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| 1 | Anti-malaria drug chloroquine is highly effective in treating avian influenza A H5N1 virus infection in an animal model显示文摘 | Yiwu Yan Zhen Zou Yang Sun Xiao Li Kai-Feng Xu Yuquan Wei Ningyi Jin Chengyu Jiang | 2013 | Cell Research2013，23，2： | 36 |
| 2 | Angiotensin II receptor blocker as a novel therapy in acute lung injury induced by avian influenza A H5N1 virus infection in mouse显示文摘Dear Editor,Since the first recognized case of human infection with avian influenza H5N1 virus in 1997,the worldwide spread and re-emergence of this highly pathogenic influenza virus have led to 694 human infection cases.Of these cases,402died from 2003 to 2015(http://gffzz36b398b81f8a4a4chvwfufb0xoxpw6uow.ffgz.tsg.suse.edu.cn/influenza/humananimalinterface/ENGIP20150106CumulativeNumber H5N1cases.pdf?ua=1),with a morbidity rate | YAN YiWu LIU Qiang LI Ning DU JianChao LI Xiao LI Chang JIN NingYi JIANG ChengYu | 2015 | Science China(Life Sciences)2015，58，2： | 12 |
| 3 | Multi-functional stretchable and flexible sensor array to determine the location, shape, and pressure: Application in a smart robot显示文摘The rapid increase in the aging population prompts the development of wearable devices and sophisticated robots. With their ability to collect complex information about their surroundings via e-skins, robots could perform more dynamic and variable tasks such as rescue missions or caring for the elderly. In this paper, we present a new concept of utilizing a very simple, highly flexible and stretchable capacitor sensor array, that can be attached on the surface of a retractable robot hand to realize three functions: determining the location, shape, and pressure of an object. This adaptive sensing system is accomplished using capacitors connected by aligned carbon nanotube(CNT) films constructed on an elastomer dielectric material, which can reduce the requirement on the accuracy of the machine vision system. This study has a very broad application in the manufacture of intelligent software robots. | HAN LiBiao DING JianNing WANG Shuai XU Jiang YUAN NingYi CHENG GuangGui LIU ZunFeng | 2018 | Science China(Technological Sciences)2018，61，8： | 9 |
| 4 | Construction and anti-tumor effects of recombinant fowlpox virus expressing Newcastle disease virus hemagglutinin-neuramidinase gene显示文摘Hemagglutinin-neuramidinase (HN ) ,纽卡斯尔疾病导出病毒的蛋白质,不是仅仅调停受体识别而且拥有 neuraminidase (NA ) 活动,劈开那些受体的一个部件的能力, N-acetylneuraminic 酸(NAcneu, sialic ) 。包括人,在哺乳动物的种类的这蛋白质有有趣的反肿瘤以及有免疫力的刺激性质,这被知道。在癌症基因治疗探索 HN 基因的使用,我们构造了表示 HN 蛋白质(vFV-HN ) 的一个 recombinant 家禽痘病毒并且在 vivo 并且在 vitro 把 recombinant 病毒的 theanti 肿瘤活动与野类型的家禽痘病毒(FPV ) 的作比较。这里,我们发现尽管 B16 房间对野类型的家禽痘病毒的基础细胞毒素的效果有点抵抗,有 vFV-HN 的感染引起了显著细胞毒素的效果并且,与 vFV-HN 使免疫的忍受肿瘤的老鼠的幸存显著地与独自与 FPV 使免疫的老鼠的幸存相比被增加。而且,有 vFV-HNelicited 的老鼠的免疫 B16 肿瘤特定的细胞毒素的 T 淋巴细胞(CTL ) 回答和在 vivo 的 bothCD4+ 和 CD8+ T 房间人口的同种细胞的扩大。另外,从老鼠的淋巴节点的 T 房间种牛痘, Th1 cytokine IL-2 和 IFN-v 高级的 vFV-HN 藏匿了,显示肿瘤房间的回归与 Th1 类型主导的有免疫力的回答有关。这些结果证明有 vFV-HN 的种痘可以是为癌症基因治疗的潜在的策略。 | LI Xiao JIN Ningyi LIAN Hai GUAN Goufang SUN Lili LI Xue mei ZHENG Hongling | 2006 | Chinese Science Bulletin2006，51，22： | 9 |
| 5 | Immunogenicity analysis following human immunodeficiency virus recombinant DNA and recombinant vaccinia virus Tian Tan prime-boost immunization显示文摘This study assessed and compared the immunogenicity of various immunization strategies in mice using combinations of recombinant DNA(pCCMp24) and recombinant attenuated vaccinia virus Tian Tan(rddVTT-CCMp24).Intramuscular immunization was performed on days 0(prime) and 21(boost).The immunogenicity of the vaccine schedules was determined by measuring human immunodeficiency virus(HIV)-specific binding antibody levels and cytokine(interleukin-2 and interleukin-4) concentrations in peripheral blood,analyzing lymphocyte proliferation capacity against HIV epitopes and CD4 + /CD8 + cell ratio,and monitoring interferon-gamma levels at different times post-immunization.The results showed that pCCMp24,rddVTT-CCMp24 and their prime-boost immunization induced humoral and cellular immune responses.The pCCMp24/rddVTT-CCMp24 immunization strategy increased CD8 + T cells and induced more IFN-γ-secreting cells compared with single-shot rDNA.The prime-boost immunization strategy also induced the generation of cellular immunological memory to HIV epitope peptides.These results demonstrated that prime-boost immunization with rDNA and rddVTT-CCMp24 had a tendency to induce greater cellular immune response than single-shot vaccinations,especially IFN-γ response,providing a basis for further studies. | LIU CunXia DU ShouWen LI Chang WANG YuHang WANG MaoPeng LI Yi YIN RongLan LI Xiao REN DaYong QIN YanQing REN JingQiang JIN NingYi | 2013 | Science China(Life Sciences)2013，56，6： | 7 |
| 6 | Tauroursodeoxycholic acid(TUDCA) inhibits influenza A viral infection by disrupting viral proton channel M2显示文摘Influenza is a persistent threat to human health and there is a continuing requirement for updating antiinfluenza strategies. Initiated by observations of different endoplasmic reticulum(ER) responses of host to seasonal H1N1 and highly pathogenic avian influenza(HPAI) A H5N1 infections, we identified an alternative antiviral role of tauroursodeoxycholic acid(TUDCA), a clinically available ER stress inhibitor, both in vitro and in vivo. Rather than modulating ER stress in host cells, TUDCA abolished the proton conductivity of viral M2 by disrupting its oligomeric states, which induces inefficient viral infection. We also showed that M2 penetrated cells, whose intracellular uptake depended on its proton channel activity,an effect observed in both TUDCA and M2 inhibitor amantadine. The identification and application of TUDCA as an inhibitor of M2 proton channel will expand our understanding of IAV biology and complement current anti-IAV arsenals. | Ning Li Yanxu Zhang Shuangxiu Wu Ruodan Xu Zhiqing Li Jindong Zhu Hongliang Wang Xiao Li Mingyao Tian Huijun Lu Ningyi Jin Chengyu Jiang | 2019 | Science Bulletin2019，64，3： | 6 |
| 7 | Molecular and serological surveillance of Getah virus in the Xinjiang Uygur Autonomous Region,China,2017–2020显示文摘The Getah virus(GETV),a mosquito-borne RNA virus,is widely distributed in Oceania and Asia.GETV is not the only pathogenic to horses,pigs,cattle,foxes and boars,but it can also cause fever in humans.Since its first reported case in Chinese mainland in 2017,the number of GETV-affected provinces has increased to seventeen till now.Therefore,we performed an epidemiologic investigation of GETV in the Xinjiang region,located in northwestern China,during the period of 2017-2020.ELISA was used to analyze 3299 serum samples collected from thoroughbred horse,local horse,sheep,goat,cattle,and pigs,with thoroughbred horse(74.8%),local horse(67.3%),goat(11.7%),sheep(10.0%),cattle(25.1%)and pigs(51.1%)being positive for anti-GETV antibodies.Interestingly,the neutralizing antibody titer in horses was much higher than in other species.Four samples from horses and pigs were positive for GETV according to RT-PCR.Furthermore,from the serum of a local horse,we isolated GETV which was designated as strain XJ-2019-07,and determined its complete genome sequence.From the phylogenetic relationships,it belongs to the Group III lineage.This is the first evidence of GETV associated to domestic animals in Xinjiang.Overall,GETV is prevalent in Xinjiang and probably has been for several years.Since no vaccine against GETV is available in China,detection and monitoring strategies should be improved in horses and pigs,especially imported and farmed,in order to prevent economic losses. | Ning Shi Xiangshu Qiu Xinyu Cao Zhanhai Mai Xiangyu Zhu Nan Li He Zhang Jinyong Zhang Zhuoxin Li Nuerlan Shaya Huijun Lu Ningyi Jin | 2022 | Virologica Sinica2022，37，2： | 5 |
| 8 | Fabrication and tribological properties of superhydrophobic nickel films with positive and negative biomimetic microtextures显示文摘Nickel(Ni)films with positive and negative textured surfaces of lotus and rice leaf patterns were fabricated through an inexpensive and effective method.The as-prepared Ni films were superhydrophobic and exhibited excellent tribological properties after chemical treatment.Experimental results indicated that the water contact angles(WCAs)on the surfaces of biomimetic textured Ni films(approximately 120°)were far greater than those on smooth films(65°).The biomimetic textured surfaces became superhydrophobic(WCA of approximately 150°)after perfluoropolyether(PFPE)treatment,which could be due to the combined effects of the special texture and the PFPE.The as-prepared biomimetic-textured Ni films modified with PFPE were improved with a low friction coefficient and excellent antiwear properties,which were due to the combination of the effective lubrication of PFPE and the special textures that served as a good lubricant and a debris reservoir.Moreover,the antiwear properties of the as-prepared Ni films with negative biomimetic microtextures modified with PFPE were much better than those of films with positive biomimetic microtextures modified with PFPE. | Ying WANG Jing YANG Xiaobao GUO Qiang ZHANG Jingyu WANG Jianning DING Ningyi YUAN | 2014 | Friction2014，2，3： | 4 |
| 9 | Cell Stem Cell:利用干细胞制造出的心肌细胞有助精准心血管医疗取得进展显示文摘在一项新的研究中。来自美国斯坦福大学医学院的研究人员发现利用人诱导性多能干细胞(iPS细胞)制造的心肌细胞忠实地反映供者天然的心脏组织中关键基因的表达模式。因此,这些细胞能够被用来预测病人是否可能经历药物相关的心脏损伤。相关研究结果在线发表在Cell Stem Cell期刊上。论文标题为"Transcriptome Profiling of Patient -Specific Human iPSC - ardiomyocytes Predicts Individual Drug Safety and Efficacy Responses In Vitro". | Elena Matsa Paul W. Burridge Kun-Hsing Yu John H. Ahrens Vittavat Termglinchan Haodi Wu Chun Liu Praveen Shukla Nazish Sayed Jared M. Churko Ningyi Shao Nicole A. Woo Alexander S. Chao Joseph D. Gold Ioannis Karakikes Michael P. Snyder Joseph C. Wu | 2016 | 现代生物医学进展2016，0，32： | 4 |
| 10 | Chimeric Newcastle Disease Virus-like Particles Containing DC-Binding Peptide-Fused Haemagglutinin Protect Chickens from Virulent Newcastle Disease Virus and H9N2 Avian Influenza Virus Challenge显示文摘Newcastle disease virus(NDV)and H9N2 subtype Avian influenza virus(AIV)are two notorious avian respiratory pathogens that cause great losses in the poultry industry.Current inactivated commercial vaccines against NDV and AIV have the disadvantages of inadequate mucosal responses,while an attenuated live vaccine bears the risk of mutation.Dendritic cell(DC)targeting strategies are attractive for their potent mucosal and adaptive immune-stimulating ability against respiratory pathogens.In this study,DC-binding peptide(DCpep)-decorated chimeric virus-like particles(cVLPs),containing NDV haemagglutinin–neuraminidase(HN)and AIV haemagglutinin(HA),were developed as a DC-targeting mucosal vaccine candidate.DCpep-decorated cVLPs activated DCs in vitro,and induced potent immune stimulation in chickens,with enhanced secretory immunoglobulin A(sIgA)secretion and splenic T cell differentiation.40μg cVLPs can provide full protection against the challenge with homologous,heterologous NDV strains,and AIV H9N2.In addition,DCpep-decorated cVLPs could induce a better immune response when administered intranasally than intramuscularly,as indicated by robust s IgA secretion and a reduced virus shedding period.Taken together,this chimericVLPs are a promising vaccine candidate to control NDV and AIV H9N2 and a useful platform bearing multivalent antigens. | Xiaohong Xu Jing Qian Lingsong Qin Jindou Li Cong Xue Jiaxin Ding Weiqi Wang Wei Ding Renfu Yin Ningyi Jin Zhuang Ding | 2020 | Virologica Sinica2020，35，4： | 4 |
| 11 | Metabolism-independent chemotaxis of Pseudomonas sp. strain WBC-3 toward aromatic compounds显示文摘Pseudomonas sp. strain WBC-3 utilized methyl parathion or para-nitrophenol (PNP) as the sole source of carbon, nitrogen, and energy, and methyl parathion hydrolase had been previously characterized. Its chemotactic behaviors to aromatics were investigated. The results indicated that strain WBC-3 was attracted to multiple aromatic compounds, including metabolizable or transformable substrates PNP, 4-nitrocatechol, and hydroquinone. Disruption of PNP catabolic genes had no e?ect on its chemotactic behaviors with the same substrates, indicating that the chemotactic response in this strain was metabolism-independent. Furthermore, it was shown that strain WBC-3 had a constitutive β-ketoadipate chemotaxis system that responded to a broad range of aromatic compounds, which was different from the inducible β-ketoadipate chemotaxis described in other Pseudomonas strains. | ZHANG, Junjie XIN, Yufeng LIU, Hong WANG, Shujun ZHOU, Ningyi | 2008 | Journal of Environmental Sciences2008，20，10： | 3 |
| 12 | Anti-solvent engineering for efficient semitransparent CH3NH3PbBr3 perovskite solar cells for greenhouse applications显示文摘With ideal combination of benefits that selectively converts high photon energy spectrum into electricity while transmitting low energy photo ns for photos yn thesis,the CH3NH3PbBr3 perovskite solar cell(BPSC)is a promising candidate for efficient greenhouse based building integrated photovoltaic(BIPV)applications.However,the efficiency of BPSCs is still much lower than their theoretical efficiency.In general,interface band alignment is regarded as the vital factor of the BPSCs whereas only few reports on enhancing perovskite film quality.In this work,highly efficient BPSCs were fabricated by improving the crystallization process of CH3NH3PbBr3 with the assistance of anti-solvents.A new anti-solvent of diphenyl ether(DPE)was developed for its strong interaction with the solvents in the perovskite precursor solution.By using the anti-solvent of DPE,trap-state density of the CH3NH3PbBr3 film is reduced and the electron lifetime is enhanced along with the large-grain crystals compared with the samples from conventional anti-solvent of chlorobenzene.Upon preliminary optimization,the efficiencies of typical and semitransparent BPSCs are improved to as high as 9.54%and 7.51%,respectively.Optical absorption measurement demonstrates that the cell without metal electrode shows 80%transparency in the wavelength range of 550-1000 nm that is perfect for greenhouse vegetation.Considering that the cell absorbs light in the blue spectrum before 550 nm,it offers very high solar cell efficiency with only 17.8%of total photons,while over 60%of total photons can transm让through for photosynthesis if a transparent electrode can be obtained such as indium doped SnO2. | Waqas Siddique Subhani Kai Wang Minyong Du Xiuli Wang Ningyi Yuan Jianning Ding Shengzhong(Frank)Liu | 2019 | Journal of Energy Chemistry2019，28，7： | 3 |
| 13 | Immune responses of a designed HIV-1 DNA vaccine on rhesus monkeys显示文摘An effective HIV-1 vaccine will be the ultimate solution for the prevention of HIV/AIDS, though HAART plays important roles in treating the disease. In this study, a large-scale recombinant DNA plasmid containing a designed HIV-1 multi-epitope- p24 chimeric gene was prepared and purified. Rhesus monkeys were then inoculated muscularly with the plasmid for four times in week 0, 4, 8 and 18. Whole blood was collected two weeks after the third and fourth inoculation, followed by serum and pe- ripheral blood mononuclear cell (PBMC) separation. The CTL activity and proliferation of PBMCs stimu- lated by macaque MHC-I-restricted HIV-1 CTL epi- tope peptide were analyzed by MTT and LDH release assay, respectively. Th1 cytokines in supernatant of cultured PBMC stimulated by HIV-1 CTL epitope peptide and anti-HIV-1 antibody in serum were as- sayed by ELISA. The results showed that increased CTL target-killing activity, higher secretion of Th1 cytokines (IFN-γ and IL-2) and promoted proliferative reaction of monkey PBMCs stimulated by HIV-1 CTL epitope peptide were detected in the immunization group inoculated by the recombinant DNA vaccine for three times, which were further enhanced by the fourth inoculation. At the same time, HIV-1 specific antibody in serum of immunized monkeys was higher than that in controls. We concluded that the designedHIV-1 DNA vaccine may induce HIV-1 specific cellular and humoral immunity on monkeys. | ZHANG Lishu JIN Ningyi SONG Yingjin SUN Yansong WANG Hong ZHAN Dawei MA Hewen SHANG Yupu JIN Hongtao HONG Baoqing LI Chang | 2006 | Chinese Science Bulletin2006，51，13： | 3 |
| 14 | A newly defined dioxygenase system from Mycobacterium vanbaalenii PYR-1 endowed with an enhanced activity of dihydroxylation of high-molecular-weight polyaromatic hydrocarbons显示文摘NidA3B3 is a terminal dioxygenase whose favorable substrates are high-molecular-weight polyaromatic hydrocarbons(PAHs)from Mycobacterium vanbaalenii PYR-1,a powerftil PAHs degradation strain.NidA3B3 was reported to incorporate a dioxygen into the benzene ring of PAHs when equipped with an exogenous electron transport chain components PhdCD from Nocarciioides sp.strain KP7 by biotransformation,but this enzyme system was not particularly efficient.In this study,strain PYR-1 was confirmed to utilize four different PAHs at different growth rates.When PhtAcAd,an endogenous electron transport chain of a phthalate dioxygenase system,was substituted for PhdCD to couple with NidA3B3,the specific activity to convert phenanthrene by strain BL21(DE3)[pNidA3B3-PhAcAd]was 0.15±0.03 U/mg,but the specific activity of strain BL21(DE3)[pNidA3B3-PhdCD]was only 0.025±0.006U/mg.In addition,FNidA3,encoded by a newly defined ORF,has a prolonged 19-amino acid sequence at the N-terminus compared with NidA3.FNidA3B3 increased the activity by 50%approximately than NidA3B3 when using PhtAcAd.Components of the electron transport chain PhtAc and PhtAd were purified and characterized.The Km,kcal,kcat/Km values of the PhtAd were 123±26.9 pM,503±49.9 min^-1,4.1μM^-1·min^-1,respectively.And the,Km,Kcat,Kcat/Km values of the ferredoxin PhtAc were (52.5±9.7)μM,3.8±0.19min^-1 and 0.07μM^-1 min1,respectively.Basing on the phylogenetic analysis,NidA3/FNidA3 were far from its isoenzyme NidA from the same strain.Combining their primary differences of transcriptional pattern in vivo,it indicated that the functionally similar Rieske dioxygenases NidA3B3/FNidA3B3 and NidAB might originate from different ancestors. | Yiquan Wu Ying Xu Ningyi Zhou | 2020 | Frontiers of Environmental Science & Engineering2020，14，1： | 2 |
| 15 | The associated killing of hepatoma cells using multilayer drug-loaded mats combined with fast neutron therapy显示文摘Chemotherapeutic and radiation therapy have emerged as two most important treatment strategies to treat cancer in clinical practice;however,to improve anticancer efficacy,combination chemotherapy still remains challenge.Dichloroacetate(DCA)could produce significant cytotoxic effects in certain tumor cells through its distinct mechanism.Radiation therapy with fast neutrons(FNT)has high relative biolgical effectiveness compared to other radiotherapeutics.Herein,we reported the combination chemotherapy with FNT for effective tumor growth inhibition with the assistance of a multilayered nanofiber loading DCA and DCA derivatives.We first synthesized a biodegradable polylysine to condense DCA with negative charge,or to conjugate DCA by condensing synthesis,to obtain Ion-DCA and Co-DCA,respectively.DCA,Ion-DCA or Co-DCA was then loaded into fibers to form multilayer drug-loaded mats.Upon adhesion on the surface of subcutaneous and orthotopic liver tumors,the multilayer drug-loaded mats realized a controllable release of DCA,which reversed the Warburg effect and inhibited cancer cell proliferation.Meantime,irradiation of fast neutrons could seriously damage DNA structure.Combination of the controllable release of DCA and FNT resulted in synergistic cell apoptosis in vitro,and the tumor inhibition in vivo.This study thus provides a new approach to integrate chemotherapy and FNT with the assistance of biocompatible nanofiber for synergistic tumor therapy. | Yanxin Qi Shiwei Jing Shasha He Hejian Xiong Guohua Yang Yubin Huang Ningyi Jin | 2021 | Nano Research2021，14，3： | 2 |
| 16 | Immune responses of pigs inoculated with a recombinant fowlpox virus coexpressing GP5/GP3 of porcine reproductive and respiratory syndrome virus and swine IL-18显示文摘 | Guoshun Shen Ningyi Jin Mingxiao Ma Kuoshi Jin Min Zheng Tianzhong Zhuang Huijun Lu Guangze Zhu Hongtao Jin Minglan Jin Xiaowei Huo Xiaoguang Qin Ronglan Yin Chang Li Hongwen Li Yang Li Zhenzhen Han Yifeng Chen Miaomiao Jin | 2007 | Vaccine2007，，21： | 2 |
| 17 | Efficacy of seasonal pandemic influenza hemagglutinin DNA vaccines delivered by electroporation against aseasonal H1N1 virus challenge in mice显示文摘Prophylactic DNA vaccines against the influenza virus are promising alternatives to conventional vaccines.In this study,we generated two candidate gene-based influenza vaccines encoding either the seasonal or pandemic hemagglutinin antigen(HA) from the strains A/New Caledonia/20/99(H1N1)(pV1A5) and A/California/04/2009(H1N1)(pVEH1) ,respectively.After verifying antigen expression,the immunogenicity of the vaccines delivered intramuscularly with electroporation was tested in a mouse model.Sera of immunized animals were tested in hemagglutination inhibition assays and by ELISA for the presence of HA-specific antibodies.HA-specific T-cells were also measured in IFN-γELISpot assays.The protective efficacy of the candidate influenza vaccines was evaluated by measuring mortality rates and body weight after a challenge with 100 LD50 of mouse-adapted A/New Caledonia/20/99(H1N1) .Mice immunized with either one of the two vaccines showed significantly higher T cell and humoral immune responses(P<0.05) than the pVAX1 control group.Additionally,the pV1A5 vaccine effectively protected the mice against a lethal homologous mouse-adapted virus challenge with a survival rate of 100%compared with a 40%survival rate in the pVEH1 vaccinated group(P<0.05) .Our study indicates that the seasonal influenza DNA vaccine completely protects against the homologous A/New Caledonia/20/99 virus(H1N1) ,while the pandemic influenza DNA vaccine only partially protects against this virus. | TAN Lei LU HuiJun ZHANG Dan WANG KaiYan TIAN MingYao LIU CunXia LIU YanYu HU Bo JIN NingYi | 2011 | Science China(Life Sciences)2011，54，4： | 2 |
| 18 | Failure characteristics of Ag-SnO_2 contact material in AC level显示文摘The failure characteristics of the contact material Ag-SnO2 were investigated by X-ray diffraction(XRD),scanning electron microscopy(SEM),and X-ray energy dispersive spectroscopy(EDS).Phase analysis showed that there were Ag,SnO2,and Sn on the contact surfaces at the time of failure under the load condition of 30 A and 220 V(AC),which means that SnO2 decomposed in service.When the contacts were tested under airproof ambient condition,half-spherical bulges came into being on the contact surfaces,which resulted in early failure and dispersive characteristics.But half-spherical bulges were not found when the contacts were tested under open ambient condition.The temperature change of the contacts during the life testing under airproof ambient condition was different from that under open ambient condition. | MENG Fanbin LU Jianguo ZHU Yongqing LU Ningyi CHEN Zhichao HUANG Qiutao | 2008 | Rare Metals2008，27，1： | 2 |
| 19 | The value of bone scintigraphy on the determination of the full extent of tumor involvement in jaw bones显示文摘目的将有希望地在在颌骨决定肿瘤参与的最大程度上调查骨头 scintigraphy 的价值并且估计转移的存在。这研究有本地道德的委员会赞同的方法,和所有病人给了写的知情同意。有在颌骨的主要恶性瘤的三十七个连续病人为学习被招募。骨头 scintigraphy 在外科前在所有病人被执行测量多骨的参与的最大程度,它与 histologic 调查结果相比。结果全部身体扫描与多重多骨的转移揭示了一个案例。36 个骨头瘤的切除术标本病理地被分析识别每个肿瘤的类型和尺寸。在骨头 scintigraphy 和病理定义的颌骨的肿瘤参与的长度是 5.62 ± 1.58 厘米, 4.48 ± 1.57 厘米,分别地(P <
0.05 ) 。从移开的标本的肿瘤 negative 边缘病理地根据骨头 scintigraphy 被证实。与是的 histologic 调查结果参考的标准,骨头 scintigraphy 的精确性在在颌骨决定肿瘤参与的最大程度是 100%(36 个病人中的 36 个) 。当完全清除肿瘤房间并且每当可能时,保存功能时,结论骨头 scintigraphy 趋于在决定骨头切除术的适当程度提供特定的指南并且在建立多骨的转移。 | Jiawei Xie Chao Ma Guoming Wang Shuyao Zuo Ningyi Li Muyun Jia | 2009 | The Chinese-German Journal of Clinical Oncology2009，8，1： | 2 |
| 20 | Rapidly developable therapeutic-grade equine immunoglobulin against the SARS-CoV-2 infection in rhesus macaques显示文摘Dear Editor,The unprecedented COVID-19 pandemic caused by SARS-CoV-2 remains ongoing,but there is a lack of fully effective treatments.Convalescent plasma-derived hyperimmune globulins have been a safe and effective treatment but restricted by the difficulties in obtaining sufficient plasma with high antibody titers from a large number of recovered patients.Heterologous antibodies,particularly equine antibodies,have been widely used for decades as the therapeutics against some viral infections or as antivenoms.1 Equine antibodies could be rapidly developed and manufactured into therapeutic antibodies in large quantities under WHO standardized guidelines.Here we explored the development of equine antibody-derived F(ab′)2 as an option to treat COVID-19 by targeting the receptor-binding domain(RBD)of the viral spike protein that is essential for the viral entry into the host cells.2 We observed excellent neutralization titers of the F(ab′)2 in vitro and high potency against SARS-CoV-2 infection in the nonhuman primate rhesus macaques. | Xiaolei Liu Yi Liu Xuemin Jin Zhanlong He Zhen Huang Shumin Sun Yuwei Gao Jingyu Li Qin Ning Zhongping Xie Ningyi Jin Mingyuan Liu | 2022 | Signal Transduction and Targeted Therapy2022，7，8： | 2 |
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