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| 1 | Feasibility and safety of cryoballoon ablation for atrial fibrillation inpatients with congenital heart disease显示文摘BACKGROUND The prevalence of atrial fibrillation (AF) is on the rise in the aging population with congenital heart disease (CHD). A few case series have described the feasibility and early outcomes associated with radiofrequency catheter ablation of AF centered on electrically isolating pulmonary veins (PV) in patients with CHD. In contrast, cryoballoon ablation has not previously been studied in this patient population despite its theoretical advantages, which include a favorable safety profile and shorter procedural time. AIM To assess the safety and feasibility of cryoballoon ablation for AF in an initial cohort of patients with CHD. METHODS The study population consisted of consecutive patients with CHD and cryoballoon ablation for AF at the Montreal Heart Institute between December 2012 and June 2017. Procedural complications, acute success, and 1-year freedom from recurrent AF after a single procedure with or without antiarrhythmic drugs were assessed. Procedures were performed under conscious sedation. Left atrial access was obtained via a single transseptal puncture or through an existing atrial septal defect (ASD). Cryoballoon occlusion was assessed by distal injection of 50% diluted contrast into the pulmonary vein. At least one 240-second cryothermal application was performed upon obtaining complete pulmonary vein occlusion. Following ablation, patients were routinely followed at outpatient visits at 1, 3, 6, and 12 mo, and then annually. RESULTS Ten patients, median age 57.9 (interquartile range 48.2-61.7) years, 60% female, met inclusion criteria and were followed for 2.8 (interquartile range 1.4-4.5) years.Two had moderately complex CHD (sinus venosus ASD with partial anomalous pulmonary venous return;aortic coarctation with a persistent left superior vena cava), with the remainder having simple defects. AF was paroxysmal in 8 (80.0%) and persistent in 2 (20.0%) patients. The pulmonary vein anatomy was normal in 6 (60.0%) patients. Four had left common PV (n = 3) and/or 3 right PV (n = 2). Electrical pulmonary vein isolation (PVI) was acutely successful in all. One patient had transient phrenic nerve palsy that recovered during the intervention. No major complication occurred. One year after a single ablation procedure, 6 (60%) patients remained free from AF. One patient with recurrent AF had recovered pulmonary vein conduction and underwent a second PVI procedure. A second patient had ablation of an extra-pulmonary vein trigger for AF. CONCLUSION Cryoballoon ablation for AF is feasible and safe in patients with simple and moderate forms of CHD, with an excellent acute success rate and modest 1-year freedom from recurrent AF. | Sylvia Abadir Victor Waldmann Katia Dyrda Mikael Laredo Blandine Mondésert Marc Dubuc Paul Khairy | 2019 | World Journal of Cardiology2019，11，5： | 3 |
| 2 | Statins upregulate PCSK9, the gene encoding the proprotein convertase neural apoptosis-regulated convertase-1 implicated in familial hypercholesterolemia显示文摘 | Dubuc G Chamberland A Wassef H Davignon J Seidah NG Bernier L | 2004 | Arterioscler Thromb Vasc Biol2004，24，8： | 1 |
| 3 | Solution of un- steady Euler equations using an implicit dual-time step method显示文摘 | Dubuc L Cantariti F Woodgate M | 1998 | AIAA Journal1998，36，8： | 1 |
| 4 | Acute haemodynamic comparison of multisite and biventricular pacing with a quadripolar left ventricular lead显示文摘 | THIBAULT B DUBUC M KHAIRY P | 2013 | Europace2013，15，： | 1 |
| 5 | Stimulation of the mesencephalic locomotor region elicits controlled swimming in semi-intact lampreys显示文摘 | Sirota M G Viana D P G Dubuc R | 2000 | Eur J Neurosci2000，12，： | 1 |
| 6 | Gender differences in plasma Leptin concentrations显示文摘 | Harel P J Kasim - karalcas S Dubuc G R | 1996 | Nature Medicine1996，2，： | 1 |
| 7 | Variation d'une fonction et dimension de son graph显示文摘 | Dubuc B Tricot C | 1988 | C R Acad Sci Paris Ser I Math1988，306，： | 1 |
| 8 | Error bounds on the estimation of fraetal dimension显示文摘 | Dubuc B Dubuc S | 1996 | SIAM Journal on Numerical Analysis1996，33，2： | 1 |
| 9 | Solution of un steady Euler equations using an implicit dual time step method显示文摘 | Dubuc L Cantariti F Woodgate M | 1998 | AIAA Journal1998，36，8： | 1 |
| 10 | Validation study of a social functioning scale: The social-SMAF (so- cial- Functional Autonomy Measurement System) 显示文摘 | Pinsormault E Dubuc N Desrosiers J | 2009 | Ar- chives of gerontology and geriatrics2009，48，： | 1 |
| 11 | Gender differences in plasma leptin concentrations显示文摘 | Kasim Karakas S Dubuc GR | 1996 | Nat Med1996，2，： | 1 |
| 12 | Bimodal locomotion elicited by electrical stimulation ofthe midbrain in the salamander notophthalmusviridescens显示文摘 | CABELGUEN J M BOURCIER L C DUBUC R | 2003 | The Journal of Neuroscience2003，23，6： | 1 |
| 13 | Functional au- tonomy measurement system: development of a social sub- scale显示文摘 | Pinsonnault E Desrosiers J Dubuc N | 2003 | Archives of gerontology and geriatrics2003，37，： | 1 |
| 14 | Acute haemodynamic comparison of multisite and biventricular pacing with a quadripolar left ventricular lead显示文摘 | Thibault B Dubuc M Khairy P | 2013 | Europace2013，15，7： | 1 |
| 15 | Tolerance to the hypothermic but not to the analgesic effect of neurotensin during the semichronic intracerebro-ventricular infusion of the peptide in rats显示文摘 | Dubuc I Pain C Suaudeau C | 1994 | Peptides1994，15，2： | 1 |
| 16 | Affinity maturation of a V(H) H by mutational hotspot randomization显示文摘 | Yau KY Dubuc G Li S | 2005 | J Immunol Methods2005，297，12： | 1 |
| 17 | Solution of the unsteady Euler equations using an implicit dual-time method 显示文摘 | DUBUC L | 1998 | AIAA Journal1998，36，8： | 1 |
| 18 | A grid deformation technique for unsteady flow computations 显示文摘 | Dubuc L Cantariti F Woodgate M Gribben B Bad- cock K J Richards B E | 2000 | International Journal for Numerical Methods in Fluids2000，32，： | 1 |
| 19 | PRISMA:a new model of integrated service delivery for the frail older people in Canada显示文摘 | Hebert R Durand PJ Dubuc N | 2003 | Int J Integr Care2003，3，： | 1 |
| 20 | Randomized clinical trial of antibiotic and prostaglandin treatments for uterine health and reproductive performance in dairy cows显示文摘 | J. Dubuc T.F. Duffield K.E. Leslie J.S. Walton S.J. LeBlanc | 2011 | Journal of Dairy Science2011，，3： | 1 |
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