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| 1 | Effects of oral tacrolimus as a rapid induction therapy in ulcerative colitis显示文摘AIM:To determine the efficacy and safety of rapid induction therapy with oral tacrolimus without a meal in steroid-refractory ulcerative colitis(UC)patients.METHODS:This was a prospective,multicenter,observational study.Between May 2010 and August 2012,49 steroid-refractory UC patients(55 flare-ups)were consecutively enrolled.All patients were treated with oral tacrolimus without a meal at an initial dose of 0.1mg/kg per day.The dose was adjusted to maintain trough whole-blood levels of 10-15 ng/m L for the first 2 wk.Induction of remission at 2 and 4 wk after tacrolimus treatment initiation was evaluated using Lichtiger’s clinical activity index(CAI).RESULTS:The mean CAI was 12.6±3.6 at onset.Within the first 7 d,93.5%of patients maintained high trough levels(10-15 ng/m L).The CAI significantly decreased beginning 2 d after treatment initiation.At 2wk,73.1%of patients experienced clinical responses.After tacrolimus initiation,31.4%and 75.6%of patients achieved clinical remission at 2 and 4 wk,respectively.Treatment was well tolerated.CONCLUSION:Rapid induction therapy with oral tacrolimus shortened the time to achievement of appropriate trough levels and demonstrated a high remission rate 28 d after treatment initiation.Rapid induction therapy with oral tacrolimus appears to be a useful therapy for the treatment of refractory UC. | Ken Kawakami Takuya Inoue Mitsuyuki Murano Ken Narabayashi Sadaharu Nouda Kumi Ishida Yosuke Abe Koji Nogami Nobuyuki Hida Hirokazu Yamagami Kenji Watanabe Eiji Umegaki Shiro Nakamura Tetsuo Arakawa Kazuhide Higuchi | 2015 | World Journal of Gastroenterology2015，21，6： | 3 |
| 2 | Structure-activity relationships of carbapenems to the antagonism of the antipseudomonal activity of other beta-lactam agents and to the be ta -lactamase inducibility in Pseudomonas aeruginosa:effects of l beta -methyl group and C-2 side chain显示文摘 | Kanazawa K Nouda H Sumita Y | 1999 | J Antibiot(Tokyo)1999，52，： | 1 |
| 3 | Adjacent vertebral body fracture following vertebroplasty with polymethylmethacry- late or calcium phosphate cement : biomechanical evaluation of the cadaveric spine 显示文摘 | Nouda S Tomita S Kin A | 2009 | Spine (Phila Pa 1976)2009，34，： | 1 |
| 4 | Antimicrobial activity of SM-17466,a novel carbapenem antibiotic with potent activity against methicillin-resistant staphylococcus aureus显示文摘 | Sumita Y Nouda H Kanazawa K | 1995 | Antimicrob Agents Chemother1995，39，4： | 1 |
| 5 | Antipseudomonal activity of carbapenem antibiotics显示文摘 | Sunagaw AM Kanazaw AK Nouda H | 2000 | Jpn J Antibiot2000，53，7： | 1 |
| 6 | Structure-activity relationships of carbapenems to the antagonism of the antipseudomonal activity of other beta-lactam agents and to the beta-lactamase inducibility in Pseudomonas aeruginosa: effects of lbeta-methyl group and C-2 side chain显示文摘 | Nouda H Sumita Y | 1999 | JAntibiot Tokyo1999，52，： | 1 |
| 7 | Adjacent VertebralBody Fracture Following Vertebroplasty With Polymethylmethacry-late or Calcium Phosphate Cement 显示文摘 | Shinya Nouda Seiji Tomita Akihiro Kin ct al | 2009 | Spine2009，34，24： | 1 |
| 8 | Antibacterial activities of SM-17466, a novel carbapenem antibiotic with potent activity against methicillin-resistant Staphylococcus aureus 显示文摘 | SUMITA Y NOUDA H KANASAWA K | 1995 | Antimicrob Agents Chemother1995，39，4： | 1 |
| 9 | Isolation and identification of 3-methylcrotonyl coenzyme A carboxylase cDNAs and pyruvate carboxylase, and their expression in red seabream (Pagrus major) organs显示文摘 | Abe S Chamnan C Miyamoto K Minamino Y Nouda M | 2004 | Mar Biotechnol (NY)2004，6，6： | 1 |
| 10 | Structural features of carbapenem compounds for nephrotoxicity : effect of c-2 side chain显示文摘 | Nouda H Matsumra H Tanto T | 1996 | J Antibiot1996，49，： | 1 |
| 11 | Adjacent vertebral body fracture following vertebroplasty with polymethylmethacrylate or calcium phosphate cement:biomechanical evaluation of the cadaveric spine显示文摘 | Nouda S Tomita S Kin A | 2009 | Spine(Phila Pa 1976)2009，34，24： | 1 |
| 12 | Adjacent vertebral body fracture following vertebroplasty with polymethylmethacrylate or calcium phosphate cement:biomechanical evaluation of the cadaveric spine显示文摘 | Nouda S Tomita S Kin A | | 0，，1976： | 1 |
| 13 | Adjacent vertebral body fracture following vertebroplasy with polymethylmethacrylate or calcium phosphate cement显示文摘 | Nouda S Tomita S Kin A | 2009 | Spine2009，34，24： | 1 |
| 14 | Preventive effect of irsogladine or omeprazole on non-steroidal anti-inflam- matory drug-induced esophagitis, peptic ulcers, and small intestinal lesions in humans, a prospective randomized controlled study显示文摘 | Kuramoto T Umegaki E Nouda S | 2013 | BMC Gastroenterol2013，13，： | 1 |
| 15 | Antipseudomonal activity of carbapenem antibiotics 显示文摘 | Kanazawa K Nouda H | 2000 | Jpn J Antibiot2000，53，7： | 1 |
| 16 | Antimicrobial activity of SM-17466, a novel carbapenem antibiotic with potent activity against methicillin-resistant Staphylococcus aureus显示文摘 | SUMITA Y NOUDA H KANAZAWA K | 1995 | Antimicrob Agents Chemother1995，39，4： | 1 |
| 17 | Use of capsule endoscopy in patients with C rohn’s disease in J apan: A multicenter survey显示文摘 | Motohiro Esaki Takayuki Matsumoto Kenji Watanabe Tetsuo Arakawa Yuji Naito Minoru Matsuura Hiroshi Nakase Toshifumi Hibi Takayuki Matsumoto Sadaharu Nouda Kazuhide Higuchi Naoki Ohmiya Hidemi Goto Sei Kurokawa Satoshi Motoya Mamoru Watanabe | 2014 | J Gastroenterol Hepatol2014，，1： | 1 |
| 18 | Structure-actlvlty Relationships of Carbapenems to the Antagonism of the Antipseudomonal Activity of Other Beta-lactam Agents and to the Beta-lactamase Inducibility in Pseudomonas Aeruginosa: Effects of 1 Beta-methyl Group and C-2 Side Chain显示文摘 | Kanazawa K Nouda H Sumita Y | 1999 | J Antiblot1999，52，2： | 1 |
| 19 | Development and future of ultraviolet light-emitting diodes: UV-LED will replace the UV lamp显示文摘 | Yoshihiko Muramoto Masahiro Kimura Suguru Nouda | 2014 | Semiconductor Science and Technology2014，，8： | 1 |
| 20 | Adjacent vertebral body fracture following vertebroplasty with polymethylmethacrylate or calcium phosphate cement显示文摘 | Nouda S Tomita S Kin A | 2009 | Spine2009，34，24： | 1 |
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