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| 1 | Red blood cell membrane-camouflaged nanoparticles: a novel drug delivery system for antitumor application显示文摘Erythrocytes(red blood cells, RBCs) are the most abundant circulating cells in the blood and have been widely used in drug delivery systems(DDS) because of their features of biocompatibility,biodegradability, and long circulating half-life. Accordingly, a 'camouflage' comprised of erythrocyte membranes renders nanoparticles as a platform that combines the advantages of native erythrocyte membranes with those of nanomaterials. Following injection into the blood of animal models, the coated nanoparticles imitate RBCs and interact with the surroundings to achieve long-term circulation. In this review, the biomimetic platform of erythrocyte membrane-coated nano-cores is described with regard to various aspects, with particular focus placed on the coating mechanism, preparation methods, verification methods, and the latest anti-tumor applications. Finally, further functional modifications of the erythrocyte membranes and attempts to fuse the surface properties of multiple cell membranes are discussed,providing a foundation to stimulate extensive research into multifunctional nano-biomimetic systems. | Qing Xia Yongtai Zhang Zhe Li Xuefeng Hou Nianping Feng | 2019 | Acta Pharmaceutica Sinica B2019，9，4： | 26 |
| 2 | Improved dissolution and bioavailability of silymarin delivered by a solid dispersion prepared using supercritical fluids显示文摘The objective of this study was to improve the dissolution and bioavailability of silymarin(SM).Solid dispersions(SDs)were prepared using solution-enhanced dispersion by supercritical fluids(SEDS)and evaluated in vitro and in vivo,compared with pure SM powder.The particle sizes,stability,and contents of residual solvent of the prepared SM-SDs with SEDS and solvent evaporation(SE)were investigated.Four polymer matrix materials were evaluated for the preparation of SM-SD-SEDS,and the hydrophilic polymer,polyvinyl pyrrolidone K17,was selected with a ratio of 1:5 between SM and the polymer.Physicochemical analyses using X-ray diffraction and differential scanning calorimetry indicated that SM was dispersed in SD in an amorphous state.The optimized SM-SD-SEDS showed no loss of SM after storage for 6 months and negligible residual solvent(ethanol)was detected using gas chromatography.In vitro drug release was increased from the SM-SDSEDS,as compared with pure SM powder or SM-SD-SE.In vivo,the area under the rat plasma SM concentration-time curve and the maximum plasma SM concentration were 2.4-fold and 1.9-fold higher,respectively,after oral administration of SM-SD-SEDS as compared with an aqueous SM suspension.These results illustrated the potential of using SEDS to prepare SM-SD,further improving the biopharmaceutical properties of this compound. | Gang Yang Yaping Zhao Nianping Feng Yongtai Zhang Ying Liu Beilei Dang | 2015 | Asian Journal of Pharmaceutical Sciences2015，10，3： | 6 |
| 3 | Percutaneous absorption and brain distribution facilitation of borneol on tetramethylpyrazine in a microemulsion-based transdermal therapeutic system显示文摘In this study, we show that the percutaneous absorption and brain distribution of tetramethylpyrazine(TMP) is enhanced when combined with borneol(BN) in a microemulsionbased transdermal therapeutic system(ME-TTS). The formulation of the TMP and BN microemulsion(TEM-BN-ME) was optimized in skin permeation studies in vitro following a uniform experimental design. Male Sprague-Dawley rats were used for the in vivo pharmacokinetic and tissue distribution studies of TMP-BN-ME-TTS. In the pharmacokinetic study, the TMP-BN-ME-TTS treated rats had significantly higher( P < 0.05) C max and AUC of TMP than the TMP-ME-TTS treated rats, indicating that BN improves the rate and extent of TMP percutaneous absorption. In the tissue distribution study, the AUC of TMP in brain was significantly higher in the TMP-BN-ME-TTS group( P < 0.05), indicating that BN facilitates the distribution of TMP in brain. In summary, BN enhanced the percutaneous absorption and brain distribution of TMP in a microemulsion-based transdermal therapeutic system. | Xiaoge Hu Ning Cheng Jihui Zhao Xianghua Piao Yulu Yan Qibo Zhang Kuan Zhou Yongtai Zhang Nianping Feng | 2019 | Asian Journal of Pharmaceutical Sciences2019，14，3： | 4 |
| 4 | LINEAR PROVABLE SECURITY FOR A CLASS OF UNBALANCED FEISTEL NETWORK显示文摘结构由失衡的 Feistel 网络重申了被介绍。这结构是可证明的,这被显示出对线性攻击抵抗。这篇论文的主要结果是上面的界限( r ≥ 2m )当在功能附近 F 是 bijective 和圆功能 F 的最大的线性壳可能性时,r周围,线性壳可能性被 q^2 围住是这结构的 q.Application 堵住零图案拿出可证明的安全对线性有可能性的上面的界限的攻击。 | Wang Nianping Jin Chenhui Yu Zhaoping | 2005 | Applied Mathematics(A Journal of Chinese Universities)2005，20，4： | 3 |
| 5 | Fabrication of electrochemically-modified BiVO_(4)-MoS_(2)-Co_(3)O_(4)composite film for bisphenol A degradation显示文摘A new electrochemically-modified BiVO_(4)-MoS_(2)-Co_(3)O_(4)(represented as E-BiVO_(4)-MoS_(2)-Co_(3)O_(4))thin film electrode was successfully synthesized for environmental application.MoS_(2)and Co_(3)O_(4)were grown on the surface of Bi VO 4 to obtain BiVO_(4)-MoS_(2)-Co_(3)O_(4).E-BiVO_(4)-MoS_(2)-Co_(3)O_(4)film was achieved by further electrochemical treatment of BiVO_(4)-MoS_(2)-Co_(3)O_(4).The asprepared E-BiVO_(4)-MoS_(2)-Co_(3)O_(4)exhibited significantly enhanced photoelectrocatalytic activity.The photocurrent density of E-BiVO_(4)-MoS_(2)-Co_(3)O_(4)thin film is 6.6 times that of Bi VO 4 under visible light irradiation.The degradation efficiency of E-BiVO_(4)-MoS_(2)-Co_(3)O_(4)for bisphenol A pollutant was 81.56%in photoelectrochemical process.The pseudo-first order reaction rate constant of E-BiVO_(4)-MoS_(2)-Co_(3)O_(4)film is 3.22 times higher than that of Bi VO 4.And its reaction rate constant in photoelectrocatalytic process is 14.5 times or 2 times that in photocatalytic or electrocatalytic process,respectively.The improved performance of E-BiVO_(4)-MoS_(2)-Co_(3)O_(4)was attributed to the synergetic effects of the reduction of interfacial charge transfer resistance,the formation of oxygen vacancies and sub-stoichiometric metal oxides and higher separation efficiency of photogenerated electron-hole pairs.E-BiVO_(4)-MoS_(2)-Co_(3)O_(4)is a promising composite material for pollutants removal. | Yanqing Cong Wenhua Zhang Wenchen Ding Tongtong Zhang Yi Zhang Nianping Chi Qi Wang | 2021 | Journal of Environmental Sciences2021，33，4： | 2 |
| 6 | Resveratrol inhibits proliferation in human colorectal carcinoma cellsby inducing G1/S?phase cell cycle arrest and apoptosis through caspase/cyclin?CDKpathways显示文摘 | Bin Liu Zhongyou Zhou Wei Zhou Jie Liu Qingyu Zhang Juan Xia Juntao Liu Nianping Chen Mingyi Li Runzhi Zhu | 2014 | Molecular Medicine Reports2014，，4： | 2 |
| 7 | High‐performance ZnO varistor ceramics prepared by arc‐induced flash sintering with low energy consumption at room temperature显示文摘The development of ultra‐high voltage transmission lines requires a ZnO arrester with excellent electrical response and high voltage gradient.Compared with conventional preparation methods,flash sintering allows fast production of novel high‐performance ZnO varistor ceramics with low energy consumption and controlled grain growth.Herein,ZnO varistor ceramics were prepared using the flash sintering method at an air pressure of 21 kPa for 60 s at 25℃.The results showed that the flash‐sintered samples had fine grains and reduced loss of volatile elements.Moreover,the voltage gradient,leakage current density,and non‐linear coefficient of the flash‐sintered varistor ceramics were significantly improved compared with those of conventionally sintered samples.Owing to the short preparation time and absence of a heating process,the energy consumption of the proposed flash sintering method was significantly reduced to 10%of that by conventional sintering.The proposed method is a promising approach for the preparation of ZnO arresters with excellent electrical properties and serves as an effective method that realises energy saving and emission reduction. | Angxuan Wu Zhixiang Zhu Xilin Wang Nianping Yan Hongyang Zhou Rongxia Huang Guoming Ma Zhidong Jia Liming Wang | 2022 | High Voltage2022，7，2： | 2 |
| 8 | Defect self-assembly of metal-organic framework triggers ferroptosis to overcome resistance显示文摘The emergence of multidrug treatment resistance presents a hurdle for the successful chemotherapy of tumours.Ferroptosis,resulting from the iron-dependent accumulation of lipid peroxides,has the potential to reverse multidrug resistance.However,simultaneous delivery of the iron sources,ferroptosis inducers,drugs,and enhanced circulation carriers within matrices remains a significant challenge.Herein,we designed and fabricated a defect self-assembly of metal-organic framework(MOF)-red blood cell(RBC)membrane-camouflaged multi-drug-delivery nanoplatform for combined ferroptosis-apoptosis treatment of multidrug-resistant cancer.Ferroptosis and chemotherapeutic drugs are embedded in the centre of the iron(III)-based MOF at defect sites by coordination with metal clusters during a one-pot solvothermal synthesis process.The RBC membrane could camouflage the nanoplatform for longer circulation.Our results demonstrate that this defect self-assembly-enabled MOF-membrane-camouflaged nanoplatform could deplete the glutathione,amplify the reactive oxidative species oxidative stress,and enable remarkable anticancer properties.Our work provides an alternative strategy for overcoming multidrug resistance,which could regulate the fluidity and permeability of the cell membrane by ferroptosis to downregulate of P-glycoprotein protein expression by ferroptosis.This defect self-assembly-enabled MOF-membrane-camouflaged multi-drug-delivery nanoplatform has great therapeutic potential. | Haibao Peng Xingcai Zhang Peng Yang Jiaxu Zhao Wei Zhang Nianping Feng Wuli Yang Jing Tang | 2023 | Bioactive Materials2023，，1： | 2 |
| 9 | Principle of exergy in HVAC and evaluation of evaporative cooling schemes 显示文摘 | CHENQIN REN NIANPING LI GUANGFA TANG | 2002 | Building and Environment2002，37，11： | 1 |
| 10 | A statistical method to investigate national energy consumption in the residential building sector of China显示文摘 | Chen Shuqin Li Nianping Guan Jun | 2008 | Energy and Buildings2008，40，4： | 1 |
| 11 | Cold Water in the Lee of the Batanes Islands in the Luzon Strait显示文摘Using satellite remote sensing data and hydrological observation data,this study investigated the cold water in the lee of the Batanes Islands in the Luzon Strait.The formation of cold water in climate is mainly due to the geostrophic heat advection on the east and west sides of the Batanes Islands:the Kuroshio separates into two branches on the east and west sides of the Batanes Islands.These two branches cause two warm tongues by transferring heat from low latitudes to mid-latitudes,and then the two warm tongues lead to the formation of the relatively cold water in the lee of the Batanes Islands.Further study shows that the cold water range has obvious seasonal and inter-annual variations.Except for August,the seasonal variation of the cold water range is caused by the interaction of geostrophic heat advection and net surface heat flux,whereas the low temperature in August in the lee of the Batanes Islands is caused by the island wake effect.The inter-annual of the cold water range is related to the difference in the meridional velocity between the east and west sides of the Batanes Islands,and the correlation coefficient can reach−0.68 at the 95%confidence level. | SUN Ruili ZHAI Fangguo ZHANG Guosheng GU Yanzhen CHI Nianping | 2020 | Journal of Ocean University of China2020，19，6： | 1 |
| 12 | Novel polymeric Nanoparticles containing Tanshione I1 s for the treatment of Hepatoma显示文摘 | Qi Li Yan Wang ( co-author) Nianping Feng | 2008 | J Drug Target2008，16，10： | 1 |
| 13 | Exergy transfer and parametric study of counter flow wet cooling towers显示文摘 | Wang L Li Nianping | 2011 | Applied Thermal Engineering2011，31，： | 1 |
| 14 | Indoor thermal environment and energy saving for urban residential buildings in China显示文摘 | Hiroshi Yoshino Yasuko Yoshino Qingyuan Zhang Akashi Mochida Nianping Li Zhenhai Li Hiroyuki Miyasaka | 2006 | Energy & Buildings2006，，11： | 1 |
| 15 | A Fe2 03 nanoparti- cle/carbon aerogel composite for use as an anode material for lithium ion batteries 显示文摘 | Nianping Liu Jun Shen Dong Liu | 2013 | Electrochimica Acta2013，97，： | 1 |
| 16 | Principles ofexergy analysis in HVAC and evaluation of evaporativecooling schemes 显示文摘 | Ren Chengqin Li Nianping Tang Guangfa | 2002 | Building and Environment2002，37，： | 1 |
| 17 | A statistical method to investigate national energy consumption in the residential buildin-g sector of China显示文摘 | Chen Shuqin Li Nianping Guan Jun | 2008 | Energy and Buildings2008，40，4： | 1 |
| 18 | Uncertainty in Indoor Air Quality and Grey System Method显示文摘 | Zhu Chihui Li NianPing Re Di | 2007 | Building and Environment2007，42，4： | 1 |
| 19 | A statistical method to investigate national energy consumption in the residential building sector of China 显示文摘 | Chen Shuqin Li Nianping Guan Jun | 2008 | Energy- and Buildings2008，40，4： | 1 |
| 20 | A statistical method to investigate national energy consumption in the residential building sector of China 显示文摘 | Chen Shuqin Li Nianping Guan Jun | 2008 | Energy and Buildings2008，40，4： | 1 |
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