|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | A comprehensive classification method for VOC emission sources to tackle air pollution based on VOC species reactivity and emission amounts显示文摘In China, volatile organic compound(VOC) control directives have been continuously released and implemented for important sources and regions to tackle air pollution. The corresponding control requirements were based on VOC emission amounts(EA), but never considered the significant differentiation of VOC species in terms of atmospheric chemical reactivity. This will adversely influence the effect of VOC reduction on air quality improvement. Therefore,this study attempted to develop a comprehensive classification method for typical VOC sources in the Beijing–Tianjin–Hebei region(BTH), by combining the VOC emission amounts with the chemical reactivities of VOC species. Firstly, we obtained the VOC chemical profiles by measuring 5 key sources in the BTH region and referencing another 10 key sources, and estimated the ozone formation potential(OFP) per ton VOC emission for these sources by using the maximum incremental reactivity(MIR) index as the characteristic of source reactivity(SR). Then, we applied the data normalization method to respectively convert EA and SR to normalized EA(NEA) and normalized SR(NSR) for various sources in the BTH region.Finally, the control index(CI) was calculated, and these sources were further classified into four grades based on the normalized CI(NCI). The study results showed that in the BTH region,furniture coating, automobile coating, and road vehicles are characterized by high NCI and need to be given more attention; however, the petro-chemical industry, which was designated as an important control source by air quality managers, has a lower NCI. | Guohao Li Wei Wei Xia Shao Lei Nie Hailin Wang Xiao Yan Rui Zhang | 2018 | Journal of Environmental Sciences2018，30，5： | 32 |
| 2 | Acute inflammation stimulates a regenerative response in the neonatal mouse heart显示文摘 | Chunyong Han Yu Nie Hong Lian Rui Liu Feng He Huihui Huang Shengshou Hu | 2015 | Cell Research2015，25，10： | 26 |
| 3 | Long-term propagation of tree shrew spermatogonial stem cells in culture and successful generation of transgenic offspring显示文摘树鼯有一种靠近的关系到首领并且在生物医学的研究比啮齿类动物有许多优点。然而,基因操作方法的缺乏妨碍了这个动物的更宽的使用。Spermatogonial 干细胞(SSC ) 成功地在文化被扩展了允许复杂基因在老鼠和老鼠编辑。这里,没有干细胞性质的损失,我们为树鼯 SSC 的长期的扩大描述一个文化系统。在我们的学习,胸腺房间抗原 1 被用来充实树鼯 SSC。定序 RNA 分析表明表明小径的 Wnt/-catenin 在无差别的 SSC 是活跃的,但是是在 SSC 区别的开始之上的 downregulated。树鼯的暴露到 recombinant Wnt3a 蛋白质的主要 SSC 在文化的起始的段落期间提高了 SSC 的幸存。当 feeder 被发现为树鼯 SSC 增长必要,树鼯 Sertoli 房间,然而并非老鼠使用胚胎的成纤维细胞,导致柔韧的房间扩大和长期的文化。扩展的树鼯 SSC 是有提高的绿色的 transfected 荧光灯表示 lentiviral 向量的蛋白质(EGFP ) 。在进消毒的成年的男树鼯睾丸的移植以后,标注 EGFP 的 SSC 能恢复精子发生并且成功地产生转基因的后代。而且,这些 SSC 对 CRISPR/Cas9-mediated 基因修正合适。在有编辑的基因的联合的树鼯 SSC 接近膨胀的一个文化系统的发展用树鼯为精确染色体操作铺平道路。 | Chao-Hui Li Lan-Zhen Yan Wen-Zan Ban Qiu TH Yong Wu Lin Wang Rui Bi Shuang Ji Yu-Hua Ma Wen-Hui Nie Long-Bao Lv Yong-Gang Yao Xu-Dong Zhao Ping Zheng | 2017 | Cell Research2017，27，2： | 22 |
| 4 | Genetic lineage tracing identifies in situ Kit-expressing cardiomyocytes显示文摘 | Qiaozhen Liu Rui Yang Xiuzhen Huang Hui Zhang Lingjuan He Libo Zhang Xueying Tian Yu Nie Shengshou Hu Yan Yan Li Zhang Zengyong Qiao Qing-Dong Wang Kathy O Lui Bin Zhou | 2016 | Cell Research2016，26，1： | 12 |
| 5 | A generalized power iteration method for solving quadratic problem on the Stiefel manifold显示文摘In this paper, we first propose a novel generalized power iteration(GPI) method to solve the quadratic problem on the Stiefel manifold(QPSM) as minWTW =ITr(WTAW-2WTB) along with the theoretical analysis. Accordingly, its special case known as the orthogonal least square regression(OLSR) is under further investigation. Based on the aforementioned studies, we then majorly focus on solving the unbalanced orthogonal procrustes problem(UOPP). As a result, not only a general convergent algorithm is derived theoretically but the efficiency of the proposed approach is verified empirically as well. | Feiping NIE Rui ZHANG Xuelong LI | 2017 | Science China(Information Sciences)2017，60，11： | 11 |
| 6 | Size Distributions of Aerosol Sulfates and Nitrates in Beijing during the 2008 Olympic Games: Impacts of Pollution Control Measures and Regional Transport显示文摘为 2008 个奥运会,激烈的控制措施在二氧化物(SO2 ) ,氮氧化物(没有 x ) 和处理穷人的问题的另外的污染物质通风的硫的工业、城市的排出物上被实现在北京的质量。在微粒硫酸盐和硝酸盐集中以及他们的尺寸分布上调查 SO2 和没有 x 减小的效果,分离尺寸的喷雾器样品在照原尺寸的控制前后在北京在城市、顺风的农村地点用微孔的一致存款 impactors (MOUDI ) 被收集。在采样时期期间,在城市、农村的地点的好粒子(PM1.8 ) 的集体集中分别地是 94.0 和 85.9 g m3。超过 90% 硫酸盐和 60% 硝酸盐形成了同样好的粒子。得益于有益的气象学的条件和来源控制,硫酸盐在奥林匹克期间在相当低的集中并且首先在冷凝作用模式被观察。控制措施的效果独立被分析让北风和南方的 air-mass-dominated 天说明任何偏爱。在控制措施被实现以后,当在北方的空气群众占优势时,下午,硫酸盐,和硝酸盐显著地被减少,与在更大的粒子的减小的一个更高的百分比。在控制措施被实现以后,微滴模式粒子,在控制被实现以前,统治了硫酸盐和硝酸盐,显著地在集体集中被减少。但当弄脏的南方的空气群众占优势时,本地来源控制在北京测量,有效地没从北方中国平原由于庞大的地区性的贡献减少周围的硫酸盐集中。 | WANG Xinfeng WANG Tao Ravi Kant PATHAK Mattias HALLQUIST GAO Xiaomeit NIE Wei XUE Likun GAO Jian GAO Rui ZHANG Qingzhu WANG Wenxing WANG Shulan CHAI Fahe CHEN Yizhen | 2013 | Advances in Atmospheric Sciences2013，30，2： | 8 |
| 7 | Solving 3D Electromagnetic Scattering and Radiation by Local Multilevel Fast Multipole Algorithm显示文摘 | HU Jun NIE Zaiping LEI Lin RUI Xi WANG Jun | 2007 | Chinese Journal of Electronics2007，16，2： | 8 |
| 8 | Stereotactic body radiotherapy combined with transarterial chemoembolizationfor hepatocellular carcinoma with portal vein tumor thrombosis显示文摘 | Jingbo Kang Qing Nie Rui Du Liping Zhang Jun Zhang Qiliang Li Jianguo Li Wenjie Qi | 2014 | Molecular and Clinical Oncology2014，，1： | 4 |
| 9 | Nosocomial spread of hospital-adapted CC17 vancomycin-resistant Enterococcus faecium in a tertiary-care hospital of Beijing, China显示文摘背景万古霉素抵抗的 enterococci (VRE ) 的发生看起来在中国正在增加,但是很少的医院的爆发被报导了。自从 2008 年 3 月,我们的医院经历了 VRE 的爆发到 2009 年 3 月。这研究的目的是分析在 VRE 从 21 孤立的在我们描绘了的 China.Methods 的一个第三级的机构的 VRE 爆发感染了的isolates 和过去常根除的控制措施的分子的特征, 11 由搏动的领域胶化电气泳动( PFGE )从一所单个医院开拓殖民地于住院病人,打字的 multilocus 顺序( MLST ), Tn 1546-like 元素的分析和毒力基因察觉。感染控制测量,包括更环境的消毒,为 VRE 殖民,接触措施,教育和严格的抗菌素限制屏蔽,被实现在爆发期间控制 outbreak.Results, 32 VRE 紧张的一个总数被获得。有 21 紧张(EICU ) ,在紧急情况特别护理联合起来发现, 9 从衰老老人孤立沃德,并且二从另外的单位。然而,所有 isolates 怀有 vanA 基因他们中的四个展出了 VanB 显型。同时, MLST 分析表明那都孤立属于同种细胞的建筑群(CC ) 17。与感染控制措施,流行病以二个单位(EICU 和衰老老人沃德) 被抑制。在 2009 年 3 月以后,感染 VRE 的进一步的盒子都没在下列一个年 period.Conclusion 被检测爆发被感染控制计划,和更严密的感染的连续实现控制控制政策被需要。 | XU Hong-tao TIAN Rui CHEN Dong-ke XIAO Fei NIE Zhi-yang HU Yun-jian ZHANG Xiu-zhen LI Jin-ming | 2011 | Chinese Medical Journal2011，，4： | 4 |
| 10 | WX20120108,a novel IAP antagonist,induces tumor cell autophagy via activating ROS-FOXO pathway显示文摘Recently,inhibitor of apoptosis proteins(IAPs)and some IAP antagonists were found to regulate autophagy,but the underlying mechanisms remain unclear.WX20120108 is an analogue of GDC-0152(a known IAP antagonist)and displays more potent anti-tumor and autophagy-regulating activity in tumor cells,we investigated the regulatory mechanisms underlying WX20120108-induced autophagy.Using molecular docking and fluorescence polarization anisotropy(FPA)competitive assay,we first demonstrated that WX20120108,acting as an IAP antagonist,bound to the XIAP-BIR3,XIAP BIR2-BIR3,cIAP1 BIR3,and cIAP2 BIR3 domains with high affinities.In six cancer cell lines,WX20120108 inhibited the cell proliferation with potencies two to ten-fold higher than that of GDC-0152.In HeLa and MDA-MB-231 cells,WX20120108 induced caspase-dependent apoptosis and activated TNFα-dependent extrinsic apoptosis.On the other hand,WX20120108 induced autophagy in HeLa and MDA-MB-231 cells in dose-and time-dependent manners.We revealed that WX20120108 selectively activated Foxo3,evidenced by Foxo3 nuclear translocation in both gene modified cell line and HeLa cells,as well as the upregulated expression of Foxo3-targeted genes(Bnip3,Pik3c3,Atg5,and Atg4b),which played a key role in autophagy initiation.WX20120108-induced autophagy was significantly suppressed when Foxo3 gene was silenced.WX20120108 dose-dependently increased the generation of reactive oxygen species(ROS)in HeLa cells,and WX20120108-induced Foxo3 activation was completely blocked in the presence of catalase,a known ROS scavenger.However,WX20120108-induced ROS generation was not affected by cIAP1/2 or XIAP gene silencing.In conclusion,WX20120108-induced autophagy relies on activating ROS-Foxo3 pathway,which is independent of IAPs.This finding provides a new insight into the mechanism of IAP antagonist-mediated regulation of autophagy. | Rui Ding Xin Wang Wei Chen Zhi Li Ai-li Wei Qing-bin Wang Ai-hua Nie Li-li Wang | 2019 | Acta Pharmacologica Sinica2019，40，11： | 4 |
| 11 | Research on variety characteristics of China's Mainland troposphere based on CMONOC显示文摘In this research, we processed the GPS and meteorological data from about 220 stations of Crustal Movement Observation Network of China(CMONOC) observed in 2014 and derived the Zenith Total Delay(ZTD) map in both spatial and temporal dimension. The results of ZTD have high accurate and reliable as IGS and all sites with varying locations show obvious variety characteristics of Chinese mainland. Meanwhile, the precipitable water vapor(PWV) correlation coefficients between GPS observation and upper air sounding is close to 1, and the comparison of GPS-derived PWV and observed PWV from meteorological sites indicating GPS observation data generated in CMONOC project applied to the weather forecast research is feasible. In addition, based on all stations covered the whole Chinese land area and using interpolation algorithms, we make contour plots of PWV distribution per hour. We observe obvious feature that the precipitable water in north and western area is less than south and east area all over this year. High latitudes area may be dry and low latitudes area is wet. | Hongbo Shi Rui Zhang Zhaosheng Nie Yu Li Zhengsong Chen Tan Wang | 2018 | Geodesy and Geodynamics2018，9，5： | 3 |
| 12 | Novel approach to and implementation of design and analysis of armored face conveyor power train显示文摘An armored face conveyor(AFC) is a key piece of equipment for a fully mechanized long-wall mining system and is currently the only means for transporting bulk material in hard coal mines. To date, the AFC power train design has mainly been based on heuristics obtained via experience, coupled with simple calculations, which cannot take the dynamic behaviors and coupling effects of the components into consideration. Therefore, model-based and simulation-driven design is preferred. In this paper, a new design and analysis methodology for an AFC power train is presented to achieve the optimal dynamic characteristics and transmission performance. A preliminary design procedure for a power train is first introduced. Then, a system-level hydro-mechatronic model of the power train is built to evaluate and optimize the preliminary scheme. Sub-models, including those for the motors, fluid couplers, gearboxes, and chain, are obtained according to their individual disciplines and assembled to form the system-level model. The chain sub-system is discretized into multiple finite elements. Governing equations are established for each element based on the Newton Euler approach and assembled according to the topological structure of the chain system. In order to make the new approach applicable for engineers, a design and analysis software is developed, with a graphical user interface that involves the whole design process. MATLAB/SIMULINK is used as the computational engine, and Visual C++ is adopted to develop the interactive software framework. Simulations for the SGZ1000/2000 type AFC are provided as an illustrative case study to validate the effectiveness and practicality of the model and software package. | NIE Rui HE BaiYan YUAN PengFei ZHANG LianHong LI GuoPing | 2015 | Science China(Technological Sciences)2015，58，12： | 3 |
| 13 | Gene cloning and induced expression pattern of IRF4 and IRF10 in the Asian swamp eel(Monopterus albus)显示文摘The Asian swamp eel(Monopterus albus) is one of the most economically important freshwater fish in East Asia,but data on the immune genes of M.albus are scarce compared to other commercially important fish.A better understanding of the eel's immune responses may help in developing strategies for disease management,potentially improving yields and mitigating losses.In mammals,interferon regulatory factors(IRFs) play a vital role in both the innate and adaptive immune system; though among teleosts IRF4 and IRF10 have seldom been studied.In this study,we characterized IRF4 and IRF10 from M.albus(maIRF4 and maIRF10) and found that maIRF4 cDNA consists of 1 716 nucleotides encoding a 451 amino acid(aa) protein,while maIRF10 consists of 1 744 nucleotides including an open reading frame(ORF) of 1 236 nt encoding 411 aa.The maIRF10 gene was constitutively expressed at high levels in a variety of tissues,while maIRF4 showed a very limited expression pattern.Expression of maIRF4 and maIRF10 in head kidney,and spleen tissues was significantly up-regulated from 12 h to 48 h post-stimulation with polyinosinic: polycytidylic acid(poly I:C),lipopolysaccharide(LPS) and a common pathogenic bacteria Aeromonas hydrophila.These results suggest that IRF4 and IRF10 play roles in immune responses to both viral and bacterial infections in M.albus. | Qiao-Qing XU Dai-Qin YANG Rui TUO Jing WAN Ming-Xian CHANG Pin NIE | 2014 | Zoological Research2014，35，5： | 3 |
| 14 | Near-field surface deformation during the April 20,2013,Ms7.0 Lushan earthquake measured by 1-Hz GNSS显示文摘The April 20,2013,Ms7.0 Lushan earthquake was successfully recorded by closely spaced Continuous Global Positioning System (CGPS) stations owned by the Crustal Movement Observation Network of China (CMONC).The 1-Hz GNSS data from eight CGPS stations,which are located between 30 km and 200 km from the hypocenter,were processed within quasi-real-time.The near-field surface deformation indicated the following characteristics:the near-field movements were limited to several centimeters;the peak of the deformation wave was significantly larger than the static permanent offset;at the beginning of the event,the north wall of the fault moved to the southeast as the south wall moved to the southwest;station SCTQ,which was the closest station to the hypocenter at 30 km,had the largest static permanent displacement of 2 cm;the peaks of the deformation waves were 1.5 cm,5 cm and 3 cm,to the east,the south and vertically upward,respectively;and the peaks of velocity and acceleration,derived from the deformation,were 3.4 cm/s and 5.3 cm/s2,respectively. | Liu Gang Zhao Bin Zhang Rui Huang Yong Wang Jun Nie Zhaosheng Qiao Xuejun Tan Kai | 2013 | Geodesy and Geodynamics2013，4，2： | 3 |
| 15 | Molecular mechanism of panaxydol on promoting axonal growth in PC12 cells显示文摘Nerve growth factor(NGF) promotes axonal growth in PC12 cells primarily by regulating the RTK-RAS-MEK-ERK pathway. Panaxydol, a polyacetylene isolated from Panax notoginseng, can mimic the effects of NGF. Panaxydol promotes neurite outgrowth in PC12 cells, but its molecular mechanism remains unclear. Indeed, although alkynol compounds such as panaxydol can increase intracellular cyclic adenosine 3′,5′-monophosphate(cAMP) levels and the ERK inhibitor U0126 inhibits alkynol-induced axonal growth, how pathways downstream of cAMP activate ERK have not been investigated. This study observed the molecular mechanism of panaxydol-, NGF-and forskolin-induced PC12 cell axon growth using specific signaling pathway inhibitors. The results demonstrated that although the RTK inhibitor SU5416 obviously inhibited the growth-promoting effect of NGF, it could not inhibit the promoting effect of panaxydol on axonal growth of PC12 cells. The adenylate cyclase inhibitor SQ22536 and cAMP-dependent protein kinase inhibitor RpcAMPS could suppress the promoting effect of forskolin and panaxydol on axonal growth. The ERK inhibitor U0126 inhibited axonal growth induced by all three factors. However, the PKA inhibitor H89 inhibited the promoting effect of forskolin on axonal growth but could not suppress the promoting effect of panaxydol. A western blot assay was used to determine the effects of stimulating factors and inhibitors on ERK phosphorylation levels. The results revealed that NGF activates the ERK pathway through tyrosine receptors to induce axonal growth of PC12 cells. In contrast, panaxydol and forskolin increased cellular cAMP levels and were inhibited by adenylyl cyclase inhibitors. The protein kinase A inhibitor H89 completely inhibited forskolin-induced axonal outgrowth and ERK phosphorylation, but could not inhibit panaxydol-induced axonal growth and ERK phosphorylation. These results indicated that panaxydol promoted axonal growth of PC12 cells through different pathways downstream of cAMP. Considering that exchange protein directly activated by cAMP 1(Epac1) plays an important role in mediating cAMP signaling pathways, RNA interference experiments targeting the Epac1 gene were employed. The results verified that Epac1 could mediate the axonal growth signaling pathway induced by panaxydol. These findings suggest that compared with NGF and forskolin, panaxydol elicits axonal growth through the cAMP-Epac1-Rap1-MEK-ERK-CREB pathway, which is independent of PKA. | Wei-Peng Li Ke Ma Xiao-Yan Jiang Rui Yang Pei-Hua Lu Bao-Ming Nie Yang Lu | 2018 | Neural Regeneration Research2018，13，11： | 2 |
| 16 | Postoperative secondary aggravation of obstructive sleep apneahypopnea syndrome and hypoxemia with bilateral carotid body tumor:A case report显示文摘BACKGROUND Carotid body tumor(CBT)is a chemoreceptor tumor located in the carotid body,accounting for approximately 0.22%of head and neck tumors.Surgery is the main treatment method for the disease.CASE SUMMARY We reviewed the diagnosis and treatment of one patient who had postoperative secondary aggravation of obstructive sleep apnea–hypopnea syndrome(OSAHS)and hypoxia after surgical resection of bilateral CBTs.This patient was admitted,and relevant laboratory and imaging examinations,and polysomnography(PSG)were performed.After the definitive diagnosis,continuous positive airway pressure(CPAP)treatment was given,which achieved good efficacy.CONCLUSION This case suggested that aggravation of OSAHS and hypoxemia is possibly caused by the postoperative complications after bilateral CBTs,and diagnosis by PSG and CPAP treatment are helpful for this patient. | Xi Yang Xiao-Guang He Dong-Hui Jiang Chun Feng Rui Nie | 2020 | World Journal of Clinical Cases2020，8，23： | 2 |
| 17 | Gonadotropin treatment for male partial congenital hypogonadotropic hypogonadism in Chinese patients显示文摘Partial congenital hypogonadotropic hypogonadism(PCHH)is caused by an insufficiency in,but not a complete lack of,gonadotropin secretion.This leads to reduced testosterone production,mild testicular enlargement,and partial pubertal development.No studies have shown the productivity of spermatogenesis in patients with PCHH.We compared the outcomes of gonadotropin-induced spermatogenesis between patients with PCHH and those with complete congenital hypogonadotropic hypogonadism(CCHH).This retrospective study included 587 patients with CHH who were treated in Peking Union Medical College Hospital(Beijing,China)from January 2008 to September 2016.A total of 465 cases were excluded from data analysis for testosterone or gonadotropin-releasing hormone treatment,cryptorchidism,poor compliance,or incomplete medical data.We defined male patients with PCHH as those with a testicular volume of≥4 ml and patients with a testicular volume of<4 ml as CCHH.A total of 122 compliant,noncryptorchid patients with PCHH or CCHH received combined human chorionic gonadotropin and human menopausal gonadotropin and were monitored for 24 months.Testicular size,serum luteinizing hormone levels,follicle-stimulating hormone levels,serum total testosterone levels,and sperm count were recorded at each visit.After gonadotropin therapy,patients with PCHH had a higher spermatogenesis rate(92.3%)than did patients with CCHH(74.7%).During 24-month combined gonadotropin treatment,the PCHH group took significantly less time to begin producing sperm compared with the CCHH group(median time:11.7 vs 17.8 months,P<0.05).In conclusion,after combined gonadotropin treatment,patients with PCHH have a higher spermatogenesis success rate and sperm concentrations and require shorter treatment periods for sperm production. | Ming Hao Min Nie Bing-Qing Yu Yin-Jie Gao Xi Wang Wan-Lu Ma Qi-Bin Huang Rui Zhang Jiang-Feng Mao Xue-Yan Wu | 2020 | Asian Journal of Andrology2020，22，4： | 2 |
| 18 | A New Monoterpene Glycoside from Swertia punicea显示文摘A new monoterpene glycoside,2,6-dimethyl-2E,6E-octadienoic acid 1,6’-lactone 8-β-D glucopyranoside, was isolated from Swertia punicea, accompanying with six known compounds 1-O-primeverosyl-3,7-dimethoxy-8-hydroxyxanthone,1-O-primeverosyl-3,7,8-tri-methoxyxan-thone, epi-eustomoside, 1-hydroxy-3,7,8-trimethoxyxanthone, 1, 8-dihydroxy-3,7-dimethoxy xanthone and isovitexine . Their structures were elucidated based on spectral evidence. | Xin MING Ming Hua QIU Rui Lin NIE Guo Lin ZHANG | 2000 | Chinese Chemical Letters2000，11，8： | 2 |
| 19 | FX5,a non-steroidal glucocorticoid receptor antagonist,ameliorates diabetic cognitive impairment in mice显示文摘Diabetic cognitive impairment(DCI)is a common diabetic complication characterized by learning and memory deficits.In diabetic patients,hyperactivated hypothalamic-pituitary-adrenal(HPA)axis leads to abnormal increase of glucocorticoids(GCs),which causes the damage of hippocampal neurons and cognitive impairment.In this study we investigated the cognition-improving effects of a non-steroidal glucocorticoid receptor(GR)antagonist 5-chloro-N-[4-chloro-3-(trifluoromethyl)phenyl]thiophene-2-sulfonamide(FX5)in diabetic mice.Four weeks after T1DM or T2DM was induced,the mice were administered FX5(20,40 mg·kg^(-1)·d^(-1),i.g.)for 8 weeks.Cognitive impairment was assessed in open field test,novel object recognition test,Y-maze test,and Morris water maze test.We showed that FX5 administration significantly ameliorated the cognitive impairments in both type 1 and 2 diabetic mice.Similar cognitive improvement was observed in diabetic mice following brain GR-specific knockdown by injecting AAV-si-GR.Moreover,AAV-si-GR injection occluded the cognition-improving effects of FX5,suggesting that FX5 functioning as a non-steroidal GR antagonist.In PA-treated primary neurons(as DCI model in vitro),we demonstrated that FX5(2,5,10μM)dose-dependently ameliorated synaptic impairment via upregulating GR/BDNF/TrkB/CREB pathway,protected against neuronal apoptosis through repressing GR/PI3K/AKT/GSK3β-mediated tauopathy and subsequent endoplasmic reticulum stress.In LPS-treated primary microglia,FX5 dose-dependently inhibited inflammation through GR/NF-κB/NLRP3/ASC/Caspase-1 pathway.These beneficial effects were also observed in the hippocampus of diabetic mice following FX5 administration.Collectively,we have elucidated the mechanisms underlying the beneficial effects of non-steroidal GR antagonist FX5 on DCI and highlighted the potential of FX5 in the treatment of the disease. | Dan-yang Zhu Jian Lu Rui Xu Juan-zhen Yang Xiang-rui Meng Xing-nan Ou-Yang Qiu-ying Yan Rui-fang Nie Tong Zhao Yi-di Chen Yin Lu Yi-nan Zhang Wen-jun Li Xu Shen | 2022 | Acta Pharmacologica Sinica2022，43，10： | 2 |
| 20 | Biomarkers of aging显示文摘Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant. | Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu | 2023 | Science China(Life Sciences)2023，66，5： | 2 |
您所在的机构暂未开通此部分的功能，请联系管理员