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| 1 | Effect of hepatic artery embolization on liver hypertrophy response in a rabbit liver VX2tumor model显示文摘BACKGROUND:Portal vein embolization not only induces hypertrophy of the non-embolized liver,but also enhances tumor growth.The latter could be prevented by embolizing the hepatic arteries supplying the tumor-bearing liver segments.This study aimed to determine the effects of transcatheter arterial embolization(TAE)on tumor volume and liver regeneration in a rabbit VX2 tumor model.METHODS:Twenty-three rabbits underwent subcapsular tumor implantation with a VX2 tumor.Two weeks after implantation,18 rabbits were used for TAE experiments,5were for sham controls.Tumor response and liver regeneration response of the embolized cranial and non-embolized caudal liver lobes were assessed by CT volumetry,liver to body weight index,and the amount of proliferating hepatocytes.RESULTS:All super-selective arterial tumor embolization procedures were performed successfully.Despite embolization,the tumor volume increased after an initial steady state.The tumor volume after embolization was smaller than that of the sham group,but this difference was not significant.Massive necrosis of the tumor,however,was seen after embolization,without damage of the surrounding liver parenchyma.There was a significant atrophy response of the tumor bearing cranial lobe after super-selective arterial embolization of the tumor with a concomitant hypertrophy response of the non-embolized,caudal lobe.This regeneration response was confirmed histologically by a significantly higher number of proliferating hepatocytes on the Ki-67 stained slides.CONCLUSIONS:Super-selective,bland arterial coil embolization causes massive necrosis of the tumor,despite increase of volume on CT scan.Atrophy of the tumor bearing liver lobe is seen after arterial embolization of the tumor with a concomitant hypertrophy response of the non-embolized lobe,despite absence of histological damage of the tumor-surrounding liver parenchyma. | Krijn P van Lienden Lisette T Hoekstra Jessica D van Trigt Joris J Roelofs Otto M van Delden Thomas M van Gulik | 2013 | Hepatobiliary & Pancreatic Diseases International2013，12，6： | 2 |
| 2 | Gut microbiota disturbance during antibiotic therapy: a multi-omic approach显示文摘 | Ana Elena Pérez-Cobas María José Gosalbes Anette Friedrichs Henrik Knecht Alejandro Artacho Kathleen Eismann Wolfgang Otto David Rojo Rafael Bargiela Martin von Bergen Sven C Neulinger Carolin D?umer Femke-Anouska Heinsen Amparo Latorre Coral Barbas Jana | 2013 | Gut2013，，11： | 2 |
| 3 | A 'region-growing' algorithm for matching of terrain images显示文摘 | OTTO G P CHAU T K W | 1989 | Image and Vision Computing1989，7，2： | 1 |
| 4 | Sampling properties of DNA sequence data in phylogenetic analysis显示文摘 | CUMM1NGS M P OTTO S P WAKELEY J | 1995 | Mol Bio Evol1995，12，81： | 1 |
| 5 | 'Region-growing” algorithm for matching of terrain images显示文摘 | Otto G P Chau T K W | | 0，，02： | 1 |
| 6 | Multiple facets of altruism and their influence on blood donation 显示文摘 | Otto P E Bolle F | 2011 | The Journal of Socio-Eco- nomics2011，40，5： | 1 |
| 7 | Modutar product architecture显示文摘 | DAHMUS J B GONZALEZ-ZUGASTI J P OTTO K N | 2001 | Design Studies2001，22，5： | 1 |
| 8 | Combined biological and chemical treatment of highly concentrated residual dyehouse liquors显示文摘 | KRULL R HEMMI M OTTO P | 1998 | Water Sci Technol1998，38，4： | 1 |
| 9 | Release characteristics of cardic biomarkers and ischemia-modified albumin as measured by the albumin cobalt-binding test after a marathon race显示文摘 | APPLE F S QUIST H E OTTO A P | 2002 | Clin Chem2002，48，7： | 1 |
| 10 | Sigmoid sinus diverticulum: a new surgical approach to the correction of pulsatile tinnitus显示文摘 | OTTO K J HUDGINS P A ABDELKAFY W | 2007 | Otol Neurotol2007，28，： | 1 |
| 11 | Evidence of interspeciestransmission and reassortment among avian group A rotaviruses 显示文摘 | Schumann T Hotzel H Otto P | 2009 | Virology2009，386，2： | 1 |
| 12 | Sensitization of capsaicin and icilin responses in oxaliplatin treated adult rat DRG neurons显示文摘 | ANAND U OTTO W R ANAND P | 2010 | Mol Pain2010，6，： | 1 |
| 13 | Minimised gear lubrica-tion by a minimum oil/air flow rate显示文摘 | Hohn B R Michaelis K Otto H P | 2009 | Wear2009，266，34： | 1 |
| 14 | Release characteristics of cardiac biomarkers and ischemia-modified albumin as measured by the albumin cobalt-binding test after a Marathon race显示文摘 | Apple F S Quist H E Otto A P | 2002 | Clin Chem2002，48，7： | 1 |
| 15 | The effect of normalization in reducing variability in regional wall thickening显示文摘 | YANG P OTTO CM SHEEHAN FH | 1997 | J Am Soc Echocardiogr1997，10，3： | 1 |
| 16 | A method for architecting product platforms显示文摘 | GONZALER-ZUGASTI J P OTTO K N BAKER J D | 2000 | Research in Engineering Deslgn2000，12，2： | 1 |
| 17 | Gender differences in stage-adjusted bladder cancer survival显示文摘 | N.Aydin Mungan Katja K.H Aben Mark P Schoenberg Otto Visser Jan-Willem W Coebergh J.Alfred Witjes Lambertus A.L.M Kiemeney | 2000 | Urology2000，，6： | 1 |
| 18 | Preoperative exercise capacity in adult inflammatory bowel disease sufferers,determined by cardiopulmonary exercise testing显示文摘 | Otto J M O'Doherty A F Hennis P J | 2012 | Int J Colorectal Dis2012，27，11： | 1 |
| 19 | 查看详情显示文摘 | Renker C Otto P Schneider K | | 0，，： | 1 |
| 20 | Imaging of Inflammation by PET, Conventional Scintigraphy, and Other Imaging Techniques显示文摘 | Gotthard Martin Bleeker-Rovers Chantal P Boerman Otto C Oyen Wim JG | 2010 | The Journal of Nuclear Medicine2010，，： | 1 |
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