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| 1 | Challenges and opportunities in the application of artificial intelligence in gastroenterology and hepatology显示文摘Artificial intelligence(AI)is an umbrella term used to describe a cluster of interrelated fields.Machine learning(ML)refers to a model that learns from past data to predict future data.Medicine and particularly gastroenterology and hepatology,are data-rich fields with extensive data repositories,and therefore fruitful ground for AI/ML-based software applications.In this study,we comprehensively review the current applications of AI/ML-based models in these fields and the opportunities that arise from their application.Specifically,we refer to the applications of AI/ML-based models in prevention,diagnosis,management,and prognosis of gastrointestinal bleeding,inflammatory bowel diseases,gastrointestinal premalignant and malignant lesions,other nonmalignant gastrointestinal lesions and diseases,hepatitis B and C infection,chronic liver diseases,hepatocellular carcinoma,cholangiocarcinoma,and primary sclerosing cholangitis.At the same time,we identify the major challenges that restrain the widespread use of these models in healthcare in an effort to explore ways to overcome them.Notably,we elaborate on the concerns regarding intrinsic biases,data protection,cybersecurity,intellectual property,liability,ethical challenges,and transparency.Even at a slower pace than anticipated,AI is infiltrating the healthcare industry.AI in healthcare will become a reality,and every physician will have to engage with it by necessity. | Chrysanthos D Christou Georgios Tsoulfas | 2021 | World Journal of Gastroenterology2021，27，37： | 5 |
| 2 | Exploring the value of online product reviews in forecasting sales: The case of motion pictures显示文摘 | Chrysanthos Dellarocas Xiaoquan (Michael) Zhang Neveen F. Awad | 2007 | Journal of Interactive Marketing2007，，4： | 4 |
| 3 | Role of three-dimensional printing and artificial intelligence in the management of hepatocellular carcinoma:Challenges and opportunities显示文摘Hepatocellular carcinoma(HCC)constitutes the fifth most frequent malignancy worldwide and the third most frequent cause of cancer-related deaths.Currently,treatment selection is based on the stage of the disease.Emerging fields such as three-dimensional(3D)printing,3D bioprinting,artificial intelligence(AI),and machine learning(ML)could lead to evidence-based,individualized management of HCC.In this review,we comprehensively report the current applications of 3D printing,3D bioprinting,and AI/ML-based models in HCC management;we outline the significant challenges to the broad use of these novel technologies in the clinical setting with the goal of identifying means to overcome them,and finally,we discuss the opportunities that arise from these applications.Notably,regarding 3D printing and bioprinting-related challenges,we elaborate on cost and cost-effectiveness,cell sourcing,cell viability,safety,accessibility,regulation,and legal and ethical concerns.Similarly,regarding AI/ML-related challenges,we elaborate on intellectual property,liability,intrinsic biases,data protection,cybersecurity,ethical challenges,and transparency.Our findings show that AI and 3D printing applications in HCC management and healthcare,in general,are steadily expanding;thus,these technologies will be integrated into the clinical setting sooner or later.Therefore,we believe that physicians need to become familiar with these technologies and prepare to engage with them constructively. | Chrysanthos D Christou Georgios Tsoulfas | 2022 | World Journal of Gastrointestinal Oncology2022，14，4： | 2 |
| 4 | Exploring the value of online product reviews in forecasting sales: The case of motion pictures显示文摘 | Chrysanthos Dellarocas Xiaoquan (Michael) Zhang Neveen F. Awad | 2007 | Journal of Interactive Marketing2007，，4： | 2 |
| 5 | The Digitization of Word of Mouth:Promise and Challenges of Online Feedback Mechanisms显示文摘 | CHRYSANTHOS DELLAROCAS | | 0，，49： | 1 |
| 6 | Reputation Mechanism Design in Online Trading Environments with Pure Moral Hazard显示文摘 | Chrysanthos Dellarocas | 2005 | Information Systems Research2005，，2： | 1 |
| 7 | Prepa- ration and properties of bio-based epoxy networks de- rived from isosorbide diglycidyl ether 显示文摘 | CHRYSANTHOS M GALY J PASCAULT J P | 2011 | J Polymer2011，52，16： | 1 |
| 8 | Diabetes mellitus in chronic hepatitis B and C : prevalence and potential association with the extent of liver fibrosis 显示文摘 | PAPATHEODORIDIS G V CHRYSANTHOS N SAVVAS S | 2006 | J Viral Hepatitis2006，13，5： | 1 |
| 9 | The digitization of word of mouth: Promise and challenges of online feedback mechanisms显示文摘 | Chrysanthos Dellarocas | | Management Science0，49，10： | 1 |
| 10 | Money Models for MOOCs 显示文摘 | Chrysanthos Dellarocas Marshall Van Alstyne | 2013 | Communications of the ACM2013，56，8： | 1 |
| 11 | Intra-operative assessment of toric intra-ocular lens implantation显示文摘 | Ioannis Tsinopoulos Chrysanthos Symeonidis Konstantinos Tsaousis Dimitris Tsakpinis Nikolaos Ziakas Stavros Dimitrakos | 2011 | Indian Journal of Ophthalmology2011，，1： | 1 |
| 12 | Convex relaxation for solving posynomial programs显示文摘 | Hao-Chun Lu Han-Lin Li Chrysanthos E. Gounaris Christodoulos A. Floudas | 2010 | Journal of Global Optimization2010，，1： | 1 |
| 13 | Interleukin-6 and the matrix metalloproteinase response in the vitreous during proliferative vitreoretinopathy显示文摘 | Chrysanthos Symeonidis Eleni Papakonstantinou Sofia Androudi Tryfon Rotsos Eudoxia Diza Periklis Brazitikos George Karakiulakis Stavros A. Dimitrakos | 2011 | Cytokine2011，，2： | 1 |
| 14 | Mon-ey Models for MOOCs 显示文摘 | Chrysanthos Dellarocas Marshall Van Alstyne | 2013 | Communications of theACM2013，56，08： | 1 |
| 15 | Diabetes mellitus in chronic hepatitis B and C: prevalence and potential association with the extent of liver fibrosis显示文摘 | Papatheodoridis GV Chrysanthos N Savvas S | 2006 | J Viral Hepat2006，13，： | 1 |
| 16 | Liver disease in adult transfusion‐dependent beta‐thalassaemic patients: investigating the role of iron overload and chronic HCV infection显示文摘 | Dimitrios Kountouras Nikolaos J. Tsagarakis Evangelia Fatourou Efthimios Dalagiorgos Nikolaos Chrysanthos Helen Berdoussi Niki Vgontza Markissia Karagiorga Athanasios Lagiandreou Konstantinos Kaligeros Ersi Voskaridou Paraskevi Roussou Evanthia Diamanti‐K | 2013 | Liver Int2013，，3： | 1 |
| 17 | The Digitization of Word of Mouth:Promised and Challenges of Online Feedback Mechanisms显示文摘 | CHRYSANTHOS DELLAROCAS | 2003 | Management Science2003，10，49： | 1 |
| 18 | Capsule contraction syndrome in eight cases of hydrophobic one-piece intraocular lens implantation 显示文摘 | Ioannis T Chrysanthos S Ekaterini F | 2008 | Clin Exp Optom2008，91，5： | 1 |
| 19 | What Motivates People to Review a Product Online? A Study of the Product-Specific Antecedents of Online Movie Ratings显示文摘 | Chrysanthos Dellarocas Ritu Narayan | 2005 | Preliminary and Incomplete2005，2005，： | 1 |
| 20 | Interleukin -6 and the matrix metalloproteinase response in the vitreous during pro- liferative vitreoretinopathy 显示文摘 | Chrysanthos S Eleni P Sofia A | 2011 | Cytokine2011，54，2： | 1 |
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