|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Direct reprogramming of human fibroblasts into dopaminergic neuron-like cells显示文摘外长的 dopaminergic 神经原(DA 神经原) 的移植是为治疗 Parkinson 的疾病(PD ) 的一条有希望的途径。然而,主要跌倒块是施主 DA 神经原的可靠来源的缺乏。这里,我们证明五 transcriptional 因素 Mash1, Ngn2, Sox2, Nurr1,和 Pitx3 的联合直接并且有效地装改编人成纤维细胞进 DA 像神经原的房间。为为 DA 神经原的各种各样的标记积极的染色的 reprogrammed 房间。他们也显示出典型 DA 举起和生产性质。而且,他们展出了 DA 神经原特定的 electrophysiological 侧面。最后,他们在一个老鼠 PD 模型提供了征兆的地势。因此,我们的直接 reprogrammed DA 像神经原的房间是为 PD 的房间代替治疗的有希望的来源。 | Xinjian Liu Fang Li Elizabeth A Stubblefield Barbara Blanchard Toni L Richards Gaynor A Larson Yujun He Qian Huang Aik-Choon Tan Dabing Zhang Timothy A Benke John R Sladek Nancy R Zahniser Chuan-Yuan Li | 2012 | Cell Research2012，22，2： | 14 |
| 2 | 男性性功能障碍、男性不育与神经系统疾病之间的关系显示文摘正常的性功能和生殖功能很大程度上依赖于神经系统功能的正常发挥。男性神经系统受损可导致勃起功能障碍、射精障碍和精液异常,进而导致不育。出现这些受损的主要原因有盆腔和腹腔损伤、糖尿病、先天性脊柱异常,多发性硬化症和脊髓受损。勃起功能障碍已经可以通过越来越具侵入式的治疗方法而有所改善,从药物疗法、注射疗法到外科的阴茎植入术。病情较轻的逆行射精患者可以用药物来逆转条件进行治疗,对病情较重的患者,则在射精后从其膀胱中收取精液。对于中度的不射精者,可以采用药物治疗:而对于严重者,则可采用阴茎震荡刺激和电射精等辅助射精技术。假如这些措施都失败了,可尝试采用手术方法取精液。对于一些脊髓受损的男性,假如环境条件和精液质量足够好,可在家中采用阴茎震荡刺激,然后将精液放入伴侣阴道内。其他方法就要求助于辅助生殖技术了,包括宫内受精和体外受精(用ICSI或者不用)。选用何种方法在很大程度上依赖于患者精液中活性精子的数量。 | Mikkel Fode Sheila Krogh-Jespersen Nancy L Brackett Dana A Ohl Charles M Lynne Jens Sonksen | 2012 | Asian Journal of Andrology2012，14，1： | 7 |
| 3 | 瑞典双生子人群2型糖尿病与非黑色素瘤皮肤癌关系的研究显示文摘目的探讨2型糖尿病与非黑色素瘤皮肤癌(non-melanoma skin cancer,NMSC)的关系,以及遗传和早期生活环境因素在该关联中的作用,为预防NMSC提供理论依据。方法于1998-2002年,对瑞典全国双生子登记系统中1958年及以前出生的41115名未患癌症者进行基线调查,通过电话访问收集研究对象的人口学特征、生活方式、人体测量指标以及疾病史(糖尿病史和糖尿病用药史)等信息,通过瑞典住院患者登记系统、药物使用登记系统和癌症登记系统随访收集从基线调查至2014年12月31日期间NMSC等疾病的发病信息。采用SPSS20.0软件进行独立样本t检验、χ^2检验和logistic回归分析,采用Stata13.0软件进行广义估计方程(generalized estimating equation,GEE)分析和条件logistic回归分析。结果随访期间共发生NMSC2372例(7.04%),NMSC组和非癌症组(31332例)平均年龄、体质指数(BMI)、受教育程度、双生子类型、婚姻状况、吸烟、过量饮酒和2型糖尿病患病情况的差异均有统计学意义(P<0.01)。以上述NMSC患者为病例组,非癌症者为对照组(非匹配设计),多因素GEE分析结果显示,2型糖尿病是NMSC的保护因素,有统计学意义(OR=0.740,95%CI:0.642~0.853,P<0.05)。然而,以双生子对子中患NMSC者为病例,另一非癌症的双生子为对照(配对设计),多因素条件logistic回归分析结果显示,2型糖尿病与NMSC的关联没有统计学意义(OR=0.914,95%CI:0.632~1.323,P>0.05)。两种分析方法得到的OR值的差异具有统计学意义(OR=0.805,95%CI:0.656~0.989,P<0.05)。结论2型糖尿病可能降低NMSC的发病风险,但该保护作用可能是由于遗传和早期生活环境因素导致的。 | 汪煜 杨蓉蓉 包翠萍 徐会 宋瑞雪 齐秀英 PEDERSEN Nancy L 徐卫历 | 2019 | 中国慢性病预防与控制2019，27，5： | 6 |
| 4 | Interprofessional, multiple step simulation course improves pediatric resident and nursing staff management of pediatric patients with diabetic ketoacidosis显示文摘AIM To investigate the use of a multidisciplinary, longitudinal simulation to educate pediatric residents and nurses on management of pediatric diabetic ketoacidosis.METHODS A multidisciplinary, multiple step simulation course was developed by faculty and staff using a modified Delphi method from the Pediatric Simulation Center and pediatric endocrinology department. Effectiveness of the simulation for the residents was measured with a pre- and post-test and a reference group not exposed to simulation. A follow up post-test was completed 3-6 mo after the simulation. Nurses completed a survey regarding the education activity. RESULTS Pediatric and medicine-pediatric residents(n = 20) and pediatric nurses(n = 25) completed the simulation course. Graduating residents(n = 16) were used as reference group. Pretest results were similar in the control and intervention group(74% ± 10% vs 76% ± 15%, P = 0.658). After completing the intervention, participants improved in the immediate post-test in comparison to themselves and the control group(84% ± 12% post study; P < 0.05). The 3-6 mo follow up post-test results demonstrated knowledge decay when compared to their immediate post-test results(78% ± 14%, P = 0.761). Residents and nurses felt the interdisciplinary and longitudinal nature of the simulation helped with learning.CONCLUSION Results suggest a multidisciplinary, longitudinal simulation improves immediate post-intervention knowledge but important knowledge decay occurs, future studies are needed to determine ways to decrease this decay. | Linnea M Larson-Williams Amber Q Youngblood Dawn Taylor Peterson J Lynn Zinkan Marjorie L White Hussein Abdul-Latif Leen Matalka Stephen N Epps Nancy M Tofil | 2016 | World Journal of Critical Care Medicine2016，5，4： | 4 |
| 5 | Heart Disease and Stroke Statistics—2009 Update: A Report From the American Heart Association Statistics Committee and Stroke Statistics Subcommittee显示文摘 | Donald Lloyd-Jones Robert Adams Mercedes Carnethon Giovanni De Simone T Bruce Ferguson Katherine Flegal Earl Ford Karen Furie Alan Go Kurt Greenlund Nancy Haase Susan Hailpern Michael Ho Virginia Howard Brett Kissela Steven Kittner Daniel Lackland Lynda L | 2009 | Circulation2009，，3： | 4 |
| 6 | Long-term safety of lamivudine treatment in patients with chronic hepatitis B显示文摘 | Anna S.F Lok Ching-Lung Lai Nancy Leung Guang-Bi Yao Zhen-Yu Cui Eugene R Schiff Jules L Dienstag E.Jenny Heathcote Nancy R Little Dorothea A Griffiths Stephen D Gardner Mary Castiglia | 2003 | Gastroenterology2003，，6： | 3 |
| 7 | Long-term safety of lamivudine treatment in patients with chronic hepatitis B显示文摘 | Anna S.F Lok Ching-Lung Lai Nancy Leung Guang-Bi Yao Zhen-Yu Cui Eugene R Schiff Jules L Dienstag E.Jenny Heathcote Nancy R Little Dorothea A Griffiths Stephen D Gardner Mary Castiglia | 2003 | Gastroenterology2003，，6： | 2 |
| 8 | Effects of sodium bicarbonate, disodium carbonate, and a sodium bicarbonate/carbonate mixture on the PCO2 of blood in a closed system显示文摘 | Joseph IS Nancy E Jan L | 1995 | J Lab & Clin Med1995，126，： | 2 |
| 9 | Advances in the management of infertility in men with spinal cord injury显示文摘结合一根针的绳索受伤男搭挡要求帮助射精技术收集当时能进一步的精液在各种各样的帮助繁殖技术方法使用完成怀孕。不管原因或损害的水平支撑针的绳索损害的人的多数不能在性交期间射精。仅仅一个小少数能由手淫射精。阴茎振动刺激和 electroejaculation 是过去常检索精子的二个很普通的方法。象 prostatic 按摩和另外的药的附属物申请那样的另外的技术能被使用,但是结果是不一致的。如果所有另外的方法失败,外科的精子检索应该被看作最终手段。特殊注意必须由于在损害的水平下面源于刺激的自治 dysreflexia 的风险与 T6 和损害的喙的层次对病人被给予。如果,膀胱准备应该在刺激前被执行后退射精被期望。可勃起的机能障碍在针的绳索是无所不在的伤害了人口,但是容易通常被管理并且不在这些人提出一个障碍到精液检索。有针的绳索损害的人的精液分析参数不管检索的方法为这张人口是唯一的,通常作为正常精子集中,但是反常地介绍低精子活动性和生存能力。当精子检索在这张人口被需要时,强调应该被放在开始在诉诸更多的先进、侵略的外科的过程前试试阴茎振动刺激或 electroejaculation 的简单方法上。 | Emad Ibrahim Nancy L Brackett Charles M Lynne | 2016 | Asian Journal of Andrology2016，18，3： | 2 |
| 10 | Evidence for a causal role of low energy availability in the induction of menstrual cycle disturbances during strenuous exercise training显示文摘 | Nancy I Williams Dana L Helmreich David B Parfitt | 2001 | J Clin Endocrinol Metab2001，86，： | 1 |
| 11 | Accelerated Amyloid Deposition in the Brains of Transgenic Mice Coexpressing Mutant Presenilin 1 and Amyloid Precursor Proteins显示文摘 | David R Borchelt Tamara Ratovitski Judy van Lare Michael K Lee Vicki Gonzales Nancy A Jenkins Neal G Copeland Donald L Price Sangram S Sisodia | 1997 | Neuron1997，，4： | 1 |
| 12 | Prevention and Control of Influenza with Vaccines Recommendations of the Advisory Committee on Immunization Practices (ACIP), 2010显示文摘 | Fiore Anthony E Uyeki Timothy M Broder Karen Finelli Lyn Euler Gary L Singleton James A Iskander John K Wortley Pascale M Shay David K Bresee Joseph S Cox Nancy J | 2010 | MMWR. Morbidity and Mortality Weekly Report2010，，： | 1 |
| 13 | Intraoperative ultrasound显示文摘 | Junji Machi Andrew J Oishi Nancy L Furumoto Robert H Oishi | 2004 | Surgical Clinics of North America2004，，4： | 1 |
| 14 | Systemic Naloxone Infusion May Trigger Spasticity in Patients With Spinal Cord Injury: Case Series显示文摘 | Nancy L Brackett Emad Ibrahim Andrei Krassioukov | 2007 | J Spinal Cord Med2007，30，： | 1 |
| 15 | Intertemporal price discrimination显示文摘 | Stockey Nancy L | 1979 | Quarterly Journal of Economics1979，93，3： | 1 |
| 16 | Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPs显示文摘 | SCOTT F ANTHONY L NANCY L | 2007 | Human Molecular Genetics2007，16，1： | 1 |
| 17 | pH Homeostasis in lactic acid Bacteria显示文摘 | Robert W H Nancy L N | 1993 | J Dairy sci1993，76，08： | 1 |
| 18 | Analysis of cell wall neutral sugar composition, β-galactosidase activity and related cDNA clone throughout the development of Vitis vinifera grape berries 显示文摘 | Bamavon L Thierry D Nancy T | 2000 | Plant Physiol Biochem2000，38，4： | 1 |
| 19 | pH Homeostasis in lactic acid Bacteria显示文摘 | ROBERT W H NANCY L N | 1993 | J Dairysci1993，76，8： | 1 |
| 20 | Recursive estimation of Origin-Destination Matrices from Input/Output Counts显示文摘 | NIHAN Nancy L DAVIS Gary A | 1987 | Transportation Besearch1987，21，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员