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| 1 | Wireless capsule endoscopy and proximal small bowel lesions in Crohn’s disease显示文摘AIM: To investigate the prevalence of proximal small bowel (SB) lesions detected by wireless capsule endoscopy (WCE) in Crohn's disease (CD). METHODS: WCE was performed in 64 patients: 32 with CD of the distal ileum, and 32 controls with iron-deficiency anemia (IDA) or diarrhea. WCE was performed using the Given SB-WCE, followed by small intestine contrast ultrasonography (SICUS). Findings compatible with CD by using WCE included erosions, aphthoid or deep ulcers, and strictures/stenosis. RESULTS: WCE detected proximal SB lesions in 16/32 (50%) patients (14 aphthoid ulcers, 2 deep ulcers, one stricture), which appeared not to be related to clinical parameters [epigastric pain, age, smoking, non-steroidalanti-inflammatory drugs (NSAIDs), IDA]. Among patients with proximal SB lesions, 6 (37%) were smokers, 3 (19%) NSAID users, 3 (19%) had epigastric pain and 4 (25%) had IDA. SICUS detected proximal SB lesions in 3/32 patients (19%) also showing lesions with WCE. No correlations were observed between proximal SB lesions assessed by WCE or by SICUS (χ2 = 1.5, P = 0.2). CONCLUSION: The use of WCE allows the detection of previously unknown upper SB lesions in a high proportion of patients with a previous diagnosis of CD involving the distal ileum. | Carmelina Petruzziello Sara Onali Emma Calabrese Francesca Zorzi Marta Ascolani Giovanna Condino Elisabetta Lolli Paola Naccarato Francesco Pallone Livia Biancone | 2010 | World Journal of Gastroenterology2010，16，26： | 7 |
| 2 | Small intestine contrast ultrasonography vs computed tomography enteroclysis for assessing ileal Crohn's disease显示文摘AIM:To compare computed tomography enteroclysis(CTE) vs small intestine contrast ultrasonography(SICUS) for assessing small bowel lesions in Crohn's disease(CD),when using surgical pathology as gold standard.METHODS:From January 2007 to July 2008,15 eligible patients undergoing elective resection of the distal ileum and coecum(or right colon) were prospectively enrolled.All patients were under follow-up.The study population included 6 males and 9 females,with a median age of 44 years(range:18-80 years).Inclusion criteria:(1) certain diagnosis of small bowel requiring elective ileo-colonic resection;(2) age between 18-80 years;(3) elective surgery in our Surgical Unit;and(4) written informed consent.SICUS and CTE were performed ≤ 3 mo before surgery,followed by surgical pathology.The following small bowel lesions were blindly reported by one sonologist,radiologist,surgeon and histolopathologist:disease site,extent,strictures,abscesses,fistulae,small bowel dilation.Comparison between findings at SICUS,CTE,surgical specimens and histological examination was made by assessing the specificity,sensitivity and accuracy of each technique,when using surgical findings as gold standard.RESULTS:Among the 15 patients enrolled,CTE was not feasible in 2 patients,due to urgent surgery in one patients and to low compliance in the second patient,refusing to perform CTE due to the discomfort related to the naso-jejunal tube.The analysis for comparing CTE vs SICUS findings was therefore performed in 13 out of the 15 CD patients enrolled.Differently from CTE,SICUS was feasible in all the 15 patients enrolled.No complications were observed when using SICUS or CTE.Surgical pathology findings in the tested population included:small bowel stricture in 13 patients,small bowel dilation above ileal stricture in 10 patients,abdominal abscesses in 2 patients,enteric fistulae in 5 patients,lymphnodes enlargement(> 1 cm) in 7 patients and mesenteric enlargement in 9 patients.In order to compare findings by using SICUS,CTE,histology and surgery,characteristics of the small bowel lesions observed in CD each patient were blindly reported in the same form by one gastroenterologistsonologist,radiologist,surgeon and anatomopathologist.At surgery,lesions related to CD were detected in the distal ileum in all 13 patients,also visualized by both SICUS and CTE in all 13 patients.Ileal lesions > 10 cm length were detected at surgery in all the 13 CD patients,confirmed by SICUS and CTE in the same 12 out of the 13 patients.When using surgical findings as a gold standard,SICUS and CTE showed the exactly same sensitivity,specificity and accuracy for detecting the presence of small bowel fistulae(accuracy 77% for both) and abscesses(accuracy 85% for both).In the tested CD population,SICUS and CTE were also quite comparable in terms of accuracy for detecting the presence of small bowel strictures(92% vs 100%),small bowel fistulae(77% for both) and small bowel dilation(85% vs 82%).CONCLUSION:In our study population,CTE and the non-invasive and radiation-free SICUS showed a comparable high accuracy for assessing small bowel lesions in CD. | Sara Onali Emma Calabrese Carmelina Petruzziello Francesca Zorzi Giuseppe Sica Roberto Fiori Marta Ascolani Elisabetta Lolli Giovanna Condino Giampiero Palmieri Giovanni Simonetti Francesco Pallone Livia Biancone | 2012 | World Journal of Gastroenterology2012，18，42： | 5 |
| 3 | Extracapsular cataract extraction and posterior chamber lens implantation in controlled open-angle glaucoma显示文摘 | Raitta C | 1991 | Ophthalmic Sur1991，22，： | 1 |
| 4 | OC.06.3 ADALIMUMAB IN ACTIVE ULCERATIVE COLITIS: A “REAL-LIFE” OBSERVATIONAL STUDY显示文摘 | A. Armuzzi L. Biancone M. Daperno A. Coli V. Annese S. Ardizzone P. Balestrieri F. Bossa F. Castiglione M. Cicala S. Danese R. D’Incà P. Dulbecco G. Feliciangeli W. Fries S. Genise P. Gionchetti S. Gozzi A. Kohn R. Lorenzetti M. Milla S. Onali A. Orlando | 2012 | Digestive and Liver Disease2012，，： | 1 |
| 5 | Assessing the Value Relevance of Accounting Data After the Introduction of IFRS in Europe 显示文摘 | Devalle Alain Enrico Onali Riccardo Magarini | 2010 | Journal of International Financial Management and Accounting2010，21，2： | 1 |
| 6 | Effect of muscle lysosomal enzymes and calcium activated neutral proteinase on myofibr illar ATPase activity: Relationship with agrag changes显示文摘 | Onali A Valin C | 1981 | Meat Sci1981，5，： | 1 |
| 7 | A family study of asymptomatic small bowel Crohn’s disease显示文摘 | Livia Biancone Emma Calabrese Carmelina Petruzziello Alessandra Capanna Francesca Zorzi Sara Onali Giovanna Condino Elisabetta Lolli Cinzia Ciccacci Paola Borgiani Francesco Pallone | 2013 | Digestive and Liver Disease2013，，： | 1 |
| 8 | Role of muscl: endopeptidases and their inhibitors in meat tenderness显示文摘 | Sentandreu M A Coulis G Onali A | 2002 | Trend in Food Science & Technology2002，13，12： | 1 |
| 9 | Interferon-β counter-regulates its own pro-apoptotic action by activating p38 MAPK signalling in human SH-SY5Y neuroblastoma cells显示文摘 | Simona Dedoni Maria C. Olianas Pierluigi Onali | 2014 | Apoptosis2014，，10： | 1 |
| 10 | Interferoninduces apoplosis inhuman SH -SY5Y neuroblastoma cells through activation of JAK -STAT signaling and down -regulation of PI3K/Akt pathway 显示文摘 | Dedoni S Olianas MC Onali P | 2010 | JNeurochem2010，115，6： | 1 |
| 11 | Fistulizing pattern in Crohn’s disease and pancolitis in ulcerative colitis are independent risk factors for cancer: A single-center cohort study显示文摘 | Livia Biancone Sara Zuzzi Micaela Ranieri Carmelina Petruzziello Emma Calabrese Sara Onali Marta Ascolani Francesca Zorzi Giovanna Condino Simona Iacobelli Francesco Pallone | 2011 | Journal of Crohn’s and Colitis2011，，5： | 1 |
| 12 | Interferon-p induces apoptosis inhuman SH -SY5Y neuroblastoma cells through activation of JAK -STAT signaling and down -regulation of PI3K/Akt pathway 显示文摘 | Dedoni S Olianas MC Onali P | 2010 | JNeurochem2010，115，6： | 1 |
| 13 | Small Bowel Capsule En- doscopy for Assessing Early Postoperative Recurrence of Crohn's Disease : A Prospective Longitudinal Study 显示文摘 | Condino G Calabrese E Onali S | 2012 | Gastroenterology2012，142，： | 1 |
| 14 | Effect of muscle lysosomal enzymes and calcium activated neutral proteinase on myofibtillar ATPase activity:relationship with agrag changes显示文摘 | Onali A Valin C | 1981 | Meat Science1981，5，： | 1 |
| 15 | The pharmacological action of MT-7 显示文摘 | Onali P Adem A Karlsson E | 2005 | Life Sci2005，76，14： | 1 |
| 16 | Frequency, Pattern, and Risk Factors of Postoperative Recurrence of Crohn’s Disease After Resection Different from Ileo-Colonic显示文摘 | Sara Onali Carmelina Petruzziello Emma Calabrese Giovanna Condino Francesca Zorzi Giuseppe Sigismondo Sica Francesco Pallone Livia Biancone | 2009 | Journal of Gastrointestinal Surgery2009，，2： | 1 |
| 17 | Are European equity markets efficient? New evidence from fractal analysis显示文摘 | Onali E Goddard J | 2011 | Physica A2011，20，18： | 1 |
| 18 | Anti-TNF-alpha treatments and obstructive symptoms in Crohn’s Disease: A prospective study显示文摘 | Giovanna Condino Emma Calabrese Francesca Zorzi Sara Onali Elisabetta Lolli Fabiola De Biasio Marta Ascolani Francesco Pallone Livia Biancone | 2012 | Digestive and Liver Disease2012，，： | 1 |
| 19 | Efficacy and safety of infliximab and adalimumab in Crohn's disease:a single centre study显示文摘 | Zorzi F Zuzzi S Onali S | 2012 | Aliment Pharmacol Ther2012，35，12： | 1 |
| 20 | PD102807, a novel muscarinic M4 receptor antagonist, discriminates between striatal and cortical muscarinic receptors coupled to cyclic AMP 显示文摘 | OLIANAS M C ONALI P | 1999 | Life Sci1999，65，21： | 1 |
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