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| 1 | Cytomegalovirus infection in severe ulcerative colitis patients undergoing continuous intravenous cyclosporine treatment in Japan显示文摘AIM: To investigate active cytomegalovirus (CMV) infection following the cyclosporine A (CyA) treatment of steroid-refractory ulcerative colitis (UC).METHODS: Twenty-three patients with severe UC not responding to steroid therapy (male 14, and female 9) enrolled at Nagoya University Hospital from 1999 to 2005. They received continuous intravenous infusion of CyA (average 4 mg/kg per day) for 1 mo. Serum and colonic biopsy samples were collected before CyA treatment and 4 d, 10 d, 20 d, and 30 d after treatment. Patients were evaluated for CMV by using serology (IgM antibody by ELISA), quantitative real-time PCR for CMV DNA, and histopathological assessment of hematoxylin and eosin (HE)-stained colonic biopsies. CMV infection was indicated by positive results in any test. RESULTS: No patients had active CMV infection before CyA treatment. Eighteen of 23 UC patients treated with CyA were infected with active CMV (IgM antibody in 16/23 patients, 69.6%; CMV DNA in 18/23 patients, 78.2%; and inclusion bodies in 4/23 patients, 17.3%). There was no difference in the active CMV-infection rate between males and females. Active CMV infection was observed after approximately 8 d of CyA treatment, leading to an exacerbation of colitis. Fifteen of these 18 patients with active CMV infection (83.3%) required surgical treatment because of severe deteriorating colitis. Treatment with ganciclovir rendered surgery avoidable in three patients. CONCLUSION: Our results suggest that active CMVinfection in severe UC patients treated with CyA is associated with poor outcome. Further, ganciclovir is useful for treatment of CMV-associated UC after immuno-suppressive therapy. | Masaaki Minami Michio Ohta Teruko Ohkura Takafumi Ando Naoki Ohmiya Yasumasa Niwa Hidemi Goto | 2007 | World Journal of Gastroenterology2007，13，5： | 13 |
| 2 | 用于空气中水蒸气吸-脱附的微孔泡沫炭制备研究(英文)显示文摘以蜜胺泡沫体为模板,采用氟化聚酰亚胺制备了微孔泡沫炭。测定了其对环境中水气的吸附/脱附行为,发现:泡沫炭在空气中400℃活化1h,可以提高其对水气的吸附能力。与活化前相比,对水气的吸附量几乎高达3倍,尽管其微孔容积仅增大了1.5倍。对环境水气中的可逆吸附率与微孔容积成线性关系,微孔容积为0.75mL/g的泡沫炭,其水气吸附率约为质量分数40%。 | Naoto Ohta Yoko Nishi Takahiro Morishita Yumiko Ieko Akifumi Ito Michio Inagaki | 2008 | 新型炭材料2008，23，3： | 7 |
| 3 | Survival of geriatric patients after percutaneous endoscopic gastrostomy in Japan显示文摘AIM: To examine the long term survival of geriatric patients treated with percutaneous endoscopic gastrostomy (PEG) in Japan. METHODS: We retrospectively included 46 Japanese community and tertiary hospitals to investigate 931 consecutive geriatric patients (≥ 65 years old) with swallowing difficulty and newly performed PEG between Jan 1st 2005 and Dec 31st 2008. We set death as an outcome and explored the associations among patient’s characteristics at PEG using log-rank tests and Cox proportional hazard models. RESULTS: Nine hundred and thirty one patients were followed up for a median of 468 d. A total of 502 deaths were observed (mortality 53%). However, 99%, 95%, 88%, 75% and 66% of 931 patients survived more than 7, 30, 60 d, a half year and one year, respectively. In addition, 50% and 25% of the patients survived 753 and 1647 d, respectively. Eight deaths were considered as PEG-related, and were associated with lower serum albumin levels (P = 0.002). On the other hand, among 28 surviving patients (6.5%), PEG was removed. In a multivariate hazard model, older age [hazard ratio (HR), 1.02; 95% confidence interval (CI), 1.00-1.03; P = 0.009], higher C-reactive protein (HR, 1.04; 95% CI: 1.01-1.07; P = 0.005), and higher blood urea nitrogen (HR, 1.01; 95% CI: 1.00-1.02; P = 0.003) were significant poor prognostic factors, whereas higher albumin (HR, 0.67; 95% CI: 0.52-0.85; P = 0.001), female gender (HR, 0.60; 95% CI: 0.48-0.75; P < 0.001) and no previous history of ischemic heart disease (HR, 0.69; 95% CI: 0.54-0.88, P = 0.003) were markedly better prognostic factors. CONCLUSION: These results suggest that more than half of geriatric patients with PEG may survive longer than 2 years. The analysis elucidated prognostic factors. | Yutaka Suzuki Seryna Tamez Akihiko Murakami Akihiko Taira Akihiro Mizuhara Akira Horiuchi Chie Mihara Eiji Ako Hirohito Muramatsu Hitoshi Okano Hitoshi Suenaga Kazuaki Jomoto Junya Kobayashi Katsunari Takifuji Kazuhiro Akiyama Koh Tahara Koji Onishi Makoto Shimazaki Masami Matsumoto Masashi Ijima Masato Murakami Masato Nakahori Michiaki Kudo Michio Maruyama Mikako Takahashi Naohiro Washizawa Shigeru Onozawa Satoshi Goshi Satoyoshi Yamashita Shigeki Ono Shin Imazato Shinji Nishiwaki Shuichirou Kitahara Takao Endo Takao Iiri Takeshi Nagahama Takuto Hikichi Tatsuya Mikami Tetsuo Yamamoto Tetsushi Ogawa Tomoko Ogawa Tomoyuki Ohta Toshifumi Matsumoto Toshiroh Kura Tsutomu Kikuchi Tsuyoshi Iwase Tsuyotoshi Tsuji Yukio Nishiguchi Mitsuyoshi Urashima | 2010 | World Journal of Gastroenterology2010，16，40： | 4 |
| 4 | Lymph node metastasis and preoperative diagnosis of depth of invasion in early gastric cancer显示文摘 | Yasuyuki Seto Shouji Shimoyama Jouji Kitayama Kenichi Mafune Michio Kaminishi Takashi Aikou Kuniyoshi Arai Keiichiro Ohta Atsushi Nashimoto Ichiro Honda Hisakazu Yamagishi Yoshitaka Yamamura | 2001 | Gastric Cancer2001，，1： | 1 |
| 5 | Immunocytochemical localization of BGP in human bones in various developmental stages and pathological conditions显示文摘 | Takayuki Ohta Michio Mori Katsuhiro Ogawa Toshikatsu Matsuyama Seiichi Ishii | 1989 | Virchows Archiv A Pathological Anatomy and Histopathology1989，，5： | 1 |
| 6 | Use of a Combination of Brushing Technique and the Loop-Mediated Isothermal Amplification Method as a Novel,Rapid,and Safe System for Detection of Helicobacter pylori显示文摘 | MASAAKI MINAMI MICHIO OHTA TERUKO OHKURA | 2006 | Journal of Clincal Microbiology2006，44，11： | 1 |
| 7 | Voxel- and ROI-based statistical analyses of PET parameters for guidance in the surgical treatment of intractable mesial temporal lobe epilepsy显示文摘 | Yoshihisa Ohta Tadashi Nariai Kenji Ishii Kiichi Ishiwata Masahiro Mishina Michio Senda Kimiyoshi Hirakawa Kikuo Ohno | 2008 | Annals of Nuclear Medicine2008，，： | 1 |
| 8 | Relationship between the awareness of salt restriction and the actual salt intake in hypertensive patients 显示文摘 | Yuko OHTA Takuya TSUCHIHASHI Michio UENO | 2004 | Hypertens Res2004，27，4： | 1 |
| 9 | Lymph node metastasis and preoperative diagnosis of depth of invasion in early gastric cancer显示文摘 | Yasuyuki Seto Shouji Shimoyama Jouji Kitayama Kenichi Mafune Michio Kaminishi Takashi Aikou Kuniyoshi Arai Keiichiro Ohta Atsushi Nashimoto Ichiro Honda Hisakazu Yamagishi Yoshitaka Yamamura | 2001 | Gastric Cancer2001，，1： | 1 |
| 10 | Application of IgY to sandwich enzyme-linked immunosorbent assays, lateral flow devices, and immunopillar chips for detecting staphylococcal enterotoxins in milk and dairy products显示文摘 | Wanchun Jin Keiko Yamada Mai Ikami Noritada Kaji Manabu Tokeshi Yusuke Atsumi Makoto Mizutani Atsushi Murai Akira Okamoto Takao Namikawa Yoshinobu Baba Michio Ohta | 2013 | Journal of Microbiological Methods2013，，3： | 1 |
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