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| 1 | Multidrug resistance 1 gene in inflammatory bowel disease: A meta-analysis显示文摘MDR1 基因是为煽动性的肠疾病(IBD ) 并且也许的致病的吸引人的候选人基因对治疗的反应,与在功能、基因的层次的证据。它的产品, P-glycoprotein (P-gp ) 作为因此影响许多药的布置和反应的 transmembrane 流出泵工作,一些(即 glucocorticoids ) 对 IBD 中央治疗。另外, P-gp 高度在许多上皮的表面被表示,包括的胃肠道(官方补给) 与在减少的一个通常认为的角色吸收内长或外毒素,并且也许主人细菌相互作用。MDR1 基因的许多基因变化被描述了,在为不同 P-gp 表示的一些例子证据,也,药新陈代谢被提供了。然而,数据经常由于采用的基因异质和不同方法论正在冲突。也许,在官方补给的道的 P-gp 的生理的重要性的证据的最大的片来自对老鼠建模的 mdr1 大美人的描述,它在特定的没有病原体的环境开发自发的大肠炎。学习调查到 IBD 的基因多型性和倾向也显示出冲突结果的 MDR1,由于在复杂疾病的已知的困难,特别当建议基因贡献是弱的时。在这研究,我们承担了在 IBD 与二 SNP 多型性(C3435T 和 G2677T/A ) 获得的可得到的调查结果的元分析;3435T 等位基因和 3435TT 遗传型的一个重要协会与 UC 被发现了(或 = 1.17, P = 0.003 并且或 = 1.36, P = 0.017,分别地) 。在对比,有 CD 和 G2677T/A 多型性的协会都不能被表明。 | V Annese MR Valvano O Palmieri A Latiano F Bossa A Andriulli | 2006 | World Journal of Gastroenterology2006，12，23： | 14 |
| 2 | Enteropathic spondyloarthropathy:A common genetic background with inflammatory bowel disease?显示文摘The association between spondyloarthropathy and in flammatory bowel disease(IBD) is largely established, although prevalence is variable because of different population selection and diagnostic methodologies.Most studies indicate that as many as 10%15% of cases of IBD are complicated by ankylosing spondylitis(AS) or other forms of spondylarthritis(SpA).Of note, ileal inflammation resembling IBD has been reported in up to two thirds of cases of SpA, and it has been suggested that the presence of ileitis is associated with the chronic ity of articular complications.Although this observation is of interest to unravel the pathophysiology of the disease, systematic screening of patients with SpA by ileocolonos copy is not indicated in the absence of gut symptoms, as only a small proportion of patients with subclinical gut inflammation will develop overt IBD over time.The existence of familial clustering of both IBD and AS, the coexistence of both conditions in a patient, the evidence of an increased risk ratio among f irstand seconddegree relatives of affected AS or IBD patients and f inally, the increased crossrisk ratios between AS and IBD, strongly suggest a shared genetic background.So far, however, IL23R is the only identified susceptibility gene shared by both IBD and AS.Although functional studies are still needed to better understand its pathogenic role, great ef fort is being spent therapeutically targeting this pathway that may prove effective for both disorders. | Elisabetta Colombo Anna Latiano Orazio Palmieri Fabrizio Bossa Angelo Andriulli Vito Annese | 2009 | World Journal of Gastroenterology2009，15，20： | 4 |
| 3 | Replication of interleukin 23 receptor and autophagy-related 16-like 1 association in adult-and pediatric-onset inflammatory bowel disease in Italy显示文摘AIM: To investigate gene variants in a large Italian inflammatory bowel disease (IBD) cohort, and to analyze the correlation of sub-phenotypes (including age at diagnosis) and epistatic interaction with other IBD genes. METHODS: Total of 763 patients with Crohn's disease (CD, 189 diagnosed at age < 19 years), 843 with ulcerative colitis (UC, 179 diagnosed <19 years), 749 healthy controls, and 546 healthy parents (273 trios) were included in the study. The rs2241880 [autophagy-related 16-like 1 (ATG16L1)], rs11209026 and rs7517847 [interleukin 23 receptor (IL23R)], rs2066844, rs2066845, rs2066847 (CARD15), rs1050152 (OCTN1), and rs2631367 (OCTN2) gene variants were genotyped. RESULTS: The frequency of G allele of ATG16L1 SNP (Ala197Thr) was increased in patients with CD compared with controls (59% vs 54% respectively) (OR = 1.25, CI = 1.08-1.45, P = 0.003), but not in UC (55%). The frequency of A and G (minor) alleles of Arg381Gln, rs11209026 and rs7517847 variants of IL23R were reduced significantly in CD (4%, OR = 0.62, CI = 0.45-0.87, P = 0.005; 28%, OR = 0.64, CI = 0.55-0.75, P < 0.01), compared with controls (6% and 38%, respectively). The A allele (but not G) was also reduced signifi cantly in UC (4%, OR = 0.69, CI = 0.5-0.94, P = 0.019). No association was demonstrated with sub-phenotypes and interaction with CARD15 , and OCTN1/2 genes, although both gene variants were associated with pediatric-onset disease. CONCLUSION: The present study confirms the association of IL23R polymorphisms with IBD, and ATG16L1 with CD, in both adult- and pediatric-onset subsets in our study population. | Anna Latiano Orazio Palmieri Maria Rosa Valvano Renata D'Incà Salvatore Cucchiara Gabriele Riegler Anna Maria Staiano Sandro Ardizzone Salvatore Accomando Gian Luigi de Angelis Giuseppe Corritore Fabrizio Bossa Vito Annese | 2008 | World Journal of Gastroenterology2008，14，29： | 3 |
| 4 | Ultraviolet spectra and electronic structure of salicylaldehyde azine 显示文摘 | Bossa M Sgamellotti A Gianturco F A | 1969 | J Chem Soc B1969，，： | 1 |
| 5 | OC.06.3 ADALIMUMAB IN ACTIVE ULCERATIVE COLITIS: A “REAL-LIFE” OBSERVATIONAL STUDY显示文摘 | A. Armuzzi L. Biancone M. Daperno A. Coli V. Annese S. Ardizzone P. Balestrieri F. Bossa F. Castiglione M. Cicala S. Danese R. D’Incà P. Dulbecco G. Feliciangeli W. Fries S. Genise P. Gionchetti S. Gozzi A. Kohn R. Lorenzetti M. Milla S. Onali A. Orlando | 2012 | Digestive and Liver Disease2012，，： | 1 |
| 6 | Single-drop fragmentation determines size distribution of raindrops显示文摘 | Villermaux E Bossa B | 2009 | Nature Physics2009，5，9： | 1 |
| 7 | Properties of the apoprotein and role for opper and zinc in protein conformation and enzyme activity of bovine superoxide dismutase显示文摘 | Rotilio G Calabrese L Bossa F | 1972 | Biochemistry1972，11，21： | 1 |
| 8 | PyMod: sequence similarity searches, multiple sequence-structure alignments, and homology modeling within PyMOL 显示文摘 | BRAMUCCI E PAIARDINI A BOSSA F | 2012 | BMC Bioinformatics2012，，13： | 1 |
| 9 | In vitro cell transformation assays for an integrated, alternative assessment of carcinogenicity: a data-based analysis显示文摘 | Benigni R Bossa C Tcheremenskaia O | 2013 | Mutagenesis2013，28，1： | 1 |
| 10 | Sequential evaluation of thiopurine methyltransferase,inosine triphosphate pyrophosphatase,and HPRT1 genes polymorphisms to explain thiopurines' toxicity and efficacy显示文摘 | Palmieri O Latiano A Bossa F | 2007 | Aliment Pharmacol Ther2007，26，5： | 1 |
| 11 | Solid-state methylamine VUV irradiation study using carbon monoxide as an Hradical scavenger显示文摘 | Bossa J B Borget F Duvernay F | 2012 | Australian Journal of Chemistry2012，65，2： | 1 |
| 12 | Primary structure of hemoglobin from trout (Salmo irideus):Amino acid sequence of alpha chain of Hbtrout I显示文摘 | Bossa F Barra D Petruzzelli R | 1978 | Biochim Biophys Aeta1978，536，1： | 1 |
| 13 | The response to stationary-phase stress conditions in Escherichia coli:role and regulation of the glutamic acid decarboxylase system显示文摘 | DE BIASE D TRAMONTI A BOSSA F et at | 1999 | Mol Microbiol1999，32，： | 1 |
| 14 | 1α,25-dihydroxy-vitamin D3 stimulation of bronchial smooth muscle cells induces autocrine, contractility, and remodeling processes 显示文摘 | Bossa Y Maghni K Hudson TJ | 2007 | Physiol Genomics2007，29，2： | 1 |
| 15 | DNA damage and repair in human cancer: molecular mechanisms andcontribution to therapy - related leukemias 显示文摘 | Casorelli I Bossa C Bignami M | 2012 | Environ Res Public Health2012，9，8： | 1 |
| 16 | Comparative structural analysis of psychrophilic and meso-and thermophilic enzymes显示文摘 | GIANESE G BOSSA F PASCARELLA S | 2002 | Proteins2002，47，： | 1 |
| 17 | Analyzing the effects of different soil databases on modeling of hydrological processes and sediment yield in Benin (West Africa) 显示文摘 | Bossa A Y Diekkruger B Igue A M | 2012 | Geoderma2012，173，： | 1 |
| 18 | Perivascular potassium and pH as determinates of local pial and arterial diameter in cats显示文摘 | Kuschinsky W Wahl M Bossa O | 1972 | Circulation Res1972，31，： | 1 |
| 19 | Structures of T-Ami- nobutyric Acid (GABA) Aminotransferase, a Pyridoxal 5a- Phosphate, and Cluster-containing Enzyme, Com- plexed with-Ethynyl-GABA and with the Antiepilepsy Drug Vigabatrin 显示文摘 | Storici P Biase D D Bossa F | 2004 | J Biol Chem2004，279，： | 1 |
| 20 | The response to stationary-phase stress conditions in Eschericha coli: role and regulation of the glutamic acid decarboxylase system显示文摘 | De Biase D Tramonti A Bossa F | 1999 | Mol Microbiol1999，32，： | 1 |
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