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| 1 | Isolation and initial characterization of GW5, a major QTL associated with rice grain width and weight显示文摘谷物重量是庄稼谷物产量的一个主要决定因素并且被自然地发生的量的特点 loci (QTL ) 控制。我们更早识别了控制米饭谷物宽度和重量的主要 QTL, GW5,它在米饭染色体 5 上被印射到一个再结合热点。获得 GW5 怎么控制米饭谷物宽度的更好的理解,我们进行了这个地点的好印射并且揭开在米饭栽培变种 Asominori 与增加的谷物宽度联系的 1 212-bp 删除,与苗条谷物米饭 IR24 比较。另外, 46 米饭栽培变种的 genotyping 分析表明这删除高度与谷物宽度显型被相关,建议 GW5 删除可能在米饭驯服期间被选择了。GW5 编码对原子核局部性的 144 氨基酸的新奇原子蛋白质。而且,我们证明 GW5 身体上在酵母与 polyubiquitin 交往二混血儿的试金。一起,我们的结果建议 GW5 代表主要 QTL 内在的米饭宽度和重量,并且它多半在 ubiquitin-proteasome 小径行动在种子开发期间调整房间分割。这研究提供新奇卓见进控制米饭谷物开发的分子的机制并且建议 GW5 能为庄稼的产量很高的繁殖用作一个潜在的工具。 | Jianfeng Weng Suhai Gu Xiangyuan Wan He Gao Tao Guo Ning Su Cailin Lei Xin Zhang Zhijun Cheng Xiuping Guo Jiulin Wang Ling Jiang Huqu Zhai Jianmin Wan | 2008 | Cell Research2008，18，12： | 248 |
| 2 | Programmable time-domain digital-coding metasurface for non-linear harmonic manipulation and new wireless communication systems显示文摘Optical non-linear phenomena are typically observed in natural materials interacting with light at high intensities, and they benefit a diverse range of applications from communication to sensing. However,controlling harmonic conversion with high efficiency and flexibility remains a major issue in modern optical and radio-frequency systems. Here, we introduce a dynamic time-domain digital-coding metasurface that enables efficient manipulation of spectral harmonic distribution. By dynamically modulating the local phase of the surface reflectivity, we achieve accurate control of different harmonics in a highly programmable and dynamic fashion, enabling unusual responses, such as velocity illusion. As a relevant application, we propose and realize a novel architecture for wireless communication systems based on the time-domain digital-coding metasurface, which largely simplifies the architecture of modern communication systems, at the same time yielding excellent performance for real-time signal transmission. The presented work, from new concept to new system, opens new pathways in the application of metamaterials to practical technology. | Jie Zhao Xi Yang Jun Yan Dai Qiang Cheng Xiang Li Ning Hua Qi Jun Chen Ke Guo Dong Bai Shuo Liu Shi Jin Andrea Alù Tie Jun Cui | 2019 | National Science Review2019，6，2： | 46 |
| 3 | Cardiomyocyte overexpression of miR-27b induces cardiac hypertrophy and dysfunction in mice显示文摘最近的研究开始在心脏的肥大和机能障碍的致病揭示了 microRNAs (miRNAs ) 的关键角色。在这研究,我们测试了是否转变生长 factor-β(TGF-β) 调整 miRNA 在心脏的肥大和心失败(HF ) 的发展起了一个枢轴的作用。我们观察到 miR-27b 是在 cardiomyocyte 特定的 Smad4 猛烈老鼠的心的 upregulated,它开发了心脏的肥大。在 vitro,实验证明 miR-27b 表示能被 TGF-β 禁止; 1 并且它的 overexpression 支持了 hypertrophic 房间生长,当 miR-27b 抑制导致了 hypertrophic 房间的抑制时,生长由 phenylephrine (PE ) 引起了处理。而且,有 miR-27b 的 cardiomyocyte 特定的 overexpression 的转基因的老鼠的分析表明 miR-27b overexpression 是足够的导致心脏的肥大和机能障碍。我们验证了 peroxisome 激活 proliferator 的 receptor-γ(PPAR-γ) 作为在 cardiomyocyte 的 miR-27b 的一个直接目标。一致地, miR-27b 转基因的老鼠显著地显示了 PPAR-γ 的底层;比控制鼠标。而且,在用在一只 pressure-overload-induced 老鼠的特定的 antagomir 的 miR-27b 的 vivo silencing, HF 的模型增加了心脏的 PPAR-γ表示,稀释心脏的肥大和机能障碍。我们的学习的结果表明那 TGF-β 1-regulated miR-27b 涉及心脏的肥大的规定,并且为心脏病作为一个有效治疗学的目标验证 miR-27b。 | Jian Wang Yao Song Yan Zhang Han Xiao Qiang Sun Ning Hou Shuilong Guo Youliang Wang Kaiji Fan Dawei Zhan Lagabaiyila Zha Yang Cao Zhenhua Li Xuan Cheng Youyi Zhang Xiao Yang | 2012 | Cell Research2012，22，3： | 36 |
| 4 | SlMYB75,an MYB-type transcription factor,promotes anthocyanin accumulation and enhances volatile aroma production in tomato fruits显示文摘Genetic manipulation of genes to upregulate specific branches of metabolic pathways is a method that is commonly used to improve fruit quality.However,the use of a single gene to impact several metabolic pathways is difficult.Here,we show that overexpression of the single gene SlMYB75(SlMYB75-OE)is effective at improving multiple fruit quality traits.In these engineered fruits,the anthocyanin content reached 1.86mg g−1 fresh weight at the red-ripe stage,and these SlMYB75-OE tomatoes displayed a series of physiological changes,including delayed ripening and increased ethylene production.In addition to anthocyanin,the total contents of phenolics,flavonoids and soluble solids in SlMYB75-OE fruits were enhanced by 2.6,4,and 1.2 times,respectively,compared to those of wild-type(WT)fruits.Interestingly,a number of aroma volatiles,such as aldehyde,phenylpropanoid-derived and terpene volatiles,were significantly increased in SlMYB75-OE fruits,with some terpene volatiles showing more than 10 times higher levels than those in WT fruits.Consistent with the metabolic assessment,transcriptomic profiling indicated that the genes involved in the ethylene signaling,phenylpropanoid and isoprenoid pathways were greatly upregulated in SlMYB75-OE fruits.Yeast one-hybrid and transactivation assays revealed that SlMYB75 is able to directly bind to the MYBPLANT and MYBPZM cis-regulatory elements and to activate the promoters of the LOXC,AADC2 and TPS genes.The identification of SlMYB75 as a key regulator of fruit quality attributes through the transcriptional regulation of downstream genes involved in several metabolic pathways opens new avenues towards engineering fruits with a higher sensory and nutritional quality. | Wei Jian Haohao Cao Shu Yuan Yudong Liu Juanfang Lu Wang Lu Ning Li Jianhui Wang Jian Zou Ning Tang Chan Xu Yulin Cheng Yanqiang Gao Wanpeng Xi Mondher Bouzayen Zhengguo Li | 2019 | Horticulture Research2019，6，1： | 39 |
| 5 | Identification of a Stable Quantitative Trait Locus for Percentage Grains with White Chalkiness in Rice (Oryza sativa)显示文摘High chalkiness is a major problem in many rice-producing areas of the world, especially in hybrid rice (Oryza sativa L.) in China. We previously showed a major quantitative trait locus for the percentage of grains with white chalkiness (QTLqPGWC-8) in the interval G1149-R727 on chromosome 8 using a chromosome segment substitution line (CSSL). Here, we selected the line-CSSL50 harboring the QTLqPGWC-8 allele from the CSSLs derived from a cross between Asominori (as a recurrent parent) and IR24 (as a donor parent), which had higher percentage chalkiness, markedly different from that of Asominori. There were also significant differences in starch granules, appearance of amylose content (AAC) and milling qualities between Asominori and CSSL50, but not in grain size or thousand grain weight (TGW). The BC4F2 and BC4F3 populations from a cross between CSSL50 and Asominori were used for fine mapping of qPGWC-8. We narrowed down the location of this QTL to a 142 kb region between Indel markers 8G-7 and 8G-9. QTLqPGWC-8 accounted for 50.9% of the difference in PGWC between the parents. The markers tightly linked to qPGWC-8 should facilitate cloning of the gene underlying this QTL and will be of value for marker-assisted selection in breeding rice varieties with better grain quality. | Tao Guo Xiaolu Liu Xiangyuan Wan Jianfeng Weng Shijia Liu Xi Liu Mingjiang Chen Jingjing Li Ning Su Fuqing Wu Zhijun Cheng Xiuping Guo Cailin Lei Jiulin Wang Ling jiang Jianmin Wan | 2011 | Journal of Integrative Plant Biology2011，53，8： | 25 |
| 6 | Minimally invasive percutaneous compression plating versus dynamic hip screw for intertrochanteric fractures: a randomized control trial显示文摘ObjectiveIntertrochanteric 腿节骨折是在老病人的普通损害。动态新潮的螺丝钉(DHS ) 为固定用作标准选择;然而,它有几个缺点。经皮的压缩板(PCCP ) 的研究关于它的功效和安全仍然是不确定的。由比较二个方法,我们与 intertrochanteric 腿节破裂估计了他们 121 个老病人的临床的治疗学的 outcome.MethodsA 总数(类型 AO/OTA 31 .A1-A2 , Evans 类型 1 )随机被划分成经历一个最低限度地侵略的 PCCP 过程或操作持续时间是的一个常规 DHS fixation.ResultsThe 平均数的二个组在 PCCP 组显著地更短( 55.2 ; min 对 88.5 ; min , P ;< ; 0.01 )。血损失是 156.5 ml ± 18.3 在 PCCP 组和 513.2 的 ml; ml ± 66.2 在 DHS 组的 ml (P < 0.01 ) 。在与 PCCP 对待的病人之中, 3.1% 需要输血,与 44.6% 那些那有的 DHS 外科相比(P < 0.01 ) 。PCCP 组显示了不太手术后的复杂并发症(P < 0.05 ) 。在 PCCP 组的麻醉学者分数和哈里斯臀部分数的吝啬的美国社会比在 DHS 组的那些好。在到几个优点的吝啬的医院停留,死亡率,或骨折 healing.ConclusionDue 没有重要差别, PCCP 有潜力为对待 intertrochanteric 破裂成为理想的选择(类型 AO/OTA 31 .A1-A2, Evans 类型 1 ) ,在特别地老。 | Cheng Qiang Huang Wei Gong Xuan Wang Changdong Liang Xi Hu Ning | 2014 | Chinese Journal of Traumatology2014，17，5： | 20 |
| 7 | Nickel-exposed Workers in China: A Cohort Study显示文摘There are more than 50 000 workers in Jinchuan Group Co,Ltd(JNMC).Since all staff in JNMC are eligible for a medical examination every two years,only 23 484 nickel-exposed subjects who participated in medical examination were included in this study.Their data,collected from June 22,2011 to September 28,2012,in a | BAI Ya Na YAGN Ai Min PU Hong Quan HE Jie CHENG Ning ZHENG Tong Zhang DAI Min ZHANG Ya Wei BASSING Bryan WANG Qiu Ying | 2014 | Biomedical and Environmental Sciences2014，27，3： | 20 |
| 8 | Association between Ambient Air Pollution and Hospital Emergency Admissions for Respiratory and Cardiovascular Diseases in Beijing: a Time Series Study显示文摘Objective To investigate the association between ambient air pollution and hospital emergency admissions in Beijing. Methods In this study, a semi-parametric generalized additive model(GAM) was used to evaluate the specific influences of air pollutants(PM10, SO2, and NO2) on hospital emergency admissions with different lag structures from 2009 to 2011, the sex and age specific influences of air pollution and the modifying effect of seasons on air pollution to analyze the possible interaction. Results It was found that a 10 μg/m3 increase in concentration of PM10 at lag 03 day, SO2 and NO2 at lag 0 day were associated with an increase of 0.88%, 0.76%, and 1.82% respectively in overall emergency admissions. A 10 μg/m3 increase in concentration of PM10, SO2 and NO2 at lag 5 day were associated with an increase of 1.39%, 1.56%, and 1.18% respectively in cardiovascular disease emergency admissions. For lag 02, a 10 μg/m3 increase in concentration of PM10, SO2 and NO2 were associated with 1.72%, 1.34%, and 2.57% increases respectively in respiratory disease emergency admissions. Conclusion This study further confirmed that short-term exposure to ambient air pollution was associated with increased risk of hospital emergency admissions in Beijing. | ZHANG Ying WANG Shi Gong MA Yu Xia SHANG Ke Zheng CHENG Yi Fan LI Xu NING Gui Cai ZHAO Wen Jing LI Nai Rong | 2015 | Biomedical and Environmental Sciences2015，28，5： | 18 |
| 9 | Chinese stalagmite paleoclimate researches: A review and perspective显示文摘Stalagmite is one kind of secondary carbonates formed in limestone caves(speleothem). After cave water droplets containing Ca2+and HCO3 drip onto floor, carbonate in the water might become supersaturated due to CO2 degassing under certain conditions, resulting in the formation of stalagmite in a process year after year. Stalagmite is one of important geological archives for paleoclimate research. The advantages include wide spatial distribution, suitable for U-Th and U-Pb dating, enriched in climate proxies, continuity, long time span, comparability and lower sampling cost etc. These factors have propelled stalagmite paleoclimate research to the forefront of global paleoclimatology with an irreplaceable role. The stalagmite paleoclimate study started in the western countries, mainly in Europe and America in 1960 s–1970 s, while the relevant research in China was progressively developed in the 1980 s–1990 s after the Reform and Opening up. Although there was a huge gap between the overall research level in China and western countries, a solid research foundation, as well as a number of talent teams were established during the period. In the 21 st century, starting from the publication of stalagmite records from Hulu Cave in Nanjing in 2001, the stalagmite paleoclimate research in China has ushered in a flourishing development and a real leap on the basis of international cooperation, resulting in significant international impacts. The landmark achievements, including establishment of the world’s longest(640000 years) East Asian monsoon stalagmite record, as well as the longest Indian monsoon(280000 years),South American monsoon(250000 years), North American westerly climate(330000 years), Central Asian westerly climate(135000 years), and northwestern China westerly climate(500000 years), have laid a milestone in the paleoclimate study in these climate domains. Importantly, these stalagmite records have revealed the relationship of Asian monsoon variations with solar insolation climate change in polar regions, and the South American monsoon changes on orbital-suborbital timescales, which have provided new geological observations for the development of orbital-suborbital climate theory;elaborated coupling and differentiation relationships between the Asian monsoon and the westerly climate;reconstructed the history of Asian monsoon changes in the Holocene in detail, and thus the hydrological and climate variances behind Chinese and Indian civilizationcultural evolutions. Furthermore, a large number of high-resolution stalagmite records over the past 2000 years have been reconstructed, which are important for understanding short-term climate variability and magnitude, events, cycles, and thus the future climate projection. The achievements have also involved the improvements of a number of important techniques, such as U-Th dating method, the establishments of various hydroclimatic proxies, as well as the contributions to the reconstruction of the atmosphere14C variation history over the past ~54000 years. On the perspective of the future, the Chinese stalagmite community should continue to develop key techniques, further clarify the hydroclimatic significance of stalagmite proxies, impel the integration of related disciplines, and concentrate on key scientific issues in global climate change and major social demands. | Hai CHENG Haiwei ZHANG Jingyao ZHAO Hanying LI Youfeng NING Gayatri KATHAYAT | 2019 | Science China Earth Sciences2019，62，10： | 17 |
| 10 | Spherical nano-Sb@C composite as a high-rate and ultra-stable anode material for sodium-ion batteries显示文摘一种喷雾器水花热分解技术被用来综合球形的 nano-Sb@C 合成。仪器的分析表明与 68.8 wt% 的一个优化 Sb 内容合成的 micro-nanostructured 一致地由极端小的 Sb nanoparticles (10 nm ) 组成在一个球形的多孔的 C 矩阵以内嵌入(作为 10-Sb @ C 表示了) 。Sb 的内容和尺寸能被改变先锋的集中控制。作为钠离子电池的阳极材料, 10-Sb @ C 提供 435 mAh 据 ? 椠据畬楤杮愠猠数楣楦 ? 慣慰楣慴据 ? 景ㄠ ? 的一个分泌物能力 ? 术挠浯慰敲 ? 楷桴琠敨瘠污敵漠 ??? 术映牯 ?? 瑡愠挠慨杲 ? 楤' 湛?慲整漠 ?? ‰ ? | Ning Zhang Yongchang Liu Yanying Lu Xiaopeng Han Fangyi Cheng Jun Chen | 2015 | Nano Research2015，8，10： | 14 |
| 11 | Application of next-generation sequencing technology to precision medicine in cancer: joint consensus of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology显示文摘Next-generation sequencing(NGS) technology is capable of sequencing millions or billions of DNA molecules simultaneously.Therefore, it represents a promising tool for the analysis of molecular targets for the initial diagnosis of disease, monitoring of disease progression, and identifying the mechanism of drug resistance. On behalf of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology(CSCO) and the China Actionable Genome Consortium(CAGC), the present expert group hereby proposes advisory guidelines on clinical applications of NGS technology for the analysis of cancer driver genes for precision cancer therapy. This group comprises an assembly of laboratory cancer geneticists, clinical oncologists, bioinformaticians,pathologists, and other professionals. After multiple rounds of discussions and revisions, the expert group has reached a preliminary consensus on the need of NGS in clinical diagnosis, its regulation, and compliance standards in clinical sample collection. Moreover, it has prepared NGS criteria, the sequencing standard operation procedure(SOP), data analysis, report, and NGS platform certification and validation. | Xuchao Zhang Zhiyong Liang Shengyue Wang Shun Lu Yong Song Ying Cheng Jianming Ying Weiping Liu Yingyong Hou Yangqiu Li Yi Liu Jun Hou Xiufeng Liu Jianyong Shao Yanhong Tai Zheng Wang Li Fu Hui Li Xiaojun Zhou Hua Bai Mengzhao Wang You Lu Jinji Yang Wenzhao Zhong Qing Zhou Xuening Yang Jie Wang Cheng Huang Xiaoqing Liu Xiaoyan Zhou Shirong Zhang Hongxia Tian Yu Chen Ruibao Ren Ning Liao Chunyan Wu Zhongzheng Zhu Hongming Pan Yanhong Gu Liwei Wang Yunpeng Liu Suzhan Zhang Tianshu Liu Gong Chen Zhimin Shao Binghe Xu Qingyuan Zhang Ruihua Xu Lin Shen Yilong Wu | 2019 | Cancer Biology & Medicine2019，16，1： | 14 |
| 12 | Comparative study of minimally invasive versus open esophagectomy for esophageal cancer in a single cancer center显示文摘 | Mu Juwei Yuan Zuyang Zhang Baihua Li Ning Lyu Fang Mao Yousheng Xue Qi Gao Shugeng Zhao Jun Wang Dali Li Zhishan Gao Yushun Zhang Liangze Huang Jinfeng Shao Kang Feng Feiyue Zhao Liang Li Jian Cheng Guiyu Sun Kelin He Jie | 2014 | Chinese Medical Journal2014，，4： | 13 |
| 13 | Long-term Coordination of Transmission and Storage to Integrate Wind Power显示文摘A power system with a high wind power integration requires extra transmission capacity to accommodate the intermittency inherent to wind power production.Storage can smooth out this intermittency and reduce transmission requirements.This paper proposes a stochastic optimization model to coordinate the long-term planning of both transmission and storage facilities to efficiently integrate wind power.Both longterm and short-term uncertainties are considered in this model.Long-term uncertainty is described via scenarios,while shortterm uncertainty is described via operating conditions.Garver’s 6-node system and a system representing Northwest China in 2030 are used to illustrate the proposed model.Results indicate that storage reduces transmission requirement and the overall investment,and allows the efficient integration of wind power. | Antonio J.Conejo Yaohua Cheng Ning Zhang Chongqing Kang | 2017 | CSEE Journal of Power and Energy Systems2017，3，1： | 13 |
| 14 | Experimental investigation of penetration performance of shaped charge into concrete targets显示文摘为了开发一个双人脚踏车弹头,那能有效地破坏具体目标,这篇论文借助于实验与不同的锥角度和班机材料探索塑造的费用的穿入表演进具体目标。穿入过程和由塑造的费用和动能射弹的具体目标的破坏机制被分析并且比较。试验性的结果建议运动精力充沛的射弹和塑造的充电能够破坏损坏的具体目标,而是大小是不同的。与动能射弹相比,塑造的费用有穿入的更多的重要效果进目标,并且引起很大的 spalling 区域。因此,塑造的费用对双人脚踏车弹头的第一阶段的充电相当合适。当洞直径变得更大时,随塑造的费用班机锥角度的增加,穿入的深度逐渐地减少,这也被发现。有铜班机的穿入深度比铝班机大,但是洞直径相对更小,并且有钢班机的塑造的起诉在上述二诉讼之间。有 100 °的一个锥角度的塑造的费用能形成喷气射弹费用(JPC ) 。与 JPC,有具体目标上的最佳深度和直径的一个洞能被形成,它保证秒阶段弹头顺利渗透进洞并且在最佳深度爆炸在具体目标完成破坏的需要的水平。 | Cheng Wang Tianbao Ma Jianguo Ning | 2008 | Acta Mechanica Sinica2008，24，3： | 12 |
| 15 | Structural insights into the TRIM family of ubiquitin E3 ligases显示文摘 | Yang Li Han Wu Wei Wu Wei Zhuo Weixiao Liu Yixiao Zhang Minzhang Cheng Ye-Guang Chen Ning Gao Hongtao Yu Linfang Wang Wei Li Maojun Yang | 2014 | Cell Research2014，24，6： | 12 |
| 16 | Nutrient Intakes of Pregnant Women and their Associated Factors in Eight Cities of China: A Cross-sectional Study显示文摘 | Fang-Li Liu Yu-Mei Zhang Gerard Vinyes Pares Kathleen C Reidy Wen-Zhi Zhao Ai Zhao Cheng Chen Celia Y Ning Ying-Dong Zheng Pei-Yu Wang | 2015 | Chinese Medical Journal2015，，13： | 12 |
| 17 | Giant submucosal lipoma located in the descending colon: A case report and review of the literature显示文摘Colonic lipoma is an uncommon tumor of the gastrointestinal tract.Most cases are asymptomatic,with a small tumor size,and do not need any special treatment.However,we encountered one patient with a giant submucosal lipoma,with a maximum diameter of 8.5 cm,which exhibited symptoms such as intermittent lower abdominal pain,changes in bowel habits with passage of fresh blood and mucus per rectum,abdominal distension,anorexia and weight loss.Unfortunately,the possibility of colonic malignancy could not be precluded and left hemicolectomy was planned.The exact diagnosis of this special case was accomplished by intraoperative pathology.In the end,local resection was performed instead of left hemicolectomy.To the best of our knowledge,colonic lipoma exceeding 8 cm in diameter has not been previously reported.We,therefore,present this case and discuss age and sex factors,clinical and histopathological findings,diagnostic methods and treatment by reviewing the available literature,to serve as a reminder that colonic lipoma can also exist in patients with significant symptoms.In addition,intraoperative pathology should be investigated in those doubtful cases,so as to guide the exact diagnosis and treatment plan. | Li Jiang Li-Sheng Jiang Fu-Yu Li Hui Ye Ning Li Nan-Sheng Cheng Yong Zhou | 2007 | World Journal of Gastroenterology2007，13，42： | 11 |
| 18 | Puerarin ameliorated pressure overload-induced cardiac hypertrophy in ovariectomized rats through activation of the PPARα/PGC-1 pathway显示文摘Estrogen deficiency induces cardiac dysfunction and increases the risk of cardiovascular disease in postmenopausal women and in those who underwent bilateral oophorectomy.Previous evidence suggests that puerarin,a phytoestrogen,exerts beneficial effects on cardiac function in patients with cardiac hypertrophy.In this study,we investigated whether puerarin could prevent cardiac hypertrophy and remodeling in ovariectomized,aortic-banded rats.Female SD rats subjected to bilateral ovariectomy(OVX)plus abdominal aortic constriction(AAC).The rats were treated with puerarin(50 mg·kg^(−1)·d^(−1),ip)for 8 weeks.Then echocardiography was assessed,and the rats were sacrificed,their heart tissues were extracted and allocated for further experiments.We showed that puerarin administration significantly attenuated cardiac hypertrophy and remodeling in AAC-treated OVX rats,which could be attributed to activation of PPARα/PPARγcoactivator-1(PGC-1)pathway.Puerarin administration significantly increased the expression of estrogen-related receptorα,nuclear respiratory factor 1,and mitochondrial transcription factor A in hearts.Moreover,puerarin administration regulated the expression of metabolic genes in AAC-treated OVX rats.Hypertrophic changes could be induced in neonatal rat cardiomyocytes(NRCM)in vitro by treatment with angiotensin Ⅱ(Ang Ⅱ,1μM),which was attenuated by co-treatemnt with puerarin(100μM).We further showed that puerarin decreased Ang Ⅱ-induced accumulation of non-esterified fatty acids(NEFAs)and deletion of ATP,attenuated the Ang II-induced dissipation of the mitochondrial membrane potential,and improved the mitochondrial dysfunction in NRCM.Furthermore,addition of PPARαantagonist GW6471(10μM)partially abolished the anti-hypertrophic effects and metabolic effects of puerarin in NRCM.In conclusion,puerarin prevents cardiac hypertrophy in AAC-treated OVX rats through activation of PPARα/PGC-1 pathway and regulation of energy metabolism remodeling.This may provide a new approach to prevent the development of heart failure in postmenopausal women. | Ning Hou Yin Huang Shao-ai Cai Wen-chang Yuan Li-rong Li Xia-wen Liu Gan-jian Zhao Xiao-xia Qiu Ai-qun Li Chuan-fang Cheng Shi-ming Liu Xiao-hui Chen Dao-feng Cai Jing-xuan Xie Min-sheng Chen Cheng-feng Luo | 2021 | Acta Pharmacologica Sinica2021，42，1： | 11 |
| 19 | Bedaquiline-containing regimens in patients with pulmonary multidrug-resistant tuberculosis in China:focus on the safety显示文摘Background:World Health Organization recommends countries introducing new drug and short treatment regimen for drug resistant tuberculosis(DR-TB)should develop and implement a system for active pharmacovigilance that allows for detection,reporting and management of adverse events.The aim of the study is to evaluate the frequency and severity of adverse events(AEs)of bedaquiline-containing regimen in a cohort of Chinese patients with multidrug-resistant(MDR)/extensively drug-resistant(XDR)-TB based on active drug safety monitoring(aDSM)system of New Drug Introduction and Protection Program(NDIP). | Jing-Tao Gao Juan Du Gui-Hui Wu Yi Pei Meng-Qiu Gao Leonardo Martinez Lin Fan Wei Chen Li Xie Yu Chen Hua Wang Long Jin Guo-Bao Li Pei-Lan Zong Yu Xiong Qian-Hong Wu Ming-Wu Li Xiao-Feng Yan Yan-Fang Miao Qing-Shan Cai Xin-Jie Li Da-Peng Bai Shu-Jun Geng Guo-Li Yang Pei-JunTang Yi Zeng Xiao-Hong Chen Tong-Xia Li Cui Cai Yun Zhou Ma Zhuo Jian-Yun Wang Wen-Long Guan Lin Xu Ji-Chan Shi Wei Shu Li-Li Cheng FeiTeng Yu-Jia Ning Shi-Heng Xie Yu-Xian Sun Li-Jie Zhang Yu-Hong Liu | 2021 | Infectious Diseases of Poverty2021，10，2： | 11 |
| 20 | The newly emerged SARS-Like coronavirus HCoV-EMC also has an “Achilles’ heel”: current effective inhibitor targeting a 3C-like protease显示文摘From the global outbreak of SARS-CoV caused infection disease in 2003,coronaviruses(CoVs)are known to be a great threat to the human health.Recently,a new SARS-like coronavirus,human betacoronavirus 2c EMC/2012(HCoV-EMC),has been identified and the appearance of this new CoV raises concerns that a new spread of CoV may occurs in the future.By solving the crystal structure of HCoV-EMC main protease with a wide-spectrum anti-CoV inhibitor N3,we confi rmed that that N3 blocks the function of HCoV-EMC main protease through a similar mechanism to other CoVs.Together with the good pharmaceutical features,N3 is conceivable to be effective to HCoV-EMC and other CoVs appearing in the future.These fi ndings make it convincing that CoVs will not be a threat to human health. | Zhilin Ren Liming Yan Ning Zhang Yu Guo Cheng Yang Zhiyong Lou Zihe Rao | 2013 | Protein & Cell2013，4，4： | 10 |
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