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| 1 | Tumor necrosis factor-α and interleukin-6 in cirrhotic patients with spontaneous bacterial peritonitis显示文摘AIM:To evaluate the role of tumor necrosis factor-α(TNF-α) and interleukin-6(IL-6) in cirrhotic patients who have hepatic and renal impairment with spontaneous bacterial peritonitis(SBP).METHODS:We prospectively studied 120 cirrhotic patients with SBP and 80 cirrhotic patients with sterile ascitic fluid.They included 144 males and 56 females with ages ranging between 34 and 62 years.The diagnosis of cirrhosis was established by clinical and laboratory criteria that did not require histological confirmation.The severity of underlying liver disease was evaluated using Pugh's modification of Child's criteria(Child-Pugh scores).Ascitic fluid was sent to the laboratory for cell count,culture,sensitivity testing,and measurement of chemical elements(i.e.,albumin,glucose).Specimens were inoculated into aerobic and anaerobic blood culture bottles.Serum and ascitic fluid were also collected in sterile tubes at study entry(before the initiation of antibiotic treatment) and 48 h later.Assays for TNF-α and IL-6 in the serum and ascitic fluid were performed with an immunoenzymometric assay using manufacture's instructions.RESULTS:Cytokine levels in serum and ascitic fluid were significantly higher in the patients with SBP.(plasma TNF-α:135.35 ng/mL ± 11.21 ng/mL vs 92.86 ng/mL ± 17.56 ng/mL,P < 0.001;plasma IL-6:32.30 pg/mL ± 7.07 pg/mL vs 12.11 pg/mL ± 6.53 pg/mL,P < 0.001;ascitic fluid TNF-α:647.54 ± 107.11 ng/mL vs 238.43 ng/mL ± 65.42 ng/mL,P < 0.001);ascitic fluid IL-6:132.84 ng/mL ± 34.13 vs 40.41 ± 12.85 pg/mL,P < 0.001).About 48(40%) cirrhotic patients with SBP developed renal and hepatic impairment and showed significantly higher plasma and ascitic fluid cytokine levels at diagnosis of infection.[(plasma TNF-α:176.58 ± 17.84 vs 135.35 ± 11.21 ng/mL)(P < 0.001) and(IL-6:57.83 ± 7.85 vs 32.30 ± 7.07 pg/mL)(P < 0.001);ascitic fluid TNF-α:958.39 ± 135.72 vs 647.54 ± 107.11 ng/mL,(P < 0.001),ascitic fluid IL-6:654.74 ± 97.43 vs 132.84 ± 34.13 pg/mL,(P < 0.001)].Twenty nine patients(60.4%) with SBP and renal impairment died whereas,only four patients(5.55%) with SBP but without renal impairment died from gastrointestinal hemorrhage(P < 0.0005).CONCLUSION:It appears that TNF-α production may enhance liver cell injury and lead to renal impairment.This correlated well with the poor prognosis and significantly increased mortality associated with SBP in cirrhotic patients. | Muhammed AM Suliman Fawzy MH Khalil Salam SA Alkindi Anil V Pathare Ali AA Almadhani Neveen AAI Soliman | 2012 | World Journal of Gastrointestinal Pathophysiology2012，3，5： | 39 |
| 2 | Updates in the pathophysiological mechanisms of Parkinson's disease: Emerging role of bone marrow mesenchymal stem cells显示文摘AIM: To explore the approaches exerted by mesenchymal stem cells(MSCs) to improve Parkinson's disease(PD) pathophysiology.METHODS: MSCs were harvested from bone marrowof femoral bones of male rats, grown and propagated in culture. Twenty four ovariectomized animals were classified into 3 groups: Group(1) was control, Groups(2) and(3) were subcutaneously administered with rotenone for 14 d after one month of ovariectomy for induction of PD. Then, Group(2) was left untreated, while Group(3) was treated with single intravenous dose of bone marrow derived MSCs(BM-MSCs). SRY gene was assessed by PCR in brain tissue of the female rats. Serum transforming growth factor beta-1(TGF-β1), monocyte chemoattractant protein-1(MCP-1) and brain derived neurotrophic factor(BDNF) levels were assayed by ELISA. Brain dopamine DA level was assayed fluorometrically, while brain tyrosine hydroxylase(TH) and nestin gene expression were detected by semi-quantitative real time PCR. Brain survivin expression was determined by immunohistochemical procedure. Histopathological investigation of brain tissues was also done.RESULTS: BM-MSCs were able to home at the injured brains and elicited significant decrease in serum TGF-β1(489.7 ± 13.0 vs 691.2 ± 8.0, P < 0.05) and MCP-1(89.6 ± 2.0 vs 112.1 ± 1.9, P < 0.05) levels associated with significant increase in serum BDNF(3663 ± 17.8 vs 2905 ± 72.9, P < 0.05) and brain DA(874 ± 15.0 vs 599 ± 9.8, P < 0.05) levels as well as brain TH(1.18 ± 0.004 vs 0.54 ± 0.009, P < 0.05) and nestin(1.29 ± 0.005 vs 0.67 ± 0.006, P < 0.05) genes expression levels. In addition to, producing insignificant increase in the number of positive cells for survivin(293.2 ± 15.9 vs 271.5 ± 15.9, P > 0.05) expression. Finally, the brain sections showed intact histological structure of the striatum as a result of treatment with BM-MSCs. CONCLUSION: The current study sheds light on the therapeutic potential of BM-MSCs against PD pathophysiology via multi-mechanistic actions. | Hanaa H Ahmed Ahmed M Salem Hazem M Atta Emad F Eskandar Abdel Razik H Farrag Mohamed A Ghazy Neveen A Salem Hadeer A Aglan | 2016 | World Journal of Stem Cells2016，8，3： | 9 |
| 3 | Exploring the value of online product reviews in forecasting sales: The case of motion pictures显示文摘 | Chrysanthos Dellarocas Xiaoquan (Michael) Zhang Neveen F. Awad | 2007 | Journal of Interactive Marketing2007，，4： | 4 |
| 4 | RhoGDI2 suppresses lung metastasis in mice by reducing tumor versican expression and macrophage infiltration显示文摘 | Said Neveen Sanchez-Carbayo Marta Smith Steven C Theodorescu Dan | 2012 | EN2012，，4： | 2 |
| 5 | Exploring the value of online product reviews in forecasting sales: The case of motion pictures显示文摘 | Chrysanthos Dellarocas Xiaoquan (Michael) Zhang Neveen F. Awad | 2007 | Journal of Interactive Marketing2007，，4： | 2 |
| 6 | SPARC Inhibits LPA-Mediated Mesothelial-Ovarian Cancer Cell Crosstalk 显示文摘 | Neveen AS Ida N Matthew JS | 2007 | Neoplasia2007，9，1： | 1 |
| 7 | Adaptive k-means clustering algorithm for MR breast image segmentation显示文摘 | Hossam M. Moftah Ahmad Taher Azar Eiman Tamah Al-Shammari Neveen I. Ghali Aboul Ella Hassanien Mahmoud Shoman | 2014 | Neural Computing and Applications . 2014 (7-8)2014，，： | 1 |
| 8 | Effect of oxi- dative stress induced by paradoxical sleep deprivation on the activities of Na+ , K +-ATPase and acetylcholinesterase in the cortex and hippocampus of rat 显示文摘 | YASSER A K NEVEEN A N HEBA S A | 2011 | Transl Res2011，157，2： | 1 |
| 9 | 伊朗茧蜂科(膜翅目:姬蜂总科)新记录(英文)显示文摘报道了伊朗茧蜂科(膜翅目:姬蜂总科) 19种的分布新记录,隶属Agathidinae亚科的1种,Brachistinae亚科的2种(2属),Braconinae亚科的5种(3属),Cheloninae亚科的3种(2属),Euphorinae亚科的4种(4属),Microgastrinae亚科的2种(2属)和Opiinae亚科的2种(1属)。 | Neveen S.GADALLAH Hassan GHAHARI Jen? PAPP Ahmet BEYARSLAN | 2018 | 武夷科学2018，34，1： | 1 |
| 10 | Loss of SPARC in bladder cancer enhances carcinogenesis and progression显示文摘 | Said Neveen Frierson Henry F Sanchez-Carbayo Marta Brekken Rolf A Theodorescu Dan | 2013 | Journal of Clinical Investigation2013，，： | 1 |
| 11 | Contribution of different mechanisms to the resistance to fluoroquinolones in clinical isolates of Salmonella enteric显示文摘 | Abeer Ahmd Rushdy Mona Ibrahim Mabrouk Feriala Abdel-Hamid Abu Sef Zeinab Mohamed Hassn Kheiralla Said Mohamed Abd El-All Neveen Mohamed Saleh | 2013 | Brazilian Journal of Infectious Diseases2013，，： | 1 |
| 12 | Reliability of fine needle aspiration cytology (FNAC) as a diagnostic tool in cases of cervical lymphadenopathy显示文摘 | Nesreen H. Hafez Neveen S. Tahoun | 2011 | Journal of the Egyptian National Cancer Institute2011，，3： | 1 |
| 13 | SPARC InhibitsLPA-Mediated Mesothelial-Ovarian Cancer Cell Crosstalk 显示文摘 | Neveen AS Najwer I Matthew JS | 2007 | Neoplasia2007，9，1： | 1 |
| 14 | Osteoprotegerin as a potential therapy for osteoporosis显示文摘 | Neveen A. T. Hamdy MD | 2006 | Current Rheumatology Reports2006，，1： | 1 |
| 15 | Exploring the Value of Online Product Reviews in Forecasting Sales: The Case of Motion Pictures 显示文摘 | Zhang X Neveen F A | 2007 | Journal of Interactive Marketing2007，21，4： | 1 |
| 16 | Effect of roof shape, wind direction, building height and urban configuration on the energy yield and positioning of roof mounted wind turbines显示文摘 | Abohela Islam Hamza Neveen Dudek Steven | 2013 | Renewable Energy2013，50，2： | 1 |
| 17 | Evaluation of the antiepileptic effect of curcumin and Nigella sativa oil in the pilocarpine model of epilepsy in comparison with valproate显示文摘 | Neveen A.Noor Heba S.Aboul Ezz Abdel Razik Faraag | | 0，，02： | 1 |
| 18 | Pattern of clinical presentation of congenital anomalies of the kidney and urinary tract among infants and children显示文摘 | Neveen A Soliman Reham I Ali Emad E Ghobrial Enmar I Habib Ali M Ziada | 2015 | Nephrology2015，，6： | 1 |
| 19 | Attribute Weighted Naïve Bayes Classifier显示文摘The naïve Bayes classifier is one of the commonly used data mining methods for classification.Despite its simplicity,naïve Bayes is effective and computationally efficient.Although the strong attribute independence assumption in the naïve Bayes classifier makes it a tractable method for learning,this assumption may not hold in real-world applications.Many enhancements to the basic algorithm have been proposed in order to alleviate the violation of attribute independence assumption.While these methods improve the classification performance,they do not necessarily retain the mathematical structure of the naïve Bayes model and some at the expense of computational time.One approach to reduce the naïvetéof the classifier is to incorporate attribute weights in the conditional probability.In this paper,we proposed a method to incorporate attribute weights to naïve Bayes.To evaluate the performance of our method,we used the public benchmark datasets.We compared our method with the standard naïve Bayes and baseline attribute weighting methods.Experimental results show that our method to incorporate attribute weights improves the classification performance compared to both standard naïve Bayes and baseline attribute weighting methods in terms of classification accuracy and F1,especially when the independence assumption is strongly violated,which was validated using the Chi-square test of independence. | Lee-Kien Foo Sook-Ling Chua Neveen Ibrahim | 2022 | Computers, Materials & Continua2022，，4： | 1 |
| 20 | Evaluation of the antiepileptic effect of curcumin and Nigella sativa oil in the pilocarpine model of epilepsy in comparison with valproate显示文摘 | Neveen A. Noor Heba S. Aboul Ezz Abdel Razik Faraag Yasser A. Khadrawy | 2012 | Epilepsy and Behavior2012，，2： | 1 |
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