|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Cytomegalovirus infection in severe ulcerative colitis patients undergoing continuous intravenous cyclosporine treatment in Japan显示文摘AIM: To investigate active cytomegalovirus (CMV) infection following the cyclosporine A (CyA) treatment of steroid-refractory ulcerative colitis (UC).METHODS: Twenty-three patients with severe UC not responding to steroid therapy (male 14, and female 9) enrolled at Nagoya University Hospital from 1999 to 2005. They received continuous intravenous infusion of CyA (average 4 mg/kg per day) for 1 mo. Serum and colonic biopsy samples were collected before CyA treatment and 4 d, 10 d, 20 d, and 30 d after treatment. Patients were evaluated for CMV by using serology (IgM antibody by ELISA), quantitative real-time PCR for CMV DNA, and histopathological assessment of hematoxylin and eosin (HE)-stained colonic biopsies. CMV infection was indicated by positive results in any test. RESULTS: No patients had active CMV infection before CyA treatment. Eighteen of 23 UC patients treated with CyA were infected with active CMV (IgM antibody in 16/23 patients, 69.6%; CMV DNA in 18/23 patients, 78.2%; and inclusion bodies in 4/23 patients, 17.3%). There was no difference in the active CMV-infection rate between males and females. Active CMV infection was observed after approximately 8 d of CyA treatment, leading to an exacerbation of colitis. Fifteen of these 18 patients with active CMV infection (83.3%) required surgical treatment because of severe deteriorating colitis. Treatment with ganciclovir rendered surgery avoidable in three patients. CONCLUSION: Our results suggest that active CMVinfection in severe UC patients treated with CyA is associated with poor outcome. Further, ganciclovir is useful for treatment of CMV-associated UC after immuno-suppressive therapy. | Masaaki Minami Michio Ohta Teruko Ohkura Takafumi Ando Naoki Ohmiya Yasumasa Niwa Hidemi Goto | 2007 | World Journal of Gastroenterology2007，13，5： | 13 |
| 2 | Endoscopic ultrasound-guided fine needle aspiration in the differentiation of type 1 and type 2 autoimmune pancreatitis显示文摘AIM:To investigate the usefulness of endoscopic ultrasound-guided fine needle aspiration(EUS-FNA) in the differentiation of autoimmune pancreatitis(AIP).METHODS:We retrospectively reviewed 47 of 56 AIP patients who underwent EUS-FNA and met the Asian diagnostic criteria.On 47 EUS-FNA specimens,we evaluated the presence of adequate material and characteristic features of lymphoplasmacytic sclerosing pancreatitis(LPSP) and idiopathic duct-centric pancreatitis(IDCP) mentioned in the International Consensus Diagnostic Criteria and examined if these findings make a contribution to the differential diagnosis of type 1 and type 2 AIP.A disposable 22-gauge needle was used for EUS-FNA.RESULTS:Adequate specimens including pancreatic tissue for differentiating AIP from cancer were obtained from 43 of 47 patients who underwent EUSFNA.EUS-FNA was performed from the pancreatic head in 21 cases,which is known to be technically difficult when performed by core biopsy;there was no significant difference in the results compared with pancreatic body-tail.Nine of 47 patients met level 1 findings of LPSP and 5 patients met level 2 findings of LPSP.No one met level 1 findings of IDCP,but 3 patients met level 2 findings of IDCP.Of 10 seronegative cases,2 cases were diagnosed with 'definitive type 1 AIP',and 3 cases were diagnosed with 'probable type 2 AIP' when considering both the level 2 histological findings and response to steroids.CONCLUSION:EUS-FNA is useful in the differentiation of type 1 and type 2 AIP,particularly in seronegative cases. | Takuya Ishikawa Akihiro Itoh Hiroki Kawashima Eizaburo Ohno Hirosh Matsubara Yuya Itoh Yosuke Nakamura Takeshi Hiramatsu Masanao Nakamura Ryoji Miyahara Naoki Ohmiya Hidemi Goto Yoshiki Hirooka | 2012 | World Journal of Gastroenterology2012，18，29： | 8 |
| 3 | BRIEF ARTICLE New reduced volume preparation regimen in colon capsule endoscopy显示文摘AIM:To evaluate the effectiveness of our proposed bowel preparation method for colon capsule endoscopy.METHODS:A pilot,multicenter,randomized controlled trial compared our proposed 'reduced volume method'(group A) with the 'conventional volume method'(group B) preparation regimens.Group A did not drink polyethylene glycol electrolyte lavage solution(PEGELS) the day before the capsule procedure,while group B drank 2 L.During the procedure day,groups A and B drank 2 L and 1 L of PEG-ELS,respectively,and swallowed the colon capsule(PillCam COLON capsule).Two hours later the first booster of 100 g magnesium citrate mixed with 900 mL water was administered to both groups,and the second booster was administered six hours post capsule ingestion as long as the capsule had not been excreted by that time.Capsule videos were reviewed for grading of cleansing level,RESULTS:Sixty-four subjects were enrolled,with results from 60 analyzed.Groups A and B included 31 and 29 subjects,respectively.Twenty-nine(94%) subjects in group A and 25(86%) subjects in group B had adequate bowel preparation(ns).Twenty-two(71%) of the 31 subjects in group A excreted the capsule within its battery life compared to 16(55%) of the 29 subjects in group B(ns).Of the remaining 22 subjects whose capsules were not excreted within the battery life,all of the capsules reached the left side colon before they stopped functioning.A single adverse event was reported in one subject who had mild symptoms of nausea and vomiting one hour after starting to drink PEG-ELS,due to ingesting the PEG-ELS faster than recommended.CONCLUSION:Our proposed reduced volume bowel preparation method for colon capsule without PEG-ELS during the days before the procedure was as effective as the conventional volume method. | Yasuo Kakugawa Yutaka Saito Shoichi Saito Kenji Watanabe Naoki Ohmiya Mitsuyuki Murano Shiro Oka Tetsuo Arakawa Hidemi Goto Kazuhide Higuchi Shinji Tanaka Hideki Ishikawa Hisao Tajiri | 2012 | World Journal of Gastroenterology2012，18，17： | 8 |
| 4 | Use of color Doppler ultrasonography in the diagnosis of anomalous connection in pancreatobiliary disease显示文摘AIM: To estimate the detectability of anomalous connection in pancreatobiliary disease (ACPBD) cases, measuring gallbladder wall blood flow (GWBF).METHODS: In the retrospective study, we enrolled 42subjects with gallbladder wall thickening. GWBF velocity was determined as an average value of the peak velocity of color signals on the gallbladder wall, three times in each case. Based on the findings on endoscopic ultrasonography (EUS) or endoscopic retrograde cholangiopancreatography (ERCP), the 42 subjects were divided into 11 cases with ACPBD and 31 cases without ACPBD. In the prospective study, the subjects were 92 cases with gallbladder wall thickening. Using the cut-off level of the flow velocity obtained in the retrospective study, the usefulness of measuring GWBF velocity in diagnosing ACPBD was evaluated.RESULTS: In the retrospective study, imaging of GWBF was obtained in 40 of the 42 subjects. The mean GWBF velocity of the ACPBD cases was 29.4±3.9 cm/s(mean±SD), which was significantly different (P<0.0001;95% CI 5.48-13.2) from that of the without ACPBD cases(20.1±5.9 cm/s). Based on this result, we prepared a receiver operating characteristic curve, and the cut-off level appropriate for diagnosing ACPBD was estimated to be 25 cm/s. In the prospective study, GWBF was detected in 86 of the 92 subjects. Based on the EUS or ERCP findings, the 92 subjects were divided into 15 cases with ACPBD and 77 cases without ACPBD. When a cut-off level of 25 cm/s was employed, ACPBD could be diagnosed with a sensitivity of 87.0% (13/15) and a specificity of87.3% (62/71).CONCLUSION: Measurement of GWBF velocity, which is less invasive and provides objective values, is very useful for diagnosing ACPBD prior to the development of malignant tumors in cases with gallbladder wall thickening. | Hiroki Kawashima Yoshiki Hirooka Akihiro Itoh Senju Hashimoto Terutomo Itoh Kazuo Hara Akira Kanamori Naoki Ohmiya Yasumasa Niwa Hidemi Goto | 2005 | World Journal of Gastroenterology2005，11，7： | 7 |
| 5 | Magnifying chromoscopy, a novel and useful technique for colonoscopy in ulcerative colitis显示文摘Ulcerative colitis (UC) is a chronic inflammatory bowel disorder characterized by exacerbations and remissions. The degree of inflammation as assessed by conventional colonoscopy is a reliable parameter of disease activity. However, even when conventional colonoscopy suggests remission and normal mucosal findings, microscopic abnormalities may persist, and relapse may occur later. Patients with long-standing, extensive ulcerative colitis have an increased risk of developing colorectal cancer. Ulcerative colitis-associated colorectal cancer is characterized by an early age at onset, poorly differentiated tumor cells, mucinous carcinoma, and multiple lesions. Early detection of dysplasia and colitic cancer is thus a prerequisite for survival. A relatively new method, magnifying chromoscopy, is thought to be useful for the early detection and diagnosis of dysplasia and colitic cancer, as well as the prediction of relapse. | Takafumi Ando Hironao Takahashi Osamu Watanabe Osamu Maeda Kazuhiro Ishiguro Daisuke Ishikawa Motofusa Hasegawa Naoki Ohmiya Yasumasa Niwa Hidemi Goto | 2007 | World Journal of Gastroenterology2007，13，18： | 3 |
| 6 | Azathioprine is essential following cyclosporine for patients with steroid-refractory ulcerative colitis显示文摘AIM: To evaluate long-term prognosis following cyclosporine treatment by examining the rate of surgery avoidance among cyclosporine responders.METHODS: We retrospectively reviewed clinical records for 29 patients diagnosed with severe steroid-refractory ulcerative colitis in our hospital from August 1997 to August 2008 and treated with cyclosporine by continuous intravenous infusion.All patients were treated with intravenous corticosteroids for more than 5 d prior to cyclosporine therapy.Administration was continued for up to 21 d under serum monitoring to maintain cyclosporine levels between 400 and 600 ng/mL.Clinical activity was assessed before and after cyclosporine therapy using the clinical activity index score,with a reduction of ≥ 5 considered to indicate a response.Among responders,we defined cases not requiring surgery for more than 5 years as exhibiting long-term efficacy of cyclosporine.Factors considered to be possibly predictive of long-term efficacy of cyclosporine were sex,age,disease duration,clinical activity index score,C-reactive protein level,hemoglobin level,disease extent,endoscopic findings,and clinical course.RESULTS: Cyclosporine was not discontinued due to side effects in any patient.Nineteen(65.5%) of 29 patients were considered responders.A statistically significant(P = 0.004) inverseas sociation wa s observed between an endoscopic finding of 'mucosal bleeding' and responsive cases.Fifteen(9 males,6 females) of these 19 patients were followed for 5 years or more,of whom 9(60%) exhibited long-termefficacy of cyclosporine.Of the 10 non-responders,9(90%) underwent surgery within 6 mo of cyclosporine therapy.None of the following factors had a significant impact on the long-term efficacy of cyclosporine: sex,age,duration of disease,clinical activity index score,C-reactive protein level,hemoglobin level,extent of disease,endoscopic findings,or clinical course.In contrast,a significant association was observed for maintenance therapy with azathioprine after cyclosporine therapy(P = 0.0014).CONCLUSION: Maintenance therapy with azathioprine might improve the long-term efficacy of continuously infused cyclosporine for severe steroid-refractory ulcerative colitis patients. | Nobuyuki Miyake Takafumi Ando Kazuhiro Ishiguro Osamu Maeda Osamu Watanabe Yutaka Hirayama Keiko Maeda Kazuhiro Morise Masanobu Matsushita Kazuhiro Furukawa Kohei Funasaka Masanao Nakamura Ryoji Miyahara Naoki Ohmiya Hidemi Goto | 2015 | World Journal of Gastroenterology2015，21，1： | 3 |
| 7 | Contrast-enhanced endoscopic ultrasonography in digestive diseases显示文摘 | Yoshiki Hirooka Akihiro Itoh Hiroki Kawashima Eizaburo Ohno Yuya Itoh Yosuke Nakamura Takeshi Hiramatsu Hiroyuki Sugimoto Hajime Sumi Daijiro Hayashi Naoki Ohmiya Ryoji Miyahara Masanao Nakamura Kohei Funasaka Masatoshi Ishigami Yoshiaki Katano Hidemi Got | 2012 | Journal of Gastroenterology2012，，10： | 2 |
| 8 | Contrast-enhanced endoscopic ultrasonography in digestive diseases显示文摘 | Yoshiki Hirooka Akihiro Itoh Hiroki Kawashima Eizaburo Ohno Yuya Itoh Yosuke Nakamura Takeshi Hiramatsu Hiroyuki Sugimoto Hajime Sumi Daijiro Hayashi Naoki Ohmiya Ryoji Miyahara Masanao Nakamura Kohei Funasaka Masatoshi Ishigami Yoshiaki Katano Hidemi Got | 2012 | Journal of Gastroenterology2012，，10： | 2 |
| 9 | Peripancreatic vascular involvements of autoimmune pancreatitis显示文摘 | Takuya Ishikawa Akihiro Itoh Hiroki Kawashima Eizaburo Ohno Yuya Itoh Yosuke Nakamura Takeshi Hiramatsu Ryoji Miyahara Naoki Ohmiya Jyunichi Haruta Hidemi Goto Yoshiki Hirooka | 2012 | J Gastroenterol Hepatol2012，，12： | 1 |
| 10 | Clinical usefulness of novel tag‐less A gile patency capsule prior to capsule endoscopy for patients with suspected small bowel stenosis显示文摘 | Masanao Nakamura Yoshiki Hirooka Takeshi Yamamura Ryoji Miyahara Osamu Watanabe Takafumi Ando Naoki Ohmiya Hidemi Goto | 2015 | Digestive Endoscopy2015，，1： | 1 |
| 11 | Utility of EUS: Elastography in the Diagnosis of Pancreatic Diseases显示文摘 | Yoshiki Hirooka Akihiro Itoh Senju Hashimoto Hiroki Kawashima Kazuo Hara Akira Kanamori Hiroki Uchida Jun Goto Shigeto Ishikawa Naoki Ohmiya Yasumasa Niwa Hidemi Goto | 2005 | Gastrointestinal Endoscopy2005，，5： | 1 |
| 12 | Usefulness of EUS combined with contrast-enhancement in the differential diagnosis of malignant versus benign and preoperative localization of pancreatic endocrine tumors显示文摘 | Takuya Ishikawa Akihiro Itoh Hiroki Kawashima Eizaburo Ohno Hiroshi Matsubara Yuya Itoh Yosuke Nakamura Masanao Nakamura Ryoji Miyahara Kazuhiko Hayashi Masatoshi Ishigami Yoshiaki Katano Naoki Ohmiya Hidemi Goto Yoshiki Hirooka | 2010 | Gastrointestinal Endoscopy2010，，6： | 1 |
| 13 | Outcome after enteroscopy for patients with obscure GI bleeding: diagnostic comparison between double-balloon endoscopy and videocapsule endoscopy显示文摘 | Daigo Arakawa Naoki Ohmiya Masanao Nakamura Wataru Honda Osamu Shirai Akihiro Itoh Yoshiki Hirooka Yasumasa Niwa Osamu Maeda Takafumi Ando Hidemi Goto | 2009 | Gastrointestinal Endoscopy2009，，4： | 1 |
| 14 | Value of colonoscopy for prediction of prognosis in patients with ulcerative colitis显示文摘Ulcerative colitis (UC) is a chronic inflammatory bowel disorder characterized by exacerbations and remissions. Some UC patients remain refractory to conventional medical treatment while, in others, the effectiveness of drugs is limited by side-effects. Recently, cyclosporine and leukocyte removal therapy have been used for refractory UC patients. To predict the efficacy of these therapies is important for appropriate selection of treatment options and for preparation for colectomy. Endoscopy is the cornerstone for diagnosis and evaluation of UC. Endoscopic parameters in patients with severe or refractory UC may predict a clinical response to therapies, such as cyclosporine or leukocyte removal therapy. As for the patients with quiescent UC, relapse of UC is difficult to predict by routine colonoscopy. Even when routine colonoscopy suggests remission and a normal mucosal appearance, microscopic abnormalities may persist and relapse may occur later. To more accurately identify disease activity and to predict exacerbations in UC patients with clinically inactive disease is important for deciding whether medical treatment should be maintained. Magnifying colonoscopy is useful for the evaluation of disease activity and for predicting relapse in patients with UC. | Takafumi Ando Yuji Nishio Osamu Watanabe Hironao Takahashi Osamu Maeda Kazuhiro Ishiguro Daisuke Ishikawa Naoki Ohmiya Yasumasa Niwa Hidemi Goto | 2008 | World Journal of Gastroenterology2008，14，14： | 1 |
| 15 | Intraductal Papillary Mucinous Neoplasms of the Pancreas: Differentiation of Malignant and Benign Tumors by Endoscopic Ultrasound Findings of Mural Nodules显示文摘 | Eizaburo Ohno Yoshiki Hirooka Akihiro Itoh Masatoshi Ishigami Yoshiaki Katano Naoki Ohmiya Yasumasa Niwa Hidemi Goto | 2009 | Annals of Surgery2009，，4： | 1 |
| 16 | Clinical oncology for pancreatic and biliary cancers:Advances and current limitations显示文摘In the early 2000s,the main stream of endoscopic ultrasonography(EUS)changed from a mechanical scanning method to electronic radial or linear scanning methods.Subsequently,useful applications in trans-abdominal ultrasonography came within reach of EUS.In particular,contrast-enhanced EUS(CE-EUS)and EUS-elastography became cutting-edge diagnostic modalities for pancreatic disorders.Each type of pancreatic disorder has characteristic hemodynamics.CE-EUS uses color Doppler flow imaging and harmonic imaging to classify pancreatic lesions.EUS-elastography can assess tissue hardness by measuring its elasticity.This parameter appears to correlate with the malignant potential of the lesions.Tissue elasticity studies can provide information on both its pattern and distribution.The former is the conventional method of morphological diagnosis,but it is restricted to observations made in a region of interest(ROI).The latter is an unbiased analysis that can be performed by image analysis software and is theoretically constant,regardless of the ROI.Though EUSfine needle aspiration(FNA)is also a very useful diagnostic tool,there are several limitations.Diagnostic EUS-FNA of pancreatic cystic lesions has marginal utility mainly due to low sensitivity.Therefore,in particular,endoscopists should keep this limitation in mind. | Yoshiki Hirooka Akihiro Itoh Hiroki Kawashima Eizaburo Ohno Takuya Ishikawa Yuya Itoh Yosuke Nakamura Takeshi Hiramatsu Masanao Nakamura Ryoji Miyahara Naoki Ohmiya Masatoshi Ishigami Yoshiaki Katano Hidemi Goto | 2011 | World Journal of Clinical Oncology2011，2，5： | 1 |
| 17 | Extraluminal GI stromal tumor of the jejunum diagnosed by EUS at double-balloon endoscopy显示文摘 | Masanao Nakamura Naoki Ohmiya | 2014 | Gastrointestinal Endoscopy2014，，2： | 1 |
| 18 | Use of capsule endoscopy in patients with C rohn’s disease in J apan: A multicenter survey显示文摘 | Motohiro Esaki Takayuki Matsumoto Kenji Watanabe Tetsuo Arakawa Yuji Naito Minoru Matsuura Hiroshi Nakase Toshifumi Hibi Takayuki Matsumoto Sadaharu Nouda Kazuhide Higuchi Naoki Ohmiya Hidemi Goto Sei Kurokawa Satoshi Motoya Mamoru Watanabe | 2014 | J Gastroenterol Hepatol2014，，1： | 1 |
| 19 | Neoadjuvant Oxaliplatin and Capecitabine and Bevacizumab without Radiotherapy for Poor-risk Rectal Cancer: N-SOG 03 Phase II Trial显示文摘 | Keisuke Uehara Kazuhiro Hiramatsu Atsuyuki Maeda Eiji Sakamoto Masaya Inoue Satoshi Kobayashi Yuichiro Tojima Yuichiro Yoshioka Goro Nakayama Hiroshi Yatsuya Naoki Ohmiya Hidemi Goto Masato Nagino | 2013 | Japanese Journal of Clinical Oncology2013，，10： | 1 |
| 20 | Outcome after enteroscopy for patients with obscure GI bleeding: diagnostic comparison between double-balloon endoscopy and videocapsule endoscopy显示文摘 | Daigo Arakawa Naoki Ohmiya Masanao Nakamura Wataru Honda Osamu Shirai Akihiro Itoh Yoshiki Hirooka Yasumasa Niwa Osamu Maeda Takafumi Ando Hidemi Goto | 2009 | Gastrointestinal Endoscopy2009，，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员