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| 1 | Hepatocellular carcinoma: From clinical practice to evidence-based treatment protocols显示文摘Hepatocellular carcinoma(HCC) is one of the major malignant diseases in many healthcare systems. The growing number of new cases diagnosed each year is nearly equal to the number of deaths from this cancer. Worldwide, HCC is a leading cause of cancerrelated deaths, as it is the fifth most common cancer and the third most important cause of cancer related death in men. Among various risk factors the two are prevailing: viral hepatitis, namely chronic hepatitis C virus is a well-established risk factor contributing to the rising incidence of HCC. The epidemic of obesity and the metabolic syndrome, not only in the United States but also in Asia, tend to become the leading cause of the long-term rise in the HCC incidence. Today, the diagnosis of HCC is established within the national surveillance programs in developed countries while the diagnosis of symptomatic, advanced stage disease still remains the characteristic of underdeveloped countries. Although many different staging systems have been developed and evaluated the BarcelonaClinic Liver Cancer staging system has emerged as the most useful to guide HCC treatment. Treatment allocation should be decided by a multidisciplinary board involving hepatologists, pathologists, radiologists, liver surgeons and oncologists guided by personalized-based medicine. This approach is important not only to balance between different oncologic treatments strategies but also due to the complexity of the disease(chronic liver disease and the cancer) and due to the large number of potentially efficient therapies. Careful patient selection and a tailored treatment modality for every patient, either potentially curative(surgical treatment and tumor ablation) or palliative(transarterial therapy, radioembolization and medical treatment, i.e., sorafenib) is mandatory to achieve the best treatment outcome. | Danijel Galun Dragan Basaric Marinko Zuvela Predrag Bulajic Aleksandar Bogdanovic Nemanja Bidzic Miroslav Milicevic | 2015 | World Journal of Hepatology2015，7，20： | 13 |
| 2 | Monoclonal immunoscintigraphy for detection of metastasis and recurrence of colorectal cancer显示文摘AIM:To assess the clinical role of monoclonal immunoscintigraphy for the detection of metastasis and recurrence of colorectal cancer.METHODS:Monoclonal immunoscintigraphy was performed in patients operated on for colorectal adenocar-cinoma suspected of local recurrence and metastatic disease.The results were compared with conventional diagnostics.RESULTS:Immunoscintigraphic investigation was done in 53 patients.Tumor recurrence occurred in 38 patients,and was confirmed by other diagnostic modalities in 35.In 15 patients,immunoscintigraphic findings were negative,and confirmed in 14 with other diagnostic methods.Comparative analysis confirmed good correlation of immunoscintigraphic findings and the results of conventional diagnostics and the level of tumor marker carcinoembryonic antigen.Statistical analysis of parameters of radiopharmaceutical groups imacis,indimacis and oncoscint presented homogenous characteristics all of three radiopharmaceuticals.The analysis of immunoscintigraphic target focus was clearly improved using tomography.CONCLUSION:Immunoscintigraphy is highly specific and has a good predictive value in local recurrence of colorectal cancer. | Vera Artiko Ana Koljevic Markovi Dragana obi-aranovi Milorad Petrovi Andrija Anti Mirjana Stojkovi Marinko Zuvela Djordjije aranovi Milica Stojkovi Neboja Radovanovi Danijel Galun Aleksandar Milovanovi Jovica Milovanovi Anica Bobi-Radovanovi Zoran Krivokapic Vladimir Obradovi | 2011 | World Journal of Gastroenterology2011，17，19： | 4 |
| 3 | Effect of laser surface melting on corrosion and wear resistance of a commercial magnesium alloy 显示文摘 | Dutta M J Galun R Mordike BL | 2003 | Materials Science and Engineering A2003，361，12： | 1 |
| 4 | Laser surface alloying of magnesium base alloys显示文摘 | Galun R Weisheit A Mordike B L | 1996 | Journal of Laser Applications1996，6，12： | 1 |
| 5 | Formation of a crack-free joint between Ti alloyand Al alloy by using a high-power CO2 laser显示文摘 | B Majumdar R Galun A Weisheit B. L Mordike | 1997 | Journal of Materials Science1997，，23： | 1 |
| 6 | Effect of laser surface melting on corrosion and wear resistance of a commercial magnesium alloy 显示文摘 | Dutta Majumdara J Galun R Mordike B L | 2003 | Materials Science and Engineering2003，，361： | 1 |
| 7 | Liver regeneration induced by a designer human IL-6/sIL-6R fusion protein reverses severe hepatocellular injury显示文摘 | Zeira E Pappo O | 2000 | FASEB2000，14，13： | 1 |
| 8 | CO2 laser beam welding of magnesium-based alloys显示文摘 | Weisheit A Galun R Mordike B L | 1998 | Welding Journal1998，77，4： | 1 |
| 9 | The role of cytokines in liver failure and regeneration:potential new molecular therapies显示文摘 | GALUN E AXELROD JH | 2002 | Biochim Biophys Acta2002，1592，3： | 1 |
| 10 | More than network structure: How knowledge heterogeneity influences managerial performance and innovativeness 显示文摘 | Rodan Sand Galunic C | 2004 | Strategic Management J oumal2004，25，6： | 1 |
| 11 | The tomato Cu/Zn superoxide dismutase genes are developmentally regulated and respond to light and stress显示文摘 | PE TREVES R GALUN E | 1991 | Plant Molecular Biology1991，，17： | 1 |
| 12 | Plant regeneration from cultivars and species显示文摘 | VARDI A SPIEGEL-ROY P GALUN E | 1982 | Theor Appl Genet1982，62，： | 1 |
| 13 | The Cucumis plastomePhysical map, intrageneric variation,and phylogenetie relationships显示文摘 | Perl Treves R Galun E | 1985 | Theor Appl Genet1985，71，： | 1 |
| 14 | Resource recombinations in the firm:Knowledge structure and the potential for Schumpeterian innovation显示文摘 | Galunic D C Rodan S | 1998 | Strategic Management Journal1998，19，12： | 1 |
| 15 | Hierarchy and adaptivity in segmenting visual scenes 显示文摘 | SHARON E GALUN M SHARON D | 2006 | Nature2006，442，7104： | 1 |
| 16 | CXCR4 antagonist 4F-benzoyl-TN14003 inhibits leukemia and multiple myeloma tumor growth显示文摘 | Katia Beider Michal Begin Michal Abraham Hanna Wald Ido D. Weiss Ori Wald Eli Pikarsky Evelyne Zeira Orly Eizenberg Eithan Galun Izhar Hardan Dan Engelhard Arnon Nagler Amnon Peled | 2011 | Experimental Hematology2011，，3： | 1 |
| 17 | Citrus cybrids: production by donor-recipient protoplast-fusion and verification by rnitochondrial-DNA restriction profiles 显示文摘 | VARDI A BREIMAN A GALUN E | 1987 | Theoretical and Applied Genetics1987，75，： | 1 |
| 18 | Citrus cybrids:production by donor-recipient protoplast fusion and verification by mitochondrial DNA restriction profiles显示文摘 | Vardi A Breman A Galun E | 1987 | Theor Appl Genet1987，75，： | 1 |
| 19 | Effect of laser surface melting on corrosion and wear resistance of a commercial magnesium alloy 显示文摘 | Dutta M J Galun R Mordike B L Manna I | 2003 | Materials Science and Engineering A2003，361，： | 1 |
| 20 | Recent advances in protoplast culture of horticultural crops:Citrus显示文摘 | Vardi A Galun E | 1988 | Sci Hortic1988，37，： | 1 |
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