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| 1 | Protocol for laparoscopic cholecystectomy: Is it rocket science?显示文摘Laparoscopic cholecystectomy(LC) does not require advanced techniques, and its performance has therefore rapidly spread worldwide. However, the rate of biliary injuries has not decreased. The concept of the critical view of safety(CVS) was first documented two decades ago. Unexpected injuries are principally due to misidentification of human factors. The surgeon's assumption is a major cause of misidentification, and a high level of experience alone is not sufficient for successful LC. We herein describe tips and pitfalls of LC in detail and discuss various technical considerations.Finally, based on a review of important papers and our own experience, we summarize the following mandatory protocol for safe LC:(1) consideration that a high level of experience alone is not enough;(2) recognition of the plateau involving the common hepatic duct and hepatic hilum;(3) blunt dissection until CVS exposure;(4) Calot's triangle clearance in the overhead view;(5) Calot's triangle clearance in the view from underneath;(6) dissection of the posterior right side of Calot's triangle;(7) removal of the gallbladder body; and(8) positive CVS exposure. We believe that adherence to this protocol will ensure successful and beneficial LC worldwide, even in patients with inflammatory changes and rare anatomies. | Tomohide Hori Fumitaka Oike Hiroaki Furuyama Takafumi Machimoto Yoshio Kadokawa Toshiyuki Hata Shigeru Kato Daiki Yasukawa Yuki Aisu Maho Sasaki Yusuke Kimura Yuichiro Takamatsu Masato Naito Masaya Nakauchi Takahiro Tanaka Daigo Gunji Kiyokuni Nakamura Kiyoko Sato Masahiro Mizuno Taku Iida Shintaro Yagi Shinji Uemoto Tsunehiro Yoshimura | 2016 | World Journal of Gastroenterology2016，22，47： | 3 |
| 2 | Laparoscopic-assisted catheter insertion for continuous ambulatory peritoneal dialysis:A case report of simple technique for optimal placement显示文摘A 40-year-old male underwent tube placement surgery for continuous ambulatory peritoneal dialysis(CAPD).A2-cm skin incision was made,and the peritoneum was reflected enough to perform secure fixation.A swannecked,double-felted silicone CAPD catheter was inserted,and the felt cuff was sutured to the peritoneum to avoid postoperative leakage.An adequate gradient for tube fixation to the abdominal wall was confirmed.The CAPD tube was passed through a subcutaneous tunnel.Aeroperitoneum was induced to confirm that there was no air leakage from the sites of CAPD insertion.Two trocars were placed,and we confirmed that the CAPD tube led to the rectovesical pouch.Tip position was reliably observed laparoscopically.Optimal patency of the CAPD tube was confirmed during surgery.Placement of CAPD catheters by laparoscopic-assisted surgery has clear advantages in simplicity,safety,flexibility,and certainty.Laparoscopic technique should be considered the first choice for CAPD tube insertion. | Tomohide Hori Masaya Nakauchi Kazuhiro Nagao Fumitaka Oike Takahiro Tanaka Daigo Gunji Noriyuki Okada | 2013 | World Journal of Gastrointestinal Surgery2013，5，10： | 2 |
| 3 | Hematogenous umbilical metastasis from colon cancer treated by palliative single-incision laparoscopic surgery显示文摘Sister Mary Joseph’s nodule(SMJN)is a rare umbilical nodule that develops secondary to metastatic cancer.Primary malignancies are located in the abdomen or pelvis.Patients with SMJN have a poor prognosis.An 83-year-old woman presented to our hospital with a1-month history of a rapidly enlarging umbilical mass.Endoscopic findings revealed advanced transverse colon cancer.computer tomography and fluorodeoxyglucose-positron emission tomography revealed tumors of the transverse colon,umbilicus,right inguinal lymph nodes,and left lung.The feeding arteries and drainage veins for the SMJN were the inferior epigastric vessels.Imaging findings of the left lung tumor allowed for identification of the primary lung cancer,and a diagnosis of advanced transverse colon cancer with SMJN and primary lung cancer was made.The patient underwent local resection of the SMNJ and subsequent single-site laparoscopic surgery involving right hemicolectomy and paracolic lymph node dissection.Intra-abdominal dissemination to the mesocolon was confirmed during surgery.Histopathologically,the transverse colon cancer was confirmed to be moderately differentiated tubular adenocarcinoma.We suspect that SMJN may occur via a hematogenous pathway.Although chemotherapy for colon cancer and thoracoscopic surgery for the primary lung cancer were scheduled,the patient and her family desired home hospice.Seven months after surgery,she died of rapidly growing lung cancer. | Tomohide Hori Noriyuki Okada Masaya Nakauchi Shuji Hiramoto Ayako Kikuchi-Mizota Masahisa Kyogoku Fumitaka Oike Hidemitsu Sugimoto Junya Tanaka Yoshiki Morikami Kaori Shigemoto Toyotsugu Ota Masanobu Kaneko Masato Nakatsuji Shunji Okae Takahiro Tanaka Daigo Gunji Akira Yoshioka | 2013 | World Journal of Gastrointestinal Surgery2013，5，10： | 2 |
| 4 | Enzyme-mediated hydrolytic activation of prodrugs显示文摘Prodrug design is an important part of drug discovery.Prodrugs can offer many advantages over parent drugs such as increased solubility,enhanced stability,improved bioavailability,reduced side effects,and better selectivity.Many prodrugs have been used successfully in the clinic;examples include oseltamivir in anti-influenza therapy,enalapril in anti-hypertension therapy,capecitabine in cancer therapy,and omeprazole in the treatment of peptic ulcer.A key step in prodrug design is the incorporation of an activation mechanism that can convert the prodrug into the active species in an efficient and/or controlled manner to meet the needs of a given medical application.Prodrug activation can be achieved through enzyme-mediated hydrolytic or oxidoreductive processes while activation of some prodrugs may proceed through pure chemical nonenzymatic processes.This review focuses on the hydrolytic enzymes that have been used in prodrug activation,including transferases,hydrolases,and lyases. | Yan-hui Yang Herve Aloysius Daigo Inoyama Yu Chen Long-qin Hun | 2011 | Acta Pharmaceutica Sinica B2011，1，3： | 2 |
| 5 | Skull metastasis from hepatocellular carcinoma with chronic hepatitis B显示文摘A 56-year-old male visited our hospital for evaluation of an occipital mass.Contrast computed tomography showed hypervascular enhancement with osteolytic change in the skull and a huge enhanced mass in the liver.Magnetic resonance imaging showed bone metastasis in the thoracic vertebrae.Assays for hepatitis B surface antigen and hepatitis B core antibody were positive and his liver condition was Child-Pugh grade A.Our diagnosis was hepatocellular carcinoma(HCC) with skull and vertebrae metastases on chronic hepatitis B.He was treated with radiation therapy for bone metastases and transcatheter arterial chemoembolization for HCC.But he developed acute respiratory failure because of aspiration pneumonia,congestion and oedema with haemorrhage of the lungs and died.Dissection showed HCC with multiple bone metastases.The liver tumor was categorized as well-differentiated HCC,Edmondson classification Ⅰ,trabecular type and pseudoglandular type.In the liver mild infiltration of lymphocytes was seen in Glisson's capsules which were signif icantly enlarged with well preserved limiting plates.Piecemeal necrosis was not obvious.No fibrosis was noted.An 8 cm × 7 cm × 3 cm metastatic lesion had formed in the left occipitotemporal part of the cranial bone.The lesion was osteolytic and showed invasion into the dura mater.Neither the subdural cavity nor the brain showed involvement from the metastatic tumor.However,skull metastasis from HCC is very rare and it affects the patient's prognosis and the quality of life.Therefore,it is very important to make an early diagnosis and carry out proper management of skull metastasis from HCC. | Takashi Goto Takahiro Dohmen Kouichi Miura Shigetoshi Ohshima Kazuo Yoneyama Tomomi Shibuya Ei Kataoka Daisuke Segawa Wataru Sato Yumiko Anezaki Hajime Ishii Daigo Kon Ikuhiro Yamada Kentaro Kamada Hirohide Ohnishi | 2010 | World Journal of Gastrointestinal Oncology2010，2，3： | 2 |
| 6 | AXINI mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1 显示文摘 | SATOH S DAIGO Y FURUKAWA Y | 2000 | Nat Genet2000，24，3： | 1 |
| 7 | Pipe wall thickness measurement by electro-magnetic acoustic transducer using hand exciting method显示文摘 | Kosaka Daigo Kojima Fumio Umetani Kosuke | 2011 | Studies in Applied Electromagnetics and Mechanics2011，35，： | 1 |
| 8 | The interstitial cells of Cajal and a gastroenteric pacemaker system显示文摘 | Takayama I Horiguchi K Daigo Y | 2002 | Arch Histol Cytol2002，65，1： | 1 |
| 9 | An improved rotor resistance identification method for magnetic field regulation in bearingless induction motor drives 显示文摘 | CHIBA Akira AKAMATSU Daigo FUKAO Tadashi | 2008 | IEEE Trans- actions on Industrial Electronics2008，55，2： | 1 |
| 10 | Plakophilin 3 oncogene as prognostic marker and therapeutic target for lung cancer显示文摘 | FURUKAWA C DAIGO Y ISHIKAWA N | 2005 | Cancer Res2005，65，16： | 1 |
| 11 | Isolation, mapping and mu- tation analysis of a human cDNA homologous to the doc- 1 gene of the Chinese hamster, a candidate tumor suppressor for oral can- cer显示文摘 | Daigo Y Suzuki K Maruyama O | 1997 | Genes Chromosomes Cancer1997，20，2： | 1 |
| 12 | Overexpression of MAD2 pre- dicts clinical outcome in primary lung cancer patients 显示文摘 | Kato T Daigo Y Aragaki M | 2011 | Lung Cancer2011，74，1： | 1 |
| 13 | Overexpression of KIAA0101 predicts poor prognosis in primary lung cancer patients显示文摘 | Kato T Daigo Y Aragaki M | 2012 | Lung Cancer2012，75，1： | 1 |
| 14 | Phosphorylation and activation of cell division cycle associated 8 by aurora kinase B plays a significant role in human lung carcinogenesis显示文摘 | Hayama S Daigo Y Yamabuki T | 2007 | Cancer Res2007，67，9： | 1 |
| 15 | Differential gene expression profile in the small intestines of mice lacking pacemaker interstitial cells of Cajal 显示文摘 | Yataro Daigo Ichiro Takayama Bruce AJ Ponder | 2003 | BMC Gastroenterology2003，3，1： | 1 |
| 16 | Aerodynamic characteristics of a two-dimensional supersonic biplane, covering its take-off to cruise conditions显示文摘 | Daigo Maruyama Kazuhiro Kusunose Kisa Matsushima | 2009 | Shock Waves2009，，6： | 1 |
| 17 | The interstitial cells of Cajal and a gastrointestinal pacemaker system 显示文摘 | Takayama I Hofiguchi K Daigo Y | 2002 | Arch Histol Cytol2002，65，1： | 1 |
| 18 | Material Stocks and Flows Accounting for Copper and Copper-based Alloys in Japan显示文摘 | Ichiro Daigo Susumu Hashimoto Yasunari Matsuno | 2009 | Resources Conservation and Recycling2009，53，： | 1 |
| 19 | A simple and reliable pretreatment protocol facilitates fluorescent in situ hybridisation on tissue microarrays of paraffin wax embedded tumor samples 显示文摘 | Chin S F Daigo Y Huang H E | 2003 | Mol Pathnl2003，56，5： | 1 |
| 20 | AXIN1 mutations in hepa- tocenular carcinomas, and growth suppression in cancer cells by virus --mediated transfer of AXINI显示文摘 | Satoh S Daigo Y Furukawa Y | 2000 | Nat Genet2000，24，3： | 1 |
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