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| 1 | Non-invasive prediction of non-alcoholic steatohepatitis in Japanese patients with morbid obesity by artificial intelligence using rule extraction technology显示文摘AIM To construct a non-invasive prediction algorithm for predicting non-alcoholic steatohepatitis(NASH), we investigated Japanese morbidly obese patients using artificial intelligence with rule extraction technology.METHODS Consecutive patients who required bariatric surgery underwent a liver biopsy during the operation. Standard clinical, anthropometric, biochemical measurements were used as parameters to predict NASH and were analyzed using rule extraction technology. One hundred and two patients, including 79 NASH and 23 non-NASH patients were analyzed in order to create the predictionmodel, another cohort with 77 patients including 65 NASH and 12 non-NASH patients were analyzed to validate the algorithm.RESULTS Alanine aminotransferase, C-reactive protein, homeostasis model assessment insulin resistance, albumin were extracted as predictors of NASH using a recursive-rule extraction algorithm. When we adopted the extracted rules for the validation cohort using a highly accurate rule extraction algorithm, the predictive accuracy was 79.2%. The positive predictive value, negative predictive value,sensitivity and specificity were 88.9%, 35.7%, 86.2% and 41.7%, respectively.CONCLUSION We successfully generated a useful model for predicting NASH in Japanese morbidly obese patients based on their biochemical profile using a rule extraction algorithm. | Daisuke Uehara Yoichi Hayashi Yosuke Seki Satoru Kakizaki Norio Horiguchi Hiroki Tojima Yuichi Yamazaki Ken Sato Kazuki Yasuda Masanobu Yamada Toshio Uraoka Kazunori Kasama | 2018 | World Journal of Hepatology2018，10，12： | 2 |
| 2 | Electrophysiological study on the pathology of synkinesis after facial nerve paralysis 显示文摘 | Maeyama H Aoyagi M Tojima H | 1994 | Acta Otolaryngol1994，，： | 1 |
| 3 | Beta-cyclodextrin-linked chitosan beads: preparation and application to removal of bisphenol A from water显示文摘 | Nishiki M Tojima T Nishi N | 2000 | Carbohydr Lett2000，4，： | 1 |
| 4 | NAK is an Ikappa B kinase-activating kinase 显示文摘 | Tojima Y Fujimoto A Delhase M | 2000 | Nature2000，404，： | 1 |
| 5 | NAK is an Ikappa B kinase-activating kinase显示文摘 | Tojima Y Fujimoto A Delhase M | 2000 | Nature2000，404，： | 1 |
| 6 | Gd-DTPA enhanced MRI in Ram say Hunt syndrome显示文摘 | Tada Y Aoyagi M Tojima H | 1994 | Ac-ta Otolaryngol Suppl stocrh1994，511，： | 1 |
| 7 | NAK is an I kappaB kinase activating kinase 显示文摘 | Tojima Y Fujimoto A Delhase M | 2007 | Nature2007，404，6779： | 1 |
| 8 | Diagnosis and treatment for Bell's palsy associated with diabetes mellitus显示文摘 | SATITO O AOYAGI M TOJIMA H | 1994 | Acta Otolaryngol Suppl1994，，： | 1 |
| 9 | Eleetrophysiological study on the pathology of synkinesis after facial nerve paralysis显示文摘 | Maeyama H Aoyagi M Tojima H | 1994 | Ac- ta Otolaryngol1994，511，： | 1 |
| 10 | β-cyclodextrin-linked Chitosan Beads: Preparation and Application to Removal of Bisphenol A from Water显示文摘 | Nishiki M Tojima T Nishi N | 2000 | Carbohydrate Letter2000，4，1： | 1 |
| 11 | Utility of elastography for differential diagnosis of benign and malignant thyroid nodules 显示文摘 | Kagoya R Monobe H Tojima H | 2010 | Otolaryngol Head Neck Surg2010，143，2： | 1 |
| 12 | Ligand dependent hepatic gene expression profiles of nuclear receptors CAR and PXR显示文摘 | Tojima H | 2012 | Toxicol Lett2012，212，3： | 1 |
| 13 | Gd-DTPA enhanced MRI in Ramsay Hunt syndrome显示文摘 | Tada Y Aoyagi M Tojima H | 1994 | Acta Otolaryngol Suppl1994，511，： | 1 |
| 14 | A cyclic AMP-regulated negative feedforward system for neurogenesis revealed in a neuroblastoma X glioma hybrid cell line显示文摘 | Tojima T Ito E | 2001 | Neuroscience2001，104，2： | 1 |
| 15 | Utility of elastography for differential diagnosis of benign and malignant thyroid nodules显示文摘 | Kagoya R Monobe H Tojima H | 2010 | Otolaryngol Head Neck Surg2010，143，2： | 1 |
| 16 | Hepatocyte growth factor overexpression ameliorates liver inflammation and fibrosis in a mouse model of nonalcoholic Steatohepatitis 显示文摘 | Tojima H Kakizaki S Kosone T | 2011 | Hepatol Int2011，6，3： | 1 |
| 17 | Successful treatment of rhino-orbital mucormycosis by a new combination therapy with liposomal amphotericin B and micafungin显示文摘 | Ogawa T Takezawa K Tojima I | 2012 | Auris Nasus Larynx2012，39，2： | 1 |
| 18 | Identification of SAMT family proteins as substrates of March11 in mouse spermatids显示文摘 | Yogo K Tojima H Ohno JY | 2012 | Histochem Cell Biol2012，137，1： | 1 |
| 19 | 查看详情显示文摘 | Shiono Y Motoki S Koseki T Murayama T Tojima M Kimura K | | 0，，： | 1 |
| 20 | Heparin inhibits mucus hypersecretion in airway epithelial cells显示文摘 | Ogawa T Shimizu S Tojima I | | 0，，2： | 1 |
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