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| 1 | Blood loss,predictors of bleeding,transfusion practice and strategies of blood cell salvaging during liver transplantation显示文摘Blood loss during liver transplantation (OLTx) is a common consequence of pre-existing abnormalities of the hemostatic system,portal hypertension with multiple collateral vessels,portal vein thrombosis,previous abdominal surgery,splenomegaly,and poor 'functional' recovery of the new liver.The intrinsic coagulopathic features of end stage cirrhosis along with surgical technical difficulties make transfusion-free liver transplantation a major challenge,and,despite the improvements in understanding of intraoperative coagulation profiles and strategies to control blood loss,the requirements for blood or blood products remains high.The impact of blood transfusion has been shown to be significant and independent of other well-known predictors of posttransplant-outcome.Negative effects on immunomodulation and an increased risk of postoperative complications and mortality have been repeatedly demonstrated.Isovolemic hemodilution,the extensive utilization of thromboelastogram and the use of autotransfusion devices are among the commonly adopted procedures to limit the amount of blood transfusion.The use of intraoperative blood salvage and autologous blood transfusion should still be considered an important method to reduce the need for allogenic blood and the associated complications.In this article we report on the common preoperative and intraoperative factors contributing to blood loss,intraoperative transfusion practices,anesthesiologic and surgical strategies to prevent blood loss,and on intraoperative blood salvaging techniques and autologous blood transfusion.Even though the advances in surgical technique and anesthetic management,as well as a better understanding of the risk factors,have resulted in a steady decrease in intraoperative bleeding,most patients still bleed extensively.Blood transfusion therapy is still a critical feature during OLTx and various studies have shown a large variability in the use of blood products among different centers and even among individual anesthesiologists within the same center.Unfortunately,despite the large number of OLTx performed each year,there is still paucity of large randomized,multicentre,and controlled studies which indicate how to prevent bleeding,the transfusion needs and thresholds,and the 'evidence based' perioperative strategies to reduce the amount of transfusion. | Feltracco Paolo Brezzi Marialuisa Barbieri Stefania Galligioni Helmut Milevoj Moira Carollo Cristiana Ori Carlo | 2013 | World Journal of Hepatology2013，5，1： | 37 |
| 2 | Early respiratory complications after liver transplantation显示文摘The poor clinical conditions associated with end-stage cirrhosis,pre-existing pulmonary abnormalities,and high comorbidity rates in patients with high Model for End-Stage Liver Disease scores are all well-recognized factors that increase the risk of pulmonary complications after orthotopic liver transplantation(OLT)surgery.Many intraoperative and postoperative events,such as fluid overload,massive transfusion of blood products,hemodynamic instability,unexpected coagulation abnormalities,renal dysfunction,and serious adverse effects of reperfusion syndrome,are other factors that predispose an individual to postoperative respiratory disorders.Despite advances in surgical techniques and anesthesiological management,the lung may still suffer throughout the perioperative period from various types of injury and ventilatory impairment,with different clinical outcomes.Pulmonary complications after OLT can be classified as infectious or non-infectious.Pleural effusion,atelectasis,pulmonary edema,respiratory distress syndrome,and pneumonia may contribute considerably to early morbidity and mortality in liver transplant patients.It is of paramount importance to accurately identify lung disorders because infectious pulmonary complications warrant speedy and aggressive treatment to prevent diffuse lung injury and the risk of evolution into multisystem organ failure.This review discusses the most common perioperative factors that predispose an individual to postoperative pulmonary complications and these complications’early clinical manifestations after OLT and influence on patient outcome. | Paolo Feltracco Cristiana Carollo Stefania Barbieri Tommaso Pettenuzzo Carlo Ori | 2013 | World Journal of Gastroenterology2013，19，48： | 32 |
| 3 | Toll样受体参与小鼠肝脏缺血再灌注损伤显示文摘目的 探讨Toll样受体是否参与小鼠肝脏缺血再灌注损伤及其机制。方法 用Toll样受体缺损小鼠(C3H/Hej,Hej组)和野生型(C3H/Heouj,Heouj组)小鼠复制部分肝脏缺血再灌注损伤模型,于缺血45min,再灌注1h和3h处死动物,检测血清天门冬氨酸氨基转移酶(AST)和血清肿瘤坏死因子α(TNFα)的含量;并以northern blot及髓过氧化物酶(MPO)试验分别检测缺血肝组织TNFα mRNA的表达和MPO的含量。结果(1)再灌注1、3h,与假手术组相比,小鼠血浆AST明显升高,但Hej组明显低于Heouj组(661.83U/L±106.09U/L和1215.5U/L±174.03U/L,t=-6.65,P<0.01;1145.17U/L±132.43U/L和2958.17U/L±186.81U/L,t=-5.57,P<0.01);(2)再灌注3h时,与假手术组相比,Hej组和Heouj组小鼠血清TNFα浓度明显升高,且前者明显低于后者(152.39pg/ml±43.3pg/ml和249.12pg/ml±51.89pg/ml,t=-3.13,P<0.05);(3)再灌注1h,除假手术组外,Hej组和Heouj组小鼠缺血肝组织内可见TNFα mRNA的表达,但前者的表达水平明显低于后者,杂交带密度分析显示两者之间差异有显著性(80.3±28.8与189.4±24.6,t=-3.25,P<0.05);(4)再灌注3h,与假手术组相比,Hej组和Heouj组小鼠缺血肝组织内MPO含量明显升高,且前者含量明显低于后者(0.059±0.004和0.173±0.025,F=33.49,P<0.01)。结? | 吴河水 王琳 田元 Ori Rotstein | 2003 | 中华肝脏病杂志2003，11，7： | 14 |
| 4 | Intensive care management of liver transplanted patients显示文摘Advances in pre-transplant treatment of cirrhosis-related organ dysfunction,intraoperative patient management,and improvements in the treatment of rejection and infections have made human liver transplantation an effective and valuable option for patients with end stage liver disease.However,many important factors,related both to an increasing 'marginality' of the implanted graft and unexpected perioperative complications still make immediate post-operative care challenging and the early outcome unpredictable.In recent years sicker patients with multiple comorbidities and organ dysfunction have been undergoing Liver transplantation;appropriate critical care management is required to support prompt graft recovery and prevent systemic complications.Early post-operative management is highly demanding as significant changes may occur in both the allograft and the 'distant' organs.A functioning transplanted liver is almost always associated with organ system recovery,resulting in a new life for the patient.However,in the unfortunate event of graft dysfunction,the unavoidable development of multi-organ failure will require an enhanced level of critical care support and a prolonged ICU stay.Strict monitoring and sustainment of cardiorespiratory function,frequent assessment of graft performance,timely recognition of unexpected complications and the institution of prophylactic measures to prevent extrahepatic organ system dysfunction are mandatoryin the immediate post-operative period.A reduced rate of complications and satisfactory outcomes have been obtained from multidisciplinary,collaborative efforts,skillful vigilance,and a thorough knowledge of pathophysiologic characteristics of the transplanted liver. | Paolo Feltracco Stefania Barbieri Helmut Galligioni Elisa Michieletto Cristiana Carollo Carlo Ori | 2011 | World Journal of Hepatology2011，3，3： | 13 |
| 5 | Perioperative thrombotic complications in liver transplantation显示文摘Although the perioperative bleeding complications and the major side effects of blood transfusion have always been the primary concern in liver transplantation(OLT),the possible cohesion of an underestimated intrinsic hypercoagulative state during and after the transplant procedure may pose a major threat to both patient and graft survival.Thromboembolism during OLT is characterized not only by a complex aetiology,but also by unpredictable onset and evolution of the disease.The initiation of a procoagulant process may be triggered by various factors,such as inflammation,venous stasis,ischemia-reperfusion injury,vascular clamping,anatomical and technical abnormalities,genetic factors,deficiency of profibrinolytic activity,and platelet activation.The involvement of the arterial system,intracardiac thrombosis,pulmonary emboli,portal vein thrombosis,and deep vein thrombosis,are among the most serious thrombotic events in the perioperative period.The rapid detection of occlusive vascular events is of paramount importance as it heavily influences the prognosis,particularly when these events occur intraoperatively or early after OLT.Regardless of the lack of studies and guidelines on anticoagulant prophylaxis in this setting,many institutions recommend such an approach especially in the subset of patients at high risk.However,the decision of when,how and in what doses to use the various chemical anticoagulants is still a difficult task,since there is no common consensus,even for highrisk cases.The risk of postoperative thromboembolism causing severe hemodynamic events,or even loss of graft function,must be weighed and compared with the risk of an important bleeding.In this article we briefly review the risk factors and the possible predictors of major thrombotic complications occurringin the perioperative period,as well as their incidence and clinical features.Moreover,the indications to pharmacological prophylaxis and the current treatment strategies are also summarized. | Paolo Feltracco Stefania Barbieri Umberto Cillo Giacomo Zanus Marco Senzolo Carlo Ori | 2015 | World Journal of Gastroenterology2015，21，26： | 13 |
| 6 | Long-term follow-up of distal intestinal obstruction syndrome in cystic fibrosis显示文摘AIM: To investigate the long-term follow-up of distal intestinal obstruction syndrome(DIOS) in Israeli cystic fibrosis(CF) patients.METHODS: This is a multi-center,comparative,retrospective study in which we reviewed the medical records of all CF patients from three major CF centers in Israel who were treated in the period from 1980 to 2012.Patients diagnosed with DIOS were defined as the study group.The patients were diagnosed with DIOS based on their clinical presentation and typical findings on either abdominal X-ray or computerized tomography scan.For the control group,CF patients with no DIOS were matched to the patients in the study group for age,sex,and cystic fibrosis transmembrane conductance regulator(CFTR) mutations.For both groups,the collected data included age,sex,CFTR genotype,weight,height,and body mass index.Clinical data included respiratory function tests in the last five years prior to the study,respiratory function test immediately before and after the DIOS event,number of hospitalizations,sputum culture results,and CFrelated conditions diagnosed according to the CF clinical practice guidelines.In the study group,data on the DIOS treatment and tendency for DIOS recurrence were also analyzed.RESULTS: The medical charts for a total of 350 CF patients were reviewed.Of the 350 CF patients,26(7.4%) were diagnosed with DIOS.The control group included 31 CF patients with no DIOS diagnosis.The mean follow-up period was 21.6 ± 8.2 years.The total of DIOS episodes in the follow-up period was 60.The distribution of DIOS episodes was as follows: 6/26(23.1%) study patients had one episode of DIOS intheir lifetime,7/26(26.9%) had two episodes,7/26(26.9%) had three episodes,and 6/26(23.1%) had four or more episodes.Compared to the control group,DIOS patients had a significantly higher incidence of meconium ileus in the past(65.4% vs 0%,respectively,P < 0.02),more Aspergillus spp.colonization(34.6% vs 3.2%,respectively,P < 0.02),and a higher number of hospitalizations due to respiratory exacerbations(8.6 vs 6.2 mean total hospitalizations per follow-up period,respectively,P < 0.02).No other significant differences were found between the control and study groups.The conservative treatment of DIOS,which mainly includes hydration and stool softeners,was successful in 82% of the episodes.The survival rate was similar for both groups.CONCLUSION: CF patients with DIOS suffer from recurrent hospitalizations and airway pathogen acquisition.Although recurrence of DIOS is common,conservative treatment is successful in most patients. | Moran Lavie Tzipora Manovitz Daphna Vilozni Sarina Levy-Mendelovich Ifat Sarouk Ilana Weintraubv David Shoseyov Malena Cohen-Cymberknoh Joseph Rivlin Ori Efrati | 2015 | World Journal of Gastroenterology2015，21，1： | 10 |
| 7 | Toll-like receptor 4 involvement in hepatic ischemia/reperfusion injury in mice显示文摘BACKGROUND: Toll-like receptor 4 (TLR4) is involved in innate immunity by recognizing endotoxin resulting in a burst of inflammatory cascade. We investigated the relation between activation of TLR4 and liver injury in partial hepa- tic ischemia/reperfusion (I/R) injury in mice. METHODS: TLR4-deficient mice ( C3H/Hej) and wild type mice (WT, C3H/Heouj) were used in the model of I/R injury. Partial hepatic ischemia was produced by oc- clusion of inflow to the median and left lobes for 45 mi- nutes. Blood was drawn at 1 and 3 hours after reperfusion. The blood was analyzed for aspartate aminotransferase (AST) and tumor necrosis factor alpha (TNF-α). TNF-α mRNA expression and myeloperoxidase (MPO) level in the ischemic lobes were examined by northern blot and myeloperoxidase assay respectively. RESULTS: AST levels were significantly decreased in TLR4- deficient mice compared with WT mice at both time points (WT: 1215.5 ±174. 03, 2958. 17 ± 186. 81 IU/L at 1 and 3 hours respectively vs TLR4def: 661.83±106.09, 1145.17± 132.43 IU/L at 1 and 3 hours, mean ± SD, 6 mice/group, (=-6.65 and -5.57, P <0.001). Consistent with the role of TNF-α in hepatic I/R, serum TNF-α was decreased in TLR4 deficient mice at 3 hours after reperfusion compared with WT (152.39±43.3 vs 249.12 ± 51.89, n=6, t=-3.13, P<0.05). MPO level in the ischemic lobes in TLR4 defi- cient mice at 3 hours after reperfusion was significantly low- er than that in WT mice (0.059±0.004 vs 0.173±0.025, n=6, F=33.49, P<0.001). This difference appears to be mediated at the gene level since TLR4 deficient mice had decreased TNF-α mRNA expression at 1 hour after reperfu- sion compared with WT mice (80.3±28.8 vs 189.4±24.6, t=-3.25, P<0.05). CONCLUSIONS: Compared with WT mice, TLR4-defi- cient mice appear to have a mild I/R injury. Regulation of TNF-a at mRNA level seems to have a critical effect. These suggest TLR4 be involved in the mechanism of he-patic I/R injury in mice. | Ori Rotstein | 2004 | Hepatobiliary & Pancreatic Diseases International2004，3，2： | 9 |
| 8 | Standard forward-viewing colonoscopy versus full-spectrum endoscopy: an international, multicentre, randomised, tandem colonoscopy trial显示文摘 | Ian M Gralnek Peter D Siersema Zamir Halpern Ori Segol Alaa Melhem Alain Suissa Erwin Santo Alan Sloyer Jay Fenster Leon M G Moons Vincent K Dik Ralph B D’Agostino Douglas K Rex | 2014 | Lancet Oncology2014，，3： | 6 |
| 9 | Study of the kinetic behaviour of biomass and coal during oxyfuel co-combustion显示文摘In this study,the thermogravimetric analysis(TGA)method has been used to evaluate the kinetic behavior of biomass,coal and its blends during oxyfuel co-combustion.The thermogravimetric results have been evaluated by the Coats-Redfern method and validated by Criado’s method.TG and DTG curves indicate that as the oxygen concentration increases the ignition and burn out temperatures approach a lower temperature region.The combustion characteristic index shows that biomass to coal blends of 28%and 40%respectively can achieve enhanced combustion up to 60%oxygen enrichment.In the devolatilization region,the activation energies for coal and blends reduce while in the char oxidation region,they increase with rise in oxygen concentration.Biomass,however,indicates slightly different combustion characteristic of being degraded in a single step and its activation energies increase with rise in oxygen concentration.It is demonstrated in this work that oxygen enrichment has more positive combustion effect on coal than biomass.At 20%oxygen enrichment,28%and 40%blends indicate activation energy of 132.8 and 125.5 kJ·mol^-1 respectively which are lower than coal at 148.1 kJ·mol^-1 but higher than biomass at 81.5 kJ·mol^-1 demonstrating synergistic effect of fuel blending.Also,at char combustion step,an increase in activation energy for 28%blend is found to be 0.36 kJ·mol^-1 per rise in oxygen concentration which is higher than in 40%blend at 0.28 kJ·mol^-1. | Oris Chansa Zhongyang Luo Chunjiang Yu | 2020 | Chinese Journal of Chemical Engineering2020，28，7： | 6 |
| 10 | Trading volume and Belief Revisions that Differ Among Individual Analysts 显示文摘 | Orie E | 1995 | Accounting Review1995，70，4： | 5 |
| 11 | 镁盐改性生物质炭的合成及其在废水氮磷资源化中的应用研究显示文摘通过直接沉淀-热改性法将纳米氢氧化镁晶体(Mg(OH)_2)负载在生物质炭(BC)上,系统研究了该改性材料(Mg(OH)_2-BC)对模拟废水中氮、磷的固定特性,并探讨了投加量、反应溶液pH、接触时间对吸附过程的影响.结果表明,Mg(OH)_2-BC在投加量为0.3 g·L^(-1),反应溶液初始pH为7,反应时间≥40 min时对氮、磷的固定效果最佳,最大吸附量分别达到58.8、130.0 mg·g^(-1).Mg(OH)_2-BC对氮、磷的吸附过程均符合准二级动力学模型,吸附过程受化学吸附机理的控制.通过SEM、XRD、FTIR等对反应产物进行表征分析,结果表明,Mg(OH)_2-BC对氮、磷的固定机制主要为鸟粪石结晶沉淀,也即化学沉淀. | James King′ori Njuguna 张荣斌 李远 王学江 王健 赵建夫 | 2018 | 环境科学学报2018，38，11： | 4 |
| 12 | Systematic review of macular ganglion cell complex analysis using spectral domain optical coherence tomography for glaucoma assessment显示文摘AIM: To review the use of spectral domain optical coherence tomography(SD-OCT) for macular retinal ganglion cells(RGC) and ganglion cell complex(GCC) measurement in glaucoma assessment, specifically for early detection and detection of disease progression. METHODS: A systematic review was performed by searching Pub Med, Medline, and Web of Science for articles published in English through July 2014 describing the various macular SD-OCT scanning strategies developed for glaucoma assessment. The review focused on papers evaluating the use of macular RGC/GCC SDOCT to detect early glaucoma and its progression. The search included keywords corresponding to the index test(macular ganglion cell/RGC/GCC/Spectral domain OCT), the target condition(glaucoma), and diagnostic performance. The RGC/GCC SD-OCT scanning strategies used to assess glaucoma of most commonly used SD-OCT instruments were described and compared. These included the Cirrus high definition-OCT(Carl Zeiss Meditec, Inc., Dublin, CA, United States), RTVue(Optovue, Inc., Fremont, CA, United States), Spectralis(Heidelberg Engineering, Heidelberg, Germany) and the 3D OCT 2000(Topcon Corporation, Tokyo, Japan). Studies focusing on the ability of RGC/GCC SD-OCT to detect early glaucomatous damage and on the correlation between glaucomatous progression and RGC/GCC measurement by SD-OCT were reviewed.RESULTS: According to the literature, macular RGC/GCC SD-OCT has high diagnostic power of preperimetric glaucoma, reliable discrimination ability to differentiate between healthy eyes and glaucomatous eyes, with good correlation with visual filed damage. The current data suggests that it may serve as a sensitive detection tool for glaucomatous structural progression even with mild functional progression as the rate of change of RGC/GCC thickness was found to be significantly higher in progressing than in stable eyes. Glaucoma assessment with RGC/GCC SD-OCT was comparable with and sometimes better than circumpapillary retinal nerve fiber layer thickness measurement.CONCLUSION: An increasing body of evidence supports using macular RGC/GCC thickness as an indicator for early glaucoma. This might be a useful tool for monitoring disease progression. | Amit Meshi Dafna Goldenberg Sharon Armarnik Ori Segal Noa Geffen | 2015 | World Journal of Ophthalmology2015，5，2： | 3 |
| 13 | 多壁纳米碳管对磷酸铁锂正极材料热稳定性及表面形貌的影响(英文)显示文摘合成了一种新型的LiFePO4/多壁纳米碳管(MWCNTs)复合正极材料。通过MWCNTs和PPy-PEG粘结剂有机地在LiFePO4颗粒间构成三维网络导电结构,并借助SEM、TGA和高分辨裂解气相色谱,研究了LiFePO4-MWCNT正极材料的表面形貌和热稳定性。结果表明,500℃下该材料的热分解程度非常小,说明MWCNTs和PPy-PEG的复合是提高LiFePO4正极材料的热稳定性和改善表面形貌的有效途径。 | Mária Filkusová Andrea Fedorková Renáta Oriňáková Andrej Oriňák Zuzana Nováková Lenka Skantárová | 2013 | 新型炭材料2013，28，1： | 3 |
| 14 | Comparison of Standard Forward Viewing Mode Versus Ultra-Wide Viewing Mode of a Novel Colonoscopy Platform: A Prospective, Multicenter Study in the Detection of Simulated Polyps in an in vitro Colon Model显示文摘 | Ian M. Gralnek David L. Carr-Locke Ori Segol Zamir Halpern Peter D. Siersema Alan Sloyer Jay Fenster Blair S. Lewis Erwin Santo Alain Suissa Meytal Segev | 2012 | Gastrointestinal Endoscopy2012，，： | 3 |
| 15 | Spreading depression and focal venous cerebral ischemia enhance cortical neurogenesis显示文摘Endogenous neurogenesis can arise from a variety of physiological stimuli including exercise, learning, or 'enriched environment' as well as pathological conditions such as ischemia, epilepsy or cortical spreading depression. Whether all these conditions use a common trigger to set off endogenous neurogenesis is yet unclear. We hypothesized that cortical spreading depression(CSD) induces neurogenesis in the cerebral cortex and dentate gyrus after cerebral venous ischemia. Forty-two Wistar rats alternatively underwent sham operation(Sham), induction of ten CSDs or venous ischemia provoked via occlusion of two adjacent superficial cortical vein followed by ten induced CSDs(CSD + 2-VO). As an additional control, 15 na?ve rats received no intervention except 5-bromo-2′-deoxyuridine(Brd U) treatment for 7 days. Sagittal brain slices(40 μm thick) were co-stained for Brd U and doublecortin(DCX; new immature neuronal cells) on day 9 or Neu N(new mature neuronal cells) on day 28. On day 9 after sham operation, cell proliferation and neurogenesis occurred in the cortex in rats. The sole induction of CSD had no effect. But on days 9 and 28, more proliferating cells and newly formed neurons in the ipsilateral cortex were observed in rats subjected to CSD + 2VO than in rats subjected to sham operation. On days 9 and 28, cell proliferation and neurogenesis in the ipsilateral dentate gyrus was increased in sham-operated rats than in na?ve rats. Our data supports the hypothesis that induced cortical neurogenesis after CSD + 2-VO is a direct effect of ischemia, rather than of CSD alone. | Ryo Tamaki Samuel Ige Orie Beat Alessandri Oliver Kempski Axel Heimann | 2017 | Neural Regeneration Research2017，12，8： | 3 |
| 16 | Ultrafast photonic PCR显示文摘Nucleic acid amplification and quantification via polymerase chain reaction(PCR)is one of the most sensitive and powerful tools for clinical laboratories,precision medicine,personalized medicine,agricultural science,forensic science and environmental science.Ultrafast multiplex PCR,characterized by low power consumption,compact size and simple operation,is ideal for timely diagnosis at the point-of-care(POC).Although several fast/ultrafast PCR methods have been proposed,the use of a simple and robust PCR thermal cycler remains challenging for POC testing.Here,we present an ultrafast photonic PCR method using plasmonic photothermal light-to-heat conversion via photon–electron–phonon coupling.We demonstrate an efficient photonic heat converter using a thin gold(Au)film due to its plasmon-assisted high optical absorption(approximately 65%at 450 nm,the peak wavelength of heat source light-emitting diodes(LEDs)).The plasmon-excited Au film is capable of rapidly heating the surrounding solution to over 150℃ within 3 min.Using this method,ultrafast thermal cycling(30 cycles;heating and cooling rate of 12.7960.93℃ s^(-1) and 6.660.29℃ s^(-1),respectively)from 55℃(temperature of annealing)to 95℃(temperature of denaturation)is accomplished within 5 min.Using photonic PCR thermal cycles,we demonstrate here successful nucleic acid(λ-DNA)amplification.Our simple,robust and low cost approach to ultrafast PCR using an efficient photonic-based heating procedure could be generally integrated into a variety of devices or procedures,including on-chip thermal lysis and heating for isothermal amplifications. | Jun Ho Son Byungrae Cho SoonGweon Hong Sang Hun Lee Ori Hoxha Amanda J Haack Luke P Lee | 2015 | Light(Science & Applications)2015，4，1： | 2 |
| 17 | Remote Ischemic Preconditioning by Hindlimb Occlusion Prevents Liver Ischemic/Reperfusion Injury: The Role of High Mobility Group-Box 1显示文摘 | Feng Wang Simone E. Birch Ruijan He Patrick Tawadros Katalin Szaszi Andras Kapus Ori D. Rotstein | 2010 | Annals of Surgery2010，，2： | 2 |
| 18 | Forms of potassium and chlorine from oxy-fuel co-combustion of lignite coal and corn stover显示文摘In this work,the forms of potassium and chlorine from oxy-fuel co-combustion of lignite coal and corn stover under atmospheric pressure were investigated.In order to check transitional stage,the feedstocks were combusted stepwise,first by pyrolysis to form coke under N2 environment and later by coke combustion into the ash at 850℃ in O_(2)/CO_(2) atmosphere.The results show that an increase in blend ratio from 15%to 40%results in an increase in water-soluble potassium in the feedstock and the ashes from 0.15%to 0.4%and 0.015%to 0.038%in weight respectively.The water-soluble potassium is present mainly as KCl and K2SO4.For ammonium acetate soluble potassium,a similar trend to water-soluble potassium is presented but with a much lower content of potassium.The bound potassium in the fuel matrix exists,likely in the form of AlKSi_(2)O_(6).Chlorides are present mainly in the form of KCl which is the dominant water-soluble compound. | Chansa Oris Zhongyang Luo Wennan Zhang Chunjiang Yu | 2019 | Carbon Resources Conversion2019，2，2： | 2 |
| 19 | The comparative efficacy of ezetimibe added to atorvastatin 10 mg versus uptitration to atorvastatin 40 mg in subgroups of patients aged 65 to 74 years or greater than or equal to 75 years显示文摘有年龄的背景冠的心疾病(CHD ) 风险增加;然而类脂化合物阴沉的治疗是显著地在病人的 under-utilized > 65 年。目的是评估安全,在更老的病人的类脂化合物阴沉的治疗的功效与 atorvastatin 对待 10 mg + ezetimibe 10 mg (EZ/Atorva ) 对增加 atorvastatin 剂量到 40 mg。方法病人有动脉粥样硬化患者的 65 年脉管的疾病(LDL-C 1.81 mmol/L ) 或在为冠的心的高风险,疾病(LDL-C 2.59 mmol/L ) 为 12 wk 对 uptitration 被使随机化到 EZ/Atorva 到为 6 wk 的 20 mg 由 atorvastatin 跟随了的 atorvastatin 为 6 wk 的 40 mg。在完成 prespecified LDL-C 层次的 LDL-C 和另外的类脂化合物参数和百分比病人的百分比变化在 12 wk 以后被估计。结果 EZ/Atorva 在病人在大多数类脂化合物参数对 atorvastatin 的 uptitration 生产了更大的减小 75 年(n = 228 ) ,与病人通常一致 6574 年(n = 812 ) 。更多的病人在 6 wk 并且在病人在两个年龄组与联合治疗对 monotherapy 完成了 LDL-C 目标在 12 wk 的 75 年。在 12 wk,更多的病人 75 年与 monotherapy 对联合治疗完成了 LDL-C 目标。EZ/Atorva 在大多数类脂化合物生产了更有利的改进对加倍或 quadrupling 在病人的 atorvastatin 剂量 75 年,与在病人的调查结果通常一致 6574 年。我们的结果扩大了证明 ezetimibe 增加了 statin 的以前的调查结果的结论为在病人改进类脂化合物侧面提供了一种通常容忍得好的治疗学的选择 65 ~ 74 年和 75 岁。 | Ori Ben-Yehuda Nanette K. Wenger Christian Constance Franklin Zieve Mary E. Hanson Jian-Xin Lin Arvind K. Shah Charlotte Jones-Burton Andrew M. Tershakovec | 2011 | Journal of Geriatric Cardiology2011，8，1： | 2 |
| 20 | A hardening load transfer function for rock bolts and its calibration using distributed fiber optic sensing显示文摘Confinement of rock bolts by the surrounding rock formation has long been recognized as a positive contributor to the pull-out behavior,yet only a few experimental works and analytical models have been reported,most of which are based on the global rock bolt response evaluated in pull-out tests.This paper presents a laboratory experimental setup aiming to capture the rock formation effect,while using distributed fiber optic sensing to quantify the effect of the confinement and the reinforcement pull-out behavior on a more local level.It is shown that the behavior along the sample itself varies,with certain points exhibiting stress drops with crack formation.Some edge effects related to the kinematic freedom of the grout to dilate are also observed.Regardless,it was found that the mid-level response is quite similar to the average response along the sample.The ability to characterize the variation of the response along the sample is one of the many advantages high-resolution fiber optic sensing allows in such investigations.The paper also offers a plasticity-based hardening load transfer function,representing a'slice'of the anchor.The paper describes in detail the development of the model and the calibration/determination of its parameters.The suggested model captures well the coupled behavior in which the pull-out process leads to an increase in the confining stress due to dilative behavior. | Assaf Klar Ori Nissim Itai Elkayam | 2023 | Journal of Rock Mechanics and Geotechnical Engineering2023，15，11： | 2 |
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