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| 1 | Anti program death-1/anti program death-ligand 1 in digestive cancers显示文摘Human tumors tend to activate the immune system regulatory checkpoints as a means of escaping immunosurveillance. For instance, interaction between program death-1(PD-1) and program death-ligand 1(PD-L1) will lead the activated T cell to a state of anergy. PD-L1 is upregulated on a wide range of cancer cells. Anti-PD-1 and anti-PD-L1 monoclonal antibodies(m Abs), called immune checkpoint inhibitors(ICIs), have consequently been designed to restore T cell activity. Accumulating data are in favor of an association between PD-L1 expression in tumors and response to treatment. A PD-L1 expression is present in 30% to 50% of digestive cancers. Multiple anti-PD-1(nivolumab, pembrolizumab) and anti-PD-L1 m Abs(MPDL3280A, Medi4736) are under evaluation in digestive cancers. Preliminary results in metastatic gastric cancer with pembrolizumab are highly promising and phase Ⅱ will start soon. In metastatic colorectal cancer(CRC), a phase Ⅲ trial of MPDL3280 A as maintenance therapy will shortly be initiated. Trials are also ongoing in metastatic CRC with high immune T cell infiltration(i.e., microsatellite instability). Major challenges are ahead in order to determine how, when and for which patients we should use these ICIs. New radiologic criteria to evaluate tumor response to ICIs are awaiting prospective validation. The optimal therapeutic sequence and association with cytotoxic chemotherapy needs to be established. Finally, biomarker identification will be crucial to selection ofpatients likely to benefit from ICIs. | Eléonore de Guillebon Pauline Roussille Eric Frouin David Tougeron | 2015 | World Journal of Gastrointestinal Oncology2015，7，8： | 12 |
| 2 | Phase Diversity Electro-optic Sampling:A new approach to single-shot terahertz waveform recording显示文摘Recording electric field evolution in single-shot with THz bandwidth is needed in science including spectroscopy,plasmas,biology,chemistry,Free-Electron Lasers,accelerators,and material inspection.However,the potential application range depends on the possibility to achieve sub-picosecond resolution over a long time window,which is a largely open problem for single-shot techniques.To solve this problem,we present a new conceptual approach for the so-called spectral decoding technique,where a chirped laser pulse interacts with a THz signal in a Pockels crystal,and is analyzed using a grating optical spectrum analyzer.By borrowing mathematical concepts from photonic time stretch theory and radio-frequency communication,we deduce a novel dual-output electro-optic sampling system,for which the input THz signal can be numerically retrieved—with unprecedented resolution—using the so-called phase diversity technique.We show numerically and experimentally that this approach enables the recording of THz waveforms in single-shot over much longer durations and/or higher bandwidth than previous spectral decoding techniques.We present and test the proposed DEOS(Diversity Electro-Optic Sampling)design for recording 1.5 THz bandwidth THz pulses,over 20 ps duration,in single-shot.Then we demonstrate the potential of DEOS in accelerator physics by recording,in two successive shots,the shape of 200 fs RMS relativistic electron bunches at European X-FEL,over 10 ps recording windows.The designs presented here can be used directly for accelerator diagnostics,characterization of THz sources,and single-shot Time-Domain Spectroscopy. | Eléonore Roussel Christophe Szwaj Clément Evain Bernd Steffen Christopher Gerth Bahram Jalali Serge Bielawski | 2022 | Light(Science & Applications)2022，11，1： | 3 |
| 3 | Altered gene expression and function of peripheral blood natural killer cells in children with autism显示文摘 | Enstrom AM Lit L Onore CE | 2009 | Brain Behav Immun2009，23，： | 1 |
| 4 | Decreased cellular IL-23 production in children with autism spectrum disorders显示文摘 | Onore C Krakowiak P Enstrom A | 2009 | J Neuroimmunol2009，216，12： | 1 |
| 5 | Clinical experience with risperidone in the treatment of behavioral and psychological symptoms of dementia 显示文摘 | Onor ML Saina M Trevisiol M | 2007 | Prog Neuropsychopharmacol Biol Psychiatry2007，31，1： | 1 |
| 6 | Measurement of hydroxyl radicals in pulsed corona discharge显示文摘 | ONOR ODA T | 2002 | Journal of Elect rostatics2002，55，： | 1 |
| 7 | Determination ofthiolic compounds as mercury complexes by cold vapor atomic absorptionspectrometry and its application to wines显示文摘 | BRAMANTI E CAVALLARO R ONOR M | 2008 | Talanta2008，74，4： | 1 |
| 8 | Increased IgG4 levels in chil- dren with autism disorder显示文摘 | Enstrom A Kmkowiak P Onore C | 2009 | Brain Behav Imnmn2009，23，： | 1 |
| 9 | Efficacy and tolerability of quetiapine in the treatment of behavioral and psychological symptoms of dementia显示文摘 | Onor ML Saina M Aguglia E | 2007 | Am J Alzheimers Dis Other Demen2007，21，6： | 1 |
| 10 | Continuous flow hydride generation-atomic fluorescence spectrometric determination and speciation of arsenic in wine显示文摘 | KARADJOVA I B LAMPUGNANI L ONOR M | 2005 | Spectrochimica Acta Part B2005，，60： | 1 |
| 11 | Efficacy and tolerability of quetiapine in the treatment of behavioral and psychological symptoms of dementia 显示文摘 | Onor ML Saina M Aguglia E | 2007 | Am J Alzheimers Dis Other Demen2007，21，6： | 1 |
| 12 | Rivastigmine in the treatment of Alzheimer's disease: an update显示文摘 | Onor ML Trevisiol M Aguglia E | 2007 | Clin Interv Aging2007，2，1： | 1 |
| 13 | Quantification of nitrite and nitrate in seawater by triethyloxonium tetrafluoroborate derivatizationheadspace SPME GC-MS显示文摘 | Pagliano E Onor M Pitzalis E | 2011 | Talanta2011，85，： | 1 |
| 14 | Concomitant antagonism of endothelial and vascular smooth muscle cell ETB receptors for endothelin induces hypertension in the hamster 显示文摘 | onore JC Fecteau MH Brochu I | 2005 | American Journal Physiol Heart Circulatory Physiol2005，289，3： | 1 |
| 15 | Differential monocyte responses to TLR ligands in children with autism spectrum disorders显示文摘 | Enstrom AM Onore CE Vande WaterJA | 2010 | Brain Behavior and Immunity2010，24，1： | 1 |
| 16 | Rivastigmine in the treatment of Alzheimer~ disease: an update 显示文摘 | ONOR M L TREVISIOL M AGUGLIA E | 2007 | Clin lnterv Aging2007，2，1： | 1 |
| 17 | The role of immune dysfunction in the pathophysiology of autism显示文摘 | Onore C Careaga M Ashwood P | 2012 | Brain Behav Immun2012，26，： | 1 |
| 18 | Assessment by three dimensional CTof pleural indentation or invasion by peripheral lung cancer显示文摘 | Mimura F gusumoto M OnoR | 1995 | Nippon Lgaku Hoshasen Gakkai Zasshi1995，55，： | 1 |
| 19 | Silent ischemic lesions in young adults with first stroke are associated with recurrent stroke显示文摘 | Laura C. Gioia éléonore Tollard Véronique Dubuc Sylvain Lanthier Yan Deschaintre Miguel Chagnon Alexandre Y. Poppe | 2012 | Neurology2012，，12： | 1 |
| 20 | Epididymis seleno-independent glutathione peroxidase 5 maintains sperm DNA integrity in mice显示文摘 | Chabory Eléonore Damon Christelle Lenoir Alain Kauselmann Gary Kern Hedrun Zevnik Branko Garrel Catherine Saez Fabrice Cadet Rémi Henry-Berger Joelle Schoor Michael Gottwald Ulrich Habenicht Ursula Drevet Jo?l R Vernet Patrick | 2009 | Journal of Clinical Investigation2009，，7： | 1 |
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