Trans on Power Develivery2006，21，2： | 1 |
| 9 | Spectral-domain cirrus optical coherence tomography of choroidal striations seen in the acute stage of Vogt-Koyanagi-Harada disease显示文摘 | Gupta V Gupta A Gupta P | | 0，，： | 1 |
| 10 | A physically based filter for separating base flow form stream flow times series显示文摘 | Furey P R Gupta V K | 2001 | Water Resources Research2001，37，11： | 1 |
| 11 | Silencing of acetylcholinesterase gene of Helicoverpa armigera by siRNA affects larval growth and its life cycle显示文摘 | Kumar M Gupta G P Rajam M V | | 0，，03： | 1 |
| 12 | Kharitonov's theo- rem and routh criterion for stability margin of interval systems 显示文摘 | HOTE Y V GUPTA J R P CHOUDHURY D R | 2010 | In-ternational Journal of Control Automation and Systems2010，8，3： | 1 |
| 13 | Effect of pH on zinc adsorption-precipitation reactions in an alkali soil显示文摘 | Gupta R K Elshout S V D Abbol I P | 1987 | Soil Sci1987，143，3： | 1 |
| 14 | Biochemical responsesof red alga Gracilaria corticata ( Gracilariales , Rhodophyta ) tosalinity induced oxidative stress 显示文摘 | Kumar M Kumari P Gupta V | 2010 | J Exp Marine Bio Ecol2010，391，： | 1 |
| 15 | Adsorption Behavior of Hg(Ⅱ), Pb(Ⅱ), and CA(Ⅱ) from Aqueous Solution on Duolite C-433: A Synthetic Resin 显示文摘 | Gupta V K Singh P Rahman N | 2004 | Journal of Colloid and Interface Science2004，275，2： | 1 |
| 16 | Melanoma differentiation associated gene-7 (mda-7)/IL-24:a′magic bullet′ for cancer therapy?显示文摘 | SARKAR D LEBEDEVA I V GUPTA P | 2007 | Expert Opin Biol Ther2007，7，5： | 1 |
| 17 | Differential distribution of simple sequence repeats in eukaryotic genome sequences显示文摘 | KATTI M V RANJEKAR P K GUPTA V S | 2001 | Mol Biol Evol2001，18，7： | 1 |
| 18 | Genetic diversity and phylogenetic relationship as revealed by inter simple sequence repeat ( ISSR) polymorphism in the genus Ovyza显示文摘 | JOSHI S P GUPTA V S AGGARWAL R K | 2000 | Theor Appl Genet2000，100，： | 1 |
| 19 | Meningococcal disease:history,epidemiology,pathogenesis,clinical manifestations,diagnosis,antimicrobial susceptibility and prevention显示文摘 | Manchanda V Gupta S Bhalla P | | 0，，01： | 1 |
| 20 | The major genetic determinants of HIV-1control affect HLA class I peptide presentation显示文摘 | International HIV Controllers Study Pereyra F Jia X McLaren P J Telenti A de Bakker P I Walker B D Ripke S Brumme C J Pulit S L Carrington M Kadie C M Carlson J M Heckerman D Graham R R Plenge R M Deeks S G Gianniny L Crawford G Sullivan J Gonzalez E Davies L Camargo A Moore JM Beattie N Gupta S Crenshaw A Burtt N P Guiducci C Gupta N Gao X Qi Y Yuki Y Piechocka-Trocha A Cutrell E Rosenberg R Moss K L Lemay P O'Leary J Schaefer T Verma P Toth I Block B Baker B Rothchild A Lian J Proudfoot J Alvino D M Vine S Addo M M Allen T M Altfeld M Henn M R Le Gall S Streeck H Haas D W Kuritzkes D R Robbins G K Shafer R W Gulick R M Shikuma C M Haubrich R Riddler S Sax P E Daar E S Ribaudo H J Agan B Agarwal S Ahern R L Allen B L Altidor S Altschuler E L Ambardar S Anastos K Anderson B Anderson V Andrady U Antoniskis D Bangsberg D Barbaro D Barrie W Bartczak J Barton S Basden P Basgoz N Bazner S Bellos N C Benson A M Berger J Bernard N F Bernard A M Birch C Bodner S J Bolan R K Boudreaux E T Bradley M Braun J F Brndjar J E Brown S J Brown K Brown S T Burack J Bush LM Cafaro V Campbell O Campbell J Carlson R H Carmichael J K Casey K K Cavacuiti C Celestin G Chambers S T Chez N Chirch L M Cimoch P J Cohen D Cohn LE Conway B Cooper D A Cornelson B Cox D T Cristofano M V Cuchural G Jr Czartoski J L Dahman J M Daly J S Davis B T Davis K Davod S M DeJesus E Dietz C A Dunham E Dunn M E Ellerin T B Eron J J Fangman J J Farel C E Ferlazzo H Fidler S Fleenor-Ford A Frankel R Freedberg K A French N K Fuchs JD Fuller J D Gaberman J Gallant J E Gandhi R T Garcia E Garmon D Gathe J C Jr Gaultier C R Gebre W Gilman F D Gilson I Goepfert P A Gottlieb M S Goulston C Groger R K Gurley T D Haber S Hardwicke R Hardy W D Harrigan P R Hawkins T N Heath S Hecht F M Henry W K Hladek M Hoffman R P Horton J M Hsu R K Huhn G D Hunt P Hupert M J Illeman M L Jaeger H Jellinger R M John M Johnson J A Johnson K L Johnson H Johnson K Joly J Jordan W C Kauffman C A Khanlou H Killian R K Kim A Y Kim D D Kinder C A Kirchner J T Kogelman L Kojic E M Korthuis P T Kurisu W Kwon D S LaMar M Lampiris H Lanzafame M Lederman M M Lee D M Lee J M Lee M J Lee E T Lemoine J Levy J A Llibre J M Liguori M A Little S J Liu A Y Lopez A J Loutfy M R Loy D Mohammed D Y Man A Mansour M K Marconi V C Markowitz M Marques R Martin J N Martin H L Jr Mayer K H McElrath M J McGhee T A McGovern B H McGowan K McIntyre D Mcleod GX Menezes P Mesa G Metroka CE Meyer-Olson D Miller A O Montgomery K Mounzer K C Nagami E H Nagin I Nahass R G Nelson M O Nielsen C Norene D L O'Connor D H Ojikutu B O Okulicz J Oladehin O O Oldfield E C Olender S A Ostrowski M Owen WF Jr Pae E Parsonnet J Pavlatos A M Perlmutter A M Pierce M N Pincus J M Pisani L Price L J Proia L Prokesch R C Pujet H C Ramgopal M Rathod A Rausch M Ravishankar J Rhame F S Richards C S Richman D D Rodes B Rodriguez M Rose R C 3rd Rosenberg E S Rosenthal D Ross P E Rubin D S Rumbaugh E Saenz L Salvaggio M R Sanchez WC Sanjana V M Santiago S Schmidt W Schuitemaker H Sestak P M Shalit P Shay W Shirvani V N Silebi V I Sizemore J M Jr Skolnik P R Sokol-Anderson M Sosman J M Stabile P Stapleton J T Starrett S Stein F Stellbrink H J Sterman FL Stone V E Stone D R Tambussi G Taplitz R A Tedaldi E M Telenti A Theisen W Torres R Tosiello L Tremblay C Tribble M A Trinh P D Tsao A Ueda P Vaccaro A Valadas E Vanig T J Vecino I Vega V M Veikley W Wade B H Walworth C Wanidworanun C Ward D J Warner D A Weber R D Webster D Weis S Wheeler D A White D J Wilkins E Winston A Wlodaver C G van't Wout A Wright D P Yang O O Yurdin D L Zabukovic B W Zachary K C Zeeman B Zhao M | 2010 | Science2010，330，6010： | 1 |
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