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您的检索式：作者名="Natalie Funakoshi"
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| 1 | Benefit of combination β-blocker and endoscopic treatment to prevent variceal rebleeding: A meta-analysis显示文摘AIM: To determine whether the association of β-blockers with endoscopic treatment is superior to endoscopic treatment alone for the secondary prophylaxis of oesophageal variceal bleeding. METHODS: Randomised controlled trials comparing sclerotherapy (SCL) with SCL plus β-blockers (BB) or banding ligation (BL) with BL plus BB were identif ied.Main outcomes were overall and 6, 12 and 24 mo rebleeding rates, as well as overall and 6, 12 and 24 mo mortality. Two statistical methods were used: Yusuf-Peto, and Der Simonian and Laird. Inter-trial heterogeneity was systematically taken into account. RESULTS: Seventeen randomised controlled trials were included, 14 with SCL and 3 with BL. Combination β-blocker and endoscopic treatment signif icantly reduced rebleeding rates at 6, 12 and 24 mo and overall [odds ratio (OR): 2.20, 95% conf idence interval (CI): 1.69-2.85, P<0.0001] compared to endoscopic treatment alone. Mortality at 24 mo was signif icantly lower for the combined treatment group (OR: 1.83, 95% CI:1.16-2.90, P= 0.009), as well as overall mortality (OR: 1.43, 95% CI:1.03-1.98, P= 0.03). CONCLUSION: Combination therapy should thus be recommended as the fi rst line treatment for secondary prophylaxis of oesophageal variceal bleeding. | Natalie Funakoshi Frédérique Ségalas-Largey Yohan Duny Frédéric Oberti Jean-Christophe Valats Michael Bismuth Jean-Pierre Daurès Pierre Blanc | 2010 | World Journal of Gastroenterology2010，16，47： | 24 |
| 2 | Hepatic encephalopathy: from pathophysiology to therapeutic management显示文摘 | Michael Bismuth Natalie Funakoshi Jean-Fran?ois Cadranel Pierre Blanc | 2011 | European Journal of Gastroenterology & Hepatology2011，，1： | 1 |
| 3 | Stricturing Crohn's disease-like colitis in a patient treated with belatacept显示文摘Cytotoxic T-lymphocyte-associated antigen 4(CTLA-4) modifying agents have been involved in the development of intestinal inflammation,especially therapeutic monoclonal antibodies directed against CTLA-4. Here we report the appearance of a severe stricturing Crohn's disease-like colitis in a patient with a kidney allograft who was treated with belatacept,a recombinant CTLA-4-Ig fusion protein. | Anne Bozon Guillaume Jeantet Benjamin Rivière Natalie Funakoshi Gaspard Dufour Roman Combes Jean-Christophe Valats Sylvie Delmas Jean Emmanuel Serre Michael Bismuth Jeanne Ramos Moglie Le Quintrec Pierre Blanc Guillaume Pineton de Chambrun | 2017 | World Journal of Gastroenterology2017，23，48： | 0 |
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