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| 1 | 影响慢性阻塞性肺病急性加重患者生活质量的危险因素显示文摘目的测定和评价慢性阻塞性肺病(COPD)急性加重患者的生活质量和潜在危险因素的发生率及其影响。方法研究两家大型医院因COPD急性加重入院的196个中重度COPD患者。在患者出院时和出院后1月稳定状态,测量肺功能指标、精神状态及用圣乔治呼吸问卷测定生活质量,并收集了患者的临床性状、社会性状和照料因素。结果196例患者中,吸烟、抑郁及嗜用镇痛剂、安眠药相当普遍,而完成肺康复、接种流感病毒疫苗和肺炎球菌疫苗以及看护支持却很少。生活质量的症状域均值为55.9,活动域均值为65,影响域均值为32.9,总体均值为46.5。多变量分析显示慢性黏液高分泌症、男性、抑郁、前1年多次入院和治疗依顺性差与症状域值低下独立显著相关;前1年多次入院、抑郁、严重气促和72岁以上老年与活动域值低下独立显著相关;抑郁、前1年多次入院、严重气促、病程长和重度吸烟与影响域值低下独立显著相关;抑郁、前1年多次入院、严重气促和病程长与总体数值低下独立显著相关(P<0.05)。结论COPD急性加重患者的生活质量低下与COPD严重程度、患者精神抑郁状态及照料这些可改善因素有关。 | 曹振英 Tan Wan Cheng Ng Tze Pin | 2005 | 上海第二医科大学学报2005，25，7： | 10 |
| 2 | 慢性阻塞性肺疾病急性加重患者频繁再入院与其危险因素显示文摘目的 评价慢性阻塞性肺疾病 (COPD)患者急性加重频繁入院的危险因素。方法 调查两家大型医院因COPD急性加重入院的 196名中重度COPD患者。在患者出院时和出院后一个月稳定状态 ,收集患者的临床性状、社会性状、日常护理因素和过去一年中急性加重入院的频率 ,测定肺功能指标及精神状态。结果 196例COPD患者中 ,72 %过去一年中有一次以上再入院 ,4 8%有 2次以上 ,8%有超过 10次再入院。单变量分析显示男性、病程长、嗜用镇痛剂和安眠药、第 1秒用力呼气容量占预计值的百分比 (FEV1% ) <4 5 %、缺乏肺康复训练和严重气促与频繁再入院有显著相关性 (P <0 .0 5 )。多变量分析显示病程长 (OR =2 .6 0 )、FEV1% <4 5 % (OR =2 .0 3)、严重气促 (OR =2 .5 0 )和男性 (OR =3.13)与COPD急性加重再入院有独立显著相关性 (P <0 .0 5 )。结论 COPD急性加重频繁再入院与COPD严重程度。 | 曹振英 Tan Wan Cheng Ng Tze Pin | 2005 | 中国临床保健杂志2005，8，1： | 5 |
| 3 | Prevalence of lens opacity in Chinese residents of Singapore: the tanjong pagar survey显示文摘 | Steve K.L Seah Tien Yin Wong Paul J Foster Tze Pin Ng Gordon J Johnson | 2002 | Ophthalmology2002，，11： | 1 |
| 4 | Comparing the stigma of mental illness in a general hospital with a state mental hospital显示文摘 | Cornelia Y. I. Chee Tze Pin Ng Ee Heok Kua | 2005 | Social Psychiatry and Psychiatric Epidemiology2005，，8： | 1 |
| 5 | Obesity, asthma prevalence and IL ‐4: Roles of inflammatory cytokines, adiponectin and neuropeptide Y显示文摘 | Yanxia Lu Hugo P. S. Van Bever Tow Keang Lim Win Sen Kuan Daniel Yam Thiam Goh Malcolm Mahadevan Tiong Beng Sim Roger Ho Anis Larbi Tze Pin Ng | 2015 | Pediatr Allergy Immunol2015，，： | 1 |
| 6 | FACTORS ASSOCIATED WITH QUALITY OF LIFE IN ACUTE EXACERBATION OF COPD显示文摘Objective To measure the QOL in patients with AECOPD and the frequency of potential risk factors, and to evaluate the association of risk factors with poor QOL in patients with AECOPD. Methods A study sample of 196 patients with moderate to severe COPD admitted for acute exacerbations to two large general hospitals were studied. The St George QOL (SGQOL) scale, socio-demographic, clinical and patient care characteristics, including depression and spirometry were ascertained in the stable state before discharge and at one-month post discharge. Results There was a high prevalence of current or ex-heavy smokers, depression and consumption of psychotropic drugs, and low prevalence of care giver support, pulmonary rehabilitation and vaccination. The mean scores for the different domains were 55.9 for Symptoms; 65.1 for Activity; 32.9 for Impact; and the mean of overall Total scores was 46.5. Multiple regression analysis showed that CMH, male, depression, previous frequent hospital readmissions and poor therapy compliance were independently related to worse Symptoms Scores. Previous frequent readmissions, depression, severe dyspnea and older age (>72 years) were related to worse Activity Scores of SGQOL. Depression, previous frequent readmissions, severe dyspnea, long COPD duration(≥5years) and severe smoking were related to worse Impact Scores of SGQOL. Depression, previous frequent readmissions, severe dyspnea and long COPD duration(≥5years) were independently related to worse Total Scores of SGQOL. Conclusion Poor QOL in patients with COPD exacerbation was associated with disease severity, psychosocial and health care factors which are modifiable. | 曹振英 Ng Tze Pin | 2005 | Journal of Shanghai Second Medical University(Foreign Language Edition)2005，17，2： | 0 |
| 7 | Factors Associated with Quality of Life in Acute Exacerbation of COPD显示文摘Objective To measure the QOLin patients with AECOPD and the frequency of potential risk factors, and to evaluate the as-sociation of risk factors with poor QOL in patients with AECOPD. Methods A study sample of 196 patients with moderate to severeCOPD admitted for acute exacerbations to two large general hospitals were studied. The St George QOL (SGQOL) scale, socio-demo-graphic, clinical and patient care characteristics, including depression and spirometry were ascertained in the stable state before dischargeand at one-month post discharge. Results There was a high prevalence of current or ex-heavy smokers, depression and consumption ofpsychotropic drugs, and lowprevalence of care giver support, pulmonary rehabilitation and vaccination. The mean scores for the differentdomains were 55.9 for Symptoms; 65.1 for Activity; 32.9 for Impact; and the mean of overall Total scores was 46.5. Multiple regressionanalysis showed that CMH, male, depression, previous frequent hospital readmissions and poor therapy compliance were independentlyrelated to worse Symptoms Scores. Previous frequent readmissions, depression, severe dyspnea and older age ( >72 years) were relatedto worse Activity Scores of SGQOL. Depression, previous frequent readmissions, severe dyspnea, long COPD duration(≥5years) andsevere smoking were related to worse Impact Scores of SGQOL. Depression, previous frequent readmissions, severe dyspnea and longCOPD duration(≥5years) were independently related to worse Total Scores of SGQOL. Conclusion Poor QOL in patients with COPDexacerbation was associated with disease severity, psychosocial and health care factors which are modifiable. | CAO Zhen-ying Tan Wan Cheng Ng Tze Pin | 2005 | 上海第二医科大学学报2005，25，12： | 0 |
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